ライフサイエンスコーパス: missing heritability

1 the complex traits remains unaccounted for ('missing heritability').

2 opment of CD has led to the acceptance of a 'missing heritability'.

3 ndings suggest a multifarious nature of the 'missing heritability'.

4 l as rare alleles might in part explain the 'missing heritability'.

5 by microRNAs, might also contribute to the 'missing heritability'.

6 f complex diseases but not to the problem of missing heritability.

7 as DNA methylation might contribute to this missing heritability.

8 plain the heritability estimates, suggesting missing heritability.

9 ht have strong effects and contribute to the missing heritability.

10 ved in BP regulation and explain part of the missing heritability.

11 e to explain a significant percentage of the missing heritability.

12 ants and covariates, may help to uncover the missing heritability.

13 ible avenue of attack for finding additional missing heritability.

14 y also partially ascertain the source of the missing heritability.

15 ts with larger effects might account for the missing heritability.

16 effects, may make a key contribution to the missing heritability.

17 explain possible reasons for this remaining "missing heritability."

18 ent dilemma in common diseases: Where is the missing heritability?

19 Here we examine potential sources of missing heritability and propose research strategies, in

20 responsible for the small additive effects, missing heritability and the lack of replication that ar

21 enotypic variance, leading to the issues of 'missing' heritability and its explanation.

22 asize the focus on delineating the basis of 'missing heritability' and shift the focus to elucidation

23 pproaches have been taken to determine this 'missing heritability' and to further characterize the kn

24 rare variants that further contribute to the missing heritability, as recently reported for SIM1.

25 ay account for a substantial portion of this missing heritability, but their discoveries have been im

26 netic variation has been invoked to explain "missing heritability," but its discovery is often neglec

27 leading many to question how the remaining, 'missing' heritability can be explained.

28 Here we provide evidence that part of the 'missing heritability' can be explained by an overestimat

29 , we show here that a substantial portion of missing heritability could arise from overestimation of

30 dological implications and contribute to the missing heritability debate.

31 Epilepsy is a disease with substantial missing heritability; despite its high genetic component

32 studies are characterized by the problem of "missing heritability." Epistasis, or genetic interaction

33 example, we examined two possible sources of missing heritability: first, variants with smaller effec

34 rare variants might explain a portion of the missing heritability for ADHD.

35 Our data indicate that the missing heritability for common autoimmune diseases may

36 Informing missing heritability for complex disease will likely req

37 s an additional hypothesis for the source of missing heritability for complex traits.

38 re mutations in GRHL3 that might explain the missing heritability for CPO, we sequenced GRHL3 in case

39 For example, 80% of the currently missing heritability for Crohn's disease could be due to

40 igate the genetic architecture and degree of missing heritability for gene expression in peripheral b

41 se results demonstrate that a portion of the missing heritability for lipid traits and CAD can be exp

42 tentially represent an important portion of "missing heritability" for human diseases.

43 ciation studies (GWAS), there still remains "missing heritability" for many traits.

44 could explain a significant portion of the "missing heritability" for other complex genetic traits.

45 n studies and could account for some of the 'missing heritability' for these diseases.

46 It is not a likely source of missing heritability, for example, or major influence on

47 e-mapping of the HLA region could narrow the missing heritability gap.

48 that are relevant to attempts to narrow the 'missing heritability' gap.

49 Much of the "missing heritability" has been revealed to be hidden in

50 Several sources for the missing heritability have been proposed, including the c

51 Multiple explanations for this 'missing heritability' have been proposed.

52 It has been argued that the missing heritability in common diseases may be in part d

53 ith large effect sizes may contribute to the missing heritability in complex traits.

54 hlights a promising strategy for identifying missing heritability in obesity and other complex traits

55 wever, there is increasing evidence that the missing heritability in psoriasis could be explained by

56 in a 'tri-allelic genotype' can account for missing heritability in some hypomorphic OCA1 albinism p

57 tion across the genome can contribute to the missing heritability in T2D and related metabolic traits

58 tag SNP, thereby accounting for some of the "missing heritability" in GWAS.

59 r approach addresses, in part, the issue of "missing heritability" in the sense that much of the heri

60 have been proposed as a possible source of 'missing heritability' in complex human diseases.

61 variants, one hypothesis is that much of the missing heritability is due to rare genetic variants.

62 To determine whether some of the missing heritability is due to rare variants conferring

63 Our results also suggest that most of the missing heritability is due to the inability to detect v

64 Therefore, the missing heritability is small for both traits.

65 A potential source of the missing heritability is the contribution of rare variant

66 One explanation for the "missing heritability" is that there are many additional

67 iling view has been that the explanation for missing heritability lies in the numerator--that is, in

68 Missing heritability may be partly due to ignored gene-g

69 Such 'missing heritability' may be partly due to gene x enviro

70 Some contribution to this 'missing heritability' may come from copy-number variants

71 ension and suggest that some portion of the "missing" heritability might be recovered through integra

72 Some of the 'missing heritability' might be explained by copy number

73 In short, missing heritability need not directly correspond to mis

74 inconsistencies and account for some of the missing heritability of blood pressure and are generally

75 ide a partial explanation for the problem of missing heritability of complex diseases.

76 genome (coding and noncoding) to fill in the missing heritability of complex disorders.

77 tial of our approach to identify some of the missing heritability of complex traits.

78 It is postulated that much of the missing heritability of CRC is enshrined in high-impact

79 There are also issues regarding the missing heritability of disease that cannot be entirely

80 ffects could substantially contribute to the missing heritability of height.

81 r findings may explain some of the so-called missing heritability of HSCR and suggest a mechanism for

82 ariants, which potentially contribute to the missing heritability of human disease.

83 it does not appear to be hiding much of the missing heritability of intelligence.

84 We hypothesized that some of the missing heritability of IQ might lie hidden in the human

85 the independent alleles contributing to the missing heritability of RA.

86 genetics has been haunted by the mystery of "missing heritability" of common traits.

87 atic mutations in cancer and explaining the "missing heritability" of quantitative traits.

88 thods may provide valuable insight into the "missing heritability" of traits and provide biological i

89 to explain a significant proportion of the 'missing heritability' of asthma.

90 can be a useful tool to explain some of the 'missing heritability' of complex trait variation.

91 variation do not substantially explain the 'missing heritability' of this complex trait.

92 uld explain additional phenotypic variance ('missing heritability') of common traits, and help identi

93 explaining additional phenotypic variance ('missing heritability') of complex diseases like SLE.

94 he identification of novel causal genes, the missing heritability paradox in complex diseases remains

95 of European ancestry in order to examine the missing heritability present in Parkinson's disease (PD)

96 bstantially advance our understanding of the missing heritability problem and have important implicat

97 ase heritability, an observation termed the 'missing heritability problem'.

98 detection is less relevant for resolving the missing heritability problem.

99 To solve this "missing heritability" problem, we implemented a strategy

100 This is referred to as the "missing heritability" problem.

101 ions with various complex diseases, yet the "missing heritability" remains alarmingly elusive.

102 e network effect may account for some of the missing heritability seen when comparing sibling-based t

103 to be identified, and a large proportion of missing heritability still needs to be accounted for.

104 d that rare variants account for some of the missing heritability that cannot be explained by common

105 It has emerged to explain the 'missing heritability' that a marginal genetic effect doe

106 The phrase 'missing heritability' was coined to refer to the gap bet

107 To investigate this missing heritability, we recruited 21 families with at l

108 However, there is a high level of reported missing heritability, where only a single heterozygous m

109 PURPOSE OF REVIEW: To discuss the basis of 'missing heritability', which has emerged as an enigma in

110 on and is considered to explain part of the 'missing heritability,' which involves marginal genetic e