ライフサイエンスコーパス: mismatched base pair

1 A:dCTP, the fingers domain closes around the mismatched base pair.

2 e ligation of substrates containing even one mismatched base pair.

3 es no cofactors and is inhibited by a single mismatched base pair.

4 cture displays little if any dependence on a mismatched base pair.

5 he hybrids thus formed contain even a single mismatched base pair.

6 recombination joint structure with a single mismatched base pair.

7 found to be correlated with the size of the mismatched base pair.

8 oligodeoxynucleotide duplexes that contain a mismatched base pair.

9 tained a G-U wobble base pair and also a G-A mismatched base pair.

10 ifically targets the T (or U) residue of the mismatched base pair.

11 tosine residues in DNA gives rise to the G/T mismatched base pair.

12 ny different species despite the presence of mismatched base pairs.

13 binds from the minor groove with ejection of mismatched base pairs.

14 at occur during DNA replication resulting in mismatched base pairs.

15 to be fairly intolerant of nicks containing mismatched base pairs.

16 ir tolerance/intolerance of nicks containing mismatched base pairs.

17 ecrease stabilizing stacking interactions of mismatched base pairs.

18 the lowest fidelity (3.2 x 10(-2)) among all mismatched base pairs.

19 have low specificity due to the tolerance of mismatched base pairs.

20 tly found using NMR methods to recognize T*G mismatched base pairs.

21 hermodynamic differences between correct and mismatched base pairs.

22 e between the stabilities of the matched and mismatched base pairs.

23 ain is less perturbed by the presence of the mismatched base pairs.

24 ctures, and most of these structures contain mismatched base pairs.

25 mic effects of unusual or modified bases and mismatched base-pairs.

26 The structure contains five mismatched base-pairs, an unusual C.CG base-triple platf

27 e found for the isolated loop contains three mismatched base-pairs: an A+-C, a G-U wobble, and a shea

28 ermal stabilities and structures of both the mismatched base pair and the perfect matched base pair d

29 mainly include DNAzymes, G-quadruplexes, and mismatched base pairs and nanomaterials cover gold nanop

30 rference, it is likely that stabilisation of mismatched base pairs and secondary structure cleavage a

31 and enrich DNA fragments containing internal mismatched base pairs and separate these fragments as a

32 tructure of a brominated RNA helix with four mismatched base pairs and sequence r(UG(Br)C(Br)CAGUUCGC

33 mplified by the retention of UDG activity on mismatched base pairs and weak XDG activity.

34 Watson-Crick base-pairs, the program handles mismatched base-pairs and chemically modified bases.

35 Mismatched base-pairs and other factors that would pertu

36 and metal complexes that selectively bind to mismatched base pairs (and not to fully paired double-st

37 asing relative yield with temperature from a mismatched base pair, and these effects are accounted fo

38 NA fragments, 373 bp long, with two adjacent mismatched base pairs, and eight DNAs with Watson-Crick

39 require that signals about the presence of a mismatched base pair are communicated from the mismatch

40 immunoglobulin loci in hypermutable B cells, mismatched base pairs are "corrected" according to the n

41 o contributes to specificity as destabilized mismatched base pairs are better substrates than stable

42 G x A mismatched base pairs are frequently found in nucleic ac

43 we showed that retrons encoding msDNAs with mismatched base pairs are mutagenic when present in mult

44 roduce a new method based on the creation of mismatched base pairs as kinetic barriers to strand disp

45 constants and lifetimes of Watson-Crick and mismatched base-pairs, as well as the solvent accessibil

46 mperature measurements comparing matched vs. mismatched base pairs at duplex DNA termini are far too

47 ed complexes having all possible matched and mismatched base pairs at the 3' side of the nick site an

48 erefore, with the increase in the G content (mismatched base pairs) at a certain concentration (e.g.,

49 idine base pairs, thereby discriminating the mismatched base pairs based on their ability to form the

50 n this family more readily accept damaged or mismatched base pairs because of a sterically more open

51 only accelerates the removal of uracil from mismatched base pairs but also enables the enzyme to gai

52 o test the possibility of visually detecting mismatched base pairs by atomic force microscopy, we pre

53 Here we demonstrate that even a single mismatched base pair can significantly decrease human ge

54 differentiating DNA duplexes containing the mismatched base pairs CC and CA at single molecule resol

55 rates containing all 16 possible matched and mismatched base pair combinations at the 3' side of a ni

56 The thermodynamic destabilization of a mismatched base pair duplex relative to the perfect matc

57 For any mismatched base pair duplex, the B-DNA domain of the hyb

58 for a role of Pol(kappa) in the extension of mismatched base pairs during normal DNA replication, and

59 ether to bypass heterologous sequences; i.e. mismatched base pairs, during homologous recombination.

60 The mismatched base pairs exhibit a solvent network as well

61 tched (containing one or two T*G, A*G or G*G mismatched base pairs) hairpin oligonucleotides were det

62 ded DNA, DNA molecules containing six or one mismatched base pairs, hairpin, and fully homologous dup

63 solvent molecules, with the exception of the mismatched base pairs, implying that specific RNA-protei

64 The positions of any mismatched base pairs in an miRNA determine which Argona

65 pares the thermal stabilities of matched and mismatched base pairs in DNA duplexes containing or not

66 program to develop agents that can recognize mismatched base pairs in DNA, a set of four polyamide tr

67 ersatile and specific recognition agents for mismatched base pairs in DNA.

68 ticodon loop and the lack of noncanonical or mismatched base pairs in the stem regions.

69 Surprisingly, the two T-G mismatched base pairs in the WP401-TGGCCG complex adopt

70 Mismatched base pairs in these heteroduplexes are cleave

71 ue to loss of viability that is triggered by mismatched base pairs in this genetic background.

72 The T:G mismatched base pair is associated with many genetic mut

73 MutS performs the task of locating mismatched base pairs, loops and lesions and initiating

74 ase beta (pol beta)/DNA complexes with three mismatched base-pairs, namely GG, CA, or CC (primer/temp

75 se exhibits greater discrimination against a mismatched base pair on the 3'-side of the nick junction

76 compete with Pol(zeta) for the extension of mismatched base pairs on damaged and undamaged DNAs.

77 The effects of helix stability and mismatched base pairs on the recognition of homology rev

78 ing a group of DNA probes, each containing a mismatched base pair or an abasic site, we found a small

79 ity to tolerate the geometric distortions of mismatched base pairs or those resulting from template-p

80 Furthermore, most of the unligatable 3' mismatched base pairs prohibit formation of the DNA-aden

81 te of base-extension for Watson-Crick versus mismatched base pairs), replications without enzymes, wi

82 cation, we developed a novel system to study mismatched base pair resolution during HIV-1 replication

83 ins are characterized by the presence of N:N mismatched base pairs sandwiched between G:C base pairs

84 plex mutant polymerase to replicate beyond a mismatched base pair severely inhibits viral replication

85 Simulations for other mismatched base pairs show that an intermediate closed s

86 lysis of cleavage patterns of all 12 natural mismatched base pairs suggests that purine bases are pre

87 own to exhibit glycosylase activity on three mismatched base pairs, T/U, G/U and C/U.

88 airpin loops with combinations of normal and mismatched base pairs that easily rearrange.

89 The introduction of mismatched base pairs that impede uncatalyzed strand exc

90 be relatively intolerant of nicks containing mismatched base pairs, the human DNA ligase IV/XRCC4 com

91 ase in response to covalent incorporation of mismatched base pairs, thereby favoring subsequent misma

92 , in which was correlated with the amount of mismatched base pairs, therefore the current DNA biosens

93 ise a simulation of branch migration through mismatched base-pairs to arrive at the underlying molecu

94 ly stacked A-form RNA stems separated by two mismatched base pairs, U(162)*Psi(39) and G(163)*A(38),

95 inate between duplexes containing matched or mismatched base pairs was impaired.

96 All other DNAs with adjacent mismatched base pairs were less stable than Watson-Crick

97 iscriminations (including T/G wobble and T/C mismatched base pairs) while maintaining the (Se)T/A vir

98 MBD4 can excise the mismatched base paired with a guanine (G:X), where X is

99 that both yeast and human Poleta extend from mismatched base pairs with a frequency of approximately

100 into the recognition by MutY of damaged and mismatched base pairs within DNA.

101 matched site; the metal complex replaces the mismatched base pair without an increase in base pair ri

102 ly, a capacity for ligating nicks containing mismatched base pairs would appear to be advantageous.