ライフサイエンスコーパス: mitochondrial RNA

1 ormed foci coincident with newly synthesized mitochondrial RNA.

2 m using Illumina deep sequencing of purified mitochondrial RNA.

3 on of non-encoded nucleotides into PHYSARUM: mitochondrial RNAs.

4 ivity in the organelle is reconstituted with mitochondrial RNAs.

5 e and dinucleotide addition in characterized mitochondrial RNAs.

6 ng the Pet 127 protein, which is involved in mitochondrial RNA 5' processing and degradation, also pa

7 t in the expression of factors implicated in mitochondrial RNA and DNA metabolism was accompanied by

8 nuclease that is involved in the turnover of mitochondrial RNA, and is essential for mitochondrial fu

9 y than the wild-type protein with endogenous mitochondrial RNAs, and that phenotype probably explains

10 that gRNAs represent only a subset of small mitochondrial RNAs, and yet an inexplicably high fractio

11 types in PS-modeled LamC mutations, as other mitochondrial RNAs are affected by inhibition of NE budd

12 f partial and extragenic editing in Physarum mitochondrial RNAs, as well as an additional 772 C, U an

13 Recently, the multiprotein mitochondrial RNA binding complex 1 (MRB1) has emerged a

14 The mitochondrial RNA binding proteins MRP1 and MRP2 form a

15 The multiprotein mitochondrial RNA-binding complex 1 (MRB1) is emerging a

16 RECC is largely RNA-free, and accessory mitochondrial RNA-binding complex 1 (MRB1) variants serv

17 The addition of LRPPRC/SLIRP, a mitochondrial RNA-binding complex, enhanced activity of

18 ng a different function in the regulation of mitochondrial RNA biology, from mRNA processing and matu

19 discuss the individual role that each has in mitochondrial RNA biology.

20 ells are potently activated by bacterial and mitochondrial RNA, but not by mammalian total RNA, which

21 urospora crassa DEAD-box protein CYT-19 is a mitochondrial RNA chaperone that promotes group I intron

22 n demonstrated for the archael, eucaryal, or mitochondrial RNAs, comparative sequence analysis has es

23 experiments have demonstrated that T.brucei mitochondrial RNAs contain both short (approximately 20

24 The mitochondrial RNA degradosome of budding yeast (mtEXO) h

25 The results suggest that mitochondrial RNA editing at the cob-908 site is necessa

26 emically mutated plant population identified mitochondrial RNA editing factor 10 (MEF10) in Arabidops

27 described role of RRM-containing proteins as mitochondrial RNA editing factors.

28 2, or KREN3 endonucleases, are essential for mitochondrial RNA editing in Trypanosoma brucei.

29 ting by down-regulation of expression of the mitochondrial RNA editing TUTase 1 by RNA interference h

30 Two mitochondrial RNA editing TUTases have been described: R

31 Kinetoplastid mitochondrial RNA editing, the insertion and deletion of

32 urrently envisioned mechanism of trypanosome mitochondrial RNA editing, U-insertion and U-deletion cy

33 Because tRNA(Gln)(UUG) is a constituent of mitochondrial RNA fractions and is encoded only by nucle

34 r complement of tRNA(Gln)(UUG) is present in mitochondrial RNA fractions, compared with 1% or less fo

35 Mitochondrial RNA gel blot analyses indicated that all f

36 lasm maize lines, inbreds, and F1 hybrids by mitochondrial RNA gel blot analyses revealed that Rf8 is

37 stinct foci, which we have previously termed mitochondrial RNA granules (MRGs).

38 2, and FASTKD5, FASTKD3 does not localize in mitochondrial RNA granules, which are sites of processin

39 Here, we discuss the recently characterized "mitochondrial RNA granules," mitochondrial subdomains wi

40 with the observation that h-mtTFB1 and human mitochondrial RNA (h-mtRNA) polymerase can also be coimm

41 Yeast SUV3 is a nuclear encoded mitochondrial RNA helicase that complexes with an exorib

42 aromyces cerevisiae has been classified as a mitochondrial RNA helicase.

43 FT1 insertion in supv3l1, a gene encoding a mitochondrial RNA helicase.

44 on of the import requirements indicates that mitochondrial RNA import proceeds by a pathway including

45 ion of a mammalian protein directly bound to mitochondrial RNA in vivo and provide a possible molecul

46 Northern analysis of mitochondrial RNAs in an atp25 temperature-sensitive mut

47 Mitochondrial RNAs in Trypanosoma brucei are post-transc

48 Mitochondrial RNAs in Trypanosoma brucei undergo posttra

49 d TFB2M correlated with the level of nascent mitochondrial RNA intensity (r = 0.896; P = 0.0156).

50 Maturation of Physarum mitochondrial RNA involves the highly specific insertion

51 l translation and reveal that f(5)C in human mitochondrial RNA is generated by oxidative processing o

52 on of non-encoded nucleotides into PHYSARUM: mitochondrial RNAs is closely linked to transcription.

53 ockdown with RNA interference did not affect mitochondrial RNA levels.

54 These properties of the mitochondrial RNA ligase are consistent with an expected

55 It was shown previously that the REL1 mitochondrial RNA ligase in Trypanosoma brucei was a vit

56 Mitochondrial RNA ligase subsequently rejoins the mRNA.

57 The function of MAR1 in mitochondrial RNA metabolism in L. tarentolae remains to

58 Further analysis of mitochondrial RNA metabolism revealed that the slo3 muta

59 the less characterized members, FASTKD3, in mitochondrial RNA metabolism.

60 , has been implicated in multiple aspects of mitochondrial RNA metabolism.

61 As a result, failures in mitochondrial RNA metabolisms were responsible for the c

62 s of modifications at U(34) of tRNAs altered mitochondrial RNA metabolisms, causing a degradation of

63 itochondrial membrane and directly regulates mitochondrial RNA (mtRNA) homeostasis and bioenergetics.

64 Mitochondrial RNA (mtRNA) polymerases are related to bac

65 In vivo, functional defects in mitochondrial RNA (mtRNA) translation and cell respirati

66 e promoter DNA template, and mutation of the mitochondrial RNA polymerase (mtRNAP) affect the kinetic

67 embly of an initiation complex that includes mitochondrial RNA polymerase (mtRNAP) and the initiation

68 Despite identification of the mitochondrial RNA polymerase (mtRNAP) from several organ

69 ication and functional characterization of a mitochondrial RNA polymerase (mtRNAP) from Trypanosoma b

70 The mitochondrial RNA polymerase (mtRNAP) of Saccharomyces c

71 chondrial DNA are transcribed by a dedicated mitochondrial RNA polymerase (mtRNAP) that is encoded in

72 tro transcription system with purified human mitochondrial RNA polymerase (POLRMT) and transcription

73 shown that human MRPL12 binds and activates mitochondrial RNA polymerase (POLRMT), and hence has dis

74 omplex comprising mitochondrial transcripts, mitochondrial RNA polymerase (POLRMT), pentatricopeptide

75 The yeast mitochondrial RNA polymerase (RNAP) is a two-subunit enz

76 The yeast mitochondrial RNA polymerase (RNAP) is composed of the c

77 n, we show that the Saccharomyces cerevisiae mitochondrial RNA polymerase (Rpo41) and its transcripti

78 ates, we have discovered that the yeast core mitochondrial RNA polymerase (Rpo41) has the intrinsic a

79 22 bp protein-coding region of the T. brucei mitochondrial RNA polymerase (TBMTRNAP) gene is predicte

80 uence similarity to Saccharomyces cerevisiae mitochondrial RNA polymerase and bacteriophage RNA polym

81 mtDNA promoters, LSP and HSP1, only requires mitochondrial RNA polymerase and h-mtTFB2 in vitro.

82 hybrid lines with different combinations of mitochondrial RNA polymerase and mtDNA genotypes.

83 an transcription elongation factor TEFM with mitochondrial RNA polymerase and nascent transcript prev

84 monstrated that mtDNA transcription requires mitochondrial RNA polymerase and Tfam, a DNA binding sti

85 ext of editing sites and the accuracy of the mitochondrial RNA polymerase argue that the mechanism of

86 that occur between the subunits of the yeast mitochondrial RNA polymerase can serve as a simple model

87 Binding of Mss116p stabilizes paused mitochondrial RNA polymerase elongation complexes in vit

88 modulates the activity of the single-subunit mitochondrial RNA polymerase encoded by RPO41.

89 ressed from an alternative transcript of the mitochondrial RNA polymerase gene (POLRMT).

90 Lines bearing certain mtDNA-mitochondrial RNA polymerase genotypic combinations show

91 nal domain (ATD) of Saccharomyces cerevisiae mitochondrial RNA polymerase has been shown to provide a

92 CSB specifically promoted elongation by the mitochondrial RNA polymerase in vitro.

93 The amino-terminal domain (ATD) of yeast mitochondrial RNA polymerase is required to couple trans

94 ndrial role by directly interacting with the mitochondrial RNA polymerase POLRMT to stimulate mtDNA t

95 fficiency of transcription initiation by the mitochondrial RNA polymerase Rpo41 and its initiation fa

96 dies of the yeast (Saccharomyces cerevisiae) mitochondrial RNA polymerase Rpo41 and its transcription

97 ient petite phenotype of a point mutation in mitochondrial RNA polymerase that affects mitochondrial

98 es, we demonstrate LRP130 complexes with the mitochondrial RNA polymerase to activate mitochondrial t

99 racterization of a developmentally regulated mitochondrial RNA polymerase transcript in the parasitic

100 n initiation factors TFAM and TFB2M on human mitochondrial RNA polymerase, and interactions of the la

101 ranscription machinery (NEP), related to the mitochondrial RNA polymerase, has been recognized only r

102 NA transcription in the presence of Tfam and mitochondrial RNA polymerase, have been identified in ma

103 P-IV lacks 262 amino-terminal amino acids of mitochondrial RNA polymerase, including the mitochondria

104 Human mitochondrial RNA polymerase, POLRMT, is required for mi

105 length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT.

106 factors, TFAM and TFB2M, in addition to the mitochondrial RNA polymerase, POLRMT.

107 hat during in vitro transcription with human mitochondrial RNA polymerase, stable and persistent RNA-

108 stem comprising the bacteriophage T7-related mitochondrial RNA polymerase, the rRNA methyltransferase

109 f the mitochondrial transcription apparatus (mitochondrial RNA polymerase, transcription factor 2B an

110 involves transient pausing by the Physarum: mitochondrial RNA polymerase.

111 ingle-subunit RNA polymerases, including the mitochondrial RNA polymerase.

112 are products of transcription synthesized by mitochondrial RNA polymerase.

113 the presence of newly synthesized RNA and/or mitochondrial RNA polymerase.

114 tive nucleoids and a direct interaction with mitochondrial RNA polymerase.

115 poisomerase I was co-immunoprecipitated with mitochondrial RNA polymerase.

116 inhibition of human polymerases and cellular mitochondrial RNA polymerase.

117 or recruitment of h-mtTFB1, h-mtTFB2 and the mitochondrial RNA polymerase.

118 Mitochondrial RNA polymerases (MtRNAPs) are members of t

119 n of which exhibits 29-37% identity with the mitochondrial RNA polymerases from other organisms in th

120 concentrations of exogenous nucleotides the mitochondrial RNA polymerases stall, generating a popula

121 ne, identified by sequence conservation with mitochondrial RNA polymerases, encodes the NEP catalytic

122 n the context of transcription initiation by mitochondrial RNA polymerases.

123 analyze the stability of different T. brucei mitochondrial RNA populations.

124 RNase mitochondrial RNA processing (MRP) is a ribonucleoprotei

125 In the yeast Saccharomyces cerevisiae, RNase mitochondrial RNA processing (MRP) is an essential endor

126 RNase mitochondrial RNA processing (MRP) is an essential ribon

127 RNase mitochondrial RNA processing (MRP) is an essential, evol

128 as potential substrates for mammalian RNase mitochondrial RNA processing (MRP).

129 RNase mitochondrial RNA processing (RNase MRP) mutants have be

130 Several steps of mitochondrial RNA processing and maturation, including R

131 PNPASE reduction impaired mitochondrial RNA processing and polycistronic transcrip

132 that splice-variants of proteins involved in mitochondrial RNA processing and translation may be invo

133 nd characterize the structural components of mitochondrial RNA processing and translation, the Mammal

134 he long noncoding RNA RNase component of the mitochondrial RNA processing endoribonuclease (RMRP) giv

135 crease in the levels of the RNA component of mitochondrial RNA processing endoribonuclease.

136 RNase mitochondrial RNA processing enzyme (MRP) is a nucleolar

137 d in association with both RNase P and RNase mitochondrial RNA processing in immunoprecipitates from

138 n RNA editing, which is an essential part of mitochondrial RNA processing in trypanosomes.

139 ion of human signal recognition particle and mitochondrial RNA processing RNAs isolated from HeLa cel

140 evisiae gene deletion strains for defects in mitochondrial RNA processing, we found that lack of any

141 Here we report that PNC components mitochondrial RNA-processing (MRP) RNA, pyrimidine tract

142 mutated and wild-type mtPAP localized to the mitochondrial RNA-processing granules thereby eliminatin

143 eover, loss of ppr results in a reduction in mitochondrial RNAs, reduced electron transport chain act

144 function, likely through a conserved role in mitochondrial RNA regulation.

145 Gln) in maintenance of mitochondrial genome, mitochondrial RNA stability, translation, and respirator

146 ew of them are identified with a function in mitochondrial RNA stability.

147 organello, we show that hTERT binds various mitochondrial RNAs, suggesting that RT activity in the o

148 rRNA maturation by-products and as part of a mitochondrial RNA surveillance pathway that eliminates s

149 g and import activities were separable and a mitochondrial RNA targeting signal was isolated that ena

150 psi residues per RNA varied from one in the mitochondrial RNAs to 57 in the cytoplasmic LSU RNA of D

151 mitochondria, here we present evidence that mitochondrial RNA transcripts (mtRNA) are not limited to

152 f d-mtTFB2 reduces the abundance of specific mitochondrial RNA transcripts 2- to 8-fold and decreases

153 of d-mtTFB2 increases both the abundance of mitochondrial RNA transcripts and the copy number of mtD

154 FB1 did not increase either the abundance of mitochondrial RNA transcripts or mitochondrial DNA copy

155 B1 does not change the abundance of specific mitochondrial RNA transcripts, nor does it affect the co

156 of the two uncharacterized genes also affect mitochondrial RNA turnover.

157 Recently, we developed mitochondrial RNA vectors that can be used to address an

158 osoma cruzi, edit their post-transcriptional mitochondrial RNA via a multiprotein complex called the

159 n of mitochondrial mRNA and transcription of mitochondrial RNA were suppressed, whereas mRNA expressi

160 The 3'-termini of maize mitochondrial RNAs were characterized by ligation of an

161 s typical of early embryos, or ribosomal and mitochondrial RNAs, while a majority of the remainder co

162 volved in generation of the 5'-ends of other mitochondrial RNAs, whose 5'-ends coincide with the 3'-e

163 ecules could be visualized by labeling total mitochondrial RNA with [alpha-32P]GTP and guanylyl trans