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1 ations in GDAP1 impede the protein's role in mitochondrial dynamics.
2 drial-encoded protein synthesis and abnormal mitochondrial dynamics.
3 ss of modified solute transporters linked to mitochondrial dynamics.
4 ce-mediated knockdown of factors involved in mitochondrial dynamics.
5 ve disorders characterized by alterations in mitochondrial dynamics.
6 are critically involved in animal and yeast mitochondrial dynamics.
7 stage-specific programs involved in cardiac mitochondrial dynamics.
8 Ser-637 phosphorylation, both indicators of mitochondrial dynamics.
9 ed levels of OPA1 protein, and impairment of mitochondrial dynamics.
10 ium signaling, metabolism, proteostasis, and mitochondrial dynamics.
11 ion of cancer cell migration and invasion by mitochondrial dynamics.
12 ting a specific role of TDP-43 in regulating mitochondrial dynamics.
13 induced substantial and widespread abnormal mitochondrial dynamics.
14 ng pharmacological and genetic modulators of mitochondrial dynamics.
15 s slingshot phosphatase to modulate neuronal mitochondrial dynamics.
16 embrane, where it functions in mitophagy and mitochondrial dynamics.
17 tworks and rescued huntingtin (HTT)-impaired mitochondrial dynamics.
18 , suggesting a possible link between SRF and mitochondrial dynamics.
19 n cytoskeleton have unanticipated effects on mitochondrial dynamics.
20 indicates a role for sacsin in regulation of mitochondrial dynamics.
21 es, are linked increasingly to dysfunctional mitochondrial dynamics.
22 ions of mitochondrial proteins that regulate mitochondrial dynamics.
23 tochondrial spheroids thus represent a novel mitochondrial dynamics.
24 seases has additionally suggested defects in mitochondrial dynamics.
25 bservations relating to MOMP, apoptosis, and mitochondrial dynamics.
26 ial membrane proteins involved in regulating mitochondrial dynamics.
27 Huntington's disease--involve disruption of mitochondrial dynamics.
28 drial fission/fusion machinery and modulates mitochondrial dynamics.
29 s in mitochondrial shape implying effects on mitochondrial dynamics.
30 n2, Opa1 and p-Drp1 leading to disruption of mitochondrial dynamics.
31 ciency has detrimental influence on neuronal mitochondrial dynamics.
32 hat TMEM135 is involved in the regulation of mitochondrial dynamics.
33 he mitochondria, where it similarly disrupts mitochondrial dynamics.
34 port that Smad2 is a critical determinant of mitochondrial dynamics.
35 thology triggered by defective or imbalanced mitochondrial dynamics.
36 her layer of complexity to the regulation of mitochondrial dynamics.
37 damaged mitochondrial components depends on mitochondrial dynamics, a process characterized by frequ
38 ofusin 2 (Mfn2) could abolish TDP-43 induced mitochondrial dynamics abnormalities and mitochondrial d
40 wth, which was associated with disruption of mitochondrial dynamics and a reduction in mitochondrial
41 c mechanisms by which gut bacteria influence mitochondrial dynamics and aging, a first step toward an
42 proximal signaling events can influence both mitochondrial dynamics and apoptosis through phosphoryla
43 vous system, alterations in and the roles of mitochondrial dynamics and associated signaling in micro
44 rial membrane potential, oxygen consumption, mitochondrial dynamics and autophagy regulating factors
45 of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under hi
46 ticular vulnerabilities that often implicate mitochondrial dynamics and axon transport mechanisms.
47 cate that IHG-1 is a novel regulator of both mitochondrial dynamics and bioenergetic function and con
48 n of mitochondria, it is not surprising that mitochondrial dynamics and bioenergetics reciprocally in
49 e new thinking in the intersecting fields of mitochondrial dynamics and bioenergetics, as treatment o
52 e mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and
54 rter (MCU) complex (MCUC) function influence mitochondrial dynamics and contribute to PAH's cancer-li
55 tion for seemingly paradoxical expression of mitochondrial dynamics and death factors in cardiomyocyt
56 cytic mitochondrial Dlp1 is a key protein in mitochondrial dynamics and decreased Dlp1 may interfere
59 and mitochondrial-encoded genes involved in mitochondrial dynamics and energy transduction in the ad
60 reduces mitochondrial dysfunction, maintains mitochondrial dynamics and enhances mitochondrial biogen
67 anisms by which cytoplasmic stimuli modulate mitochondrial dynamics and functions are largely unknown
68 In the present study, we examined changes in mitochondrial dynamics and functions triggered by alpha
69 nonical Wnt ligand, is a potent activator of mitochondrial dynamics and induces acute fission and fus
72 everal pieces of evidence suggested impaired mitochondrial dynamics and its association with the path
73 uccinate on hMSC migration via regulation of mitochondrial dynamics and its related signaling pathway
75 othrombotic status, relies on alterations in mitochondrial dynamics and metabolism that may be preven
76 ogical disorders is associated with aberrant mitochondrial dynamics and mitochondrial degeneration.
77 interorganelle lipid exchange and influence mitochondrial dynamics and mitochondrial DNA maintenance
78 tability, abnormalities in the regulation of mitochondrial dynamics and mitochondrial quality control
79 ated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is mis
81 the latest findings regarding the impact of mitochondrial dynamics and mitophagy on the development
82 ons, including oxidative phosphorylation and mitochondrial dynamics and morphology, and is essential
84 scribe novel functions for NIK in regulating mitochondrial dynamics and motility to promote cell inva
87 apeutic target against BPA-mediated impaired mitochondrial dynamics and neurodegeneration in the hipp
88 However, the relationship between altered mitochondrial dynamics and neurodegeneration is incomple
89 drial and synaptic toxicities, and maintains mitochondrial dynamics and neuronal function in AD neuro
91 chondrial Ser/Thr phosphatase that modulates mitochondrial dynamics and participates in both apoptoti
92 species, for furthering the understanding of mitochondrial dynamics and pathology in transmitochondri
93 ase models to study the relationship between mitochondrial dynamics and peripheral neurodegeneration.
94 ), and increasing evidence suggests abnormal mitochondrial dynamics and quality control as important
97 iation represents an additional link between mitochondrial dynamics and recognizable neurological syn
98 Parkinson's disease, has been implicated in mitochondrial dynamics and removal in cells including ne
99 Drp1 enzymatic activity, increases abnormal mitochondrial dynamics and results in defective anterogr
101 and plant-specific aspects of CL biology in mitochondrial dynamics and the organism response to envi
102 open a new dimension to our understanding of mitochondrial dynamics and the role of miRNA in mitochon
103 novel function for NP1 in the regulation of mitochondrial dynamics and trafficking during apoptotic
104 accharide colanic acid (CA), which regulates mitochondrial dynamics and unfolded protein response (UP
105 relationships between parkin gene activity, mitochondrial dynamics, and aging have not been explored
106 cesses as diverse as EGF receptor signaling, mitochondrial dynamics, and invasion by apicomplexan par
107 ral proteins involved in electron transport, mitochondrial dynamics, and mitochondrial protein synthe
108 ic processes such as endocytosis, autophagy, mitochondrial dynamics, and permeabilization during apop
110 n recent years, evidence linking metabolism, mitochondrial dynamics, and protein homeostasis (proteos
112 causes mitochondrial depolarization, reduces mitochondrial dynamics, and restricts turnover of cellul
113 a determinative effect in the regulation of mitochondrial dynamics, and therefore neuronal function.
114 ein-protein interactions, (2) alterations in mitochondrial dynamics, and/or (3) post-translational mo
115 sterol, and phospholipid metabolism; altered mitochondrial dynamics; and reduced bioenergetic functio
117 sential in mammals, and even mild defects in mitochondrial dynamics are associated with disease.
124 eveal that adrenergically-induced changes to mitochondrial dynamics are required for BA thermogenic a
127 s thus identify actin-mediated disruption of mitochondrial dynamics as a direct mechanism of tau toxi
129 dicate the potential value of restoration of mitochondrial dynamics as an innovative therapeutic stra
136 Drp1 interaction, mRNA and protein levels of mitochondrial dynamics, biogenesis and synaptic genes, m
137 evels of SS31, (2) mRNA levels and levels of mitochondrial dynamics, biogenesis proteins and synaptic
139 an physiology can be restored by rebalancing mitochondrial dynamics, but this concept remains to be v
141 type full-length tau (termed htau) disrupted mitochondrial dynamics by enhancing fusion and induced t
143 , we explored the involvement of an abnormal mitochondrial dynamics by investigating the changes in t
144 that SLC25A46 may play an important role in mitochondrial dynamics by mediating mitochondrial fissio
149 Our findings indicate that perturbations of mitochondrial dynamics can cause nigrostriatal defects a
151 ies and less ATP, and to the deregulation of mitochondrial dynamics, causing in consequence the accum
152 how that a subset of SLC25A46 interacts with mitochondrial dynamics components and the MICOS complex.
153 Novel proteins and pathways that control mitochondrial dynamics continue to be discovered, indica
154 icating that deregulation of calcineurin and mitochondrial dynamics contributes to high-risk and poor
156 we investigated the involvement of Parkin in mitochondrial dynamics, distribution, morphology, and re
157 s and protein levels of genes related to the mitochondrial dynamics-Drp1 and Fis1 (fission), Mfn1, Mf
158 his study demonstrates a rapid regulation of mitochondrial dynamics during acute kidney injury and id
159 ulation of BAX in mitochondria and regulates mitochondrial dynamics during apoptosis in rat and mouse
160 The Bcl-2 family has been shown to regulate mitochondrial dynamics during cell death in mammals and
163 highlight the evolutionary context in which mitochondrial dynamics emerged and consider unanswered q
164 ces mitochondrial dysfunction, and maintains mitochondrial dynamics, enhances mitochondrial biogenesi
165 ces mitochondrial dysfunction, and maintains mitochondrial dynamics, enhances mitochondrial biogenesi
167 emonstrated that it has a profound impact on mitochondrial dynamics (fusion and fission) and clearanc
168 ng evidence has shown that proper control of mitochondrial dynamics (fusion and fission) is required
169 erall, our data unmask an important role for mitochondrial dynamics governed by Mfn1 and Mfn2 in Agrp
172 and suggest that enhancing SIRT3 to improve mitochondrial dynamics has potential as a strategy for i
176 ryonic and postnatal RGCs and the roles that mitochondrial dynamics have in regulating neurite growth
178 association with mitochondria imbalance and mitochondrial dynamics impairs axonal transport of mitoc
179 , and (4) screening for regulators of muscle mitochondrial dynamics in a high-throughput format.
180 important for regulating signaling-dependent mitochondrial dynamics in astrocytic processes remains u
181 hus, DISC1 acts as an important regulator of mitochondrial dynamics in both axons and dendrites to me
183 ondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts
186 nd actin assembly, involving Rab11a-mediated mitochondrial dynamics in E4orf4-induced signaling.
188 Our results show that Bax and Bak regulate mitochondrial dynamics in healthy cells and indicate tha
189 ediated knockdown, 15 of the genes modulated mitochondrial dynamics in human neuronal cultures and fo
191 ls, and very little is currently known about mitochondrial dynamics in mature axons of the mammalian
192 igenesis, little is known about the roles of mitochondrial dynamics in metastasis, the major cause of
193 ite mitochondrial fragmentation and impaired mitochondrial dynamics in motor neurons expressing IMS m
194 s though to initiate, suggests that impaired mitochondrial dynamics in motor neurons may be involved
195 regulating Milton GlcNAcylation, OGT tailors mitochondrial dynamics in neurons based on nutrient avai
197 found that PINK1/Parkin similarly influenced mitochondrial dynamics in rat midbrain dopaminergic neur
198 EM reconstruction argues for a major role of mitochondrial dynamics in regulating neuronal survival.
200 These observations shed light on the role of mitochondrial dynamics in the biology and drug response
201 nson's disease (PD) have implicated aberrant mitochondrial dynamics in the disease pathology, but the
202 respiratory chain defects, we review altered mitochondrial dynamics in the etiology of specific neuro
203 t a fluorescence method to selectively image mitochondrial dynamics in the mouse nervous system, in b
204 tionship between mutant huntingtin (Htt) and mitochondrial dynamics in the progression of Huntington'
205 studies suggest that Akt3 is a regulator of mitochondrial dynamics in the vasculature via regulation
206 ittle is known about the normal functions of mitochondrial dynamics in these neurons, especially in a
207 Little is known about the involvement of mitochondrial dynamics in tolerance of skeletal muscle a
208 his shortcoming, we developed tools to study mitochondrial dynamics in vivo in optically accessible z
210 al cellular biological process controlled by mitochondrial dynamics in VMH regulation of systemic glu
211 protein Drp1 and factors that cause abnormal mitochondrial dynamics, including GTPase Drp1 enzymatic
214 Drp1 S-palmitoylation accompanied by altered mitochondrial dynamics, increased glycolysis, glutaminol
215 d biochemical studies revealed that impaired mitochondrial dynamics-increased mitochondrial fragmenta
216 tion and calcium homeostasis trigger altered mitochondrial dynamics, indicating compromise of mitocho
217 is not entirely clear the impact of impaired mitochondrial dynamics induced by alpha-syn on neurodege
222 the dendritic tree, indicating that abnormal mitochondrial dynamics is an early event in the pathogen
228 d OPA1, suggesting that proper regulation of mitochondrial dynamics is particularly vital to neurons.
231 their fusion and fission, a process termed 'mitochondrial dynamics', is crucial for neurons, given t
232 tt, in association with mitochondria, alters mitochondrial dynamics, leading to mitochondrial fragmen
233 Expanding evidence suggests that impaired mitochondrial dynamics likely contribute to the selectiv
234 apies that target aberrant regulation of the mitochondrial dynamics machinery and characterizing the
235 12V)-mediated cellular transformation on the mitochondrial dynamics machinery and observe a positive
236 Our data indicate that interference with mitochondrial dynamics may be an unappreciated strategy
238 ogether, these results suggest that impaired mitochondrial dynamics may contribute to the selective d
239 he hope that pharmacological manipulation of mitochondrial dynamics may have therapeutic benefit.
240 r prognosis in glioblastoma, suggesting that mitochondrial dynamics may represent a therapeutic targe
241 s and protein levels of genes related to the mitochondrial dynamics, mitochondrial biogenesis and syn
243 gy demand, are particularly dependent on the mitochondrial dynamics, mitophagy represents a key mecha
246 s, highlighting the association of defective mitochondrial dynamics, mtDNA multiple deletions, and al
247 mitochondrial membrane protein implicated in mitochondrial dynamics, nucleoid organization, protein t
248 We also show that the Wnt-5a effects on mitochondrial dynamics occur with an increase in both in
250 Here, we have studied the dependence of mitochondrial dynamics on the Miro GTPases that reside i
252 now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including s
254 nvey its neurotoxicity by evoking defects in mitochondrial dynamics, organelle trafficking and fissio
255 udies have greatly expanded our knowledge of mitochondrial dynamics, our understanding in vivo remain
258 ur findings support the notion that abnormal mitochondrial dynamics plays an early and causal role in
259 uced synaptic loss, suggesting that abnormal mitochondrial dynamics plays an important role in ADDL-i
261 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynamics proteins of 49 and 51 kDa (MiD49
268 isms through which BCL2-like proteins affect mitochondrial dynamics remain to be fully understood.
270 ctivity, oxidative stress detoxification and mitochondrial dynamics, resulting in increased levels of
271 ent beta-cells, demonstrating that defective mitochondrial dynamics solely affect substrate supply up
272 ese differential degradation rates depend on mitochondrial dynamics, suggesting a mechanism coupling
273 n import, mitochondrial DNA replication, and mitochondrial dynamics, suggesting that these interorgan
274 ined the relationship between mutant Htt and mitochondrial dynamics/synaptic viability in HD patients
276 fn1 and Mfn2 may be responsible for abnormal mitochondrial dynamics that we found in the cortex of HD
278 d Parkin act in a common pathway to regulate mitochondrial dynamics, the involvement of which in the
279 intracellular [Ca(2+)] increases and alters mitochondrial dynamics through a mechanism involving the
281 hese data suggest that mutant TDP-43 impairs mitochondrial dynamics through enhanced localization on
282 is known to participate in the regulation of mitochondrial dynamics through interaction with the mito
283 These results suggest that the regulation of mitochondrial dynamics through TMEM135 is critical for p
284 nism coupling weak physical segregation with mitochondrial dynamics to achieve a distillation-like ef
285 erae Type-III-secreted effector that targets mitochondrial dynamics to dampen host innate immune sign
286 rmed "MECA," that functions in parallel with mitochondrial dynamics to distribute and position the es
291 nce of parkin, PINK1, and alpha-synuclein on mitochondrial dynamics uncovers a common function of the
292 Cellular membrane remodeling events such as mitochondrial dynamics, vesicle budding, and cell divisi
294 roles of Bcl-2 family proteins in regulating mitochondrial dynamics, we carried out a detailed analys
295 Consistent with a role for NIK in regulating mitochondrial dynamics, we demonstrate that Drp1 is requ
296 -like family (KLF) transcription factors, or mitochondrial dynamics were altered by inhibiting dynami
298 , its establishment and maintenance requires mitochondrial dynamics, which can be controlled by the m
299 at least in part, by an alteration in normal mitochondrial dynamics, which results in increased mitoc
300 Understanding how lipid metabolism regulates mitochondrial dynamics will reveal its role in cellular
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