ライフサイエンスコーパス: mislocalize

1 ondria, and the L122P mutant protein did not mislocalize.

2 precursor cells showed that mutant proteins mislocalize.

3 hand side of the cell or two nuclei with one mislocalized.

4 produces bicaudal embryos when oskar mRNA is mislocalized.

5 eased by 25%, and hemidesmosome proteins are mislocalized.

6 audin-3, apical tight-junction proteins, are mislocalized.

7 of membrane proteins in microvilli, is also mislocalized.

8 some other fragments lacking this region are mislocalized.

9 as rhodopsin, arrestin, and transducin, are mislocalized.

10 oteins exhibited reduced expression and were mislocalized.

11 SHORTROOT and SCARECROW are misexpressed or mislocalized.

12 ing NHE1-KRA2 because scaffolding by NHE1 is mislocalized.

13 -)Nrl(-/-) mice was minimal, and opsins were mislocalized.

14 tor, the CD is disorganized and REMPA-YFP is mislocalized.

15 e SH3 domain is overexpressed, paramyosin is mislocalized.

16 ore, enzymes that support aECM stability are mislocalized.

17 Golgi, Rh1 is aberrantly glycosylated and is mislocalized.

18 ongation zone of twd1 roots, attributable to mislocalized ABCB transporters and suppressed by an auxi

19 n both growth and nuclear segregation due to mislocalized actin assembly.

20 Dkk-1 exposure induced mislocalized activation of Cdc42 in migrating cells, whi

21 with suggestions that AlgL serves to degrade mislocalized alginate that is trapped in the periplasmic

22 of apical-basal polarity, such as ZO-1, were mislocalized along the lateral and basal membranes of fi

23 esulting intermicrovillar adhesion links are mislocalized along the microvillar axis rather than enri

24 We show that SCA5 beta-spectrin dominantly mislocalizes alpha-spectrin and ankyrin-2, components of

25 swollen, but neither opsin nor arrestin was mislocalized, although IFT88 accumulated in the distal r

26 raspeckle function in human diseases because mislocalized amyotrophic lateral sclerosis (ALS)-linked

27 rtain LPS biosynthesis enzymes causes Hap to mislocalize and accumulate in the periplasm, where it is

28 However, they can also mislocalize and cause stress to the bacterial cell, whic

29 Without chromophore, cone opsins are mislocalized and cones degenerate rapidly (e.g., Rpe65(-

30 tion, the ER enzyme glucosidase I (Gls1) was mislocalized and degraded in the vacuole.

31 The SNARE protein Vamp7B was mislocalized and enriched on the contractile vacuoles of

32 e ERM proteins ezrin, radixin, and moesin is mislocalized and found uniformly along the plasma membra

33 n a parAB2 deletion mutant, chromosome II is mislocalized and frequently fails to segregate, yielding

34 In mdx muscle, nNOSbeta was mislocalized and its association with the Golgi complex

35 mutants lacking Schwann cells, the nerve is mislocalized and the axons remain in the epidermis.

36 cytic adaptors known to bind PI(4,5)P(2) are mislocalized and the defects in FM1-43 dye uptake and ad

37 SENP2, we observe that many nucleoporins are mislocalized and, in some cases, reduced in level when S

38 in facilitated exit from mitosis by possibly mislocalizing and functionally inactivating cyclin B1.

39 Septins and actin were mislocalized, and cell wall synthesis was very abnormal,

40 nded, pseudopodial activity is increased and mislocalized, and chemotaxis is impaired.

41 the absence of INO80, H2A.Z nucleosomes are mislocalized, and H2A.Z levels at promoters show reduced

42 ull mice, PLCbeta2 was undetectable, NHERF-1 mislocalized, and IP3 R3 more intensely stained, along w

43 of JAM-A, other tight junction proteins were mislocalized, and pseudocanaliculi, which form the apica

44 that the STGD3 truncated mutant may generate mislocalized, and therefore toxic, keto intermediates of

45 a competition-based approach to specifically mislocalize APC-dependent RNAs suggests that localizatio

46 apical domains and terminal cells displayed mislocalized apical proteins.

47 ells overexpressing or depleted of kinastrin mislocalize astrin and show the same mitotic defects as

48 tring protein (CSP) and SNAP25, are severely mislocalized at hip14 mutant synapses.

49 In apm-2 mutants, clathrin is mislocalized at synapses, and synaptic vesicle numbers a

50 ed reduced expression of CD103 (Itgae), were mislocalized away from airway epithelia, and demonstrate

51 E6 attenuates repair by causing RAD51 to be mislocalized away from both transient and persistent DSB

52 -eGFP and RhoaCT32-eGFP fusion proteins were mislocalized away from the plasma membrane in embryonic

53 ce of Crumbs or aPKC phosphorylation of Baz, mislocalized Baz recruits adherens junction components a

54 nteraction and thereby inhibits autophagy by mislocalizing Beclin 1 to the dynein motor complex.

55 When Fin1 is mislocalized, bipolar spindles fail to assemble but the

56 pgp-2(-) embryos mislocalize birefringent material into the intestinal lu

57 Expression of mislocalized Bni1p constructs has a dominant-negative ef

58 at inhibition of acid sphingomyelinase (ASM) mislocalizes both the K-Ras isoforms K-Ras4A and K-Ras4B

59 cause RalA and RalB are equally effective in mislocalizing both murine and human p27, we focus on Ral

60 rains lacking substrates that are toxic when mislocalized, both LolA and LolB can be completely bypas

61 Both Rab8a and Rab10 were mislocalized by the expression of dominant-negative myos

62 abnormal anchorage of radial glial endfeet, mislocalized Cajal-Retzius cells, and neuronal overmigra

63 tion of CLASP2 in migrating neurons leads to mislocalized cells in deeper cortical layers, abnormal p

64 bryos accumulate ceramide in the ER but also mislocalize ceramide to the mitochondria, compromising t

65 n autoimmune pancreatitis (AIP) by restoring mislocalized CFTR protein to the apical ductal membrane.

66 iciently polymerized, resulting in fewer and mislocalized curli fibers.

67 estion, we generated knockin mice expressing mislocalized cytoplasmic FUS and complete FUS knockout m

68 -43 (hTDP-43-WT) to determine the effects of mislocalized cytoplasmic TDP-43 on neuronal viability.

69 Cells loose their apical-basal polarity, mislocalize DE-cadherin, and delaminate from the main ep

70 s capacity for mesenchymal condensation with mislocalized distributions of chondroitin sulfate proteo

71 FADD-D protein is also mislocalized during cell cycle progression.

72 In summary, we demonstrate that claudin-7 is mislocalized during the malignant transformation of esop

73 an-Cre results in fusion proteins that often mislocalize, exhibit mutant phenotypes, and dramatically

74 ly, however, these patch mutations result in mislocalized exocyst complexes that remain intact.

75 increased expression of aquaporin-2 mRNA but mislocalized expression of aquaporin-2 protein in the cy

76 ce of the nucleation machinery, resulting in mislocalized fibers.

77 mplified, mRNA overexpressed, and protein is mislocalized from cell-cell junctions in human breast ca

78 Pathological TDP-43 is mislocalized from its nuclear location to the cytoplasm,

79 the remaining alpha- and beta-subunits were mislocalized from the light-sensitive outer segment comp

80 Lastly, Scribble was mislocalized from TJs and its expression down-regulated

81 n telomeres is abrogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iP

82 We propose that branching begins when mislocalized FtsZ triggers the insertion of inert peptid

83 Aurora B normalization redirects the mislocalized furrow proteins to their proper location, c

84 Aggregation of mislocalized FUS into non-amyloid inclusions is believed

85 and mRNA splicing patterns, indicating that mislocalized FUS results in loss of its normal function.

86 Rock inhibition increased the generation of mislocalized ganglion/amacrine cells at the expense of r

87 ncoded by 44 TetO(7)-orf strains resulted in mislocalized GFP-Nic96.

88 al of the C-terminal domain, which partially mislocalizes gp210/Nup210 away from NPCs, efficiently re

89 aseIV), which depletes cellular PI(4,5)P(2), mislocalizes HIV-1 Gag to the cytosol and greatly reduce

90 Separase is also overexpressed and mislocalized in a wide range of human cancers, including

91 Nups were mislocalized in adult intestinal nuclei and in embryos f

92 naptic ribbon protein, was less abundant and mislocalized in adult wud mutants.

93 NA processing, are abnormally aggregated and mislocalized in ALS and FTLD, while the expansion in the

94 microtubules and is hyperphosphorylated and mislocalized in Alzheimer's disease.

95 eoblast stem cells and progenitor cells were mislocalized in beta1-integrin(RNAi) animals without sig

96 n-1 loss-of-function (lf) mutants, SLO-1 was mislocalized in body-wall muscle but its transcription a

97 likely conserved substrate of fly CCT and is mislocalized in both cct and in dfmr1 mutant embryos.

98 d, an apically localized adaptor protein, is mislocalized in both crb mutant cells and Crb overexpres

99 ronal progenitors, becomes overexpressed and mislocalized in cancer cells from a variety of human tum

100 Strikingly, OGT is mislocalized in cardiac mitochondria from diabetic rats.

101 reduced and, additionally, Sir proteins are mislocalized in cells lacking CAF-1 and Rtt106p.

102 Pma1p was not mislocalized in concanamycin-treated cells, but a signif

103 the key lipid metabolizing enzyme, lipin, is mislocalized in dTorsin-KO cells, and dTorsin increases

104 ivated these proteins, and mutant human Int6 mislocalized in HeLa cells.

105 n ligase activity towards dysbindin and were mislocalized in heterologous cells.

106 xpression is either decreased or the protein mislocalized in human HCC.

107 t germ cell nuclei, nucleoporins (Nups) were mislocalized in large plaques beginning at meiotic entry

108 he nuclear envelope protein emerin, which is mislocalized in Lmna mutant cells and also linked to EDM

109 (NIS; aka SLC5A5), which is upregulated and mislocalized in many human carcinomas.

110 nd a recently identified Chk1 substrate, was mislocalized in mitotic Chk1(+/-) mammary epithelia.

111 of the mutants were transport-competent but mislocalized in mouse liver.

112 luR localization are also grossly reduced or mislocalized in mtg mutants, including the dPix-dPak-Doc

113 nstrated that viral capsids assemble but are mislocalized in nuclei of cells infected with the mutant

114 NUP-1 is mislocalized in NUP-2 knockdown cells and vice versa, im

115 Moreover, the KASH protein ZYG-12 was mislocalized in ooc-5 gonads.

116 ylated rod PDE6 catalytic subunits partially mislocalized in Pde6d(-/-) rods, whereas rhodopsin was u

117 ulator of rhodopsin ciliary trafficking, was mislocalized in photoreceptor cells of rpgrip1 mutants.

118 Here we demonstrate that NF-E2 is mislocalized in PMF cells and that aberrant NF-E2 locali

119 Mad2 is mislocalized in Smurf2-depleted cells, suggesting that S

120 spatial regulator of MSP disassembly, MSP is mislocalized in sperm lacking GSP-3/4.

121 main myristoylated kinases in T cells, were mislocalized in the absence of Nmt activity.

122 , endothelial cells with venous identity are mislocalized in the aorta, suggesting that ephrin B2/Eph

123 the cytoskeleton protein betaII spectrin are mislocalized in the axon, and assembly of the node of Ra

124 ted to the nucleus, but mutant isoforms were mislocalized in the cytoplasm.

125 These proteins can be mislocalized in the cytosol due to mutations in their ta

126 nts, when tactile stimuli are systematically mislocalized in the direction of the movement.

127 Mutant receptor tyrosine kinases are mislocalized in the endoplasmic reticulum (ER) of AML an

128 ochlea in vivo; however, tricellulin becomes mislocalized in the inner ear sensory epithelia of ILDR1

129 that, in Myo7a-mutant mice, RPE65 is partly mislocalized in the light.

130 ted in Rs1-KO, and some PSD95 and mGluR6 was mislocalized in the outer nuclear layer (ONL).

131 Moreover, the tight junction protein ZO-1 is mislocalized in the tal1-deficient endocardium, indicati

132 Laminin is mislocalized in this mutant, as are the membrane-associa

133 ane cell fate regulator, SCRAMBLED (SCM), is mislocalized in ugt80B1 mutants, underscoring the aberra

134 Pma1p is mislocalized in vma mutants but remains at the plasma me

135 ctivation, and the mutant Dax-1-TIF2 complex mislocalizes in living cells.

136 The mechanism by which rhodopsin mislocalizes in rod photoreceptor neurons is not well un

137 hese transgenic rods without chromophore was mislocalized; in R-opsin's presence, however, S-opsin tr

138 Interestingly, the 26S proteasome is mislocalized into foci, which are colocalized with nucle

139 contraction begins, MYO-3 and UNC-89 become mislocalized into large foci and animals die.

140 Here, we report that progerin/LADelta50 mislocalizes into insoluble cytoplasmic aggregates and m

141 However, Vps34-deficient T cells have mislocalized intracellular Eea1, HGF-regulated tyrosine

142 Toxic gain of TBPH did not downregulate or mislocalize its own expression, indicating that a domina

143 Mutations in SLC4A1 that mislocalize its product, the chloride/bicarbonate exchan

144 isplay defective cell polarity, resulting in mislocalized junctional complexes and loss of adhesion t

145 s of L-type calcium channel blockers did not mislocalize K-Ras, suggesting a mechanism that is unrela

146 Silencing of GPR31 expression partially mislocalized KRAS4B, slowed the growth of KRAS-dependent

147 of nodes, disrupted paranodal junctions, and mislocalized Kv1 K(+) channels.

148 ress response pathways that are activated by mislocalized lipopolysaccharide may collectively contrib

149 unction is to prevent lethal accumulation of mislocalized lipoproteins.

150 ficking tasked with protecting the cell from mislocalized lipoproteins.

151 opsins mistrafficked as reported previously, mislocalized M-opsin was degraded whereas mislocalized S

152 , Ubr4 is responsible for the degradation of mislocalized MEC-2 multimers.

153 , UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell stimulatio

154 lost in the presence of polyglutamine, which mislocalizes MOAG-2/LIR-3 from the nucleus to the cytoso

155 sitioned centrosomes and Golgi apparatus and mislocalized molecules of the slit diaphragm.

156 PRG inhibition reduces or mislocalizes monophosphorylated myosin light chains in f

157 ifically alters EC directional migration and mislocalized MT organizing center (MTOC)/Golgi and myosi

158 On the other, the mislocalized mutant PTEN results in a significantly decr

159 ociated with previously characterized matrix-mislocalized-mutant tafazzins to include the rapid degra

160 A activity resulting, in part, from severely mislocalized myospryn and the type II regulatory subunit

161 In contrast, defective farnesylation mislocalizes nascent adhesion sites, suggesting that LKB

162 ivo, dysferlin null muscle was found to have mislocalized nuclei and vacuolation.

163 otably, all types of defective spindles have mislocalized NuMA (nuclear mitotic apparatus protein), a

164 topes abolishes binding to the karyopherins, mislocalized NXF1 to the cytoplasm, and significantly co

165 sin-2, a major anterograde IFT motor, causes mislocalized opsin, followed by rapid cell death.

166 t likely results secondarily from binding to mislocalized opsin.

167 Immunofluorescence correctly identified mislocalized or absent staining in 100% of the discovery

168 , localizing to the position of PGCs whether mislocalized or trapped in the endoderm.

169 pole plasm posteriorly and in degrading any mislocalized Oskar that results from leaky translational

170 Miranda mislocalizes oskar mRNA/Staufen complexes to the oocyte

171 (Psp) stress response system is activated by mislocalized outer-membrane secretin components of prote

172 SS2 expression was increased and the protein mislocalized over the entire tumor cell membrane.

173 A Pins S401A mutant mislocalizes over the cell cortex and causes spindle ori

174 spadias is a urethral tube defect defined by mislocalized, oversized, or multiple openings of the pen

175 phosphorylation not only stabilizes p27 and mislocalizes p27 to the cytoplasm but also promotes RhoA

176 tablishing its function as release factor of mislocalized palmitoylated proteins in the acylation cyc

177 protein thioesterases (APTs) depalmitoylate mislocalized palmitoylated proteins on endomembranes.

178 Surprisingly, these mislocalized PCs did not maintain adjacent zymogenic lin

179 Ror2 and Wnt5a mutants with mislocalized PGCs corroborate the microenvironmental reg

180 ed two green fluorescent protein (GFP)-fused mislocalized PGK mutants, the transit peptide deletion m

181 dysregulation of Numb expression results in mislocalized Plk1 and poor centrosomal gamma-tubulin rec

182 Overexpression of Cep152 (1-217) mislocalizes Plk4, but both Cep152 and Plk4 are able to

183 The majority of the mislocalized PMCs in miR-31 KD embryos did not express V

184 ion formation as evidenced by loss of Caspr, mislocalized potassium Kv1.2 channels, and abnormal myel

185 ing to ineffective H2AX dephosphorylation by mislocalized PP4c phosphatase rather than ongoing DNA da

186 the population of prefrontal neurons grossly mislocalized presaccadic stimuli as being closer to the

187 The mechanisms of mislocalized protein (MLP) degradation are unknown.

188 hown to be important in the TRC pathway, the mislocalized protein degradation pathway, and the endopl

189 sults in a specific stabilization of a model mislocalized protein derived from the amyloid precursor

190 d demonstrate the importance of accumulating mislocalized protein per se, rather than specific signal

191 ese data reveal that, in a cellular context, mislocalized protein ubiquitination is the result of a d

192 xposed hydrophobic transmembrane domain of a mislocalized protein, thereby preventing BAG6 recruitmen

193 Mislocalized proteins (MLPs) are protected from aggregat

194 Mislocalized proteins bearing a signal sequence that did

195 wn to enhance the proteasomal degradation of mislocalized proteins by selectively promoting their ubi

196 (fs) mutations that encode DNase-active but mislocalized proteins cause disease.

197 ow that the BAG6-dependent ubiquitination of mislocalized proteins is completely reversible and ident

198 TA actively promotes the deubiquitination of mislocalized proteins that are already covalently modifi

199 t, repair, or hydrolyze mutant, damaged, and mislocalized proteins.

200 ity occurred in cells expressing the nuclear mislocalized PTEN-K62R mutant, whereas elevated cytosoli

201 r subset of cases with an unusual pattern of mislocalized punctate MHC II staining and intermediate l

202 Indeed, cytoplasmically mislocalized RB could be efficiently confined to the nuc

203 id-1 in a forward genetic screen for mutants mislocalizing RBF-1 rabphilin, a RAB-27 effector.

204 In the absence of the VXPX motif, mislocalized rhodopsin is actively cleared through secre

205 ciliary membrane projections that accumulate mislocalized rhodopsin.

206 indings thus describe a novel link between a mislocalized RNA binding protein implicated in ALS (RBM4

207 We propose that in retinal disease, mislocalized rod opsin gains access to cAMP signaling, w

208 y, mislocalized M-opsin was degraded whereas mislocalized S-opsin accumulated in Lrat(-)(/-) cones be

209 We found that mislocalized scaffolding by the plasma membrane Na-H exc

210 Thus, we demonstrate that high levels of mislocalized SCRIB functions as a neomorph to promote ma

211 ce and humans possess both downregulated and mislocalized Scribble.

212 Mislocalized secretins induce psp gene expression, and k

213 serving as a sensor of DNA from pathogens or mislocalized self-DNA.

214 ions and eliminating the need for washout of mislocalized sensor.

215 n results in unstable dendritic protrusions, mislocalized shaft-synapses, and loss of compartmentaliz

216 iosis I, leading to monopolar, multiple, and mislocalized spindles.

217 During replication stress, the mislocalized Stn1 may inappropriately promote Pol alpha

218 ular basement membrane marker collagen IV is mislocalized, suggesting that ECs fail to recognize the

219 also appear when the septal protein FtsZ is mislocalized, suggesting that peptidoglycan modification

220 upled to pervasive incorporation of H2A.Z by mislocalized SWR-C alters chromatin composition and cont

221 processes into the outer nuclear layer, and mislocalized synaptic complexes.

222 r framework for Msp1-dependent extraction of mislocalized TA proteins from the outer mitochondrial me

223 AAA+ ATPase Msp1 limits the accumulation of mislocalized TA proteins on mitochondria.

224 ht promote the extraction and degradation of mislocalized TA proteins to maintain mitochondrial integ

225 Likely as a result of failing to extract mislocalized TA proteins, yeast with combined mutation o

226 Mislocalized tail-anchored (TA) proteins of the outer mi

227 matin, abnormally clustered centromeres, and mislocalized telomeres.

228 In agreement, conditional cbk1 mutants mislocalize the cis-Golgi mannosyltransferase Och1, are

229 In a genetic screen for mutants that mislocalize the dendritic marker human transferrin recep

230 Mutations that alter cell curvature and mislocalize the intermediate filament crescentin cluster

231 Septin mutants mislocalize the leading-edge protein (LEP) complex requi

232 events ATR activation through its ability to mislocalize the MRN complex.

233 barentsz, and Tropomyosin II mutants, which mislocalize the mRNA anteriorly.

234 epleting each presumed trafficking component mislocalizes the same set of apical membrane molecules b

235 he tumor suppressor p53 in human cells, thus mislocalizing the proteins in the cytosol.

236 Once mislocalized, they are recognized by the Hsp70 chaperone

237 Two distinct truncating mutants were mislocalized throughout the axon and phenocopied the arr

238 tic vesicles and active zone proteins mostly mislocalize to dendrites in animals defective for both P

239 his system causes a subset of TA proteins to mislocalize to mitochondria.

240 nents of the cytoplasmic fibrils of the NPC, mislocalize to the cytoplasm.

241 -of-function mutants, presynaptic components mislocalize to the DA9 dendrite.

242 ail to develop properly, and some OS markers mislocalize to the inner segments and outer nuclear laye

243 t SAMHD1 mutants of the cyclin-binding motif mislocalized to a nuclear compartment and had reduced ab

244 Cx32 was mislocalized to an intracellular location in hepatocytes

245 abundant in the basolateral membrane and was mislocalized to apical bundles in ap1b1 mutant hair cell

246 pindle pole body (SPB), Kar9p-L304P-3GFP was mislocalized to both SPBs.

247 lls express low levels of E-cadherin that is mislocalized to cytoplasmic vesicles.

248 -33 and unc-44 mutants, axonal proteins were mislocalized to dendrites and vice versa, suggesting bid

249 percentage of C150S-Rds and cone opsins were mislocalized to different cellular compartments in cones

250 tissues, Cx43 was found to be pathologically mislocalized to lateral sides of cardiomyocytes.

251 owed both glyphosate sensitivity and FD5-GFP mislocalized to nuclei.

252 mentia (FTD) cases, and LSD1 is specifically mislocalized to pathological protein aggregates in these

253 During mitosis, Pins is mislocalized to the apical surface in the absence of Par

254 ish Clrn1; in contrast, hCLRN1(N48K) largely mislocalized to the cell body with a small amount reachi

255 e N-terminal 15 amino acids caused MP1 to be mislocalized to the cytoplasm and nucleus.

256 tochemical analysis also showed that p27 was mislocalized to the cytoplasm in the majority of osteosa

257 Ect2 is overexpressed and mislocalized to the cytoplasm of NSCLC cells where it bi

258 In NSCLC cells, Ect2 is mislocalized to the cytoplasm where it binds the PKCiota

259 addition, FSGS-linked ACTN4 mutants not only mislocalized to the cytoplasm, but also lost their abili

260 These results suggest that mutant TDP-43 is mislocalized to the cytoplasm, where it exhibits a toxic

261 aroid and nuclear pore complex proteins were mislocalized to the cytoplasm.

262 W-E) in complex with CDK2 are preferentially mislocalized to the cytoplasm.

263 oteinopathies, in which this protein becomes mislocalized to the cytoplasm; however, it is unclear wh

264 ICL and thiolase were mislocalized to the cytosol but only ICL was stabilized

265 ized to peroxisomes in 4-d-old seedlings but mislocalized to the cytosol in 8-d-old seedlings.

266 CTR1 was similarly mislocalized to the cytosol in the heart of knockin mice

267 cases of Alzheimer disease it is cleaved and mislocalized to the cytosol, leading to accumulation.

268 aN13) lacking the first 13 residues was also mislocalized to the endoplasmic reticulum although it re

269 ations present in the stem domain of POMGnT1 mislocalized to the endoplasmic reticulum, highlighting

270 ues) exhibited undetectable activity and was mislocalized to the endoplasmic reticulum, suggesting th

271 Further, mutant receptors were mislocalized to the inner segments and perinuclear regio

272 and the gap junction protein connexin 43 was mislocalized to the lateral myocyte border.

273 ly reduced in diabetic samples, where OGT is mislocalized to the matrix.

274 he tissues of these mice would be strikingly mislocalized to the nucleoplasm, but this was not the ca

275 ytoplasmic intermediate filament network and mislocalized to the nucleus.

276 In addition, cone opsin mislocalized to the outer nuclear layer and the outer pl

277 articularly prominent with OspC mutants that mislocalized to the periplasm or contained C-terminal ep

278 otably, opsin stimulated sprouting only when mislocalized to the plasmalemma of the rod cell body.

279 We previously reported that XPA mislocalized to the progerin-induced DNA double-strand b

280 y injury to other peripheral axons that were mislocalized to the skin, neighboring skin cells, and ma

281 ouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentritic domain of neurons, b

282 D1 (PIN1), PIN2, and AUXIN-RESISTANT1 (AUX1) mislocalized to the vacuolar membrane of the mutant.

283 ot only depleted but the residual PKA-Calpha mislocalizes to heavier cell fractions and is not phosph

284 ciliary basal body, whereas defective TAPT1 mislocalizes to the cytoplasm and disrupts Golgi morphol

285 cated in the nucleus, however, in disease it mislocalizes to the cytoplasm where it aggregates to for

286 eficient Env7C13-15S is also kinase dead and mislocalizes to the cytoplasm.

287 The remaining P23H-hRho-GFP mislocalizes to the inner segment and outer nuclear laye

288 show that Ctr2-1, a mutant form of Ctr2 that mislocalizes to the plasma membrane, requires the Fre1 p

289 Although proteolysis prevents CENP-A from mislocalizing to euchromatin, regulatory factors have no

290 These new tools were used to mislocalize transmembrane and cytoplasmic GFP fusion pro

291 th the function of GFP fusion protein and to mislocalize (trap) GFP fusions to the plant cytoplasm in

292 ubuloreticular and sarcolemmal membranes and mislocalized triads and mitochondria in skeletal muscle

293 DP-25 and TDP-35 and that protection against mislocalized/truncated TDP-43 was observed for HSPB8 in

294 Mislocalized Wee1B or Myt1 is not able to maintain meiot

295 -specific proteins (U1-70K, U1A and U1C), co-mislocalize with FUS to the cytoplasm in ALS patient fib

296 4,5)P2 binding, 29KE/31KE, has been shown to mislocalize within the cell, leading to particle assembl

297 anGAP protein is enzymatically wild type but mislocalized within cells and, for reasons that remain u

298 RAD-23 abundance is increased and RAD-23 is mislocalized within motor neurons.

299 which are null for lamins A/C, LAP2alpha is mislocalized within nuclear aggregates, and this is corr

300 PRX lacking O-GlcNAcylation is mislocalized within the myelin sheath of these mutant an