ライフサイエンスコーパス: mitochondrial function

1 are mediated through alterations in hepatic mitochondrial function.

2 dria, we observed only a minor impairment of mitochondrial function.

3 vitro and in vivo and effectively protected mitochondrial function.

4 onic ischemia, especially those which impact mitochondrial function.

5 T3) is emerging as an important regulator of mitochondrial function.

6 +) release, indicating that PC1 can modulate mitochondrial function.

7 of constitutive Nox4 activity in regulating mitochondrial function.

8 ase activity, triacylglycerol secretion, and mitochondrial function.

9 OMM-associated E3 ubiquitin ligase, controls mitochondrial function.

10 g downstream oxidative damage and preserving mitochondrial function.

11 in glucose tolerance and improved markers of mitochondrial function.

12 o acid transport, serotonin homeostasis, and mitochondrial function.

13 ansferase (OGT) or O-GlcNAcase (OGA) impairs mitochondrial function.

14 rotein interactions and complexes facilitate mitochondrial function.

15 in neurite growth, dendritic complexity, and mitochondrial function.

16 ctivation of the ISR with the attenuation of mitochondrial function.

17 ion of processing intermediates and impaired mitochondrial function.

18 xpression that is crucial to skeletal muscle mitochondrial function.

19 poses an urgent need for simple measures of mitochondrial function.

20 s induce parkinsonian features by disrupting mitochondrial function.

21 chronic inflammation and hormone therapy on mitochondrial function.

22 inflammation, oxidative stress, and cardiac mitochondrial function.

23 dmill exercise and its downstream effects on mitochondrial function.

24 erm via a mechanism that could be related to mitochondrial function.

25 pha (PGC-1alpha) gene, a master regulator of mitochondrial function.

26 ic form improves ATP synthase efficiency and mitochondrial function.

27 or outcome, probably as a result of impaired mitochondrial function.

28 the importance of RNA processing for correct mitochondrial function.

29 ing skin conditions characterized by reduced mitochondrial function.

30 F-alpha and Bax levels, and improved cardiac mitochondrial function.

31 the nucleus and that drift is independent of mitochondrial function.

32 ress, diminished mtDNA damage, and increased mitochondrial function.

33 s by reduced TOR, insulin/IGF signalling and mitochondrial function.

34 o identify genes that are directly linked to mitochondrial function.

35 impairments in mitochondrial biogenesis and mitochondrial function.

36 or overexpression and that PrP(C) may affect mitochondrial function.

37 hat EPA acts downstream and independently of mitochondrial function.

38 in adipose cells to promote thermogenic and mitochondrial function.

39 r mitochondrion, is an indirect biomarker of mitochondrial function.

40 in neurite growth, dendritic complexity, and mitochondrial function.

41 fusion are important mechanisms to maintain mitochondrial function.

42 inducing mitochondrial biogenesis to restore mitochondrial function.

43 anistic link of VCP-mediated preservation of mitochondrial function.

44 ) reactive oxygen species reflecting altered mitochondrial function.

45 required for brown fat gene programming and mitochondrial function.

46 ide that binds to cardiolipin and stabilizes mitochondrial function.

47 ression of genes regulating inflammation and mitochondrial function.

48 ss by blocking Gp91phox or calpain-1 rescues mitochondrial functions.

49 oteome in CD patients indicative of impaired mitochondrial functions.

50 e uptake and fermentation, and regulation of mitochondrial functions.

51 d cells still maintain mitochondria and many mitochondrial functions.

52 the identification of compounds that target mitochondrial functions.

53 -1alpha (Pgc-1alpha) is critical for cardiac mitochondrial functions.

54 RT/HIV-1-exposed infants, indicating altered mitochondrial functioning.

55 xpression caused muscle wasting, and reduced mitochondrial function, 12S rRNA expression, and SMAD7 e

56 area, there is approximately 50% decrease in mitochondrial function, affecting all substrates.

57 Qualitative changes in mitochondrial function also occur, and do so at more mod

58 usly observed in genetic models of defective mitochondrial function, also are present in human failin

59 ming recognized as key regulators of diverse mitochondrial functions, although their direct substrate

60 esis, whereas pharmacological enhancement of mitochondrial function ameliorates age-associated neurog

61 species, indicating the retention of typical mitochondrial function among Orobanchaceae species.

62 been made in understanding how cells monitor mitochondrial function and activate the response, as wel

63 hepatocyte-specific ablation of Fas improves mitochondrial function and ameliorates high-fat-diet-ind

64 ogy was evaluated by electron microscopy and mitochondrial function and autophagy were assessed by im

65 damage and on aging-associated reductions in mitochondrial function and biogenesis for 8weeks in old

66 inhibiting fission also results in decreased mitochondrial function and cardiac impairment, suggestin

67 Mutations in the PYCR1 gene alter mitochondrial function and cause the connective tissue d

68 ial dynamics, biogenesis and synaptic genes, mitochondrial function and cell viability and mitochondr

69 Mitochondrial function and cell viability were maintaine

70 r is upregulated and its inhibition improves mitochondrial function and cell viability.

71 Targeting mitochondrial function and cellular bioenergetics upstre

72 Mechanistically, BIM deficiency improved mitochondrial function and decreased oxidative stress an

73 Here, we examined the relationship between mitochondrial function and dopamine neuron dysfunction a

74 sildenafil that, through adverse effects on mitochondrial function and endoplasmic reticulum stress,

75 antly in necdin-null cortical neurons, where mitochondrial function and expression of the PGC-1alpha

76 This method can be used to study changes in mitochondrial function and fuel utilisation in live skel

77 CLUH preserves oxidative mitochondrial function and glucose homeostasis, thus pre

78 ncer cell proliferation in part by enhancing mitochondrial function and identify TIG as a clinically

79 ellular microRNA-210 (miR-210) would enhance mitochondrial function and improve survival of young mur

80 st that TRPM2 has a basic role in sustaining mitochondrial function and in cell survival that applies

81 bolic adaptation to hypoxia causes decreased mitochondrial function and increased lactate production.

82 ort the negative role of mutant alpha-syn in mitochondrial function and indicate that mdivi-1 has a h

83 Loss of FXN causes impaired mitochondrial function and iron homeostasis.

84 n results in enhanced, rather than impaired, mitochondrial function and is mediated, in part, by beta

85 e that GNP radiosensitisation is mediated by mitochondrial function and it is the first report applyi

86 two mitochondria-targeted inhibitors alters mitochondrial function and leads to reactive oxygen spec

87 , alterations in glycolysis/gluconeogenesis, mitochondrial function and lipid biosynthesis were ident

88 These studies show thatatRA regulates mitochondrial function and lipid metabolism and that inc

89 th diverse biological activities, may impact mitochondrial function and longevity.

90 Given that alterations in both mitochondrial function and lysosomal activity are key fe

91 Using biochemical methods, we also studied mitochondrial function and measured soluble Abeta in bra

92 ates and demonstrates the role of ZDHHC13 in mitochondrial function and metabolism in liver.

93 mic ablation of BCO2 led to perturbations in mitochondrial function and metabolism in the TCA cycle,

94 ntaining cells responded to dysregulation of mitochondrial function and metabolism.

95 a-inducible transcription factor expression, mitochondrial function and mitophagy.

96 the finding of age-associated alterations in mitochondrial function and morphology in NSCs, these dat

97 f knockdown, there were extensive changes in mitochondrial function and networking, which augmented t

98 genetic backgrounds would show variation in mitochondrial function and oxidative stress markers conc

99 a direct and critical role in lysosomal and mitochondrial function and PD pathogenesis and highlight

100 sing biochemical and immunoblotting methods, mitochondrial function and phosphorylated Tau were measu

101 MYC ablation impairs glycolysis, mitochondrial function and proliferation of ECs while it

102 eport that creatine enhances oligodendrocyte mitochondrial function and protects against caspase-depe

103 isturbances in the kidney and alterations in mitochondrial function and reactive oxygen species gener

104 The present work evaluates mitochondrial function and recycling in human fibroblast

105 drial fusion is essential for maintenance of mitochondrial function and requires the prohibitin ring

106 ally ill patients is accompanied by impaired mitochondrial function and structure, and by increased m

107 n of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associa

108 alveolar epithelial cells and restoration of mitochondrial function and that TH may thus represent a

109 ncrease cardiac energy production, improving mitochondrial function and the efficiency of SERCA in HF

110 transcripts were several proteins related to mitochondrial function and the metabolism of lipids.

111 development of treatments that will enhance mitochondrial function and their transition into clinica

112 ripts were enriched for pathways involved in mitochondrial function and tight junction signaling.

113 mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism

114 he effect of miR-542-3p/5p was determined on mitochondrial function and transforming growth factor-be

115 Mitochondrial function and ultrastructure are maintained

116 etabolism, urea cycle, cell replication, and mitochondrial functions and increase in expression of gl

117 ong SM high-energy phosphate concentrations, mitochondrial function, and EI in HFrEF and HFpEF patien

118 mtDNA) copy number is a surrogate measure of mitochondrial function, and higher mtDNA copy number in

119 s identify DsbA-L as a critical regulator of mitochondrial function, and its down-regulation in the l

120 se hypotheses, we studied contractile force, mitochondrial function, and mitochondrial structure in d

121 s to determine if differences in metabolism, mitochondrial function, and oxidative stress underlie th

122 ogy of oxidative stress, relevant aspects of mitochondrial function, and stress-related cell death pa

123 LKO) and monitored their energy homeostasis, mitochondrial function, and susceptibility to diet-induc

124 levels of mitochondrial and synaptic genes, mitochondrial function, and ultra-structural changes in

125 trol the expression of key genes involved in mitochondrial functions, and their ablation results in i

126 sensitivity, dendritic spine density, brain mitochondrial function, apoptosis and cognition in obese

127 Consequently, autophagy-lysosome flux and mitochondrial function are compromised in the Drosophila

128 Although deficits in mitochondrial function are often associated with energy

129 Altered metabolic and mitochondrial functions are hallmarks of MM and most oth

130 Mitochondrial functions are intrinsically linked to thei

131 neage progression of adult NSCs and identify mitochondrial function as a potential target to ameliora

132 sive changes in ribosomal protein levels and mitochondrial function as early disease stages are initi

133 tones and proteins related to enhancement of mitochondrial function as well as antioxidant protection

134 are linked to a role for dHNF4 in promoting mitochondrial function as well as the expression of Hex-

135 drug's ability to interfere with mSTAT3 and mitochondrial function, as demonstrated by site-directed

136 Alterations in mitochondrial function, as observed in neurodegenerative

137 nt study help us to understand modulation of mitochondrial function, as well as how mitochondria can

138 In mitochondrial function assays designed to detect amounts

139 mucosal ATP, highlighting the importance of mitochondrial function associated with ATP production in

140 ghted roles for LIN28 in maintaining the low mitochondrial function associated with primed pluripoten

141 These results indicate that distinct mitochondrial functions associated with respiration are

142 KIC is an inhibitor of mitochondrial function at disease relevant concentration

143 m by increasing ATP production and enhancing mitochondrial function, attributable to increased oxygen

144 ber of processes including the regulation of mitochondrial function, autophagy and endocytic dynamics

145 Parameters of pancreatitis, mitochondrial function, autophagy, ER stress, and lipid

146 Although the role of CL in mitochondrial function, biogenesis, and genome stability

147 parameters, brain insulin sensitivity, brain mitochondrial function, brain apoptosis, and dendritic s

148 hypoxic response was associated with reduced mitochondrial function but was reversible by overexpress

149 omeostasis, or proteostasis, is required for mitochondrial function, but its role in cancer is contro

150 ts suggest that the accumulated ROS disrupts mitochondrial function by altering their membrane polari

151 ide (AICAR) has been shown to improve muscle mitochondrial function by increasing mitochondrial bioge

152 Disruption of mitochondrial function by linoleic acid, a fatty acid ac

153 ivity of mutant APP and Abeta levels and (4) mitochondrial function by measuring H2O2, lipid peroxida

154 heart from Dox-cardiotoxicity via improving mitochondrial function by not only repressing mitochondr

155 This study found that enhancement of mitochondrial function by reducing microRNA-210 (miR-210

156 tegies that effectively preserves or improve mitochondrial function by targeting key component of the

157 of miR-7 is partly exerted through promoting mitochondrial function by targeting VDAC1 expression.

158 t confirmation of the effect of a variant on mitochondrial function can be challenging.

159 Increased mitochondrial function can correlate with increased reac

160 Mechanistically, TST selectively augmented mitochondrial function combined with degradation of reac

161 Alterations in mitochondrial function contribute to diabetic cardiomyop

162 lex IV-deficient mice, we found that reduced mitochondrial function did not result in overt deficits

163 As such, ERK1/2 down-regulates mitochondrial function directly by phosphorylation of up

164 inase (AMPK), which is intimately coupled to mitochondrial function due to its activation by LKB1-dep

165 Maintenance of mitochondrial function during stress conditions is vital

166 Thus, understanding mechanisms of mitochondrial function during tumorigenesis will be crit

167 1alpha,25(OH)2D3 regulates mitochondrial function, dynamics, and enzyme function, w

168 east lacking RP paralogs required for normal mitochondrial function (e.g., RPL1b).

169 atable synthetic derivative, FBA, modulating mitochondrial function, efficiency, and dynamics, can be

170 Mitochondrial fission-induced mitochondrial function elevates mitochondrial ROS (mtROS

171 Concordantly, PDK3 knockdown improved mitochondrial function, emphasizing the role of PDK3 ina

172 tivation of estrogen receptor beta increases mitochondrial function, energy expenditure, and brown ad

173 thermore, SRp55 depletion inhibits beta-cell mitochondrial function, explaining the observed decrease

174 Moreover, reduced mitochondrial function facilitated TNF-alpha-mediated NF

175 The proximal tubule epithelium relies on mitochondrial function for energy, rendering the kidney

176 However, the implications of altered mitochondrial function for tumorigenesis in LFS are uncl

177 on and metabolism, including vasoregulation, mitochondrial function, glucose uptake, fatigue and exci

178 The impact of ischemia on mitochondrial function has been extensively studied in t

179 Abnormal mitochondrial function has been found in patients with f

180 Although associations between aging and mitochondrial function have been identified using mammal

181 well tolerated small molecule that disrupts mitochondrial function; however, its underlying mechanis

182 mediator of mitochondrial fission, regulates mitochondrial function; however, the cell-specific and t

183 ectroscopy can provide an in vivo measure of mitochondrial function; however, the wider application o

184 P mice, suggesting that reduced Drp1enhances mitochondrial function in AD neurons.

185 These observations identify that reduced mitochondrial function in alpha-cells exerts potently pr

186 for NR4A3 in the maintenance of homeostatic mitochondrial function in CD103+ DCs, although this is l

187 Accordingly, we investigated mitochondrial function in cell culture and mouse models

188 statin A and sodium butyrate (SB) ameliorate mitochondrial function in cells expressing mutant huntin

189 th elamipretide on left ventricular (LV) and mitochondrial function in dogs with heart failure (HF).

190 Furthermore, we found impaired mitochondrial function in hepatocytes of Zdhhc13-deficie

191 r of mitochondrial RNA, and is essential for mitochondrial function in human cells.

192 nown whether thyroid hormones (THs) regulate mitochondrial function in human epidermis, we treated or

193 ifies THs as potent endocrine stimulators of mitochondrial function in human epidermis, which down-re

194 ature and measurement of oxygen kinetics and mitochondrial function in intact tissue in all nephron s

195 date the consequences of this interaction on mitochondrial function in isolated mitochondria and live

196 hape and substantiate a pro-survival role of mitochondrial function in melanoma cells after oncogenic

197 r the long non-coding RNA SAMMSON in driving mitochondrial function in melanoma.

198 sis in wild-type mice, but failed to improve mitochondrial function in miR-133a-deficient mice.

199 ignificance of Parkin for the maintenance of mitochondrial function in neurons and provides a novel t

200 ial of this method for investigating in vivo mitochondrial function in new cohorts of growing clinica

201 and oxidative stress, and preserved cardiac mitochondrial function in obese-insulin resistant rats.

202 ht into the role of carbohydrate overload on mitochondrial function in other hepatic diseases, such a

203 The authors show that Tug1 regulates mitochondrial function in podocytes by epigenetic target

204 scribed a role for Tug1 in the regulation of mitochondrial function in podocytes.

205 dentified in affected individuals, preserves mitochondrial function in ppa2Delta yeast.

206 Forced expression of necdin enhances mitochondrial function in primary cortical neurons and h

207 AlthoughatRA treatment improves mitochondrial function in skeletal muscle in rodents, it

208 arboxykinase expression, type IA fibers, and mitochondrial function in skeletal muscle.

209 tation and distribution deficits and improve mitochondrial function in the CRND8 neurons both in vitr

210 Impairments of mitochondrial function in the heart are linked intricate

211 al muscle in rodents, its role in modulating mitochondrial function in the liver is controversial, an

212 AD(P)H FLIM revealed a comparable decline in mitochondrial function in the pancreatic islets of aged

213 ndrial superoxide anion levels and increased mitochondrial function in the paraventricular nucleus of

214 n by reducing oxidative stress and improving mitochondrial function in the paraventricular nucleus, a

215 udies have implicated impaired lysosomal and mitochondrial function in the pathogenesis of PD.

216 the 6 weeks of SS31 treatment compared with mitochondrial function in the untreated APP mice.

217 R site and ex vivo studies confirmed altered mitochondrial function in these fish.

218 nslocase in the mechanism underlying altered mitochondrial function in VCP-related degeneration, and

219 tes of oxygen consumption (CMRO2) and assess mitochondrial function in vivo Basal respiration and max

220 Here we assessed neuronal and mitochondrial functioning in primary enteric neurons of

221 and activity in megakaryocytes and preserve mitochondrial functions in platelets in the presence of

222 our optometabolic tools allow modulation of mitochondrial functions in single cells and defined cell

223 ents which have been associated with reduced mitochondrial function, in particular mitochondrial resp

224 k environmental and intracellular stimuli to mitochondrial functions, including fission/fusion, ATP p

225 Mechanistically, inhibition of mitochondrial function increased autophagy and decreased

226 Given that impairment of mitochondrial function is a common pathological componen

227 Therefore, presynaptic mitochondrial function is critical for the short-term dy

228 Intact presynaptic mitochondrial function is critical for the short-term dy

229 This niche-supported, inducible mitochondrial function is dependent on protein kinase C

230 Thus, mitochondrial function is important for the development

231 py and/or therapy in muscle disease in which mitochondrial function is important.

232 Pase (SERCA) expression is downregulated and mitochondrial function is reduced in HF, perhaps partly

233 Mitochondrial function is tightly linked to their morpho

234 of neurotoxicity, the link between Abeta and mitochondrial function is unclear.

235 Ablation of BCO2 impairs mitochondrial function leading to oxidative stress.

236 This shift in mitochondrial function leads to extensive glycogen accum

237 generated colonic rho(0) cells with reduced mitochondrial function linked to ATP production by selec

238 (PPARgamma), insulin signaling molecules and mitochondrial function markers.

239 We propose that impaired mitochondrial function marks the progression from metabo

240 has been suggested but not demonstrated that mitochondrial function may be abnormal in FD.

241 ndicating that lumican-induced disruption of mitochondrial function may be the mechanism of sensitiza

242 This metabolic disturbance and alteration in mitochondrial function may lead to further cellular inju

243 AFLD, suggesting that alterations in hepatic mitochondrial function may precede diabetes-related live

244 Mitochondrial function, motility and architecture are ea

245 tylaspartate (NAA), an indicator of neuronal mitochondrial function, normalized to creatine (Cr) leve

246 , thus reproducing the effects of disrupting mitochondrial function observed in LFS mice.

247 Impaired mitochondrial function occurred before intracellular pot

248 Interventions aimed at restoring the mitochondrial function of atherosclerotic-MSCs improve t

249 An impaired mitochondrial function of atherosclerotic-MSCs underlies

250 These mitochondrial functions of BMI1 are independent of its p

251 re, we provide evidence of additional, extra-mitochondrial functions of this membrane-anchored protei

252 at have been associated with a disruption of mitochondrial function or transport (reviewed in [1, 2])

253 tance significantly impaired glucose uptake, mitochondrial function, oxygen consumption rates, glycol

254 ino acid and proline catabolism are very old mitochondrial functions particularly enriched at the lat

255 ulator of placental amino acid transport and mitochondrial function, placental mTOR folate sensing ma

256 Reestablishment of bdh2 restores mitochondrial function, prevents premature mitochondrial

257 vestigations showed that cyclin D1 inhibited mitochondrial function, promoted glycolysis, and reduced

258 d oxidative stress reduction, SIRT1-mediated mitochondrial function promotion, and pAKT signaling.

259 small hydroxylamine compound BGP-15 improved mitochondrial function, protecting neurons from dying in

260 itical for the maintenance and regulation of mitochondrial function, quality and distribution.

261 t mensacarcin disturbs energy production and mitochondrial function rapidly.

262 Mitochondrial function refers to a broad spectrum of fea

263 ied through bioinformatics analyses involved mitochondrial function; results from immunoblotting, imm

264 Investigation of mitochondrial function revealed a decrease in mitochondr

265 Macrolides 1 and 2 inhibit mitochondrial function similar to oligomycin A and apopt

266 Key mitochondrial functions such as ATP production, Ca(2+) u

267 l membrane potential (Deltapsim) and coupled mitochondrial functions such as ATP synthesis by oxidati

268 YY1 show enrichment in ribosomal functions, mitochondrial functions such as bioenergetics, and funct

269 transcript profiles, focusing on several key mitochondrial functions, such as the tricarboxylic acid

270 urther investigation revealed that increased mitochondrial function suppressed the shift to primarily

271 el, methodological approach, and features of mitochondrial function tested.

272 ch has a greater physiological importance in mitochondrial function than previously recognized.

273 stent with an evolutionarily conserved extra-mitochondrial function, the ortholog of PHB2 in Caenorha

274 ts demonstrate that ERK1/2 rapidly regulates mitochondrial function through a novel pathway, EGFR/ERK

275 of miR-210 inhibition to enhance and protect mitochondrial function through upregulation of mitochond

276 In cells with reduced mitochondrial function, TNF-alpha facilitated AMPKalpha2

277 ation, suggesting a requirement for adequate mitochondrial function to maintain glutamate release dur

278 teins and suggest novel strategies to tailor mitochondrial function to physiological and pathological

279 Pol may alter one or more of these host mitochondrial functions to gain a replicative advantage

280 lammatory processes, cellular signaling, and mitochondrial function ultimately mitigating myocardial

281 city in the AD-A LCLs we examined changes in mitochondrial function using the Seahorse XF96 analyzer

282 muscarinic receptor-dependent regulation of mitochondrial function via AMPK.

283 es to metabolic stress caused by compromized mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1alp

284 skeletal muscle development, metabolism, and mitochondrial function,viaits interaction with numerous

285 Moreover, disturbed mitochondrial function was ameliorated and the mitochond

286 pectrometry-based metabolomics analyses, and mitochondrial function was analyzed by confocal microsco

287 The elevated mitochondrial function was associated with induction of

288 The impact of lactate on mitochondrial function was examined with a focus on the

289 Mitochondrial function was maintained in the SS31-treate

290 p a treatment strategy based on potentiating mitochondrial function, we investigated the effect of th

291 To improve understanding of mitochondrial function, we used chemical cross-linking m

292 plex inhibitors of the respiratory chain) on mitochondrial function were also studied.

293 involved in apoptosis, stress-signaling and mitochondrial function, were inversely found down-regula

294 UpperB exposure impaired mitochondrial function, whereas LowerB exposure signific

295 caveolin - membrane repair and regulation of mitochondrial function - which may be novel features of

296 rgeting PGC-1alpha, a positive regulator for mitochondrial function, which is disturbed by maternal d

297 mulate fatty acid beta-oxidation and improve mitochondrial function, which may present a novel cardio

298 p106(-/-) motor neurons revealed deficits in mitochondrial function, with an inhibition of Complex I

299 EK293 Tet-on G1 and G2 cells led to impaired mitochondrial function, with markedly reduced maximum re

300 o IR and chemotherapy and partially restored mitochondrial function without affecting IR or chemother