ライフサイエンスコーパス: mitochondrial genome

1 ion of the GR with the control region of the mitochondrial genome.

2 gion of the ATP8 and ATP6 genes of the human mitochondrial genome.

3 osphorylation (OXPHOS) system encoded by the mitochondrial genome.

4 of coevolution on the mitoribosome with the mitochondrial genome.

5 e to measure the mutation load of the entire mitochondrial genome.

6 flowers are male sterile due to the foreign mitochondrial genome.

7 a G to A mutation at nucleotide 11778 of the mitochondrial genome.

8 scribe epiallelic DNA methylation within the mitochondrial genome.

9 ait to a particular region in the Drosophila mitochondrial genome.

10 fission in maintaining the integrity of the mitochondrial genome.

11 rnessed to dissect function and evolution of mitochondrial genome.

12 present upstream of (G+C)-rich tracts in the mitochondrial genome.

13 and a progressive somatic mutagenesis of the mitochondrial genome.

14 rved alpha4/Tap42 protein in cells lacking a mitochondrial genome.

15 ects mutations in the multiple copies of the mitochondrial genome.

16 and illuminate evolutionary dynamics of the mitochondrial genome.

17 d with the expected sequences encoded by the mitochondrial genome.

18 Equally important, it coats and packages the mitochondrial genome.

19 nsible for the replication and repair of the mitochondrial genome.

20 cant amount of off-target reads are from the mitochondrial genome.

21 bute to the high level of foreign DNA in its mitochondrial genome.

22 t coordinate these dispersed elements of the mitochondrial genome.

23 st for signals of molecular selection on the mitochondrial genome.

24 ting a duplicated sequence in the I. pulchra mitochondrial genome.

25 s the only polymerase known to replicate the mitochondrial genome.

26 ng a need for differential expression of the mitochondrial genome.

27 the 99% nonsynthetic nuclear genome, or the mitochondrial genome.

28 an DNA, from which we assembled two complete mitochondrial genomes.

29 nits are encoded on both the nuclear and the mitochondrial genomes.

30 ell as communication between the nuclear and mitochondrial genomes.

31 of tandem repeats among all the known insect mitochondrial genomes.

32 y but also for segregation of the replicated mitochondrial genomes.

33 d mediates the segregation of the replicated mitochondrial genomes.

34 XPHOS gene promoters in both the nuclear and mitochondrial genomes.

35 d 2 rRNA sequences were in typical of insect mitochondrial genomes.

36 d the utility of 454 sequencing for dipteran mitochondrial genomes.

37 re able to anneal selectively to the mutated mitochondrial genomes.

38 mplex I is a product of both the nuclear and mitochondrial genomes.

39 caused by mutations in both the nuclear and mitochondrial genomes.

40 gest structure in the canyon, have identical mitochondrial genomes.

41 ell as communication between the nuclear and mitochondrial genomes.

42 organisation in comparison to other metazoan mitochondrial genomes.

43 ed the genomes (0.04x-7.25x, mean 2.16x) and mitochondrial genomes (20.8x-1,311.0x, mean 482.1x) of e

44 nnaeus, 1758) transcriptome, nearly complete mitochondrial genomes, 430 unlinked high-quality SNPs sh

45 f mitochondrial DNA haplogroup variation and mitochondrial genome abundance in the relationship of PM

46 mitochondrial DNA copy number, a measure of mitochondrial genome abundance, mediated 12% of the asso

47 encoded across the nuclear, chloroplast and mitochondrial genomes accounting for 1355 genes (1460 tr

48 -tree distance matrix for each of the three- mitochondrial genome alignments and greatly outperformed

49 partitions found in three mid- to large-size mitochondrial genome alignments.

50 are mosaics of core subunits encoded by the mitochondrial genome and additional nuclear-encoded prot

51 e was also a significant interaction between mitochondrial genome and age (p=0.002), with a strong pr

52 cluded the complete loss of variation in the mitochondrial genome and along long stretches of the nuc

53 latory network that builds and maintains the mitochondrial genome and drives the expression of the en

54 ENs to induce breaks in distinct loci of the mitochondrial genome and found that breaks adjacent to t

55 during replication or possibly repair of the mitochondrial genome and how well it tolerates potential

56 The evolution of the mitochondrial genome and its potential adaptive impact s

57 and AtPHB6 influences the expression of the mitochondrial genome and leads to the activation of alte

58 of ribosomes comprising rRNAs encoded by the mitochondrial genome and mitochondrial ribosomal protein

59 ajor role in modulating the evolution of the mitochondrial genome and proteome.

60 hase checkpoints), pif1Delta (maintenance of mitochondrial genome and telomere length), cac1Delta cac

61 m, we have shown that both the source of the mitochondrial genome and the presence or absence of a ds

62 We use complete ancient mitochondrial genomes and genome-wide nuclear DNA survey

63 Complete mitochondrial genomes and low-coverage autosomal genomes

64 DNA (mtDNA) affects both the copy number of mitochondrial genomes and patterns of gene expression ac

65 r dataset includes 54 previously unpublished mitochondrial genomes and significantly increases the co

66 We have analyzed the mitochondrial genomes and transcriptomes of four species

67 e identity and length at CSB 2 amongst human mitochondrial genomes and used in vitro transcription to

68 , the complete chloroplast genome, a partial mitochondrial genome, and a nuclear-ddRAD matrix separat

69 introns and intergenic regions, reads in the mitochondrial genome, and reads originating in viral gen

70 (approximately 153 kb) and a nearly complete mitochondrial genome (approximately 450 kb in 120 scaffo

71 New analyses suggest that large, gene-rich mitochondrial genomes are more common than previously th

72 al gene retention, suggesting that gene-rich mitochondrial genomes are not a product of their early d

73 Given that mitochondrial genomes are polyploid, cells with advantag

74 rnal inheritance in most animals and plants, mitochondrial genomes are predicted to accumulate mutati

75 rigenesis, and rare human tumors with mutant mitochondrial genomes are relatively benign.

76 Mitochondrial genomes are separated from the nuclear gen

77 ty of compositions and evolution of myriapod mitochondrial genomes are shown to be more complex than

78 For example, gene-rich mitochondrial genomes are thought to be indicative of an

79 Plant mitochondrial genomes are usually transmitted to the pro

80 s sperm formation begins, hundreds of doomed mitochondrial genomes are visualized within the two huge

81 e normalized numbers of reads mapping to the mitochondrial genome as a proxy for the amount of mtDNA,

82 ibutes to the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome

83 Here we present 90 mitochondrial genomes as well as genome-wide data sets f

84 ing model to study adaptive evolution in the mitochondrial genome, as the three extant Old World came

85 sentative M. musculus sequence (the 16.3 kb mitochondrial genome), at 100%, 100%, and 96.7% consensu

86 pe specimens, we assembled 14 plastid and 15 mitochondrial genomes attributed to the red algae Pyropi

87 The MA-1 mitochondrial genome belongs to haplogroup U, which has

88 active, long OPA1 forms, which stabilize the mitochondrial genome but do not preserve mitochondrial c

89 es mitochondrial dysfunction and renders the mitochondrial genome, but not the nuclear genome suscept

90 ete replacement of the temperature-sensitive mitochondrial genome by a wild-type genome but also stab

91 DNA transfer and enables modification of the mitochondrial genome by DNA transmitted from a sexually

92 likely to be a source of instability for the mitochondrial genome by perturbing the normal progressio

93 ates how small-scale sequence changes in the mitochondrial genome can achieve broad-scale regulation

94 Defects in mitochondrial genome can cause a wide range of clinical

95 Their mitochondrial genome carries only three protein-coding g

96 Defects in both the nuclear and mitochondrial genomes cause mitochondrial dysfunction vi

97 Whether the nuclear and mitochondrial genomes coevolved will need a thorough inv

98 Mitochondrial genomes compete for transmission from moth

99 The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA net

100 recipitation reveals that Stat3 binds to the mitochondrial genome, consistent with direct transcripti

101 The larger I. pulchra mitochondrial genome contains both ribosomal genes, 21 t

102 These findings indicate the involvement of mitochondrial genome copy number and sequence in an orga

103 rovide a robust nexus for nuclear control of mitochondrial genome copy number, since use of common in

104 variant calling and annotation do not handle mitochondrial genome data appropriately.

105 plast genomes were fairly conserved, but the mitochondrial genomes differed significantly among popul

106 proline metabolism and demonstrated that the mitochondrial genome differentially affects genomic QTLs

107 By examining the mitochondrial genome diversity and isotopic ratios of 74

108 Complete mitochondrial genomes documented a diversification of ma

109 s the power of 454 sequencing for generating mitochondrial genome drafts without PCR has not yet been

110 Additionally, we found evidence of mitochondrial genome duplications allowing replication a

111 ctive of this study was to determine whether mitochondrial genome-encoded proteins are regulated by m

112 than represses, the translation of specific mitochondrial genome-encoded transcripts.

113 The mitochondrial genome encodes for critical components of

114 Moreover, the mitochondrial genome encompasses over a thousand nuclear

115 /Cas9 platform, could prompt a revolution in mitochondrial genome engineering and biological understa

116 Questions include how plant mitochondrial genome evolution can be placed on a sexual

117 (HGT) has played an important role in plant mitochondrial genome evolution.

118 The mitochondrial genome exists in numerous structural confo

119 Here we describe the first mitochondrial genome for Rhyparochromidae: a complete mi

120 Here we report an almost complete mitochondrial genome for the litoptern Macrauchenia.

121 using an Illumina MiSeq, to obtain the first mitochondrial genome for the vetigastropod family Turbin

122 We generated complete or nearly complete mitochondrial genomes for Cochliomyia hominivorax, Haema

123 utility of 454 sequencing to obtain complete mitochondrial genomes for dipterans without the aid of c

124 Complete mitochondrial genomes for two corn rootworm species, Dia

125 Mitochondrial aprataxin (APTX) protects the mitochondrial genome from the consequence of ligase fail

126 rial genomic variation in the first multiple mitochondrial genomes from a single prehistoric populati

127 Bison cf. priscus We extracted and sequenced mitochondrial genomes from both this bison and from the

128 e homologs in recently sequenced nuclear and mitochondrial genomes from diverse land plants.

129 ated the first genome-wide sequence data and mitochondrial genomes from eleven archaeological Guanche

130 Here, we report the recovery of full mitochondrial genomes from four and partial nuclear geno

131 different picture emerges from the 843 whole mitochondrial genomes from modern Finns analyzed here.

132 We present partial mitochondrial genomes from one S. populator sample and t

133 hondrial genome reduction, we also assembled mitochondrial genomes from picozoans and colponemids and

134 In this study, we sequenced complete mitochondrial genomes from three congeneric Decemunciger

135 were large, including acquisition of entire mitochondrial genomes from three green algae and one mos

136 of nuclear sequence, in addition to complete mitochondrial genomes generated using light-coverage Ill

137 We have developed a novel mitochondrial genome haplogroup-defining algorithm using

138 on pig biochemical traits linking different mitochondrial genome haplotypes.

139 at their absence leads to an accumulation of mitochondrial genomes harboring deleterious structural v

140 We conclude that the mitochondrial genome has been maintained to ensure the c

141 es more than 1,850 described species, but no mitochondrial genome has been sequenced to date.

142 , the state of methylation in the vertebrate mitochondrial genome has been unclear.

143 The mitochondrial genome has evolved under selection for min

144 The mitochondrial genome has long been implicated in age-rel

145 The Y chromosome and the mitochondrial genome have been used to estimate when the

146 Moreover, only four complete Asterid mitochondrial genomes have been made publicly available.

147 Multichromosomal mitochondrial genomes have recently been found in multip

148 st of its functionalities (i.e., assembly of mitochondrial genomes, heteroplasmic fractions, haplogro

149 Pups receiving the C57BL/6J or BALB/cJ mitochondrial genome (i.e., females crossed with Her2 ma

150 This study sequenced the entire mitochondrial genome in a renal transplant cohort of 64

151 ation of Acinetobacter-like DNA in the human mitochondrial genome in acute myeloid leukemia samples.

152 Here we identified the full mitochondrial genome in circulating extracellular vesicl

153 the mitochondrion and was the source of the mitochondrial genome in contemporary eukaryotes.

154 s the dominant selective force acting on the mitochondrial genome in Tachycineta, three mitochondrial

155 e novo assembly and annotation of a complete mitochondrial genome in the Ericales order from the Amer

156 -dependent transcriptional regulation of the mitochondrial genome in vivo and are consistent with pre

157 the dissimilar intrinsic stabilities of the mitochondrial genomes in A. nidulans and P. anserina.

158 New analysis of rapidly evolving mitochondrial genomes in calcaronean sponges has demonst

159 a population-based resequencing of complete mitochondrial genomes in Europe and the Middle East, in

160 The mitochondrial genomes in renal chromophobe and thyroid c

161 ctions for recombination between co-resident mitochondrial genomes in various heteroplasmic Drosophil

162 idium daphniae gen. et sp. nov., possesses a mitochondrial genome including genes for oxidative phosp

163 t insertions are derived from throughout the mitochondrial genome, including the D-loop, and have int

164 We report four complete mitochondrial genomes, including two rearranged mitochon

165 o simultaneously compare how the nuclear and mitochondrial genomes incorporate and remove ribonucleot

166 ncluding a replicative advantage for deleted mitochondrial genomes inferred by their smaller size--im

167 re tool that can reliably and easily extract mitochondrial genome information from exome and whole ge

168 irst time in mammals, we identify a complete mitochondrial genome insertion within the nuclear genome

169 ve identified a number of nearly full-length mitochondrial genome insertions into nuclear chromosomes

170 uring DNA synthesis is a prominent source of mitochondrial genome instability; however, the precise m

171 ral role of MMEJ in maintenance of mammalian mitochondrial genome integrity and is likely relevant fo

172 ious roles in the maintenance of nuclear and mitochondrial genome integrity in most eukaryotes.

173 nvolved in maintenance and compaction of the mitochondrial genome into nucleoids.

174 Our findings support the hypothesis that the mitochondrial genome is altered greatly as a result of t

175 This mitochondrial genome is comprised of 16,345 bp, and cont

176 oordinated replication and expression of the mitochondrial genome is critical for metabolically activ

177 ragment spanning the entire major arc of the mitochondrial genome is generated.

178 This is because the mitochondrial genome is placed in a novel nuclear enviro

179 Thus, although functional replacement of the mitochondrial genome is possible, even low levels of het

180 The mitochondrial genome is transcribed by a single-subunit

181 latin in the form of a prodrug to attack the mitochondrial genome lacking NER machinery and in vivo d

182 ring cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can lead to a

183 bolic processes, studies of variation in the mitochondrial genome may offer opportunities to establis

184 Mitochondrial genomes (mitochondrial DNA, mtDNA) encode

185 port here the first complete sequence of the mitochondrial genome (mitogenome) of the whale shark obt

186 previous studies and newly determined whole mitochondrial genome (mitogenome) sequences for 16 perco

187 d the complete plastid genome (plastome) and mitochondrial genome (mitogenome) sequences from three g

188 Currently, complete mitochondrial genomes (mitogenomes) are available from a

189 We provide mitochondrial genomes (mitogenomes) from archival type s

190 The first completed mitochondrial genomes (mitogenomes) from parasitic mistl

191 Only six mitochondrial genomes (mitogenomes) have been previously

192 entation, rests in part on expression of the mitochondrial genome (mtDNA) and coordination with expre

193 tudy, we examine the accumulation of somatic mitochondrial genome (mtDNA) mutations in skin fibroblas

194 e two species of the 22 tRNAs encoded by the mitochondrial genome (mtDNA); whether there is tissue-sp

195 Although mitochondrial genomes (mtDNA) accumulate elevated levels

196 Here we analyze 55 complete human mitochondrial genomes (mtDNAs) of hunter-gatherers spann

197 The availability of complete mitochondrial genome (mtgenome) data for Diptera, one of

198 , there is negative selection for pathogenic mitochondrial genome mutations.

199 oordination of expression of the nuclear and mitochondrial genomes occurs at the complex assembly lev

200 y identified, suggesting that introns in the mitochondrial genome of annelids may be more widespread

201 The complete mitochondrial genome of cranberry was annotated obtainin

202 zing mtDNA in human breast CSCs; rather, the mitochondrial genome of CSCs displayed an overall decrea

203 nces and successfully assembled the complete mitochondrial genome of Doedicurus sp., one of the large

204 The mitochondrial genome of Geranium brycei contains at leas

205 mitochondrial DNA (mtDNA) suggests that the mitochondrial genome of mammals is copied by an unorthod

206 generation sequencing to obtain the complete mitochondrial genome of Nycteria parasites from African

207 rial genome for Rhyparochromidae: a complete mitochondrial genome of Panaorus albomaculatus (Scott, 1

208 , we analyzed intraspecific variation in the mitochondrial genome of S. noctiflora.

209 ra and Isodiametra pulchra, and the complete mitochondrial genome of the acoel Archaphanostoma ylvae.

210 the kinetoplast, an organelle containing the mitochondrial genome of the parasite (kDNA), with an acc

211 cestries and analyzed 241 sequences from the mitochondrial genome of the species Demodex folliculorum

212 g identified three missense mutations in the mitochondrial genome of this cell line, coding for ND5,

213 nd expression of its kinetoplast (kDNA), the mitochondrial genome of this parasite and a putative tar

214 kDNA, the mitochondrial genome of trypanosomatids, is a DNA networ

215 The complete mitochondrial genomes of 41 families with OXPHOS deficie

216 tory of the region, we analyzed the complete mitochondrial genomes of 52 ancient skeletons from prese

217 In addition, mitochondrial genomes of at least some calcaronean spong

218 The structurally similar mitochondrial genomes of Chromera and Vitrella differ in

219 Overall, the first mitochondrial genomes of ferns show a mix of features sh

220 The mitochondrial genomes of flowering plants exist both as

221 sequenced and annotated the nearly complete mitochondrial genomes of four species of each these trib

222 The mitochondrial genomes of Geraniaceae display a number of

223 This study examined the complete mitochondrial genomes of L. trifolii, L. huidobrensis an

224 800 years and combined this dataset with 206 mitochondrial genomes of modern Armenians.

225 We sequenced the nuclear and mitochondrial genomes of Paramicrosporidium saccamoebae

226 generation sequencing approach, the complete mitochondrial genomes of R. multicaudata and Trypanobia

227 s, as deduced from four completely sequenced mitochondrial genomes of this species.

228 Here, we sequenced the mitochondrial genomes of wild-type or autophagy-deficien

229 eritance at two levels, eliminating paternal mitochondrial genomes or destroying mitochondria deliver

230 ternal transmission model, symbiont and host mitochondrial genomes pass through the same individuals

231 umber of mitochondria per cell and number of mitochondrial genomes per mitochondrion, is an indirect

232 Analysis of whole mitochondrial genomes places the three larger species as

233 Our data suggests that the mitochondrial genome plays a role in DNAm-age relationsh

234 allelic heterogeneity, with both nuclear and mitochondrial genomes potentially liable.

235 lagellate Diplonema papillatum (Euglenozoa), mitochondrial genome rearrangements have resulted in nea

236 To comprehensively examine mitochondrial genome reduction, we also assembled mitoch

237 the mechanisms of inheritance in fragmented mitochondrial genomes remain mysterious.

238 d mtDNA processing is essential for faithful mitochondrial genome replication and might be required f

239 y on the genes encoding TFAM, which controls mitochondrial genome replication and transcription, and

240 A mitochondrial genome representing each of the CMS cytoty

241 iRs displayed distinct interactions with the mitochondrial genome requiring specific stoichiometric a

242 ion factor MOC1 and aberrantly expresses the mitochondrial genome, resulting in enhanced photosynthet

243 Thus, these mitochondrial genomes retain a full gene complement but

244 The annotation of cranberry mitochondrial genome revealed the presence of two copies

245 Analyses of the mitochondrial genomes revealed extensive recombination,

246 mble and interpret a data set of 143 mammoth mitochondrial genomes, sampled from fossils recovered fr

247 n, this method enabled us to reconstruct the mitochondrial genome sequence from a Middle Pleistocene

248 contaminants and show that the reconstructed mitochondrial genome sequence is more closely related to

249 Additionally, a finished mitochondrial genome sequence of 135,790 bp was obtained

250 We report the complete mitochondrial genome sequence of the flowering plant Amb

251 of other migrations, we obtained 1,331 whole mitochondrial genome sequences from 34 populations spann

252 The HmtDB resource hosts a database of human mitochondrial genome sequences from individuals with hea

253 Here, we use mitochondrial genome sequences from ten securely dated a

254 Here we describe mitochondrial genome sequences from the acoels Paratomel

255 We aligned and analyzed mitochondrial genome sequences from thirty-nine pleurone

256 ative genomic analyses, we examined complete mitochondrial genome sequences obtained from nine, broad

257 We present the first study to use whole mitochondrial genome sequences to examine phylogenetic a

258 g gDNA derived from P. falciparum Plasmodium mitochondrial genome sequences were subsequently reconst

259 we analyzed extensive genomic data including mitochondrial genome sequences, sequences from 20 autoso

260 chnologies and hence greater availability of mitochondrial genome sequences, there is a strong need f

261 hilst highlighting the necessity of complete mitochondrial genome sequencing in the diagnostic work-u

262 These cybrid cells were subjected to mitochondrial genome sequencing, copy number detecting a

263 ta generated from three leafminers' complete mitochondrial genomes should provide valuable informatio

264 Tumor mitochondrial genomes show distinct mutational patterns

265 Sequencing of recombinant mitochondrial genomes showed that the noncoding region,

266 that XPD plays crucial role(s) in protecting mitochondrial genome stability by facilitating an effici

267 ered in leaf morphology, heat tolerance, and mitochondrial genome stability.

268 Phylogenetic reconstruction based on mitochondrial genomes suggests that Rhyparochromidae is

269 We evaluate mitochondrial genome support for a sister Esociformes an

270 mples, (b) RNA than DNA samples, and (c) the mitochondrial genome than the nuclear genome.

271 harness naturally occurring mutations in the mitochondrial genome that impair male fertility while ha

272 dent evolution between species has generated mitochondrial genomes that are extremely diverse, with t

273 ing of tRNAs is a well-documented process in mitochondrial genomes that changes the identity of a tRN

274 The dramatically rearranged mitochondrial genomes, the limited set of transcripts, a

275 Although divergent in their mitochondrial genomes, the mammoths had similar nuclear

276 mtDNA deletions of different sizes; smaller mitochondrial genomes therefore do not appear to have an

277 and replication might limit options for the mitochondrial genome to escape restriction.

278 The TAC links the single-unit mitochondrial genome to the basal body of the flagellum

279 t of the ERMES, is postulated to connect the mitochondrial genomes to actin filaments, whereas in try

280 st effectively evaluate both the nuclear and mitochondrial genomes to obtain a molecular diagnosis fo

281 the evolutionary history of this group using mitochondrial genomes to reconstruct phylogenetic and bi

282 le in both expression and replication of the mitochondrial genome, transcription initiation by mtRNAP

283 findings indicate that random segregation of mitochondrial genomes under uniparental inheritance can

284 formed a computational analysis of the human mitochondrial genome using the "Pattern Finder" G-quadru

285 ns and colponemids and re-annotated existing mitochondrial genomes using hidden Markov model gene pro

286 The number of mitochondrial genomes varies depending on the cell's ene

287 The cranberry mitochondrial genome was assembled and reconstructed fro

288 A canonical fungal mitochondrial genome was recovered from P. saccamoebae t

289 communication exists between the nuclear and mitochondrial genomes, we hypothesized that there are di

290 The Lantang and Xiang mitochondrial genomes were highly homologous with only 1

291 Three complete mitochondrial genomes were successfully recovered and an

292 the 16 nuclear chromosomes, but not for the mitochondrial genome, whose reconstruction still represe

293 er cells with advantageous levels of damaged mitochondrial genomes will selectively proliferate to fa

294 which harbors an unusually large and complex mitochondrial genome with more than 50 circular-mapping

295 The highly rearranged mitochondrial genomes with a variation in gene flanking

296 onstrate that TFAM uniformly coats the whole mitochondrial genome, with no evidence of robust TFAM bi

297 tent with the relatively conserved nature of mitochondrial genomes within annelids.

298 ochondrial genomes, including two rearranged mitochondrial genomes within Haemosporidia.

299 orm has already been utilized for generating mitochondrial genomes without using conventional long ra

300 hydrophobic membrane proteins encoded by the mitochondrial genomes would be recognized by the signal