ライフサイエンスコーパス: mislocalization

1 get proteins and results in their controlled mislocalization.

2 ze nuclear p27 must also prevent cytoplasmic mislocalization.

3 ning of the photoreceptor layer and cellular mislocalization.

4 mreB mutant aberrant morphology due to PBP1 mislocalization.

5 ected by motif mutations that caused TbetaRI mislocalization.

6 omplete loss of Tyrp2, and significant Vamp7 mislocalization.

7 nism and physiological consequences of Pma1p mislocalization.

8 e protein and induce GEF binding and protein mislocalization.

9 le, ZO1, E-cadherin and N-cadherin and their mislocalization.

10 photoreceptor morphology, and correct opsin mislocalization.

11 essing Ter349Glu rhodopsin exhibited partial mislocalization.

12 al within 327-336 aa further facilitated the mislocalization.

13 he roles of trafficking signals in rhodopsin mislocalization.

14 ephrin-A1 result in protein aggregation and mislocalization.

15 spholipid transport activity and subcellular mislocalization.

16 knockdown of p97/VCP corrected ATP7A(T994I) mislocalization.

17 TIM1(10A) with EB1 is responsible for the ER mislocalization.

18 ium and to investigate the effect of protein mislocalization.

19 G-CSF combined with targeting to correct NE mislocalization.

20 hallmarks of ALS, such as gliosis and TDP-43 mislocalization.

21 olar cells together with correction of opsin mislocalization.

22 anes by bafilomycin A1 treatment caused Gls1 mislocalization.

23 lly disrupts this interaction led to exocyst mislocalization and a block in exocytosis in vivo withou

24 ic fractions, these findings demonstrate the mislocalization and accumulation of abnormal TDP-43 in t

25 AnxA6 overexpression caused mislocalization and accumulation of Stx6 and integrins i

26 emarkably, deletion of Scyl1 resulted in the mislocalization and accumulation of TDP-43 (TAR DNA-bind

27 entiation arrest, and was associated with NE mislocalization and activation of the unfolded protein r

28 ive response DNA-binding protein 43 (TDP-43) mislocalization and aggregation are hallmark features of

29 t is truncated at the C terminus, leading to mislocalization and aggregation in other organelles.

30 Tar DNA binding protein 43 (TDP-43) mislocalization and aggregation is a hallmark of amyotro

31 These studies revealed severe mislocalization and aggregation of NUPs and defective nu

32 Mislocalization and aggregation of the huntingtin protei

33 on of wild-type MLL5 was able to rescue PLK1 mislocalization and aMTOC formation in MLL5-KD cells, wh

34 the N-Ras hypervariable region induced N-Ras mislocalization and attenuated aberrant progenitor growt

35 sual pigments, led to alleviation of S-opsin mislocalization and cone degeneration in the knock-in mi

36 ted in shorter photoreceptor outer segments, mislocalization and decrease in visual pigments, decreas

37 Deficiency of ICMT, RAB7, or RAB8 led to mislocalization and diminished processing of NOTCH1-GFP.

38 is dominant-negative and causes IFT protein mislocalization and disrupted ciliogenesis.

39 3A protein may be one of the reasons for its mislocalization and disrupted function in cells of patie

40 In addition, Gbeta(3) deletion causes mislocalization and downregulation of most cascade eleme

41 ndicate that mutant beta-III spectrin causes mislocalization and dysfunction of mGluR1alpha at dendri

42 ymatic activity of RPE65, causing cone opsin mislocalization and early cone degeneration in the mutat

43 re, we show a correlation between centrosome mislocalization and ectopic axon formation in bashful (l

44 Cytoplasmic mislocalization and elevated half-life is a characterist

45 However, these mutations resulted in mislocalization and enhanced degradation of TRPL after p

46 rations of the basement membrane, led to ESC mislocalization and exhaustion of the ESC pool.

47 either of these two proteins, we found Golgi mislocalization and extensive aberrant dendrite formatio

48 host cell signaling, leading to transporter mislocalization and hyposecretion, promoting bacterial c

49 egulating FUS-mediated toxicity, cytoplasmic mislocalization and incorporation into stress granules (

50 BAI1 knockdown results in Par3/Tiam1 mislocalization and loss of activated Rac1 and filamento

51 Arabidopsis homolog SND1 causes both protein mislocalization and loss of target DNA binding, with a r

52 d as an FTLD model, but lack cortical TDP-43 mislocalization and neurodegeneration.

53 Together, the data show that both mislocalization and rod outer segment morphogenesis are

54 harmonin exhibits microvillar protocadherin mislocalization and severe defects in brush border morph

55 Six compounds that caused mislocalization and varying degrees of altered movement

56 n the loss of an interaction or function via mislocalization and/or loss of an essential transmembran

57 x Point Spread Function, we account for such mislocalizations and simultaneously measure 3D molecular

58 binding affinity, the degree of cytoplasmic mislocalization, and ALS disease severity are correlated

59 -) mice showed impaired cone function, opsin mislocalization, and cone degeneration similar to that i

60 protein's transport activity, result in its mislocalization, and reduce its stability.

61 Low protein expression, protein mislocalization, and reduced G protein binding were iden

62 morphisms demonstrated reduced expression or mislocalization, and these events were associated with e

63 re, we describe a previously uncharacterized mislocalization artifact of Entacmaea quadricolor red fl

64 RNA-processing granules thereby eliminating mislocalization as a cause of defective polyadenylation.

65 Our findings establish telomerase mislocalization as a novel cause of DC, and suggest that

66 keleton and identify loss of Glu-MTs and RNA mislocalization as common outcomes of ALS pathogenic mut

67 ur data identifies mitochondrial dysfunction/mislocalization as the likely cellular basis for ARSACS

68 This phenotype may be attributed to hopanoid mislocalization because a double mutant deficient in bot

69 olocalized extensively with EB1 and drove ER mislocalization by pulling ER tubules into the spindle.

70 Saccadic mislocalization, by contrast, is robust and resistant to

71 The mislocalization can be rescued by transfection with wild

72 rophic cardiomyocyte growth, and connexin 43 mislocalization caused by cnNfat3 expression.

73 over the WT ZnT-2; this was associated with mislocalization, decreased stability, and loss of zinc t

74 Quantifying the size of this mislocalization demonstrates that past lesion-deficit re

75 Other rhodopsin mutations cause receptor mislocalization, diminished/constitutive activity, or fa

76 Ras mislocalization does not correlate with protein kinase C

77 Mislocalizations during an axial scan of a single molecu

78 Surprisingly, we found no trace of mislocalization, even for saccades cancelled close to th

79 Using an Rgf3 conditional mutant and mislocalization experiments, we found that Art1 and Rgf3

80 CaBP7 depletion induces lysosome mislocalization, extension of intercellular bridge lifet

81 This results in TbetaRII mislocalization from the basolateral to both the basolat

82 n of the 51-KLDK-54 motif in CnaB causes its mislocalization from the septum to the nucleus, suggesti

83 the clinical significance of cytoplasmic p27 mislocalization in 164 cases of resected gastric cancer

84 in muscle cells, and dyb-1(lf) caused SLO-1 mislocalization in both types of cells without altering

85 ion in maintaining genomic stability and its mislocalization in cancers, suggests an important role o

86 27 at T157 and T198 to cause cytoplasmic p27 mislocalization in gastric cancer, and that p27 mislocal

87 e validated their utility by analyzing their mislocalization in intestinal cells lacking the function

88 sensory cortex when observing touch, suggest mislocalization in previous studies, and instead highlig

89 duction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-def

90 ed in colonic Caco-2 cells, similar to ezrin mislocalization in the colon of PTPsigma(-/-) mice follo

91 d to a reduction of TRPL content and partial mislocalization in the dark.

92 eneration that was associated with rhodopsin mislocalization in the photoreceptors and reduced cone c

93 Erf2-like human protein, did not rescue Ras1 mislocalization in these cells.

94 hotoreceptor structure and reversal of opsin mislocalization in treated areas expressing human RPGR p

95 e prevalent NPM1c+ mutation that causes NPM1 mislocalization in ~30% of AML patients results in exces

96 he psychophysical phenomenon of perisaccadic mislocalization, in which observers misperceive the posi

97 the CCC-associated WASH complex causes LDLR mislocalization, increased lysosomal degradation of LDLR

98 FUS mislocalization increases as disease progresses, and mut

99 of FUS and TDP-43 and found that cytoplasmic mislocalization is a common prerequisite for SG recruitm

100 We found that rhodopsin mislocalization is a facilitated process for which a sig

101 K-Ras4B mislocalization is also recapitulated in ASM-deficient N

102 localization in gastric cancer, and that p27 mislocalization is an adverse prognostic feature in gast

103 Rhodopsin mislocalization is associated with blinding diseases cal

104 If this mislocalization is initiated by saccade preparation, one

105 rod photoreceptor cells triggered by protein mislocalization is likely the mechanism of disease progr

106 We conclude that perisaccadic mislocalization is not a direct consequence of saccade p

107 A similar mislocalization is observed with cerebellar Purkinje neu

108 FUS mislocalization is rescued by the addition of the wild-t

109 1 (ins/ins) retinas have extensive L/M-opsin mislocalization, lack CNGB3 labelling in the L/M-cones,

110 Mice lacking CRALBP exhibited M-opsin mislocalization, M-cone loss, and impaired cone-driven v

111 Cytoplasmic p27 mislocalization may be an additional indicator of high-g

112 athological protein and the rescue of TDP-43 mislocalization may be critical for halting or reversing

113 , our findings indicate that cytoplasmic FUS mislocalization not only leads to nuclear loss of functi

114 ffinities for Unc119a and leads to a partial mislocalization of a low affinity mutant of NPHP3.

115 tyrosine (Y20), whose alteration results in mislocalization of a portion of IFITM3 to the cell perip

116 compromised in these cells, resulting in the mislocalization of a soluble nuclear marker.

117 n linked to this predictive remapping is the mislocalization of a stimulus flashed around the time of

118 We show that GCS inhibition results in the mislocalization of actin and the ERM proteins, key cytos

119 The finding that mislocalization of active phosphotransferase is the basi

120 In addition to a mislocalization of AIM1 from the actin cytoskeleton in i

121 F3 mutant proteins in HEK293T cells revealed mislocalization of all but one mutant in the cytoplasm,

122 beta1-integrin exhibited down-regulation and mislocalization of alpha3- and alpha5-integrins by immun

123 h, disorganized outer rod segment discs, and mislocalization of and reduction in rhodopsin early in p

124 triglyceride-filled vesicles in enterocytes, mislocalization of apolipoprotein B, and loss of chylomi

125 ice led to a reduced scotopic photoresponse, mislocalization of ATP8A2 to the inner segment and cell

126 Mislocalization of Aurora B correlated with dephosphoryl

127 Mislocalization of axonal proteins can result in misasse

128 Further, loss of raw results in mislocalization of beta-catenin away from the cell surfa

129 hibited excessive dendritic arborization and mislocalization of cell bodies in vivo These cellular de

130 mpromises epithelial integrity manifested by mislocalization of cell polarity markers, lateralization

131 loss of Tmem30a in mouse cone cells leads to mislocalization of cone opsin, loss of photopic electror

132 These defects were associated with mislocalization of cone opsins to the nuclear and synapt

133 s slow photoreceptor degeneration with early mislocalization of cone opsins, features resembling thos

134 Disruption of the BTB coincided with mislocalization of connexin43, which was present through

135 was highly stabilized in a cka2Delta strain, mislocalization of Cse4 was mild, suggesting that Cse4 m

136 hanger regulatory factor-1 resulted in gross mislocalization of cystic fibrosis transmembrane conduct

137 showed that these lateral buds resulted from mislocalization of DivIVA, a major determinant in facili

138 and aberrant H3K79 methylation, possibly by mislocalization of DOT1L.

139 tions of tropical pancreatitis, a reversible mislocalization of ductal CFTR in AIP, the association o

140 p0071 resulted in tight junction defects and mislocalization of E-cadherin in mouse inner medullary c

141 This leads to downregulation or mislocalization of EC-specific gene expression and resul

142 Here we demonstrate that in addition to this mislocalization of electron density, a class II IN mutat

143 sitive and Gram-negative bacteria and causes mislocalization of essential membrane-associated protein

144 ion mimics the Weyers cellular phenotype-the mislocalization of EVC-EVC2 within cilia and impaired ac

145 sporadic ALS cases also revealed cytoplasmic mislocalization of EWSR1.

146 rt a two-hit hypothesis, whereby cytoplasmic mislocalization of FUS protein, followed by cellular str

147 ICMT deficiency induced mislocalization of GFP-RAB7 and GFP-RAB8 from endomembra

148 This results in mislocalization of glycosomal enzymes, causing metabolic

149 protein implicated in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-re

150 se activity of this mutant, resulting in the mislocalization of H3K4me3 from the promoter-proximal re

151 SERPINH1 that results in destabilization and mislocalization of HSP47 and secondarily has similar eff

152 uit reduces transcriptional strength through mislocalization of incoming viral genomes away from PML

153 sts display defective receptor recycling and mislocalization of key muscle proteins, including caveol

154 Loss of DLC2 induces the mislocalization of Kif1B, increased Cdc42 activity and c

155 ofluorescent staining revealed a cytoplasmic mislocalization of KLF8 in PARP-1(-/-) cells or when the

156 The mutant protein also causes mislocalization of Lck to Rab11(+) perinuclear endosomes

157 Furthermore, Commd1 depletion results in mislocalization of LDLR, accompanied by decreased LDL up

158 only in nuclear envelope defects, including mislocalization of LEM domain proteins and extensive inv

159 defects in astral MT dynamics, as well as in mislocalization of LGN and NuMA, leading to misoriented

160 Moreover, our analyses demonstrated the mislocalization of lysosomal cathepsins within the cytos

161 crystals, a defect previously linked to the mislocalization of magnetosome proteins.

162 letion of the methyltransferase Ezl3p caused mislocalization of meiosis-induced DNA double-strand bre

163 Furthermore, mislocalization of mitochondria at synapses among motor

164 results in increased Mmr1p phosphorylation, mislocalization of Mmr1p, defects in association of Mmr1

165 ressed in cancer, leading to the cytoplasmic mislocalization of multiple tumor suppressor proteins.

166 dystrophin deficiency causes a decrease and mislocalization of muscle-specific neuronal nitric oxide

167 al in FUS and thereby facilitate cytoplasmic mislocalization of mutant proteins.

168 Rac1 inhibition led to mislocalization of myosin II, as well as to disruption o

169 In one, ELANE mutations lead to mislocalization of NE.

170 f Neph1CD in podocytes prevented PAN-induced mislocalization of Neph1.

171 rophy (DMD), loss of dystrophin leads to the mislocalization of nNOSmu from the sarcolemma to the cyt

172 cytiotrophoblasts results in the subcellular mislocalization of one of the major lactate transporters

173 n translation, leading to a loss of GSCs and mislocalization of oocytes in the ovary.

174 ession and for bacterial survival during the mislocalization of outer membrane secretin proteins.

175 rdingly, the down-regulation and cytoplasmic mislocalization of p120ctn has been reported in all subt

176 These findings suggest that cytoplasmic mislocalization of p27 despite BCR-ABL1 inhibition by ty

177 Cytoplasmic mislocalization of p27 induced by H. pylori may be an im

178 lly at T157, thereby promoting the cytosolic mislocalization of p27(KIP1).

179 xpression of the Tmc2a N terminus results in mislocalization of Pcdh15a within hair bundles, together

180 division, and depletion of FtsX(Spn) caused mislocalization of PcsB but not the FtsZ(Spn) early-divi

181 t Msp1, human ATAD1 limits the mitochondrial mislocalization of PEX26 and GOS28, orthologs of Pex15 a

182 bble, and Dlg1 within perinuclear puncta and mislocalization of plasma membrane-associated Lin7C to t

183 Reduction in Numb expression resulted in mislocalization of Plk1 at both metaphase and anaphase,

184 ctive Psp system are highly sensitive to the mislocalization of pore-forming secretin proteins.

185 ss of PI3K-C2alpha-derived PtdIns3P leads to mislocalization of PRE markers such as TfR and Rab11, re

186 a near-complete loss of cilia from OSNs and mislocalization of proteins normally enriched in cilia.

187 brane segment in the beta-subunit results in mislocalization of Psd1 and reduced enzymatic activity.

188 In this model, germline mislocalization of Pten causes inappropriate social beha

189 ing sequence in chemotaxis pathway mRNAs, or mislocalization of Puf118 and its target mRNAs to the ce

190 5 peptide, into these transgenic rods caused mislocalization of R-opsin and S-opsin to the perinuclea

191 BLOC-3 subunits Hps1 and Hps4 results in the mislocalization of Rab32 and Rab38 and reduction in pigm

192 This is further supported by mislocalization of Rab8, a key regulator of opsin carrie

193 Talpid3 depletion also led to mislocalization of Rab8a, a small GTPase thought to be e

194 ge factors, defects in Rac1 degradation, and mislocalization of Rac signaling components.

195 The mislocalization of RAD51 away from DSBs in cells express

196 The mutation causes mislocalization of RASA3 to the cytosol in scat red cell

197 s do not form rod outer segments and display mislocalization of rhodopsin, suggesting a role for RPGR

198 orporation, shortening of the kinocilia, and mislocalization of ribeye b clusters.

199 The aggregation and mislocalization of RNA-binding proteins leads to the abe

200 Consistent with mislocalization of Serca1 and Ryr1, calcium handling was

201 oss-mediated epithelial integrity defects to mislocalization of serine protease Hepsin and to oncogen

202 nt reduction in the basal pool of PI3P and a mislocalization of several membrane skeleton proteins kn

203 ting SGPL1 mutations resulted in subcellular mislocalization of SGPL1.

204 Abnormal mTORC1 activation caused mislocalization of slit diaphragm proteins and induced a

205 ent with these findings and the postsynaptic mislocalization of SLO-1, we observed an increase in mus

206 the ALS-causing FUS R495X NLS mutation, and mislocalization of Sm proteins is RRM-dependent.

207 Depletion of alpha-COP resulted in mislocalization of SMN and actin at the leading edge at

208 Moreover, mislocalization of SMN disrupts CB integrity and likely

209 udy, we find that FUS inclusions lead to the mislocalization of specific RNAs from fibroblast cell pr

210 nhibitor of trafficking, Retro94, causes the mislocalization of STX5, an altered cVAC morphology, and

211 ry of postmortem spinal cord tissue revealed mislocalization of TAF15 in motor neurons of patients wi

212 of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-4

213 y, BACE reduction decreases the postsynaptic mislocalization of tau in ArcTau mice and reduces the as

214 Our data demonstrate the mislocalization of tau in the somatodendritic compartmen

215 The assumption that mislocalization of tau into the somatodendritic compartm

216 oligomers (Abetao's) for 15 min, we induced mislocalization of tau into the spines under resting con

217 ibit increased levels of TDP-43, subcellular mislocalization of TDP-43, and decreased cell survival.

218 models of ALS and results in the cytoplasmic mislocalization of TDP-43.

219 letion of TRiC causes loss of TCAB1 protein, mislocalization of telomerase and scaRNAs to nucleoli, a

220 outflow tract myocardialization, leading to mislocalization of the aorta.

221 pendently of each other and independently of mislocalization of the apical determinant Crumbs (Crb).

222 Various RPE defects, including mislocalization of the apical marker ezrin, and disrupte

223 Widespread reactive gliosis, including mislocalization of the astrocytic water channel aquapori

224 i-saccadic vision is also characterized by a mislocalization of the briefly presented stimulus closer

225 using short-hairpin RNA results in dramatic mislocalization of the cadherin complex and junctional a

226 adaptor protein Ankyrin G (AnkG) results in mislocalization of the cell adhesion molecule Neurofasci

227 of Ste5 to the plasma membrane due to severe mislocalization of the cellular phosphatidylinositol 4-p

228 We also found mislocalization of the CMA lysosomal receptor LAMP2A and

229 Protein localization defects caused by mislocalization of the cognate mRNA were rescued by intr

230 and latency of corrective saccades, and (2) mislocalization of the corrective (second) saccade in th

231 in several ways, one of which is cytoplasmic mislocalization of the cyclin-dependent kinase inhibitor

232 ning gene molecule interacting with CasL and mislocalization of the Drosophila homolog of the human R

233 conduction defects were accompanied by overt mislocalization of the gap junction protein connexin43 (

234 t defects in TGN acidification together with mislocalization of the Golgi-enriched vacuolar H(+)-ATPa

235 ider canalicular structures correlating with mislocalization of the junctional protein, cingulin.

236 ed protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve.

237 ening mitotic checkpoint signaling caused by mislocalization of the Mad1 binding partner Mad2.

238 how that loss of AtPH1 function leads to the mislocalization of the metal uptake transporter NRAMP1 t

239 Subcellular mislocalization of the microtubule-associated protein Ta

240 dietary iron despite reduced expression and mislocalization of the mutant protein.

241 Knockdown of either protein causes mislocalization of the other, and endogenous anillin inc

242 The concomitant mislocalization of the PIKfyve product PI(3,5)P2 trigger

243 In addition to mislocalization of the plasma membrane proteins, Golgi m

244 ing the localization of the mRNA resulted in mislocalization of the protein and vice versa.

245 f the mutated allele in HEK cells revealed a mislocalization of the protein in the cytoplasm, leading

246 dissociation of CENP-A from centromeres and mislocalization of the protein to noncentromeric sites.

247 ding to the absence of the protein in sperm, mislocalization of the protein when injected in mouse GV

248 nges in ion transporter expression or simply mislocalization of the protein.

249 muscle displayed reduced sAnk1.5 levels and mislocalization of the sAnk1.5/KCTD6 complex.

250 Immunostaining showed mislocalization of the sarcoplasmic reticulum proteins S

251 in that task but did not alter the classical mislocalization of the visual stimulus.

252 mutants generated for tn, showed no relative mislocalization of the Z-disk proteins alpha-Actinin and

253 genes required for endocytosis show similar mislocalization of these proteins to dendrites, and stro

254 its trafficking to the photoreceptor OS and mislocalization of this protein likely leads to RP-relat

255 ted in up-regulation of Lmod2 expression and mislocalization of Tmod1.

256 ion of the mutant TRIM63 was associated with mislocalization of TRIM63 to sarcomere Z disks, impaired

257 Despite the mislocalization of TRP-3/SPE-41 in spe-38 mutant spermat

258 tein in the patient's melanocytes caused the mislocalization of tyrosinase from melanosomes to the pl

259 We further suggest that the mislocalization of ubH2B to the cytoplasm has additional

260 e AP3 complex in mouse mocha fibroblasts and mislocalization of VAMP7.

261 Furthermore, mislocalization of villin from the membrane was prognost

262 Mislocalization of viral capsids in infected cell nuclei

263 PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid

264 gulatory formins dDAAM and Diaphanous caused mislocalization of Zipper and induced ectopic heart lumi

265 nfected monolayer, and severe disruption and mislocalization of ZO-1 and claudin-1 proteins.

266 As for vision, the mislocalizations of time and space for touch stimuli may

267 R motifs, and determined the impact of SHOC2 mislocalization on ERK signalling.

268 n adult cones, we observed a drastic nuclear mislocalization on the basal side of the ONL that affect

269 terference with gH/gL or gH/gL/gO, i.e., the mislocalization or blocking of entry mediators, occurs i

270 t the expression of gH/gL/UL128-131 causes a mislocalization or downregulation of epithelial cell pro

271 slation and are incompatible with either the mislocalization or misfolding hypotheses, which require

272 ions we identified in TTC7A result in either mislocalization or reduced expression of TTC7A.

273 nctions as a safeguard against misfolding or mislocalization prior to its proteolytic removal by CtpA

274 kly in Myo7a-mutant mice, perhaps due to its mislocalization, providing a plausible explanation for i

275 f photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused

276 This mislocalization resulted from the altered membrane prope

277 sters NRF2 and thereby causes its subnuclear mislocalization, resulting in impaired NRF2 transcriptio

278 n of eye eccentricity predicted a pattern of mislocalization that matches the errors made by human ob

279 In this study, the XPA mislocalization to DSBs occurred at stalled or collapsed

280 CENP-A mislocalization to ectopic sites may disrupt chromatin-b

281 ns) in preventing budding yeast CENP-A(Cse4) mislocalization to euchromatin by mediating its proteoly

282 ndle pole separation as a consequence of its mislocalization to nonkinetochore MTs.

283 gnificant loss of PLB membrane anchoring and mislocalization to the cytoplasm and nucleus.

284 Our data show pre-mRNA mislocalization to the cytoplasm, where the RNAs are tar

285 essor, can acquire oncogenic activities upon mislocalization to the cytoplasm.

286 knockdown of HSP60 attenuates APP and Abeta mislocalization to the mitochondria.

287 Unregulated kinase activity caused ezrin mislocalization toward the basolateral domain, whereas e

288 fact can lead to significant lateral (x, y) mislocalizations (up to approximately 50-200 nm).

289 Remarkably, Cx43 mislocalization was also evident in autopsied left ventr

290 In cultured cells, mislocalization was observed at high expression levels w

291 In 97 cases (59%), cytoplasmic p27 mislocalization was observed, and this was associated wi

292 This mislocalization was prevented by either PARP-1 re-expres

293 ansgenic rats, ubiquitin aggregation and FUS mislocalization were developed primarily in the entorhin

294 terestingly, spindle misorientation and NuMA mislocalization were reversed by treatment with a low do

295 The lack of acetaminophen toxicity and Cx32 mislocalization were reversed upon infection with recomb

296 in characteristics of a murine model of Pten mislocalization were used to further evaluate abnormalit

297 only used fluorescent proteins caused severe mislocalization when fused to homo-oligomers.

298 nal confers toxicity to rhodopsin and causes mislocalization when the VXPX cilia-targeting motif is a

299 st that SCN disease pathogenesis includes NE mislocalization, which in turn triggers dysfunctional su

300 sA mutants displayed growth defects and raft mislocalization, which were accompanied by reduced neutr