ライフサイエンスコーパス: mitochondrial fission

1 role in mitochondrial dynamics by mediating mitochondrial fission.

2 function could be prevented by inhibition of mitochondrial fission.

3 nvasion, Drp1 mitochondrial localization, or mitochondrial fission.

4 tion-competent Drp1 that can be accessed for mitochondrial fission.

5 ility that MARCH5 is a negative regulator of mitochondrial fission.

6 ochondrial division and fusion by catalyzing mitochondrial fission.

7 of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission.

8 dynamin superfamily, is the main mediator of mitochondrial fission.

9 -related protein 1 (Drp1), a key mediator of mitochondrial fission.

10 tin has recently emerged as a participant in mitochondrial fission.

11 e mitochondria participates in Drp1-mediated mitochondrial fission.

12 ce deficient in Mff, a protein important for mitochondrial fission.

13 mitofusin mitochondrial fusion proteins and mitochondrial fission.

14 mitochondria, suggesting that BTICs increase mitochondrial fission.

15 and ionomycin-induced Drp1 accumulation and mitochondrial fission.

16 1), responsible for membrane scission during mitochondrial fission.

17 n-like protein 1, a host protein involved in mitochondrial fission.

18 min-related protein 1) is a key regulator of mitochondrial fission.

19 p1 mitochondrial translocation and increased mitochondrial fission.

20 hepsin E, in promoting emphysema by inducing mitochondrial fission.

21 ch are intermediate states in the process of mitochondrial fission.

22 he dynamin-like protein DRP1, which promotes mitochondrial fission.

23 ltiple receptors can recruit Drp1 to mediate mitochondrial fission.

24 of cellular dysfunctions including excessive mitochondrial fission.

25 we show that both Fis1 and Mff have roles in mitochondrial fission.

26 Drp1, which plays a major role in regulating mitochondrial fission.

27 tions of GTPases and adaptors sufficient for mitochondrial fission.

28 Mff interaction, assembly into spirals, and mitochondrial fission.

29 min-related protein 1, which participates in mitochondrial fission.

30 interactions, blocking Dnm1 recruitment and mitochondrial fission.

31 concentrations (e.g., 50 muM) used to target mitochondrial fission.

32 hondrial network, consistent with defects in mitochondrial fission.

33 /Mfn-2 expression, which promotes a state of mitochondrial fission.

34 inases that phosphorylate serine 616, causes mitochondrial fission.

35 corresponding to 3 or 4 cycles of unopposed mitochondrial fission.

36 ial for physiological and pathophysiological mitochondrial fission.

37 anti-aging effects of midlife Drp1-mediated mitochondrial fission.

38 gene encoding an annotated protein promoting mitochondrial fission.

39 reticulum and a pattern suggesting increased mitochondrial fission.

40 ribosomal disassembly, calcium overload and mitochondrial fission.

41 cium ([Ca(2+)]cyto), aerobic glycolysis, and mitochondrial fission.

42 the AMPK-mediated blockage of Drp1-mediated mitochondrial fission.

43 30c-5p-dependent inhibition of Drp1-mediated mitochondrial fission.

44 smic guanosine triphosphatase that catalyzes mitochondrial fission.

45 regulated S637 phosphorylation, resulting in mitochondrial fission.

46 d that it is a key effector of AMPK-mediated mitochondrial fission.

47 1 is implicated as a passive tether in yeast mitochondrial fission.

48 ted protein 1 (Drp1) hydrolyzes GTP to power mitochondrial fission, a process required for organelle

49 er, we demonstrate a regulatory link between mitochondrial fission activity and cell cycle exit in fo

50 cells lacking Mdm33 show strongly decreased mitochondrial fission activity indicating that Mdm33 is

51 Thus, DRP1-dependent mitochondrial fission activity is a novel regulator of t

52 Reintroduction of mitochondrial fission activity or inhibition of the mito

53 When DRP1-driven mitochondrial fission activity was unopposed by fusion a

54 showed that these contacts are important for mitochondrial fission activity.

55 However, how mitochondrial fission affects progression of DN in vivo

56 ctron microscopy studies suggested increased mitochondrial fission and accumulation of fragmented mit

57 poptosis-related lncRNA (CARL), can suppress mitochondrial fission and apoptosis by targeting miR-539

58 le for the dysfunction of PHB2 and regulates mitochondrial fission and apoptosis by targeting PHB2.

59 of Dynamin-related protein 1 (DRP1), causing mitochondrial fission and apoptosis.

60 he results show that PHB2 is able to inhibit mitochondrial fission and apoptosis.

61 R-539 sponge that regulates PHB2 expression, mitochondrial fission and apoptosis.

62 ondrial fission process 1 (MTFP1) to control mitochondrial fission and apoptosis.

63 bserved that a super-low dose of LPS induces mitochondrial fission and cell necroptosis in primary mu

64 tivation of Drp1, a molecule responsible for mitochondrial fission and cell necroptosis.

65 s dynamin-related protein 1 (Drp1)-dependent mitochondrial fission and cell sensitivity to stress-ind

66 We recently reported increased mitochondrial fission and decreased fusion, increased am

67 in an individual mitochondrion, followed by mitochondrial fission and degradation of the damaged dau

68 hosphorylation limited its ability to induce mitochondrial fission and degrade MFN1 and MFN2 but did

69 artment, or MDC, followed by release through mitochondrial fission and elimination by autophagy.

70 und, Arabidopsis CL plays a dominant role in mitochondrial fission and exerts this function, at least

71 on the mitochondria occurs upon induction of mitochondrial fission and F-actin accumulates on the mit

72 Paradigms have held that mitochondrial fission and fragmentation are the result o

73 urpose of this study is to determine whether mitochondrial fission and fragmentation can be an adapti

74 for the evolving conceptual framework, where mitochondrial fission and fragmentation play a role in t

75 mortality in mammals when applied in midlife.Mitochondrial fission and fusion are important mechanism

76 Axonal transport of mitochondria and mitochondrial fission and fusion contribute to this reju

77 occur in conjunction with imbalances in the mitochondrial fission and fusion equilibrium, although t

78 so cardiac-specific genetic manipulation of mitochondrial fission and fusion factors has proven usef

79 letely understood although an involvement of mitochondrial fission and fusion has been suggested.

80 s suggest that manipulating the processes of mitochondrial fission and fusion has considerable potent

81 ting evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondria

82 of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as we

83 he importance of SLC25A46 and fine tuning of mitochondrial fission and fusion in pontocerebellar hypo

84 s suggest that the polymorphic regulation of mitochondrial fission and fusion in reactive microglia i

85 mitochondrial dysfunction and imbalances in mitochondrial fission and fusion induced by oxidative or

86 these stimuli mechanistically connect to the mitochondrial fission and fusion machinery is poorly und

87 Mitochondrial fission and fusion play critical roles in

88 tive phosphorylation enzyme complexes, or of mitochondrial fission and fusion proteins.

89 ugh biogenic renewal and mitophagic culling; mitochondrial fission and fusion, 2 components of mitoch

90 also act as regulatory factors that control mitochondrial fission and fusion.

91 genetically restoring the proper balance of mitochondrial fission and fusion.

92 role of the actin cytoskeleton in regulating mitochondrial fission and fusion.

93 iogenesis or mitophagy, or the regulation of mitochondrial fission and fusion.

94 ing analysis revealed that reduced levels of mitochondrial fission and increased fusion, biogenesis a

95 Siah2 as a key regulator of hypoxia-induced mitochondrial fission and its physiological significance

96 tion were linked mechanistically to aberrant mitochondrial fission and its regulation by dynamin-rela

97 not present in DIDS treated cells, including mitochondrial fission and loss of plasma membrane integr

98 Thus, FUNDC1 integrates mitochondrial fission and mitophagy at the interface of

99 Interference of HCV-induced mitochondrial fission and mitophagy by Drp1 silencing su

100 phospho-mimic mutant (S637D-Drp1), restored mitochondrial fission and mitophagy in response to creno

101 These results suggest that HCV-induced mitochondrial fission and mitophagy serve to attenuate a

102 membrane potential (DeltaPsim) and promoted mitochondrial fission and mitosis.

103 estruction, cyclin C promotes stress-induced mitochondrial fission and programmed cell death, indicat

104 hate-hydrolyzing mechanoenzyme important for mitochondrial fission and programmed cell death.

105 we show that Shh signaling activity reduces mitochondrial fission and promotes mitochondrial elongat

106 to cytoplasmic relocalization that triggers mitochondrial fission and promotes programmed cell death

107 cycling of mitochondrial DLP1 complex during mitochondrial fission and provide a novel therapeutic ta

108 naling and dampened response to PDGF-induced mitochondrial fission and reactive oxygen species levels

109 Here, we show that glucose load results in mitochondrial fission and reduced reactive oxygen specie

110 an be mimicked using a treatment that blocks mitochondrial fission and rescued by decreasing mitochon

111 bitor of Drp1, Mdivi1, significantly blunted mitochondrial fission and rescued key pathologic feature

112 rved role for actin and myosin in regulating mitochondrial fission and show that excess actin stabili

113 Here, we describe a new pathway mediating mitochondrial fission and subsequent mitophagy under hyp

114 Furthermore, by genetically controlling mitochondrial fission and thereby inducing mild proton l

115 on of MiD49 is a novel mechanism controlling mitochondrial fission and, consequently, the cellular re

116 first to identify links between cathepsin E, mitochondrial fission, and caspase activation/apoptosis

117 osphorylation is required for Ras-associated mitochondrial fission, and its inhibition is sufficient

118 he Drp1 receptor Mff is a major regulator of mitochondrial fission, and its overexpression results in

119 1 phosphorylation at serine 616, and thus of mitochondrial fission, and suggest that there are intera

120 VCP recruitment coincides temporally with mitochondrial fission, and VCP is required for proteasom

121 m by which stress-induced gene induction and mitochondrial fission are coordinated through translocat

122 We identified a previously unknown mitochondrial fission arrest phenotype that results in e

123 AND We demonstrate a novel role for cardiac mitochondrial fission as a normal adaptation to increase

124 tion completely, and we identified decreased mitochondrial fission as the potential driving force for

125 Furthermore, not only mitochondrial fission but also fusion is regulated throu

126 t mouse cardiac myocytes not only interrupts mitochondrial fission, but also markedly upregulates Par

127 the drug mdivi-1 prevented radiation-induced mitochondrial fission, but respiratory chain function in

128 O2 rapidly (<5 minutes) causes mitochondrial fission by a cyclin-dependent kinase- medi

129 HIF-1alpha activation in human PAH leads to mitochondrial fission by cyclin B1/CDK1-dependent phosph

130 nges in mitochondrial redox status increased mitochondrial fission by increased ubiquitination of AKA

131 respectively)-have been proposed to promote mitochondrial fission by recruiting the GTPase dynamin-r

132 nstrating that the ER activity in regulating mitochondrial fission can be induced by exogenous agents

133 a to the nerve terminal, and a disruption in mitochondrial fission can contribute to the preferential

134 ngs indicate that interventions that promote mitochondrial fission could delay the onset of pathology

135 Furthermore the mitochondrial fission defect in patient fibroblasts was

136 Inhibition of mitochondrial fission disrupted both the age-dependent s

137 these two processes, especially the role of mitochondrial fission during mitophagy, remains unclear.

138 We observed mitochondrial fission during osmotic stress, but blockin

139 tor-1 (mdivi-1), a putative inhibitor of the mitochondrial fission Dynamin-Related Protein-1 (Drp1).

140 The essential mediator of mitochondrial fission, dynamin-related protein 1 (DRP1),

141 To initiate mitochondrial fission, dynamin-related proteins (DRPs) m

142 ar mechanism for the involvement of VPS35 in mitochondrial fission, dysregulation of which is probabl

143 The activity of the mitochondrial fission enzyme dynamin-related protein 1 (

144 nd MiD51 form discrete foci at mitochondria, mitochondrial fission events still occurred.

145 A screen for substrates of AMPK identified mitochondrial fission factor (MFF), a mitochondrial oute

146 Mitochondrial fission factor (Mff), a tail-anchored memb

147 One such Drp1 partner protein, mitochondrial fission factor (Mff), is essential for mit

148 eins-mitochondrial fission protein 1 (Fis1), mitochondrial fission factor (Mff), mitochondrial dynami

149 binding to the MOM resident adaptor protein mitochondrial fission factor (Mff).

150 pon necrosis induction, PGAM5S recruited the mitochondrial fission factor Drp1 and activated its GTPa

151 ndrial dynamics through interaction with the mitochondrial fission factor Drp1 in fed cells and in au

152 Genetic inhibition of the activity of the mitochondrial fission factor dynamin-related protein 1 (

153 ciation with the Drp1-anchoring protein Mff (mitochondrial fission factor), and basal and protonophor

154 stabilizing the protein complex of the major mitochondrial fission factor, DYNAMIN-RELATED PROTEIN3.

155 ein 1 (Drp1) and its mitochondrial receptor, mitochondrial fission factor.

156 ced a dose-dependent increase in total Dnm1l mitochondrial fission factor; although more active membr

157 oteins, large GTPases that serve as the main mitochondrial fission factors.

158 perturbs mitochondrial dynamics by promoting mitochondrial fission followed by mitophagy, which atten

159 the canonical Wnt-3a ligand had no effect on mitochondrial fission-fusion events, suggesting that thi

160 The process of mitochondrial fission-fusion has become a focus of atten

161 e that Wnt-5a/Ca(2+) signaling regulates the mitochondrial fission-fusion process in hippocampal neur

162 rial traffic, and a significant shift in the mitochondrial fission-fusion steady state.

163 nd 3D ultrastructural analyses, we show that mitochondrial fission/fusion in reactive microglia is di

164 ence suggests that Parkin interacts with the mitochondrial fission/fusion machinery to mediate the tu

165 d previously that a missense mutation in the mitochondrial fission gene Dynamin-related protein 1 (Dr

166 Increased expressions of mitochondrial fission genes, decreased expression of fus

167 16) describe a novel interaction between the mitochondrial fission GTPase Drp1 and phosphatidic acid

168 Multiple isoforms of the mitochondrial fission GTPase dynamin-related protein 1 (

169 Specifically, we show that inhibition of the mitochondrial fission GTPase dynamin-related protein-1 (

170 Mitochondrial fission has been linked to the pathogenesi

171 Drp1, a key regulator of mitochondrial fission, has been shown to be activated an

172 of atherosclerosis by reducing Drp1-mediated mitochondrial fission in an AMPK-dependent manner.

173 otential therapeutic treatment of disrupting mitochondrial fission in cocaine addiction.

174 es-accelerated atherosclerosis by inhibiting mitochondrial fission in endothelial cells.

175 d formin 2 (INF2) was required for efficient mitochondrial fission in mammalian cells.

176 ed' mitochondria, and show that induction of mitochondrial fission in midlife, but not in early life,

177 tes from within mitochondria and the role of mitochondrial fission in mitophagy.

178 DRP1 activation is responsible for increased mitochondrial fission in PAH PASMCs and that DRP1 inhibi

179 Thus, mitochondrial fission in response to AC uptake is a crit

180 49 or MiD51 can mediate Drp1 recruitment and mitochondrial fission in the absence of Fis1 and Mff.

181 GTP-hydrolyzing mechanoenzyme that catalyzes mitochondrial fission in the cell.

182 rmally clustered tubular ER induces enhanced mitochondrial fission in the early stages of DN formatio

183 We demonstrate a role for altered mitochondrial fission in the NAc, during early cocaine a

184 Promoting Drp1-mediated mitochondrial fission, in midlife, facilitates mitophagy

185 ose a model for regulation of Drp1-dependent mitochondrial fission, in which posttranslational modifi

186 Drp1-a Dynamin-related protein that promotes mitochondrial fission-in midlife, prolongs Drosophila li

187 o study one aspect of mitochondrial dynamics-mitochondrial fission-in mouse DA neurons, we deleted th

188 Mitochondrial fission-induced mitochondrial function ele

189 In this study, we found that perturbation of mitochondrial fission induces a unique mitochondrial unc

190 so correlates with sensitivity to Mdivi-1, a mitochondrial fission inhibitor.

191 ochondrial division inhibitor 1 (mdivi-1), a mitochondrial fission inhibitor.

192 Mitochondrial fission is a crucial cellular process medi

193 It is, however, unknown whether mitochondrial fission is a prerequisite for proliferatio

194 esults provide new evidence that controlling mitochondrial fission is an effective strategy for ameli

195 Mitochondrial fission is an obligatory, early step in ma

196 as DA from term rabbits, we demonstrate that mitochondrial fission is crucial for O2-induced constric

197 rpose of this study was to determine whether mitochondrial fission is crucial for O2-induced DA const

198 When mitochondrial fission is disabled, AC-induced increase i

199 Mitochondrial fission is essential for the degradation o

200 In mammals, mitochondrial fission is executed by dynamin-related pro

201 Mitochondrial fission is fundamentally important to cell

202 Mitochondrial fission is important for organelle transpo

203 In this study, we report that mitochondrial fission is important for the progression o

204 Mitochondrial fission is mediated by a dynamin-related G

205 Mitochondrial fission is mediated by the dynamin-related

206 tein Drp1, we demonstrate in this study that mitochondrial fission is necessary for glucose-stimulate

207 his study we evaluated whether inhibition of mitochondrial fission is neuroprotective against alpha-s

208 We show here that blocking mitochondrial fission is neuroprotective in the PTEN-ind

209 Mitochondrial fission is thought to be part of a quality

210 Here, we show that mitochondrial fission is triggered by mechanical forces.

211 Dynamin-related protein 1, a regulator of mitochondrial fission, is an important determinant of re

212 gradation of Dnm1, the main factor mediating mitochondrial fission, is impaired in the absence of BLM

213 (Dlp1; official name DNM1L), which promotes mitochondrial fission, is lower in astrocytes from the b

214 eta2 nAChRs, rate of mitochondrial movement, mitochondrial fission, levels of reactive oxygen species

215 Mitochondrial fission-linked GTPase activity was signifi

216 The mitochondrial fission machinery is best understood in th

217 surfaces - results in the recruitment of the mitochondrial fission machinery, and subsequent division

218 has been shown to recruit to peroxisomes the mitochondrial fission machinery, thus enabling prolifera

219 Abeta catabolism as well as hyperactivating mitochondrial fission machinery.

220 erved indicative of elevated activity of the mitochondrial fission machinery.

221 e with ER-mitochondria contact sites and the mitochondrial fission machinery.

222 by a mechanism independent of the canonical mitochondrial fission machinery.

223 rmation was highly dependent on a functional mitochondrial fission machinery.

224 pporting a revised model for assembly of the mitochondrial fission machinery.

225 ation of an autophagic marker, Parkin, and a mitochondrial fission marker, Drp1, in differentiated ne

226 Pharmacological targeting of mitochondrial fission may be a promising therapy for car

227 Collectively, these data suggest mitochondrial fission may be a target for treating MAPK-

228 Suppression of mitochondrial fission may be a therapeutic approach for

229 Thus targeting dysregulated Drp1-dependent mitochondrial fission may provide a novel strategy for s

230 Thus targeting dysregulated Drp1-dependent mitochondrial fission may provide a novel strategy for s

231 These results suggest that Drp1-dependent mitochondrial fission may regulate susceptibility to hea

232 min GTPase Drp1 plays a critical role during mitochondrial fission, mechanisms controlling its recrui

233 Mitochondrial fission mediated by the GTPase dynamin-rel

234 We show here that E50K expression induces mitochondrial fission-mediated mitochondrial degradation

235 ing this phenotype, through knockdown of the mitochondrial fission-mediating GTPase Drp1, inhibits tu

236 ase of dynamin-related protein-1 (Drp1), the mitochondrial fission mediator, in nucleus accumbens (NA

237 hus, in addition to their canonical roles in mitochondrial fission, Mff and Drp1 also act as regulato

238 rticular, the cast of characters involved in mitochondrial fission needs to be clarified.

239 Drp1 then further constricts membranes until mitochondrial fission occurs.

240 oevolved to meet the unique requirements for mitochondrial fission of different organisms.

241 protein 1 (Drp1), an essential component of mitochondrial fission, on the pathogenesis and progressi

242 x is resolved by the findings that excessive mitochondrial fission or inhibition of fusion alleviates

243 indings provide mechanistic insight into how mitochondrial fission participates in regulating mitocho

244 Abnormal mitochondrial fission participates in the pathogenesis o

245 Aberrant mitochondrial fission plays a pivotal role in the pathog

246 tochondrial transmembrane potential, blocked mitochondrial fission, prevented the release of proapopt

247 e, we tested whether inhibition of excessive mitochondrial fission prevents mtHtt-induced pathology.

248 complex 1 (mTORC1) stimulates translation of mitochondrial fission process 1 (MTFP1) to control mitoc

249 ondrial network through the targeting of the mitochondrial fission process 1 protein MTP18, leading t

250 xamples, including altMiD51, a 70 amino acid mitochondrial fission-promoting protein encoded in MiD51

251 everal mitochondrial outer membrane proteins-mitochondrial fission protein 1 (Fis1), mitochondrial fi

252 ed absence of the STAT2 protein and that the mitochondrial fission protein DRP1 (encoded by DNM1L) is

253 The fragmentation does not require the mitochondrial fission protein Drp1 and involves a direct

254 ment in neurons suppressed expression of the mitochondrial fission protein Drp1 and the E3 ubiquitin

255 the mitochondrial apoptosis pathway and the mitochondrial fission protein Drp1 contribute to mitotic

256 with down-regulated expression of the major mitochondrial fission protein DRP1 had mitochondrial ele

257 nd immunostaining analysis revealed that the mitochondrial fission protein Drp1 interacted with Abeta

258 protein MFN2 nor inhibition/ablation of the mitochondrial fission protein DRP1 was able to do so, im

259 ed amyloid beta (Abeta) interaction with the mitochondrial fission protein Drp1, increased mitochondr

260 By acute pharmacological inhibition of mitochondrial fission protein Drp1, we demonstrate in th

261 on, at least in part, via suppression of the mitochondrial fission protein dynamin-like GTPase Drp1.

262 ent study, we found a marked upregulation of mitochondrial fission protein dynamin-related protein 1

263 Recently, mitochondrial fission protein dynamin-related protein 1

264 oped a selective inhibitor (P110-TAT) of the mitochondrial fission protein dynamin-related protein 1

265 ted in increased E3 ubiquitin ligase parkin, mitochondrial fission protein dynamin-related protein 1,

266 rthermore, glutamate increased the levels of mitochondrial fission protein markers pDrp1 and Fis1 and

267 al movement was sharply reduced, whereas the mitochondrial fission protein pDrp-1 was increased in al

268 hibited by chemical antagonists of the yeast mitochondrial fission protein, Dnm1.

269 lial reactions, caused the activation of the mitochondrial fission protein, dynamin-related protein 1

270 his effect is mediated by phosphorylation of mitochondrial fission protein, dynamin-related protein 1

271 ion with an unchanged OMM (visualized by Eos-mitochondrial fission protein-1).

272 We also found that the mitochondrial fission proteins Drp1 and Mff negatively r

273 Mitochondrial fission, regulated by dynamin-related prot

274 amin-related protein 1 (DRP1), a mediator of mitochondrial fission, regulates mitochondrial function;

275 Our present study reveals a model of mitochondrial fission regulation that is composed of CAR

276 R-30c-5p led to the up-regulation of Drp1, a mitochondrial fission regulator and a target gene of p53

277 Mitochondrial fission requires the dynamin GTPase Drp1,

278 Deletion of DNM1, required for mitochondrial fission, restored the tubular mitochondria

279 Acutely inhibiting mitochondrial fission reversibly suppressed axon growth

280 hondrial fragmentation in GCDC by inhibiting mitochondrial fission significantly decreased not only R

281 n the liver, we demonstrated that decreasing mitochondrial fission substantially diminished ROS level

282 Although inhibiting Drp1-mediated mitochondrial fission suppresses the segregation of mito

283 In both cell lines, the inhibition of mitochondrial fission that leads to a mitochondrial stru

284 DRP1 is thereby recruited to the MAM, and mitochondrial fission then occurs.

285 Inhibition of mitochondrial fission through expression of the dominant

286 rown adipocytes was reduced by inhibition of mitochondrial fission through transient Drp1 DN overexpr

287 e results suggest a potential application of mitochondrial fission to control mitochondrial reactive

288 NIK promotes mitochondrial fission, velocity, and directional migrati

289 Overall, succinate promotes DRP1-mediated mitochondrial fission via GPR91, consequently stimulatin

290 Mitochondrial fission was associated with increased lact

291 fusion or dynamin-related protein 1-mediated mitochondrial fission was conditionally interrupted in c

292 Following resuscitation from cardiac arrest, mitochondrial fission was evidenced by dynamin-related p

293 n-related protein 1 (Drp1), the initiator of mitochondrial fission, was inhibited by reduced RIP3 pro

294 anism of PINK1 PD: The loss of PINK1 impairs mitochondrial fission, which causes defective assembly o

295 n.Key to maintaining mitochondrial health is mitochondrial fission, which facilitates the dynamic exc

296 es dynamin-related protein 1 (Drp1)-mediated mitochondrial fission, which is triggered by AC uptake.

297 that inhibition of DRP1-dependent excessive mitochondrial fission with a P110-TAT-like inhibitor may

298 lectron microscopy associated Dnm1l-mediated mitochondrial fission with increased biogenesis, rather

299 ttle is known about what determines sites of mitochondrial fission within the mitochondrial network.

300 Inhibition of Drp1-induced mitochondrial fission within VacA-intoxicated cells inhi