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1 was attenuated in the presence of NF1 (exoA-minus).
2 s depth range (that is, its mean buoyancy is minus 0.5 per cent), although this anomaly may be concen
4 ction), fructose storage (fructose ingestion minus (13)C-fructose oxidation), fructose conversion int
5 ) but not MBTS (P=0.40) subjects (pre-Fontan minus 14-month mean, -3.25+/-8.24% versus 0.99+/-8.80%;
9 degrees Celsius occurs within 20 seconds at minus 20 degrees Celsius and within 30 seconds at minus
10 20 degrees Celsius and within 30 seconds at minus 30 degrees Celsius, consuming only 3.8 per cent an
11 gram at a 50 per cent state of charge and at minus 30 degrees Celsius, delivering 6.4-12.3 times the
14 we found that Sox9 engages TUBB3 promoter at minus 980 base pairs from the transcriptional start site
15 26), executive function (Trail-Making Test B minus A; range, -290 to 290), and spatial ability (Card
16 resholded statistical T maps (hypometabolism minus amyloid burden), resulting from voxel-based statis
19 age-adjusted axial length difference (ALD) (minus and plus denotes myopia and hypermetropia, respect
21 replication strategy allows TBSV to separate minus- and plus-strand syntheses in time and regulate as
23 3-year progression-free survival rate (ABVD minus AVD) was 1.6 percentage points (95% CI, -3.2 to 5.
26 < 0.05), and the changes in M/I (detraining minus baseline) correlated directly with changes in CD i
27 Using the change score (peak at induction minus baseline) for bleeding on probing and probing dept
28 of treatment (LDX minus baseline vs placebo minus baseline) on these behavioral and neural markers o
31 hted averages, where net inputs equal inputs minus biomass removal) despite relatively low P inputs.
32 tes (orders Perissodactyla + Cetartiodactyla minus cetaceans) were merged with host trait data and IU
33 avorable outcome (experimental group [21.0%] minus control group [17.2%]) in the modified intention-t
34 At age 2 years, the difference (intervention minus control) in BMI (calculated as weight in kilograms
37 tex (ACC) that signal the net value (benefit minus cost) of rewards that will be received oneself and
39 and FA/B(-*) and by the characteristic light-minus-dark absorbance difference spectrum in the QY regi
41 Cin8Kin switched frequently between plus and minus directionality along single MTs, demonstrating tha
42 rands - asymmetric DNA methylation; plus and minus DNA stands - symmetric DNA methylation) in MeDIP-S
43 where DNA methylation predominates (plus or minus DNA strands - asymmetric DNA methylation; plus and
53 ermis, NOCA-1 functions redundantly with the minus end protection factor Patronin/PTRN-1 to assemble
56 LIS1) in the interaction of end tracking and minus end-directed human dynein complexes with these sit
58 , using proteomic profiling, we identify the minus end-directed microtubule motor protein HSET as a d
60 esin-14s are commonly known as nonprocessive minus end-directed microtubule motors that function main
61 abE engage myosin-5 as well as plus end- and minus end-directed microtubule motors, providing an expe
62 ingle microtubules, but reverts to canonical minus end-directed motility when anchored on the surface
63 ng of nuclear congression and identified two minus end-directed motors operating in parallel in this
67 r domains with their neighbors inhibit their minus end-directed stepping action, but not their plus e
68 r Klp2, a kinesin-14, converts Cut7 from net minus end-directed to net plus end-directed stepping.
71 bule-dependent motors, we establish that the minus end-directed transport of SVs requires the dynein/
72 decreases dynein binding to APC to stimulate minus end-directed transport, which could modulate endoc
73 ons in Myo6, the gene encoding the (F-actin) minus end-directed unconventional myosin, myosin VI, cau
74 Cytoplasmic dynein drives the majority of minus end-directed vesicular and organelle motility in t
78 in-5 acting normally restrains the number of minus end-distal microtubules that are transported into
79 hinner and contained a greater proportion of minus end-distal microtubules, suggesting that kinesin-5
84 the velocity of dynein-dependent microtubule minus-end (towards the nucleus) movement of EGF and BDNF
85 that microtubule rotational diffusion about minus-end attachment points contributes to kinetochore c
86 otubule-binding domain and is independent of minus-end binders gamma-TuRC, CAMSAP1, and KANSL1/3.
87 hile CAMSAP3/Marshalin is a microtubule (MT) minus-end binding protein that regulates MT networks.
88 including a recently described family of MT minus-end binding proteins called calmodulin-regulated s
89 er of the Patronin/Nezha/CAMSAP family of MT minus-end binding proteins, suppresses dapk-1 epidermal
90 Thus, NuMA may serve as a mitosis-specific minus-end cargo adaptor, targeting dynein activity to mi
91 1, the heavy chain of the cytoplasmic dynein minus-end directed microtubule motor, in a genetic scree
92 es (MTs) are substrates upon which plus- and minus-end directed motors control the directional moveme
93 we present cryo-EM structures of the unique minus-end directed myosin VI motor domain in rigor (4.6
95 ariable central domain cooperate to suppress minus-end dynamics in vitro and that both regions are re
98 umerous studies have observed a role for the minus-end microtubule motor dynein in HIV-1 infection, t
101 otubule length, disrupted astral microtubule minus-end organization, and increased levels of the pola
103 -dependent aberrant long spindle microtubule minus-end protrusions that push the properly segregated
105 anization, i.e., polymer length, number, and minus-end spacing, is regulated and how it impinges on a
106 kinesin-5 Cin8 was shown to switch from fast minus-end- to slow plus-end-directed motility upon bindi
108 -binding domain and recruits the microtubule minus-end-binding protein, Patronin, to form cortical nc
109 dynein is a molecular motor responsible for minus-end-directed cargo transport along microtubules (M
110 the role of tetrameric Kif25, a microtubule minus-end-directed kinesin-14 motor, in preventing prema
111 analysed the motility of the six members of minus-end-directed kinesin-14 motors in the moss Physcom
112 HIP) (FHF) complex, which interacts with the minus-end-directed microtubule motor dynein and its acti
114 nsisting of the plus-end tracker EB1 and the minus-end-directed molecular motor Kinesin-14 is suffici
115 whether the mechanism of the unconventional minus-end-directed motility differs fundamentally from t
119 ative actions of the bipolar kinesin-5 and a minus-end-directed motor, which then pulls the sliding M
121 -directed motors are balanced by forces from minus-end-directed motors that pull spindle poles togeth
124 lus ends leading, so "mal-oriented" MTs with minus-end-out are transported toward the cell body while
125 gery, we detected equal numbers of plus- and minus-end-out microtubule orientations throughout the de
126 r than non-uniform microtubules, uniparallel minus-end-out microtubules are the signature of dendrite
127 wth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon, con
130 ur results show that cortical dynein slides 'minus-end-out' microtubules from the axon, generating un
134 mixed polarity into a configuration in which minus ends are away from the chromosomes, enabling forma
139 MTs is balanced by depolymerization of their minus ends at the poles, producing poleward flux, while
142 translocation of peroxisomes to microtubule minus ends indicates that mammalian Hook proteins activa
143 c field by designing a charged surface of MT minus ends labeled with dsDNA via a streptavidin-biotin
148 AC model, minus-end-directed motors bind the minus ends of MTs as cargo and transport them poleward a
151 MT tracks, whereas in the SAFE model, all MT minus ends that reach the pole are depolymerized by kine
152 t new minus ends within seconds, reanchoring minus ends to the spindle and delivering them to poles.
153 in/dynactin are specifically enriched at new minus ends within seconds, reanchoring minus ends to the
155 MA's friction being lower when moving toward minus ends, EB1's lower toward plus ends, and PRC1's exh
157 hows how mammalian CAMSAP proteins stabilize minus ends, providing a key piece to the puzzle of how t
159 y capture and stabilize existing microtubule minus ends, which then template new microtubule growth.
166 family members also bind specifically to MT minus-ends and protect them against kinesin-13-induced d
169 /Patronin family all localize to and protect minus-ends but have evolved distinct effects on MT dynam
174 dels of microtubule growth, we conclude that minus-ends of KMTs have selectively detached and depolym
177 cargo adaptor, targeting dynein activity to minus-ends to cluster spindle microtubules into poles.
178 ynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predi
184 ninferiority margin of -2.75 (50% of placebo minus escitalopram), so noninferiority could not be clai
185 ss was defined as the transpulmonary (airway minus esophageal) pressure during end-inspiratory pause
186 a drops to 37% with the use of precipitation minus evapotranspiration (P-E), a measure that represent
187 stimated for 2000 to 2014 as observed deaths minus expected deaths (estimated from 1999 mortality rat
189 er performing units as ICUs with an observed minus expected duration of mechanical ventilation greate
190 erforming units as ICUs that had an observed minus expected duration of mechanical ventilation less t
192 ntly (p < 0.01) poorer performance (observed minus expected duration of mechanical ventilation, > 0.5
193 ntly (p < 0.01) better performance (observed minus expected duration of mechanical ventilation, < -0.
196 erences in diversification rates (speciation minus extinction) between habitats are often weak and in
199 t month 12, the difference between study eye minus fellow eye improvement in group 2 patients of 0.53
200 t month 18, the difference between study eye minus fellow eye improvement in our acute group 2 gene t
202 lence in mean between groups (awake-regional minus general anaesthesia 0.169, 95% CI -2.30 to 2.64).
203 ps (number of impacts, 6 vs 41 [lower impact minus higher impact = 35; 95% CI, 21-51; P < .001]; line
204 ear acceleration, 99g vs 1112g [lower impact minus higher impact= 1013; 95% CI, 621 - 1578; P < .001]
205 9 radian/s2 vs 65016 radian/s2 [lower impact minus higher impact= 57427; 95% CI , 31123-80498; P < .0
207 intraobserver, and interimage variability (1 minus intraclass correlation coefficient) and agreement
210 naive patients with liver metastases plus or minus limited extrahepatic metastases were randomly assi
211 oplast DNA methylation levels in plus versus minus mating type gametes followed by chloroplast DNA hy
212 a transpulmonary pressure gradient (mean PAP minus mean PAWP) <12 mm Hg, and pulmonary vascular resis
213 c pulmonary pressure gradient (diastolic PAP minus mean PAWP) <7 mm Hg, a transpulmonary pressure gra
214 WS (median SWS after diuretic administration minus median SWS before diuretic administration) were co
216 ground carbon uptake (growth and recruitment minus mortality) by approximately 76% per year, mostly b
217 in) are 15-times more frequent than in pilus-minus mutant cells (0.2 events/min), indicating the pili
218 he same for wild-type cells (12 s) and pilus-minus mutant cells (13 s), suggesting the pili do not pl
223 ost tissue enhanced virulence of the oxalate-minus mutants, whereas supplementing with oxalate did no
227 event rate), the delta gap (predicted delta minus observed delta), and the predicted number needed t
228 The event-rate gap (predicted event rate minus observed event rate), the delta gap (predicted del
229 Measures: The RMSE of the residuals (fitted minus observed values) for the 3 regression models was u
232 cells with reduced microvilli ("microvillus-minus," or MVM) but retaining normal tight junctions.
233 ed inorganic N (DIN) mass reductions (inflow minus outflow) were greater in the Dry Basin than in the
234 mate [95% IE] 59-68) and IPD caused by PCV13 minus PCV7 serotypes declined by 93% (91-94), by July, 2
235 o declined by 12-32% and IPD caused by PCV13 minus PCV7 type IPD declined by 58-72%, depending on age
237 ositive end-expiratory pressure, DeltaP [PIP minus PEEP], tidal volume, dynamic compliance [Cdyn]) or
238 exercise time increment between groups (PCI minus placebo 16.6 s, 95% CI -8.9 to 42.0, p=0.200).
239 difference between groups (solanezumab group minus placebo group) in the change from baseline was -0.
240 d treatment difference at week 9 (citalopram minus placebo) was -0.93 (95% CI, -1.80 to -0.06), P = .
242 sitively correlated with the effect of PSEs (minus PNEs) on number of puffs taken from a cigarette (r
245 e posttest HR, and HR difference (resting HR minus posttest HR) were measured and musculoskeletal pai
246 and overlapping seasonal differences (post- minus preintervention change) between control and interv
248 identified by computational analysis of ribo-minus RNA generated from human umbilical venous endothel
250 ry site, alpha4 threonine 126 located on the minus side of alpha4 that contributes to the accessory s
251 large mammals; and (3) (with an appropriate minus sign) sloths undertaking suspended locomotion acro
252 ntion-to-treat population (safety population minus sites excluded with Good Clinical Practice violati
254 s hepatic steatosis at nonenhanced CT (liver minus spleen CT attenuation < 1 HU) without evidence of
255 , an RC DNA species with a covalently closed minus strand but an open plus strand (closed minus-stran
258 f the plus strand in RC DNA, suggesting that minus-strand closing can occur before plus-strand proces
260 minus strand but an open plus strand (closed minus-strand RC DNA [cM-RC DNA]) was detected by this ap
261 y simple process that involves complementary minus-strand RNA [(-)RNA] synthesis and subsequent (+)RN
263 had little or no effect on the formation of minus-strand strong-stop cDNA but caused a significant r
264 egration site sequences into plus-strand and minus-strand subpopulations, and use this to identify th
266 ol extracts from Centaurea scabiosa, Arctium minus, Taraxacum officinale, Centaurea nigra and Cirsium
267 There was minimal mean difference (eFick minus Td = -0.02 L/min/m2, or -0.4%) but wide 95% limits
268 ups (difference in median of oral vitamin D3 minus that of UVB: 1.5 mg/dL; 95% CI: -5.0, 7.0 mg/dL).
270 ng >5 days; where LOS was the discharge date minus the admission date plus 1) among 33,920 patients w
271 the amount from the seventh to the ninth day minus the amount from the first to the third day, divide
272 ucted by nonlinear least square fitting of 1 minus the change in R2*divided by R2*at baseline as a fu
273 sured children (defined as the reimbursement minus the cost of care) were compared across hospital ty
274 s the ACC signal the net value (the benefits minus the costs) of rewards that others will receive?
275 l tissue from fish transferred to SW plus or minus the deiodinase inhibitor, iopanoic acid, revealed
278 4-14) and defined vaccine effectiveness as 1 minus the incidence rate ratio, expressed as a percentag
280 rm and calculated vaccine effectiveness (one minus the odds ratio of vaccination) by comparing infant
283 nces (rate of the end point in those with AF minus the rate in those without AF per 1000 person-years
284 nergy balance (equal to daily energy intakes minus the REE), and survival were recorded.Of 390 enroll
285 baseline, the false-positive result rate (1 minus the specificity rate) for Lung-RADS was 12.8% (95%
286 lated as the maximum possible residence time minus the sum of residence time of source organs, assumi
287 he relative abundance of positive correlates minus the sum of the relative abundance of negative corr
288 ydraulic safety margin (stem water potential minus the water potential at which 50% of conductivity i
289 from Artemisia tridentata ssp. Spiciformis, minus their chloroplast targeting regions, are 71% ident
290 uding all participants assigned to treatment minus those who withdrew due to a non-treatment-related
292 e mass balance (that is, total precipitation minus total sublimation minus runoff) and a dynamic term
294 evaluating the efficacy of chemotherapy plus/minus trastuzumab suggested that the magnitude of trastu
296 ll-length and internal RNA transcripts of U3-minus vectors are reduced in the nuclei of transfected c
297 DB motility and suggest that an imbalance of minus versus plus end-directed microtubule motility in n
299 ed m(6)A residues on the IAV plus (mRNA) and minus (vRNA) strands and used synonymous mutations to ab
300 onsoon (ISM) rainfall differences (with dust minus without dust) change from -9% to 23% of long-term
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