ライフサイエンスコーパス: minor

1 t herbivores on plant populations are likely minor.

2 the incidence of major (>1000 copies/mL) and minor (50-1000 copies/mL) viremic episodes (VEs) and fac

3 The OntoNotes annotation guidelines, with minor adaptations, were used.

4 ctually absorbed in the treatment cycle with minor additional resources and effort.

5 As a result, only minor adjustments to the composition of the cytosol or t

6 Pigmentation was the most common minor adverse event, with a 3.53% treated-vein pigmentat

7 Minor adverse events occurred in 22% of patients in the

8 fter the procedure, and rates of serious and minor adverse events within 30 days of the procedure.

9 ay of complement in the carriers of rs800292 minor allele (Ile62 in factor H) led to decreased releas

10 single-nucleotide polymorphism: rs149133391, minor allele [C] frequency = 0.01, P = 7.9 x 10(-9)) and

11 We show that the minor allele A of rs3811047 is significantly associated

12 Each additional copy of the minor allele at this SNP associated with 7% higher serum

13 LHS of a gene-by-environment interaction for minor allele carrier status at the TLR4 haplotype define

14 24 SNPs and insertion-deletion variants with minor allele frequencies >1% and imputation quality scor

15 Common coding variants with minor allele frequencies (MAF) >1% that were identified

16 le-nucleotide polymorphisms (SNPs) with high minor allele frequencies and in SNPs located in the pred

17 Associations between polymorphisms (minor allele frequency >/= 15%) in 4 genes and seizure o

18 udy (GWAS) including low-frequency variants (minor allele frequency >/=0.005) for BUA and VOS using a

19 nce components method with variants having a minor allele frequency >/=1%.

20 We grouped low-frequency variants (minor allele frequency </= 5%) by a genome-wide sliding

21 One SNV with a minor allele frequency <0.01, (rs3025380 at DBH) was gen

22 betes Audit and Research, Tayside Scotland), minor allele frequency (=0.02), and randomized clinical

23 ately describes how heritability varies with minor allele frequency (MAF), linkage disequilibrium (LD

24 en Family (ERF) study, we identified a rare (minor allele frequency (MAF)=1%) missense c.1114C>T muta

25 P = 5.38 x 10(-10), odds ratio (OR) = 0.68, minor allele frequency (MAF)cases = 0.0059, MAFcontrols

26 M single-nucleotide polymorphisms (SNP) with minor allele frequency 1%) to general cognitive function

27 cleotide variants (SNVs), rs11544484 (V256I, Minor Allele Frequency = 0.27) and rs2293925 (R525W, MAF

28 orts identified in CYP2R1 the low-frequency (minor allele frequency = 2.5%) synonymous coding variant

29 no association with diabetes risk (combined minor allele frequency [MAF] 0.22%; odds ratio [OR] 2.02

30 A total of 42 unique or rare (population minor allele frequency below 1%) nonsynonymous genetic v

31 s (39%), and TT in 85 patients (10%), with a minor allele frequency of 30%.

32 n approach to correct this bias using LD and minor allele frequency stratified inference (LDMS).

33 1998 associated nominally with BCG osteitis; minor allele frequency was 0.215 in 130 BCG osteitis cas

34 We enumerated 49,138 rare (<1% minor allele frequency) pLoF mutations.

35 and partitioning heritability by chromosome, minor allele frequency, and functional annotations and t

36 Intervention Trial Evaluating Rosuvastatin], minor allele frequency=0.018) was used to replicate the

37 his study showed associations between rs1535 minor allele homozygosity and rs174448 major allele carr

38 The minor allele of rs1057233 (G), within the previously rep

39 Furthermore, we show that the minor allele of rs322931 predicts expression of microRNA

40 The detected locus harbors a minor allele that elevates the risk of leaf collapse res

41 The C (minor) allele decreased EPHA2 transcriptional activity r

42 termind-like 3 (MAML3) replicated nominally; minor alleles of rs345983 and rs1344110 were associated

43 tein 2B as a hotspot for the accumulation of minor alleles that facilitate a more effective suppressi

44 ven by the apparently continuous turnover of minor alleles, which could serve as the source of drug-r

45 rant methylation changes, often present in a minor allelic fraction in clinical samples such as plasm

46 arrier to prevent unwanted reactions against minor allergens.

47 During treatment, minor allergic symptoms of urticarial and dyspnea were o

48 llergome, with the largest quantities of the minor Amb a 4 and major Amb a 1 allergens, and as unique

49 ized, impacted, spill-site sediment released minor amounts of cis- and up to 35 mug/L of trans-4-MCHM

50 t not Akt or HIF-1alpha, activation and only minor AMPKalpha phosphorylation dysfunction.

51 Minor amputations not affecting the wound site were also

52 incidence of new persistent opioid use after minor and major surgical procedures.

53 nsitization protocol, adverse reactions were minor and responded to treatment with corticosteroids an

54 ng intensity (very major, major, minor, very minor, and nonteaching hospitals) based on the resident-

55 Ten weeks following transplantation of a minor antigen (HY) sex-mismatched heart graft, the lymph

56 APP cleaving enzyme 1 (BACE1) cleaves APP at minor Asp(1) site to generate C99 for amyloid beta prote

57 ements quickly and in various ways with only minor biochemical intervention.

58 With the exception of minor bleeding at the injection site in a few animals in

59 in the proportions of patients with major or minor bleeding between groups that did vs did not receiv

60 ion of life-threatening bleeding or major or minor bleeding events in patients with ipsilateral steno

61 Minor bleeding is the most common complication of dermat

62 a c-index for out-of-hospital TIMI major or minor bleeding of 0.73 (95% CI 0.61-0.85) in the derivat

63 sis in Myocardial Infarction (TIMI) major or minor bleeding stratified by trial, and developed a nume

64 ombolysis In Myocardial Infarction major and minor bleeding.

65 anticoagulants, with no excess of major and minor bleedings and less incidence of variceal bleeding.

66 Genome-wide analyses demonstrated minor but clear involvement of SAC3B in regulating siRNA

67 rison to the 6-month follow-up, except for a minor but significant improvement in cylinder and, at 4

68 estry in a Romanian Eneolithic sample with a minor, but sizeable, contribution from Anatolian farmers

69 Finally, we detect minor, but statistically significant, changes in express

70 ry, evidence of anatomical injury defined as minor by an injury severity score between 2 and 8 and no

71 Each minor (C) allele corresponded to an additional 20 mg da

72 f tissue of Neurachne munroi (C4), Neurachne minor (C3-C4), and Neurachne alopecuroidea (C3).

73 The N. alopecuroidea and N. minor CA1a isoforms were imported into chloroplasts of N

74 However, the universally conserved minor capsid gene vp3 could be deleted without a loss in

75 bset of the major capsid protein L1 from the minor capsid protein L2, which remains in complex with t

76 results suggest that the P17 protein is the minor capsid protein of Bam35 and P24 is the penton prot

77 entry into the host cell by retention of the minor capsid protein, L2, and the viral genome instead o

78 ect signatures for the hexon, penton, fiber, minor capsid, and core proteins.

79 mavirus (hrHPV) testing to triage women with minor cervical lesions generates many referrals.

80 riage step after hrHPV testing in women with minor cervical lesions.

81 Minor changes (2.3%) mostly consisted of follicular lymp

82 ate coatings with or without vanillin showed minor changes compared to control grapes.

83 ttern to trigger an operant task evoked only minor changes in its electrophysiological properties.

84 while IL-1beta-treated cells exhibited only minor changes in metabolism, DMOG treatment decreased iT

85 f the cytoskeletal rheology and structure to minor changes in parameters or initial conditions enable

86 als the existence of special points at which minor changes in signal levels lead to strong epistatic

87 d forelimb (FL) muscles there were only four minor changes in the chimpanzee clade, and all were reve

88 Minor changes in the length and sequence of the integras

89 on removal of TRF1 or TRF2, we observed only minor changes in the telomere volume in most of our expe

90 leability of TraA recognition, and seemingly minor changes to its variable region reprogram recogniti

91 ne learning approach with up-sampling of the minor class.

92 D1t-phytoprostanes were the predominant and minor classes, respectively.

93 There were minor clinical differences between patients harboring sp

94 an unbalance this advantage, selecting for a minor clone resistant to chemotherapy.

95 Using this approach, we expanded minor clones and obtained epithelial cell-specific DNA/R

96 There were 12 minor complications (grade I or II) and 11 major complic

97 We also found that sites fitting the minor component are enriched for copy number variants an

98 amicin lack PTC readthrough activity but the minor component gentamicin B1 (B1) is a potent readthrou

99 ure immunoprofile, but they appeared to be a minor component of the infiltrate.

100 TX-f as dominant toxin, whereas OVTX-f was a minor component of very few strains.

101 The minor-component distribution is overdispersed with highe

102 Breaksea Orthogneiss includes suitably dense minor components (e.g. eclogite) capable of foundering a

103 e, due to the high content of oleic acid and minor components with antioxidant and bioactive properti

104 ignals, enabling the detection of signals of minor components.

105 , while uraninite and U((VI)) represent only minor components.

106 principal component analysis of 15 selected minor compounds (mainly ethyl dodecanoate, ethyl tetrade

107 droxamate-Zn(2+) coordination geometry and a minor conformer (30%) with monodentate hydroxamate-Zn(2+

108 The minor conformer is not visible in lower resolution struc

109 troke and the barriers involved in it are of minor consequence to the selectivity of forward over bac

110 ous/nanocrystalline beta-Ga2O3 phase, with a minor constituent of In2O3 with significantly larger coh

111 ) that dominate the honey matrix, and of the minor constituents of protein, phenols and flavonoids.

112 acity of 125 mA h g(-1), which may include a minor contribution of hydronium storage, a good rate cap

113 s elemental Hg (Hg(0)) deposition, with only minor contributions from the deposition of Hg(ii) via pr

114 DNA with an extra base, 7 A's, may only be a minor contributor to GagPol polyprotein.

115 rboviral diseases were considered to be only minor contributors to global mortality and disability.

116 ucture for serine and histidine tRNAs, while minor cysteine and selenocysteine tRNA species may have

117 two possible indole regioisomers, along with minor decomposition products.

118 d between 27.5 and 21 ka only correlate with minor decreases in Greenland dust records.

119 The three Cys mutants have minor defects in cell culture growth but a high incidenc

120 s reported being able to quickly correct the minor deficiencies identified.

121 major depression, dysthymic disorder, and/or minor depression; lived with a consenting legal guardian

122 on isolates shows that they sometimes have a minor difference in sensitivity in vitro and in planta.

123 rences into rat ASIC3 (rASIC3) produced only minor differences in channel function, and replacing the

124 tween different actinides-can be ascribed to minor differences in covalency, that is, the degree to w

125 Although there were minor differences in sensitivity and specificity among M

126 tructures are highly similar, with only some minor differences in surface loop regions.

127 other vital biological readouts, where only minor differences were found between the preparations.

128 Although minor differences were noted in clinical and concurrent

129 Current guideline recommendations still hold minor differences.

130 Minor dihydro and tetrahydro products are also observed.

131 Concordance, major discrepancies, and minor discrepancies were calculated and analyzed by pair

132 During S-phase, minor DNA damage may be overcome by DNA damage tolerance

133 of clinically useful methylation changes in minor DNA populations.

134 as they only exhibit mild motor phenotypes, minor dopamine metabolism abnormalities, and no signs of

135 Minor early postoperative complications, such as graft i

136 However, this modification had only a minor effect on Cga expression and no effect on H3K9ac.

137 (from 5.5 to 775 ms), whereas it only had a minor effect on deactivation kinetics.

138 d T2D prevalence in the USA, but have a more minor effect on the obesity.

139 ependent splicing of HIV-1 transcripts, with minor effects on cellular splicing, supports the view th

140 o the total technical variance and have only minor effects on downstream analyses, such as detection

141 ation of the cysteine residue to alanine has minor effects on overall protein function.

142 Cycloheximide had minor effects on overall ribosome density, which affecte

143 ectin improves metabolic health but has only minor effects on reproductive functions in this PCOS-lik

144 euroligins impair synapse function with only minor effects on synapse numbers, raising fundamental qu

145 l reduction of H3K27ac, but has surprisingly minor effects on transcription from either enhancers or

146 While soils had relatively minor effects, climate was the dominant predictor for mo

147 while in the North and Central-West coasts a minor effort, at shallower waters and across a wider ran

148 ter further optimization, the discovery of a minor enantiomeric impurity with agonist activity led to

149 DeltaG (double dagger)r contains only a minor enthalpic contribution that roughly corresponds to

150 membrane-bound PI3Kalpha molecule, but this minor enzyme inhibition is overwhelmed by the marked enh

151 ent interactions were detected for GYD, some minor epistases were detected for NP and NFGP.

152 The effects of minor flue gas components (SO2, NO, NO2, H2O, and O2) on

153 aring plants are now recognized as important minor food components due to several organoleptic and he

154 Seasonality was minor for CO2 emissions, whereas CH4 and N2 O fluxes dis

155 e was aerobically oxidized by microbes and a minor fraction (0.07%) was transferred to the atmosphere

156 clear even though Usp14 is present on only a minor fraction (30-40%) of the 26S in WT mouse embryonic

157 If only a minor fraction of CA-SP is present, multi-layered tube f

158 A minor fraction of dendrimers, however, localize to endop

159 form of EDA1 was the main form of EDA but a minor fraction of EDA2 was also found in fetal bovine se

160 and Thermo Fisher NGS fusion panel reported minor fusions that were not detectable by FISH.

161 es in the United States were investigated in minor gallinaceous poultry species (i.e., species for wh

162 search is in examining the susceptibility of minor gallinaceous species to HPAI virus, as this poultr

163 se new features, STR-Seq can identify a 0.1% minor genome fraction in a DNA mixture composed of diffe

164 Minor grains such as sorghum, millet, quinoa and amarant

165 xic interstrand cross-links (ICLs) and bulky minor groove adducts normally recognized by Fanconi anem

166 ethodology, DNAphi, for predicting EP in the minor groove and confirmed the direct role of EP in prot

167 pounds, derived from existing classes of DNA minor groove binders, were designed, synthesized, and ev

168 imilar mechanism involving contacts with the minor groove of DNA and oligomerization.

169 ized class cannot be accommodated within the minor groove of DNA due to a change in the shape of the

170 ntaining side chains designed to bind in the minor groove of DNA while spanning a wide range of base

171 PDB-ID: 5LIT) shows that the drug covers the minor groove of DNA, displaces bound water and interacts

172 he proteins make important contacts with the minor groove of DNA.

173 e derivatives, which preferentially bind the minor groove of double-stranded DNA, inhibit vaccinia vi

174 tin binding through interaction with the DNA minor groove that flanks PU.1-binding motifs.

175 approach using small molecules to target the minor groove to control expression by an allosteric mech

176 f poly(A) sequences associated with narrowed minor groove width.

177 step parameters, helix parameters, and major/minor groove widths to examine how the presence of multi

178 ling that is due to alkylation of DNA in the minor groove.

179 erting a beta sheet 'wing' into the adjacent minor groove.

180 PBDs) are a family of sequence-selective DNA minor-groove binding agents that form a covalent aminal

181 These results show how RNA Pol II copes with minor-groove DNA alkylation and establishes a mechanism

182 ophysical effect directly, rather than using minor-groove width as an indirect measure for shape read

183 s on an AT-sequence, we show that the ICD of minor-groove-bound 4',6-diamidino-2-phenylindole (DAPI)

184 sed immunogenicity and speed of evolution in minor-group lineages may contribute to the very large nu

185 Those caused by a subset known as the minor-group members of rhinovirus species A (RV-A) are c

186 Minor-group rhinoviruses are more immunogenic in laborat

187 coexistence of many serotypes of major- and minor-group RVs.

188 Here we present evolutionary evidence that minor-group viruses are also more immunogenic in humans.

189 Two other minor groups of strains including Saprochaete suaveolens

190 (>/=2 log-reduction in 2 weeks; n = 13) and minor (>/=1 to </=2 log-reduction in 2 weeks; n = 2) vir

191 ematopoietic-restricted, leukemia-associated minor H antigen, HA-1; (2) a CD8 coreceptor to promote f

192 solved R1a-Y2619 lineage, which was likely a minor haplogroup among the Hebrews.

193 red by donor T cells specific for particular minor histocompatibility (H) antigens.

194 histocompatibility complex-matched multiple minor histocompatibility antigen-mismatched alloHCT usin

195 In both a minor histocompatibility antigen-mismatched as well as a

196 e amino acid mutations also alter binding to minor human-type glycans, suggesting that host adaptatio

197 the docking transition state and tertiary A-minor hydrogen bond interactions form after the docking

198 low panels become more complex, detection of minor immune cell populations by traditional gating usin

199 Shearing (1000s(-1)) had a minor impact reducing digestibility and thereby enhancin

200 Whilst historically regarded as being of minor importance in European livestock, recent evidence

201 Typically, each round of optimization yields minor improvement in stability, and multiple rounds are

202 For at least one template, minor improvements in assay repeatability are also shown

203 to-scan for patients randomized to CBT, with minor increases (3.8%) for waitlist participants.

204 Since even minor increases in CBT can impair physical and cognitive

205 ed predominantly by plant species, with only minor influences of factors such as local soil type, for

206 ia TRPC6 or Orai1 channels and caused only a minor inhibition of P2X1-dependent Ca(2+) entry.

207 jured patients with those of 6 patients with minor injuries (ISS </= 4).

208 icipants were identified as having sustained minor injury by the combination of three standard criter

209 Depression and anxiety soon after minor injury may help predict important markers of long-

210 cohort study of psychological outcomes after minor injury.

211 y organic enriched surface layers containing minor inorganic seawater components such as magnesium an

212 The RNA structure of Pistol also contains A-minor interactions, which seem to be important to mainta

213 Moreover, 144 minor intron-containing RNAs were differentially express

214 For species with minor inverted repeat (IR) boundary changes in the plast

215 ient areas, while Brn3b(+) Ret(+) RGCs shows minor ipsilateral projections to the olivary pretectal n

216 ts after recent transient ischemic attack or minor ischemic stroke: 18 patients with culprit carotid

217 f the natural product in 69 % yield from the minor isomer present in an equilibrating mixture of labi

218 r analysis remains challenging and resolving minor isomeric variants can be difficult, in particular

219 to relatively fast evolution and have only a minor, largely modulatory role in gene regulation under

220 132 can markedly extend CWD latency when the minor leucine allele (132L) is present.

221 P-derived epithelial cells expressed at best minor levels of C3aR.

222 mited 0-4-g range of soybean oil, there were minor linear increases in the chylomicron AUC for lutein

223 ealth; these conditions represent or reflect minor metabolic stresses.

224 valenol, deoxynivalenol-3-glucoside, and the minor metabolite culmorin.

225 ht into the vehicle content of strategic and minor metals of current interest.

226 country-level information on three important minor metals often considered critical.

227 Although not every minor methylation differences between cells are detectab

228 ponents were ranked according to importance (minor, moderate, major, critical, and death) and tempora

229 A minor modification can further improve the quality of ac

230 Additionally, minor modification of the seeds with Pd allows their loc

231 ASCO statements and minor modifications were added to enhance the applicabil

232 rations on the xylan backbone, together with minor motifs with consecutive glucuronation.

233 disorders and 107 (70%) of 152 patients with minor motility disorders reported symptoms during the ST

234 e of 12 individuals with normal neurology or minor neurological conditions (N/MC individuals).

235 hogenic focal retrograde amnesia following a minor neurological episode; and (iv) patients with gaps

236 alpha, unlike NLS1 that associates with the minor NLS-pocket.

237 However, only a minor number of ISGs were common to WT and STAT1-, STAT2

238 nefit of correcting any single one was often minor; on average, correcting a patient's cardiac output

239 148 or ORF25 causes attenuation in vivo to a minor or major extent, respectively.

240 and in that hydroxylation represents only a minor pathway.

241 the OH radical addition to C4 position is a minor pathway.

242 treatment step for the removal of conductive minor phases of Cu2S/Cu2Se.

243 Flavonols and anthocyanins were minor phenolic compounds.

244 osition causes the accumulation of an MftA** minor product.

245 p''2Zr)(Cp''Zr)(mu,eta(2:2:1)-As5)] (2) as a minor product.

246 or major products (ethylene and methane) and minor products (ethanol, glyoxal, glycolaldehyde, ethyle

247 rted regions of the medial arcopallium and a minor projection from the caudomedial nidopallium.

248 hosphate diesters accounted for a relatively minor proportion of summation operatorPFASs, while perfl

249 This analysis predicts that even minor reductions in childhood vaccination, driven by vac

250 ant variants, and our results suggested that minor resistant variants may emerge de novo shortly afte

251 ine, and has historically been regarded as a minor respiratory pathogen.

252 ined as complete response, partial response, minor response, stable disease, or progressive disease.

253 Whereas minor retinal ultrastructural defects were observed at a

254 The membrane lipid does have a minor role by modulating the timing of the kinetics, wit

255 t atmospheric N deposition rates, implying a minor role for modern N deposition on the trajectory of

256 y high temperature with (*)OH contributing a minor role in activating PS to SO4(*-).

257 n haemosporidian parasites and have played a minor role in the gopher-chewing lice system.

258 l machinery, and that hormones likely play a minor role in the initial steps of early embryo developm

259 ecedent climate conditions play a relatively minor role, except in few specific eco-regions.

260 We conclude that although Munc13-2 plays a minor role, Munc13-4 is essential for regulated exocytos

261 of the RVE8 clade, RVE3 and RVE5, play only minor roles in the regulation of clock function.

262 Furthermore, eight additional minor soil horizons dated between 27.5 and 21 ka only co

263 pported monolayers exhibited clear major and minor strain axes, they were not correlated with nuclear

264 of unaligned RNA reads uncovered 207 unknown minor strand (passenger) microRNAs of known microRNA loc

265 CAS was mostly attributed to periprocedural minor stroke (OR: 2.43; 95% CI: 1.71 to 3.46).

266 and was mostly attributed to periprocedural minor stroke.

267 ue to greater protein oligomerization from a minor structural change.

268 nsitivity of stability-activity relations to minor structural changes and the crucial role that these

269 king hydrophobic patch of a Cu-azurin causes minor structural distortion of the protein blue Cu site

270 in 8 s, enabling us to track the fluctuating minor structures' appearance and disappearance on a tens

271 ogenesis, proliferation, and stemness, and a minor subpopulation (19%) with many overexpressed cancer

272 drogen dependence, defining the character or minor subpopulations of androgen-independent cells that

273 However, the mutant undergoes only minor substrate binding-induced heme iron spin state shi

274 n includes in essence a ferrous iron center, minor superoxide character of the noninnocent ligand, si

275 t to demonstrate allosensitization following minor surgery with ;low-volume bone graft.

276 d transcription assays demonstrated that the minor T allele variation at rs604723 increased the activ

277 with rs1012178 near the PENK gene, where the minor T-allele associated with a 0.057 pmol/L higher pro

278 mbers of the Council of Teaching Hospitals), minor teaching hospitals (other hospitals with medical s

279 Among small (</=99 beds) hospitals, 187 minor teaching hospitals had lower overall 30-day mortal

280 as 8.1% at major teaching hospitals, 9.2% at minor teaching hospitals, and 9.6% at nonteaching hospit

281 rat islets in vitro and was associated with minor tissue reactions after 28 days.

282 re spread from Spain, across Europe and Asia Minor, to Mongolia and China.

283 ErbB4 expression did not change, whereas the minor-to-major splice variant ratios increased with age.

284 this interpretation, in monkey DLPFC, higher minor-to-major variant ratios predicted lower PSD95+ pun

285 widespread intron retention, particularly of minor U12 introns, in the spinal cord of mice 30 d after

286 of converging white matter bundles (forceps minor, uncinate fasciculus, cingulum and fronto-striatal

287 Cryptic minor variant mycobacterial subpopulations exist below t

288 ext-generation sequencing in resolving these minor variant subpopulations.

289 d displayed greater kinase activity than the minor variant, suggesting that the effect of ErbB4 signa

290 In cell culture, the major, but not the minor, variant increased excitatory synapse number on PV

291 ess, we also report a continuous turnover of minor variants, which could give rise to the emergence o

292 CCRA to 45-69% when CCRA were present, with minor variation among CCRA genera.

293 Analysis of individual plants reveals minor variation in the positions of complex centromeres

294 e acidity and colour of the oils, as well as minor variations in the fatty acid profile.

295 Although minor variations in the neonatal (immediately at birth)

296 es of teaching intensity (very major, major, minor, very minor, and nonteaching hospitals) based on t

297 ined VS throughout follow-up, 8% experienced minor VEs only, and at least 1 major VE was documented i

298 racterization included analysis of major and minor volatile compounds, volatile sulphur compounds, me

299 g/100g FW zeaxanthin dipalmitate and further minor xanthophyll esters, prevailing in a presumably liq

300 n determined for this reaction, suggesting a minor yield of methanol or stabilized trioxide as a prod