ライフサイエンスコーパス: mitochondrial mRNA

1 educed mitochondrial DNA content and reduced mitochondrial mRNA.

2 rry out guide-RNA-dependent U-insertion into mitochondrial mRNA.

3 generate open reading frames in trypanosomal mitochondrial mRNAs.

4 required for U-insertion/deletion editing of mitochondrial mRNAs.

5 he leaderless or nearly leaderless nature of mitochondrial mRNAs.

6 for correcting the coding sequences of many mitochondrial mRNAs.

7 affinity to 5'-untranslated regions of yeast mitochondrial mRNAs.

8 ation phenomenon required for translation of mitochondrial mRNAs.

9 ement to facilitate degradation of T. brucei mitochondrial mRNAs.

10 specific for the 5'-untranslated regions of mitochondrial mRNAs.

11 equences in 5'-untranslated regions of yeast mitochondrial mRNAs.

12 is required for 5' end processing of several mitochondrial mRNAs.

13 eletion of uridines at specific sites within mitochondrial mRNAs.

14 eotide sequence present in all S. cerevisiae mitochondrial mRNA 5'-UTLs that is a potential rRNA bind

15 mLRPPRC1 and causes non-uniform increases of mitochondrial mRNAs, accumulation of some unprocessed mi

16 The interaction with mitochondrial mRNAs also produces a dramatic inhibition

17 asts showed decreased steady-state levels of mitochondrial mRNAs, although the length of poly(A) tail

18 significantly higher levels of steady-state mitochondrial mRNA and butyrate-induced p21(WAF1/Cip1) a

19 Mitochondrial mRNA and rRNA levels are reduced in rpm2-1

20 Expression of mitochondrial mRNA and transcription of mitochondrial RN

21 The expression of mitochondrial mRNA and tRNA was dependent upon LRPPRC le

22 rotein that associates with both nuclear and mitochondrial mRNAs and as such is a potential candidate

23 oteins, and (b) selected transcriptional and mitochondrial mRNAs and proteins in human muscle.

24 -dependent degradation pathway for T. brucei mitochondrial mRNAs and reveal an unprecedented role for

25 ciable effects on the steady-state levels of mitochondrial mRNAs and rRNAs.

26 transport profiles of mitochondrial and non-mitochondrial mRNA, and differences in transport paramet

27 es short and long A-tails typically found in mitochondrial mRNAs, and decreases the abundance of neve

28 ifically to 5'-untranslated regions of yeast mitochondrial mRNAs, and transcripts containing these re

29 rance, perhaps involved in recruiting unique mitochondrial mRNAs; and it has a polypeptide exit tunne

30 Several mitochondrial mRNAs are affected by interferon treatment

31 Mammalian mitochondrial mRNAs are basically leaderless, having few

32 l process in kinetoplastid parasites whereby mitochondrial mRNAs are modified through the specific in

33 A-containing cargoes, including granules and mitochondrial mRNA, are transported within neuronal proj

34 LRPPRC in post-transcriptional regulation of mitochondrial mRNAs between tissues.

35 specifically removes poly(A) extensions from mitochondrial mRNAs both in vitro and in mitochondria of

36 is and proteomics, that byps are retained in mitochondrial mRNAs but not translated.

37 osoma brucei inserts and deletes uridines in mitochondrial mRNAs by a series of enzymatic steps that

38 diting in Trypanosomatids creates functional mitochondrial mRNAs by extensive uridylate (U) insertion

39 RNA editing produces mature trypanosome mitochondrial mRNAs by uridylate (U) insertion and delet

40 ce for binding of 5'-untranslated regions of mitochondrial mRNAs by yeast mitochondrial NADP+-specifi

41 hetic neurons to include the nuclear-encoded mitochondrial mRNA coding for COXIV.

42 lleviation of catalytic inhibition of IDH by mitochondrial mRNA correlates with the property of allos

43 ia, or that a mechanistically unique type of mitochondrial mRNA editing has evolved within the dinofl

44 Mitochondrial mRNA editing in trypanosomatid parasites i

45 Although mitochondrial mRNA editing is widespread in some eukaryo

46 In kinetoplastid mitochondrial mRNA editing, post-transcriptional inserti

47 hic Parkinson's disease (IPD), expression of mitochondrial mRNA encoding the ND1 subunit of mitochond

48 Although no consistent effects on mitochondrial mRNA expression were observed, complementa

49 and that NF-kappa B can negatively regulate mitochondrial mRNA expression.

50 The levels of mitochondrial mRNAs for subunits I and II of cytochrome

51 hen subjected to poly(A) tail-length assays, mitochondrial mRNAs from affected individuals were shown

52 rized the transport of mitochondrial and non-mitochondrial mRNA in differentiated axons and dendrites

53 ate uridine (U) addition/deletion editing of mitochondrial mRNAs in kinetoplastid protozoa.

54 nscriptional process that creates functional mitochondrial mRNAs in Kinetoplastids.

55 Translation of mitochondrial mRNAs in Saccharomyces cerevisiae depends

56 dence of extensive substitutional editing of mitochondrial mRNAs in the dinoflagellate species Pfiest

57 nd deletion RNA editing generates functional mitochondrial mRNAs in Trypanosoma brucei Editing is cat

58 Mitochondrial mRNAs in Trypanosoma brucei undergo extens

59 nd deletion RNA editing generates functional mitochondrial mRNAs in Trypanosoma brucei.

60 the U insertion and deletion RNA editing of mitochondrial mRNAs in trypanosomes.

61 actions between 3' processing and editing of mitochondrial mRNAs in trypanosomes.

62 DNA shuffling, we have mapped the termini of mitochondrial mRNAs in wheat, a monocot, and compared th

63 protein complex called the editosome cleaves mitochondrial mRNA, inserts or deletes uridine nucleotid

64 ethyltransferase, demonstrates that m(1)A in mitochondrial mRNA interferes with translation.

65 Maturation of Trypanosoma brucei mitochondrial mRNA involves massive posttranscriptional

66 The mitochondrial mRNA is modified by oligo- or polyadenylat

67 n vivo selection that links cell survival to mitochondrial mRNA localization.

68 l disorders, our findings reveal a defect of mitochondrial mRNA maturation associated with human dise

69 uridylate insertion or deletion cycles is a mitochondrial mRNA maturation process catalyzed by multi

70 levels and half-lives of a subset of mature mitochondrial mRNAs: ND2, ND3, CYTB, COX2, and ATP8/6.

71 Northern analyses of six mitochondrial mRNAs (normalized to mtDNA) reveal that tr

72 The mitochondrial mRNA of the parasitic protozoa Trypanosoma

73 Several mitochondrial mRNAs of the kinetoplastid protozoa do not

74 The coding sequence of several mitochondrial mRNAs of the kinetoplastid protozoa is cre

75 The coding sequence of several mitochondrial mRNAs of the kinetoplastid protozoa is cre

76 in vitro but did not affect the stability of mitochondrial mRNAs or alter the expression of nuclear g

77 ase did not affect the number or sequence of mitochondrial mRNA poly(A) tails, where unexpectedly we

78 to stabilize mitochondrial mRNAs, to promote mitochondrial mRNA polyadenylation, and to coordinate mi

79 Furthermore, within the non-mitochondrial mRNA pool, we observed two distinct popula

80 Dramatically elevated levels of the COX2 mitochondrial mRNA-specific translational activator prot

81 These findings demonstrate the control of mitochondrial mRNA synthesis by a protein that has an es

82 ocesses such as kinetoplast DNA replication, mitochondrial mRNA synthesis, glycosyl phosphatidylinosi

83 d and has features that allow it to regulate mitochondrial mRNA synthesis.

84 e second pathway results in slow turnover of mitochondrial mRNA (t(1/2) of approximately 3 h) and is

85 increased the levels of mutant COX3 and COX2 mitochondrial mRNAs that were destabilized by mutations

86 brucei editosome catalyzes the maturation of mitochondrial mRNAs through the insertion and deletion o

87 ivators, suggesting an organized delivery of mitochondrial mRNAs to the translation system.

88 the post-transcriptional level to stabilize mitochondrial mRNAs, to promote mitochondrial mRNA polya

89 iting is a process that creates translatable mitochondrial mRNA transcripts from cryptogene encoded R

90 ments indicate a role for MRB1590 in editing mitochondrial mRNA transcripts, in particular the transc

91 e caused primarily by inhibition of the COX1 mitochondrial mRNA translation, a finding confirmed by l

92 In Trypanosoma brucei, most mitochondrial mRNAs undergo internal changes by RNA edit

93 Human mitochondrial mRNAs utilize the universal AUG and the un

94 suppress cbp1 ts alleles and stabilize many mitochondrial mRNAs, was also isolated.