ライフサイエンスコーパス: minimal

1 under conditions where photon absorption is minimal.

2 in the brain, when systemic inflammation was minimal.

3 surrounding matter so the stopping power is minimal.

4 e regeneration after injury is thought to be minimal.

5 mall to none, and the harms of screening are minimal.

6 Results In areas with no or minimal abnormalities on CT images, small areas of incre

7 For instance, three minimal absent words of the human genome were found in E

8 irst external-memory algorithm for computing minimal absent words.

9 demonstrated a favorable safety profile with minimal acute or procedural adverse events.

10 undance in response to changes in diets with minimal additional imposed constraints on the model.

11 H2 O2 -NO cooperative anticancer effect with minimal adverse effect.

12 ntaining aza-glycine and we demonstrate that minimal alteration to the peptide backbone conformation

13 The presented design consisted of minimal alterations to the front-end of the instrument a

14 l requirement that TFP motors need to have a minimal amount of effective angular rigidity in order fo

15 proportion of patients may be treated with a minimal amount of intervention requiring 1 or 2 anti-vas

16 NMR spectra of isolated MOS indicated minimal amounts of branched saccharides.

17 Placebo effects were minimal and associated with the number of postbaseline a

18 Patients with minimal and stable ventilator settings may be suitable c

19 mpared between studies with low BPE (mild or minimal) and those with high BPE (moderate or marked) by

20 However, the degree of LV enlargement was minimal, and few participants developed a dilated LV.

21 number of neurons, viral gene expression is minimal, and infectious virus is not released.

22 es to be directly compared and determine the minimal antibody titers required to halt transmission in

23 mechanism can be created through engineering minimal antisense RNAs.

24 , on these trials the initial grip force was minimal, appropriate for the midline movement, and not t

25 of ligands specifically for Ni has received minimal attention.

26 aglycones were evaluated to determine their minimal bactericidal concentrations (MBC) against the sp

27 termolecular interactions on adsorption were minimal based on SEC analysis.

28 Minimal biofilm eradication concentration (MBEC) was det

29 M and was more prevalent in cases with no or minimal/borderline SHM.

30 attractive tool for labeling proteins with a minimal, bright tag in quantitative high-resolution imag

31 Volumetric bone changes were minimal but statistically significant, with more bone lo

32 cted interval cancers were more likely to be minimal cancers.

33 The structures provided insights into a minimal Cas9 scaffold and revealed the remarkable mechan

34 ) (uniform CD50 and variable CD58 for NLPHL; minimal CD50, bright CD58 expression for CHL).

35 that the pH switch sequence insertion caused minimal change at pH 8 but a ca. 50 degrees C drop in th

36 g event in primary glomerulopathies, such as minimal change disease and primary FSGS, and glucocortic

37 corticoid responsiveness in 35 patients with minimal change disease or primary FSGS.

38 in children with histopathologic findings of minimal change glomerulopathy and FSGS, respectively.

39 In controls, there was minimal change in J-ST point elevation, conduction delay

40 CMIP5 models indicate that there will be minimal change in storm-surge heights from 2010 to 2100

41 e THz polarization state, and which exhibits minimal change in the electric field amplitude and polar

42 nb2 mRNA and Cyclin B2 protein level undergo minimal changes during meiotic reentry.

43 is also compatible with life and results in minimal changes in gene expression.

44 These minimal changes in the MCCB could not be responsible for

45 ene expression, 3.5 months' diabetes induced minimal changes.

46 landscape model for chromatin organization [Minimal Chromatin Model (MiChroM)] to generate an ensemb

47 nd free of major functional disability, with minimal clinical symptoms.

48 quantitative evaluation of cartilage volume (minimal clinically important difference not yet defined)

49 nge of change in letters read, -121 to +101; minimal clinically important difference, 7 letters), ana

50 ale range, 0 [no pain] to 20 [extreme pain]; minimal clinically important improvement, 3.94).

51 using this integrated two-stage device with minimal cluster dissociation, 99% recovery of large clus

52 In many cases they require minimal coding, just a mathematical description of the d

53 dded at 0.1 wt % provided the most effective minimal combination of carbon substrate and inoculum to

54 ng regions between two proteins by searching minimal common sequence fragments of the interacting pro

55 alysis looks at the subgroup of 157 men with minimal comorbidities or no comorbidity (median follow-u

56 peripheral blood mononuclear cells, and had minimal complement-dependent cytotoxicity activity simil

57 d visual recovery, good visual outcomes, and minimal complications in most patients.

58 urization, in the presence of H2S gas with a minimal concentration in ppm range.

59 Release from this ground state in minimal conditions offers a system for delineating devel

60 witching motility emerges from these initial minimal conditions.

61 Both implementations require minimal configuration while remaining flexible to experi

62 suggested that B. subtilis sigma1.1 requires minimal conformational changes for accommodating RNAP in

63 discuss a set of experimental strategies and minimal consensus criteria for the validation of SUMOyla

64 tatory amino acid receptors is well studied, minimal consideration has been given to targeting mitoch

65 However, achieving even minimal control over the growth of two-dimensional later

66 of external inputs (constituting a so-called minimal control topology, or MCT).

67 can selectively remove pharmaceuticals with minimal coremoval of nutrients to enhance nutrient recov

68 There was minimal correlation between contrast use and patients' A

69 We engineered a minimal CPC comprised of the dimerized last third of the

70 on the engineering and characterization of a minimal CPC, we suggest that spindle association is impo

71 Overall, no or only minimal crestal bone changes were observed with a mean D

72 e brains of mice deficient for a gene in the minimal critical deletion region for PWS (Snord116p-/m+)

73 Cortisol in human sweat was established with minimal cross-talk for 0-48 hours post-antibody sensor f

74 IP-derived reaction deletion sets represent minimal cut sets (MCSs).

75 There are minimal data on serial FGF23 measurements in CKD.

76 ucture determination to high resolution with minimal data.A number of parameters influence the resolu

77 dmission risk to approach plateau periods of minimal day-to-day change, and (3) extent to which adjus

78 sociation, as well as for those that require minimal deactivation of the (3)MLCT state through low-ly

79 internal elastic lamina macromolecules with minimal deformation of the sensitive endothelial cell.

80 important variables (forest-averaged lowest minimal depth, 1.2 and 1.5, respectively), followed by t

81 Retreat was minimal despite oceanic and climatic conditions during t

82 e to SMO inhibitors than sporadic BCCs, with minimal development of resistance.

83 There was minimal difference between methods when statistical sign

84 rovskite-based n-i-p planar solar cells show minimal discrepancies between stabilized efficiency (19.

85 intraperitoneal (90)Y-mAbs for treatment of minimal disease and shown that such treatments are unlik

86 e a deficiency in T, B, and NK cells, showed minimal disease at cutaneous sites but developed persist

87 lished role for treating micrometastatic and minimal disease.

88 = 5% tumor involvement will be classified as minimal disease.

89 to generate targeted barcoded libraries with minimal DNA input, flexible target selection and a very

90 The minimal domain within the Int3 protein required to activ

91 We found that the minimal domains required for efficient Ede1 localization

92 g microscopy and spectroscopy, we prepared a minimal DQD in a wide band-gap semiconductor matrix.

93 Body-composition changes are minimal during lactation.

94 l, -.217 to .016; P = .02) during year 1 but minimal effect in subsequent years or on other neurocogn

95 RNA-seq analysis reveals that PHF5A-Y36C has minimal effect on basal splicing but inhibits the global

96 the extraction and settling procedure have a minimal effect on driving transformation processes.

97 r UPF1 significantly induced p53beta but had minimal effect on p53gamma.

98 epair as infants; however, patients reported minimal effect on QOL or day-to-day activities.

99 larger species of missing mammals, but has a minimal effect on small species, which take longer to be

100 RPE and retinal damage at doses that caused minimal effects in wild-type mice, and adoptive transfer

101 roles between MYPT1 and MBS85, resulting in minimal effects of MYPT1 knockout on contraction.

102 (CTF) content in secreted exosomes, but had minimal effects on APP lysosomal degradation.

103 We conclude that general anesthetics have minimal effects on bilayer properties at clinically rele

104 Knockdown had minimal effects on cell proliferation but blocked tumor

105 to enhance cofilactin filament severing with minimal effects on cofilin occupancy, whereas filament t

106 Elevated CO2 had minimal effects on plant and soil N metrics and their re

107 oimaging data suggest the gut microbiome has minimal effects on regional brain volumes at 1 and 2 yea

108 arieties in less than a year with relatively minimal effort and investment.

109 ansient and steady-state kinetics to model a minimal eight-state ATPase cycle.

110 results illustrate how sequences outside of minimal enhancer regions can evolve functionally through

111 can-intermediate group reveals insights into minimal enzymatic requirements for building a peptidogly

112 ng, or tenderness (days 8-10); and more than minimal erythema, swelling, or tenderness (days 14-21).

113 patrick skin types V to VI and I to IV, with minimal erythemal doses to monochromatic UV-B, UV-A, and

114 paper also quantifies the availability of a minimal essential set of information in large armed conf

115 n the standardized group, all patients had a minimal evaluation regardless of the type of uveitis (co

116 ss was primarily due to cell depletion, with minimal evidence of Treg conversion to a non-Foxp3-expre

117 ty onset, no evidence of estrous cycles, and minimal fecundity.

118 s and an optical fibre-based readout ensures minimal field perturbations compared to conductive probe

119 cing assays are biased toward mutations with minimal fitness impacts and fluctuation tests typically

120 CDRs predicted to bind the minimal FLAG peptide (Asp-Tyr-Lys-Asp) were grafted onto

121 mily have diverged in a radial manner from a minimal flavin-binding scaffold.

122 er is initially quenched by water, producing minimal fluorescence and no measurable singlet oxygen ge

123 e function and overall the effect sizes were minimal (fold change <1.1).

124 Minimal follow-up was 3 years with a rate of 97%.

125 lipodial motility, we systematically explore minimal free-boundary models of actin-myosin contractili

126 equences evolving following the principle of minimal frustration, which allows proteins to rapidly fo

127 s, even if the switch to aflibercept shows a minimal functional benefit over that to ranibizumab, vis

128 It is characterized by photopsia, minimal funduscopic changes, and electroretinographic ab

129 hologs reveals key amino acid residues and a minimal fusogenic peptide motif that is necessary for pr

130 PknG mutant displayed minimal growth in nutrient-limited conditions, suggestin

131 gnostic data within a short time frame, with minimal hands-on time, and can therefore potentially be

132 t cause obvious disorientation or asterixis (minimal HE [MHE]/grade 1 HE) is important.

133 unction test and histological study revealed minimal hepatocyte, biliary epithelium and vascular endo

134 uman H3N2 IAVs, suggesting that there may be minimal herd immunity in humans.

135 s feasible over this time interval even with minimal hominin introgression.

136 (WD/DD) liposarcomas has been reported to be minimal, however traditional response criteria may not a

137 and exploit their own internal models, with minimal human hand engineering.

138 otosynthetic temperature acclimation provide minimal (if any) improvement in model performance over s

139 is of the data indicates that there was only minimal impact due to the treatment in the rumen.

140 biting BET bromodomains, which resulted in a minimal impact on MYC transcription, but did not result

141 localized to the bulge site, thereby having minimal impact on the cleavage site.

142 g-DNMT3A methylates regions of interest with minimal impact on the global DNA methylome and transcrip

143 These His-tags are generally assumed to have minimal impact on the properties of the fusion protein,

144 By contrast, E2F3 repression has minimal impact on tissue proliferation or homeostasis in

145 the hospital characteristics examined had a minimal impact or no impact on the payment differential.

146 elief compared with radiotherapy alone, with minimal improvement in dysphagia progression-free surviv

147 kened basal lamina, whereas GC migration was minimal in DBP-FW animals.

148 ertebrates, but typically unidirectional and minimal in full-grown animals.

149 accumbens core and dorsal striatum, is also minimal in the shell in part due to elevated acetylcholi

150 herapy first increases costs while providing minimal incremental benefit.

151 Compound 1f was most potent with a minimal inhibitory concentration (MIC) of 12.5 mug/mL an

152 L) at concentrations 100-fold lower than the minimal inhibitory concentration against bacteria.

153 ce piperacillin underdosing when facing high minimal inhibitory concentration pathogens.

154 4 T cell proliferation requires an invariant minimal intensity of TCR signaling that is not modulated

155 al networks allow for selective binding with minimal interfaces, suggesting that binding specificity

156 Minimal intermittent stimulation led to body weight gain

157 ized clinical trials on the effectiveness of minimal interventional treatments for participants with

158 s metallized polyethylene textile achieves a minimal IR emissivity (10.1%) on the outer surface that

159 Development of a minimal keto-deoxyoctulosonate (Kdo)-lipid A domain in E

160 s stable incorporation into biomolecules and minimal kinetic isotope effect.

161 riggers exocytosis with high probability and minimal latency.

162 ing of this class of steel alloy is based on minimal lattice misfit to achieve maximal precipitate di

163 lloys by high-density nanoprecipitation with minimal lattice misfit.

164 rtation of Rubidium ((87)Rb) cold atoms with minimal loss and heating with as few as three conveyor b

165 f risk status, the proposed tests incur only minimal loss of power in relation to existing dispersion

166 chondrial-depleted cells for up to 30 d with minimal loss of viability, for longitudinal studies.

167 cells constantly recycle nutrients to ensure minimal loss of vital substrates into the urine.

168 rts directional EET to reaction centers with minimal losses due to thermal dissipation.

169 "generally recognized as safe" material with minimal, low-energy bioprocessing, two independent aquac

170 ome severity was defined by CIWA-Ar score as minimal (< 10), moderate (10-20), and severe (> 20).

171 18)F]-FDG uptake by day 4 postinfection with minimal lymph node enlargement, indicating that elevated

172 stitute, in a nonnative heterologous host, a minimal machinery capable of building Tfp.

173 otein receptor (SNARE) proteins comprise the minimal machinery that triggers fusion of transport vesi

174 table remission, pharmacologic remission, or minimal manifestations based on the Myasthenia Gravis Fo

175 DPH exhibits very minimal matrix-induced background signals for the analys

176 th an ERRAGG ratio less than 1, and received minimal mean (SD) readmission penalties (0.08% [0.12%];

177 There was a minimal mean change in central subfield thickness from b

178 te secretome of A. nosocomialis strain M2 in minimal medium and demonstrate that pathogenic Acinetoba

179 es measured in two media are necessary: in a minimal medium containing only derivatized metabolites a

180 growth and fast swimming, while evolution in minimal medium results in fast growth and slow swimming.

181 As a model system we used the lipidated minimal membrane anchor of the GTPase, N-Ras (tN-Ras).

182 ure maximal absolute coronary blood flow and minimal microcirculatory resistance.

183 raphic and MR images with the ordinal scale: minimal, mild, moderate, or marked.

184 ive drinking water conditions to determine a minimal model (3 reactions, 8 constants) applicable for

185 Using a minimal model of ill-fitting, sticky particles, we demon

186 Here, we introduce a family of minimal model systems that exhibits solid-solid phase tr

187 he principle of maximum entropy-and builds a minimal model using only three constraints: 1) protein s

188 tabolism were analyzed according to the oral minimal model.

189 n of evolvable life and what constitutes the minimal molecular basis of life remains far from complet

190 the most important correlate of success was minimal monocyte activation, as predicted by previous in

191 nd-see strategy, non-mutilating surgery, and minimal-morbidity chemotherapy (in the case of tumour pr

192 ed motif could be a necessary and sufficient minimal motif for translocation.

193 fy and amplify DNA from complex samples in a minimal number of steps.

194 between muaq and 1/(Ld - Lc) where Lc is the minimal obtainable droplet length and approximately equa

195 ge distribution of NO3(-) is anisotropic and minimal on nitrogen.

196 We formulated a minimal one-dimensional partial differential equation mo

197 The large dilution ensured minimal optical interference from the nanomaterial when

198 Conclusion Relative to MR studies with minimal or mild BPE, those with moderate or marked BPE w

199 ation after a breakthrough event is based on minimal or no clinical trial evidence.

200 ection at the point-of-care and at home with minimal or no instrumentation, it is necessary to stream

201 atinine, <25% increase from baseline) or had minimal or no transplant glomerulopathy (Banff cg0-1).

202 nterval: 0.65-0.79; p<0.0001), and a second "minimal overlap" analysis also found that ICD use was as

203 ind that Muller glia tile retinal space with minimal overlap.

204 Ps was demonstrated in aqueous solution with minimal oxygen produced at pH7.4, whereas it increased s

205 showed mathematically that there is a unique minimal pathway of unlinking replication links by reconn

206 We conclude that the minimal pathway of unlinking replication links that was

207 e from Nkx2-1(+) foregut progenitors and the minimal pathways claimed to regulate their distinct line

208 since they permit to characterize cells with minimal perturbation and manipulation, at the benefit of

209 trast, the conserved loop sequence tolerated minimal perturbations.

210 in the methotrexate group achieved clear or minimal PGA (p=0.083).

211 fold and a catalytic site characteristic of minimal PLP catalytic domains.

212 Subjects had minimal pre-existing hemagglutination inhibiting (HAI) a

213 ification of new experimental compounds with minimal prior information.

214 conds to microseconds markedly decreases the minimal pulse energy required for AP generation, providi

215 most common neuro-ophthalmologic finding was minimal pupillary reaction to light (25%).

216 wide range of physiological conditions with minimal pyruvate cycling and detects increased hepatic V

217 (II), approximately 23% of FeTOTAL, exhibits minimal reactivity with TcO4(-) and CrO4(2-) and much sl

218 analysis in a massively parallel manner with minimal reagent use.

219 370), while postnatal vaccination produced a minimal reduction, with an incidence of 728 per 100,000

220 ng persisting infection are characterized by minimal replication and genetic changes.

221 Recently, the Saccharomyces cerevisiae minimal replication reaction has been successfully recon

222 be identified initially-MISST begins with a minimal representative set of known structures and searc

223 single-cell whole-genome sequencing, with a minimal requirement for sequencing depth (>0.5X).

224 n of multiple mitogenic inputs may alter the minimal requirement for TCR signaling in CD8 T cells.

225 ration represents a novel CIA pathway with a minimal requirement of the CIA-targeting factors and rep

226 Here we define the minimal requirements for TCR antigen specificity, throug

227 , the EAACI Specialty Committee proposes the minimal requirements for training and certification of s

228 , the therapeutic mechanism is unclear, with minimal research supporting its use in RP.

229 Purpose Minimal residual disease (MRD) and genetic abnormalities

230 determine the role of end-of-induction (EOI) minimal residual disease (MRD) assessment in the identif

231 Our objective was to evaluate minimal residual disease (MRD) at the end of induction t

232 articularly leukemias, the ability to detect minimal residual disease (MRD) is increasingly influenci

233 We determined the clinical significance of minimal residual disease (MRD) levels as measured by flo

234 ng leukemia stem cells (LSCs), which sustain minimal residual disease and are responsible for CML rel

235 ation of baseline genetics and assessment of minimal residual disease are expected to further improve

236 Purpose Immunologic surveillance of minimal residual disease in chronic myelogenous leukemia

237 omposite complete responses, 5 of which were minimal residual disease negative by flow cytometry.

238 Minimal residual disease status warrants consideration a

239 Negative marrow minimal residual disease was attained in 20 (80%) of 25

240 be used to prognose patient outcome, monitor minimal residual disease, assess tumour resistance to th

241 nfirms the clinical significance of a novel, minimal residual disease-based algorithm to predict shor

242 The overall intent-to-treat minimal residual disease-negative (MRD(-)) remission rat

243 esponse, relapse, and methods of determining minimal residual disease.

244 orly understood population is referred to as minimal residual disease.

245 rement method that is fast, label-free, uses minimal resources and allows direct identification of ge

246 At least a "minimal" response occurred in 51% of the antipsychotic g

247 ant decrease in complications for M = 0 (ie, minimal risk cases) was also identified comparing the cu

248 ndoscopies than the original criteria with a minimal risk of missing VNT in most of the main etiologi

249 ies and no clinical events during follow-up (minimal-risk cohort).

250 ailable pretest variables discriminates such minimal-risk patients, for whom deferred testing may be

251 ons or exposure to ischemia alone results in minimal S-nitrosation of protein thiols.

252 ass spectrometer in approximately 20 s, with minimal sample preparation.

253 ke plasma/tissue/blood samples, CSF requires minimal sample preparation: in this protocol, only the a

254 and inorganic components, together with the minimal sample size required, demonstrate the value of t

255 Minimal sample treatment was required and the obtained r

256 rate constants and that variants lacking the minimal sequence motif bind competitively with consensus

257 B 402)] optimized for their clonal growth in minimal serum, they produced transformed foci without tr

258 plex nuclear movements seen in vivo, using a minimal set of experimentally determined ingredients.

259 such studies and scaffold technologies, but minimal side-by-side evaluation of platforms for both th

260 to at least 1 antidepressant course meeting minimal standards for treatment dose and duration, parti

261 featured participants speaking under either minimal stress, high stress, or while recovering from st

262 wt % in mono- and biactinide frameworks with minimal structural density.

263 The representations require only minimal structural input allowing straightforward implem

264 rative photostimulation strategy to identify minimal subsets of channelrhodopsin (ChR2)-expressing ne

265 ng to their topology and presented using the minimal surface area method.

266 ophases, where membranes conform to periodic minimal surfaces dividing two nonpenetrating aqueous sub

267 with radiographic evidence of metastases and minimal symptoms, enzalutamide or abiraterone plus predn

268 ection following ischemic injury in vivo The minimal syntaxin 1A-binding sequence of Kv2.1 C terminus

269 An easily accessible (minimal synthetic steps) and structurally planar selenop

270 This result holds for both minimal synthetic viral circuits and full-length virus.

271 hing higher molecular weight copolymers with minimal termination.

272 us growth and size oscillations, we create a minimal theoretical framework for the growth and dynamic

273 We identified the minimal threshold that the participants could detect, an

274 For uniaxial ZnO and LaAlO3, which have minimal THz absorption across the measurement bandwidth,

275 volume [BTV], and time-activity curves with minimal time to peak [TTPmin]) were evaluated and correl

276 o their soft mechanical nature that leads to minimal tissue damages and immune responses.

277 IgG and anti-CD47 treated tumors resulted in minimal to moderate lymphocytic infiltrate, while the or

278 Despite this growth, however, there is still minimal to no identified palliative care development in

279 l/fl);Cre(+) or Smad1(fl/fl);Cre(+) mice had minimal to no iron loading, suggesting a gene dosage eff

280 Cell-dependent minimal to no toxicity of Inh2-B1, and its abilities to

281 of somatic hypermutation (SHM) ranging from minimal to pronounced.

282 s antiangiogenic and antitumour effects with minimal toxicity and should be investigated further.

283 t two enzalutamide-resistant xenografts with minimal toxicity.

284 chieve the required therapeutic potency with minimal toxicity.

285 The ARC is efficiently assembled with minimal training, and each experiment can be run for up

286 lections of mutant lines were generated with minimal transformation attempts and in a relatively shor

287 of complete extraction of the monacolins and minimal transitions between the monacolins during analys

288 Nevertheless, it remains unclear whether the minimal treatment response to binocular treatment was ow

289 Minimal trypsinolysis followed by high resolution mass s

290 uential treatment was antagonistic and had a minimal tumor inhibitory effect compared with individual

291 shows that many Tn7-like transposons contain minimal type I-F CRISPR-Cas systems that consist of fuse

292 The private cost burden is minimal under standard and tax instruments, and if firms

293 Finally, minimal use of intermediary steps as well as direct, lat

294 tion and the surrogacy threshold effect, the minimal value of HR for PFS to predict a non-null effect

295 response statistics toward a given mean with minimal variance.

296 RVT in the LC is anchored in the tissue with minimal variation in glaucomatous eyes.

297 terning of oppositely charged residues shows minimal variation.

298 eral lines of evidence suggest that there is minimal vertical transmission of fungi from seeds to the

299 rochromatin was not a limiting factor in the minimal volume of the nuclei.

300 This shows that epithelial cells respond to minimal wounds in a collective fashion by increased cont