ライフサイエンスコーパス: minus-end-directed motor

1 Cytoplasmic dynein is the major microtubule minus end-directed motor.

2 a gal suggests that the head of Nod may be a minus-end-directed motor.

3 ongression depends on the cooperation of two minus end-directed motors.

4 T, the human homologue of the KAR3 family of minus end-directed motors.

5 ng, suggesting that they were transported by minus end-directed motors.

6 by the opposing activities of plus end- and minus end-directed motors.

7 bidirectionally, employing both plus-end and minus-end directed motors.

8 ytoskeleton has pointed instead to roles for minus-end-directed motors.

9 be created by complexes combining plus- and minus-end-directed motors.

10 rucial role in the coordination of plus- and minus-end-directed motors.

11 formation of aggresomes, suggesting that the minus-end-directed motor activities of cytoplasmic dynei

12 ndrites indicate that models suggesting that minus end-directed motor activity is sufficient for dend

13 es, where it then organizes microtubules via minus-end-directed motor activity.

14 tor, the clustering of their minus ends by a minus-end-directed motor, and the loss of MTs by dynamic

15 mic dynein complex is an active, microtubule minus-end-directed motor, as expected.

16 However, in the SAC model, minus-end-directed motors bind the minus ends of MTs as

17 ve studied the shape of myosin VI, the actin minus-end directed motor, by negative stain and metal sh

18 Cytoplasmic dynein is a large minus end-directed motor complex with multiple functions

19 along microtubules by using the microtubule minus-end-directed motor complex of dynein/dynactin.

20 dynein/dynactin, a multi-subunit microtubule minus-end-directed motor complex, and NuMA, a microtubul

21 Our data reveal the novel finding that a minus-end-directed motor contributes to the organization

22 es (MTs) are substrates upon which plus- and minus-end directed motors control the directional moveme

23 d simulations, we propose a model on how two minus end-directed motors cooperate to ensure spindle po

24 r to translocation of the MTOC, in which the minus end-directed motor cytoplasmic dynein, localized a

25 Instead, we found that mutations in the minus-end-directed motor cytoplasmic dynein, completely

26 plus end-directed motor, kinesin-II, and the minus end-directed motor, cytoplasmic dynein in highly p

27 at links cargos of aggregated protein to the minus end-directed motor, cytoplasmic dynein.

28 We find that while the minus-end directed motor Dynein cooperates with Dynactin

29 While it is clear that the minus-end-directed motor dynein is required for this pro

30 Inhibitory antibodies indicated that the minus-end-directed motor dynein is required to prevent p

31 the transport of a subset of cargoes by the minus-end-directed motor dynein, although the full exten

32 in that mediates linkage of cargoes with the minus-end-directed motor dynein.

33 Here, we have characterized the roles of two minus end-directed motors, dynein and Ncd, in such proce

34 Cytoplasmic dynein is the microtubule minus-end-directed motor for the retrograde axonal trans

35 ac-man model, in which 1) kinetochore-based, minus end-directed motors generate poleward forces for a

36 cortex required Bud6p, Bim1p, and dynein, a minus-end-directed motor helping tether the receding plu

37 involved in organelle transport) and ncd (a minus-end-directed motor involved in chromosome segregat

38 Cell biologists have long speculated that a minus end-directed motor localized at kinetochores contr

39 Likewise, minus end-directed motors may move cargoes toward anteri

40 motors containing the stalk and neck of the minus-end-directed motor, Ncd, fused to the motor domain

41 se mitotic spindles with inactive kinesin-14 minus-end-directed motors often have shorter spindle len

42 ng of nuclear congression and identified two minus end-directed motors operating in parallel in this

43 ge, is transported to the nucleus via the MT minus-end-directed motor protein dynein.

44 a wide range of cellular functions for this minus-end-directed motor protein.

45 Kar3 is the minus-end-directed motor protein; Cik1 binds to Kar3 and

46 mobilized on microtubules by the activity of minus end-directed motor proteins that interact either d

47 ted with centrosomal microtubules (C-MTs) by minus end-directed motor proteins.

48 g microtubules, driven by teams of plus- and minus-end-directed motor proteins.

49 Drosophila Ncd, the other well characterized minus-end directed motor that is a homodimer, Kar3 is a

50 Kinesin-14 family proteins are minus-end directed motors that cross-link microtubules a

51 Cytoplasmic dynein is a microtubule minus-end-directed motor that is thought to power the tr

52 -directed motors are balanced by forces from minus-end-directed motors that pull spindle poles togeth

53 ative actions of the bipolar kinesin-5 and a minus-end-directed motor, which then pulls the sliding M