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1 e mechanism for translational inhibition and miscoding.
2 ansient initial selection process to promote miscoding.
3 eby inhibiting translocation and stimulating miscoding.
4 axis are difficult to investigate because of miscoding.
5 tant S12 mutants display decreased levels of miscoding.
6 end maturation of 16S rRNA and translational miscoding.
7 ly rescue translocation defects arising from miscoding.
8 ments that explain their observed effects on miscoding.
9 ed to make suboptimal choices reflecting the miscoding.
10 Results generated here for replicating the miscoding 8-oxo-G are compared to those published for th
11 tructural changes in the ribosome induced by miscoding agents in vitro with their in vivo phenotype.
16 ation, several of the mutations that promote miscoding alter residues located at the S4-S5 interface.
18 vivo, our data show that they are absolutely miscoding and may be refractory to repair after transles
19 e (I), oxanine, and uracil, all of which are miscoding and mutagenic in DNA and can interfere with RN
25 RNA decoding and translocation suggests that miscoding antibiotics may impact protein synthesis by im
27 sine-to-inosine (A-to-I) editing, ruling out miscoding as a possible mechanism for mitochondrial malf
28 his collection includes mutants that promote miscoding, as well as those that restrict decoding error
30 ion in its D-arm achieves elevated levels of miscoding by accelerating these forward rate constants i
32 itro studies indicate that these lesions are miscoding, can block the progression of DNA polymerases,
33 t/second step conformations, resembling tRNA miscoding caused by altered equilibrium between open/clo
35 ects underlie their biological processing as miscoding DNA lesions whose mutagenic properties may con
40 The propensity of aminoglycosides to induce miscoding errors that suppress the termination of protei
42 iota, and dTTP misincorporation is the major miscoding event by all four Y-family human DNA pols.
45 ping breast, ovary, and endometrial cancers, miscoding events occurring at model estrogen-derived DNA
46 C codon mistranslation arises primarily from miscoding events such as the selection of noncognate his
47 nts exploring the role of the E-site tRNA in miscoding failed to recapitulate the observations of ear
56 on of these studies showed that HOPdG is not miscoding in vivo at the level of sensitivity of these s
57 encing patterns of modified bases, including miscoding, insertions and deletions (indels), and trunca
61 nd that the 4-OHEN-dC DNA adduct is a highly miscoding lesion generating C --> T transitions and C --
64 -HOPdG has been shown previously not to be a miscoding lesion when replicated in Escherichia coli.
67 on, we found that N3-CMdT and O(4)-CMdT were miscoding lesions and predominantly directed the misinse
68 ly may contain abasic sites, cross-links, or miscoding lesions are acquired by the environmental bact
69 characteristic DNA damage pattern caused by miscoding lesions that differs from present day DNA sequ
70 lkylated substrates have been performed, the miscoding nature of these and related individually alkyl
72 arious data sources and made corrections for miscoding of important diseases (eg, ischaemic heart dis
75 into ensemble information encoding, such as "miscoding" of the response position and lack of distinct
76 he correct repair of the abundant and highly miscoding oxidative DNA lesion 7,8-dihydro-8-oxo-2'-deox
77 utations in the rRNAs that result in various miscoding phenotypes and resistance to known ribosome-ta
79 was proposed that S(6)mG, owing to its high miscoding potential (pairing preferentially with thymine
80 olymerases may differ significantly in their miscoding potential and that in vitro analysis can be us
81 the susceptibility of X to depurination, its miscoding potential during replication by polymerases, a
86 -2'-deoxyarabinoguanosine to investigate the miscoding potential of N(2),3-epsilonG by Y-family human
89 t dG-N2-TAM in the K-ras sequence has higher miscoding potential than that in the nonspecific sequenc
90 that both of these adducts have considerable miscoding potential with some of these polymerases, that
93 us estrogen quinone-derived DNA adducts have miscoding potential: G --> A and A --> G transitions and
96 extensively investigated lesion, due to its miscoding properties and its potential role in mutagenes
97 of 2 may be an important determinant of its miscoding properties and its reactivity to nucleophiles
106 ersion to forms that react with DNA, and the miscoding properties of the resulting DNA adducts that c
110 ctive in blocking translesion synthesis, its miscoding properties were similar to other dG-N(2)-BPDE
113 aneous deamination to thymine glycol and the miscoding property of the latter may account, in part, f
115 om increased decoding by near-cognate tRNAs (miscoding) rather than from decreased efficiency of term
117 codon positions was strongly and moderately miscoding, respectively, and it was decoded as an adenos
118 the combined effects of poor repair and high miscoding resulted in 10(2)- to 10(3)-fold increase in t
121 ended products were analyzed to quantify the miscoding specificity and frequency of dX using two-phas
122 Pol eta and kappaDeltaC showed more broad miscoding spectra; direct incorporations of dCMP and dAM
123 In contrast, antibiotics that do not cause miscoding, such as tetracycline, chloramphenicol, erythr
124 e BPDE-dG, but the subsequent extension from miscoding termini depends on REV1-polzeta in a RAD18-dep
127 cates that the dynamics for misreplicating a miscoding versus a non-instructional DNA lesion are diff
130 vations of earlier studies; the frequency of miscoding was unaffected by the presence of E-site-bound
131 hat these 8-oxoG-derived lesions are equally miscoding when replicated in E. coli lacking MutY; no si
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