ライフサイエンスコーパス: mitochondrially

1 ever, small amounts were also detected extra-mitochondrially.

2 growing hair follicles, particularly in the mitochondrially abundant bulb.

3 redox behavior in plastids and a sub-set of mitochondrially altered lines.

4 ction preferentially degraded polyadenylated mitochondrially and non-mitochondrially encoded RNAs ove

5 e cox17 mutants are able to express both the mitochondrially and nuclearly encoded subunits of cytoch

6 lucose transporter 1 (Glut1) and accumulates mitochondrially as ascorbic acid (mtAA).

7 Furthermore, in AD brains, mitochondrially associated APP formed stable approximate

8 APDH-driven mitophagy by phosphorylating the mitochondrially associated GAPDH at threonine 246 follow

9 -type copy of mrp1, additionally require the mitochondrially associated nuclear mutation ptp1-1 for v

10 expression of ARMCX3 increased the amount of mitochondrially associated Sox10.

11 We hypothesized that arginine catabolism via mitochondrially bound arginase augments ureagenesis by s

12 itochondria through incorporation of smaller mitochondrially-bound Drp1 units.

13 ) in the cytoplasm surrounding mitochondria (mitochondrially centered) and (2) traversing the space b

14 The second mitochondrially-centered process involves complex molecu

15 11 specifically activates translation of the mitochondrially coded mRNA for cytochrome c oxidase subu

16 Translation of mitochondrially coded mRNAs in Saccharomyces cerevisiae

17 cAMP levels did not affect the synthesis of mitochondrially coded protein reporters in glucose-grown

18 Leader peptides are relatively unusual in mitochondrially coded proteins: indeed mammalian Cox2p l

19 xidase affect the catalytic functions of its mitochondrially coded subunits.

20 tochondrial function and cell viability in a mitochondrially compromised human cell model.

21 Surprisingly, in mitochondrially defective neurons, but not neuroprogenit

22 eloped two complementary assays sensitive to mitochondrially derived ATP in individual, living hippoc

23 e then show that to meet these energy needs, mitochondrially derived ATP is rapidly dispersed in axon

24 plicated in Leigh disease markedly decreases mitochondrially derived ATP levels in axons, thus inhibi

25 he dependence of synaptic vesicle cycling on mitochondrially derived ATP levels, we developed two com

26 The first is a functional assay for mitochondrially derived ATP that uses the extent of syna

27 ACLY produces cytosolic acetyl-CoA from mitochondrially derived citrate.

28 chondrial origin suggests the existence of a mitochondrially derived compartment.

29 These results reveal the critical role of mitochondrially derived formate in mammalian development

30 of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosoli

31 were identifiable in taxa possessing another mitochondrially derived organelle, the mitosome.

32 Mitochondrially derived peptides represent a new class o

33 T lymphocytes and generate higher levels of mitochondrially derived reactive oxygen species (ROS).

34 dria are recruited to phagosomes and produce mitochondrially derived reactive oxygen species, which a

35 endogenous antioxidants or the production of mitochondrially derived ROS.

36 l that was independent of other oxidants and mitochondrially derived ROS.

37 anganese-superoxide dismutase (Sod2) removes mitochondrially derived superoxide (O(2)) at near-diffus

38 ese superoxide dismutase supports a role for mitochondrially derived superoxide in 6-hydroxydopamine

39 ts entering the cytoplasmic methyl cycle are mitochondrially derived.

40 Transient increases in mitochondrially-derived reactive oxygen species (ROS) ac

41 ferentially via TRPA1 through the actions of mitochondrially-derived ROS.

42 of the SHR/SST-2 model and the potential of mitochondrially-directed agents to mitigate oxidative st

43 The transcript is mitochondrially encoded and maps to a region upstream of

44 Expression of the mitochondrially encoded ATP6 and ATP8 genes is translati

45 Incorporation of labeled precursors into mitochondrially encoded Atp6, Atp8, Atp9, and Cytb prote

46 drial inner membrane protein that stabilizes mitochondrially encoded ATP6/8 mRNA.

47 ase experiments have enabled us to track the mitochondrially encoded Atp6p, Atp8p and Atp9p subunits

48 o physically interact with newly synthesized mitochondrially encoded Atp9 protein in a posttranslatio

49 Defects in mitochondrially encoded complex I subunits should be add

50 ell line carrying a nonsense mutation in the mitochondrially encoded complex IV subunit 1 gene.

51 ysis to assay the transcript levels of three mitochondrially encoded components of the cytochrome c o

52 iogenesis identified Cox1p, one of the three mitochondrially encoded core subunits, in two high-molec

53 ient interaction previously observed for the mitochondrially encoded COX subunits with Oxa1.

54 es the cotranslational membrane insertion of mitochondrially encoded COX subunits, is well documented

55 the respiratory chain subunits that included mitochondrially encoded COX1 (47.5%; P = .004), COX2 (32

56 mutants by restoring normal synthesis of the mitochondrially encoded Cox1p subunit of COX.

57 -encoded COX subunits that interact with the mitochondrially encoded Cox1p.

58 The mitochondrially encoded cytochrome b forms, with cytochr

59 Sequencing of the mitochondrially encoded cytochrome b gene placed these m

60 equence in the 5'-untranslated region of the mitochondrially encoded cytochrome b mRNA in Saccharomyc

61 ficantly increased protein expression of the mitochondrially encoded cytochrome C oxidase I (MTCO1),

62 Interestingly, expression of the mitochondrially encoded cytochrome c oxidase III and cyt

63 The amino- and carboxy-terminal domains of mitochondrially encoded cytochrome c oxidase subunit II

64 WT included: in striatum, lower VDAC and the mitochondrially encoded cytochrome oxidase subunit I rel

65 cent observations that there appears to be a mitochondrially encoded defect in complex I activity of

66 l DNA and exhibit no activity for the partly mitochondrially encoded enzyme cytochrome c oxidase.

67 ing diabetic insult led to downregulation of mitochondrially encoded F0 component ATP6.

68 nuclear gene PNT1 block the translocation of mitochondrially encoded fusion proteins across the inner

69 deletion in a highly conserved region of the mitochondrially encoded gene for cytochrome c oxidase (C

70 that either a specific sequence element or a mitochondrially encoded gene product is required for pro

71 Both nuclear and mitochondrially encoded gene products of the oxidative p

72 berrant chimera in which portions of several mitochondrially encoded genes are fused to an unknown re

73 uble-strand break repair genes and repressed mitochondrially encoded genes.

74 uridines added or deleted comes from small, mitochondrially encoded guide RNAs (gRNAs).

75 a counterpart of ND1, which is one of seven mitochondrially encoded hydrophobic subunits, and is con

76 self is unstable in the absence of assembled mitochondrially encoded integral membrane proteins of co

77 d that the expression of several nuclear and mitochondrially encoded mitochondrial enzymes was decrea

78 Mutations in the mitochondrially encoded MTATP6 gene typically cause infa

79 A cytosine to adenine transversion in the mitochondrially encoded NADH dehydrogenase subunit 2 (mt

80 We report an unusual molecular defect in the mitochondrially encoded ND1 subunit of NADH ubiquinone o

81 More than half of mitochondrially encoded polypeptides form part of the re

82 equired to terminate the synthesis of all 13 mitochondrially encoded polypeptides, the true physiolog

83 Z(L) could, thus, process both nuclear- and mitochondrially encoded pre-tRNAs.

84 quence evolution among published nuclear and mitochondrially encoded protein-coding loci differ signi

85 Expression of the mitochondrially encoded proteins Cytochrome oxidase subu

86 omparisons here of amino acid sequences from mitochondrially encoded proteins give a single most pars

87 ropose mitomiRs can translationally regulate mitochondrially encoded proteins in spatially distinct m

88 The machinery that inserts mitochondrially encoded proteins into the inner membrane

89 Mitochondrially encoded proteins were differentially aff

90 lity to synthesize low levels of a subset of mitochondrially encoded proteins.

91 Cs displayed features pointing to defects in mitochondrially encoded respiratory chain subunits at ea

92 '-end status, and in vivo stability of major mitochondrially encoded RNA classes.

93 se P RNA-tRNA(Pro) gene cluster, so that the mitochondrially encoded RNA subunit was thought to be co

94 raded polyadenylated mitochondrially and non-mitochondrially encoded RNAs over their non-adenylated c

95 ication of a large number of variants in the mitochondrially encoded rRNA (mt-rRNA) genes, the eviden

96 The mitochondrially encoded substrates interact directly wit

97 sts of nine nuclear encoded subunits and the mitochondrially encoded subunit cytochrome b.

98 nal myoblast cultures, the expression of the mitochondrially encoded subunit I of cytochrome c oxidas

99 Cox18, are required for assembly of Cox2, a mitochondrially encoded subunit of cytochrome c oxidase.

100 ee modules, each containing one of the three mitochondrially encoded subunits and a different subset

101 ression of Atp6p, Atp8p, and Atp9p, the only mitochondrially encoded subunits of ATP synthase.

102 hydrophobic reaction center formed by three mitochondrially encoded subunits with which 9-10 nuclear

103 se Afg1 that promotes the degradation of CcO mitochondrially encoded subunits.

104 lated, the mitochondrial DNA is reduced, and mitochondrially encoded transcripts and proteins are als

105 sition of m(5)C at the anticodon loop in the mitochondrially encoded transfer RNA methionine (mt-tRNA

106 es and revealed the unexpected presence of a mitochondrially encoded tRNA (mt-tRNA) that usurps this

107 A mutation hot spot (9821insA) in the mitochondrially encoded tRNA arginine (mt-Tr) locus (tRN

108 ed by mitochondrial DNA are translated using mitochondrially encoded tRNAs and rRNAs.

109 mitochondrial genome, most of them in the 22 mitochondrially encoded tRNAs.

110 tes the insertion of proteins (nuclearly and mitochondrially encoded) into the inner membrane.

111 so required for the maturation of Rpm1r, the mitochondrially-encoded RNA subunit of the enzyme.

112 Mutations in the mitochondrially-encoded subunits of the complex have bee

113 Although Sirtuin 3 (SIRT3), a mitochondrially enriched deacetylase and activator of fa

114 ectrophotometric assay of enzyme activity in mitochondrially-enriched tissue homogenates, requiring a

115 ty of Mip1p and also affects the levels of a mitochondrially-expressed protein, Cox3p.

116 Mitochondrially generated ATP was specifically reduced i

117 housands of dispersed bioenergetic genes via mitochondrially generated high-energy intermediates perm

118 precursor is expressed in S.cerevisiae, the mitochondrially generated mature form is separated by ge

119 nt of alpha-tocopherol in the elimination of mitochondrially generated O2(./-)

120 Mitochondrially generated reactive oxygen species are cr

121 f mitochondrial DNA, and increased levels of mitochondrially generated reactive oxygen species that c

122 mitochondrial function from damage caused by mitochondrially generated ROS during apoptotic induction

123 h it is ER translocated, processed, and then mitochondrially imported.

124 ial range of approximately 10 microm in both mitochondrially labeled fixed cells, and in the membrane

125 Here we present evidence that the mitochondrially localized active caspase-9 and -3 result

126 The mitochondrially localized aldehyde dehydrogenase in D. m

127 re we show that exogenously expressed Mcu is mitochondrially localized and increases mitochondrial Ca

128 We confirmed p46Shc to be mitochondrially localized and showed that the major mito

129 ism and delivery to cytochrome c oxidase and mitochondrially localized CuZn-superoxide dismutase (Sod

130 Mitochondrially localized cytochrome c-GFP and BFP-Bcl-2

131 cheme, we identified the beta-subunit of the mitochondrially localized electron transfer flavoprotein

132 Messenger RNA expression levels for 198 mitochondrially localized energy production components,

133 Further, we demonstrate that this mitochondrially localized enzymatic activity can be expl

134 ersicum) fruit by altering the expression of mitochondrially localized enzymes of the tricarboxylic a

135 Dihydroorotate dehydrogenase (DHOD), a mitochondrially localized flavoenzyme, catalyzes the rat

136 ough the p46Shc isoform has been known to be mitochondrially localized for 11 years, its function in

137 chondrial ancestry, both by affiliation with mitochondrially localized fungal homologues and by the s

138 We conclude that mitochondrially localized human AGXT2 is able to effecti

139 Mitochondrially localized JNKs but not upstream activato

140 ied libraries of 3' UTR regions from a known mitochondrially localized mRNA by nonhomologous random r

141 Instead, mitochondrially localized NLRP3 potentiated reactive oxy

142 Manganese superoxide dismutase (MnSOD) is a mitochondrially localized primary antioxidant enzyme, kn

143 In most cases, the mitochondrially localized procaspase-9 and -3 are releas

144 may translocate to the mitochondria, or the mitochondrially localized procaspases may be activated b

145 Since the mitochondrially localized Psd1 enzyme provides a major r

146 se 1 (PINK1) or parkin genes, which encode a mitochondrially localized serine/threonine kinase and a

147 YGG(C/A)RRC, upstream of the genes encoding mitochondrially localized tRNAs in T. brucei.

148 oth drugs are activated by a NADH-dependent, mitochondrially localized, bacterial-like, type I nitror

149 orms are proteolytically processed to form a mitochondrially localized, mature PanK2.

150 oxalase II isozyme (GLY1) that appears to be mitochondrially localized.

151 One antibody reacts with a mitochondrially located 45 kDa polypeptide (p45) which c

152 utoimmunity directed against well-identified mitochondrially located autoantigens in individuals with

153 ts of the 2-oxo-acid dehydrogenase family of mitochondrially located enzymes that share a lipoylated

154 monocotyledons and eudicotyledons have twin, mitochondrially located mitochondrial carrier family car

155 cy and autoimmunity specifically directed to mitochondrially located PDC-E2 and subsequent biliary du

156 se a and b double mutant (ntra ntrb) and the mitochondrially located thioredoxin o1 (trxo1) mutant.

157 EM011-induced apoptosis has a mitochondrially-mediated component, which was attenuated

158 These, in turn, can be toxic to mitochondrially nonmutant cells that import them to sati

159 tions do not affect expression of either the mitochondrially or nuclearly encoded subunits of the enz

160 o compensate reasonably well for the loss in mitochondrially produced ATP.

161 is augmented in growth conditions requiring mitochondrially produced energy.

162 ggest a positive feedback mechanism in which mitochondrially produced NO induces expression of COX5b,

163 It has been proposed that this mitochondrially produced NO is a component of hypoxic si

164 its cellular NOS isoform, and the effects of mitochondrially produced NO on bioenergetics have been c

165 The effects of mitochondrially produced NO on bioenergetics were studie

166 ulfide bond formation, which is dependent on mitochondrially produced oxidants.

167 low cytometry, showed a dramatic increase in mitochondrially produced reactive oxygen species (ROS) a

168 ted only after a specific threshold level of mitochondrially produced ROS was exceeded, and did not i

169 Small increases in levels of mitochondrially produced superoxide radicals have a prot

170 e, we studied the effect of DEP chemicals on mitochondrially regulated death mechanisms.

171 otective immune response but instead undergo mitochondrially regulated programmed cell death.

172 egradation could be a mechanism by which the mitochondrially released Omi/HtrA2 activates caspases du

173 h glycolytic bloodstream stage parasites and mitochondrially respiring procyclic stage parasites were

174 growth of myeloid progenitors in vitro, and mitochondrially restricted STAT3 and STAT3-Y705F, both t

175 The N-terminal and C-terminal domains of mitochondrially synthesized cytochrome c oxidase subunit

176 Evidence from other organisms suggests that mitochondrially synthesized fatty acids are required for

177 o the inability to generate lipoic acid from mitochondrially synthesized fatty acids.

178 which is clearly implicated in the export of mitochondrially synthesized iron/sulfur clusters.

179 To study in vivo the export of mitochondrially synthesized protein from the matrix to t

180 Thus, mitochondrially synthesized proteins may not have the sa

181 Our objective was to test the mitochondrially targeted agent, MitoQ, alone and in comb

182 We orally administered the mitochondrially targeted anti oxidant MitoQ in order to

183 Calcium chelators act similarly and mitochondrially targeted anti-oxidants also abrogate the

184 mitochondrial electron transport chain and a mitochondrially targeted antioxidant (Mito Q) fully prev

185 other treatments, namely administration of a mitochondrially targeted antioxidant (MitoQ) and inhibit

186 use and human skin, topical application of a mitochondrially targeted antioxidant prevents and mitiga

187 MitoQ, a mitochondrially targeted antioxidant, decreased LPS-indu

188 g was abolished by low concentrations of the mitochondrially targeted antioxidants 10-(6'-ubiquinonyl

189 ROS than normal human lung fibroblasts, and mitochondrially targeted antioxidants attenuated profibr

190 Mitochondrially targeted antioxidants markedly attenuate

191 er transfection of cultured hepatocytes with mitochondrially targeted ApaLI, we found a rapid, direct

192 ing recombinant viral vectors expressing the mitochondrially targeted ApaLI.

193 , expression of ER-targeted Bcl-x(L) but not mitochondrially targeted Bcl-x(L) was required to restor

194 xL-KO cells was restored by re-expression of mitochondrially targeted Bcl-xL.

195 chroman 2-carboxylic acid (TROLOX) or of the mitochondrially targeted but redox-inactive analogs decy

196 f mitochondrial [Ca(2+)] ([Ca(2+)]m) using a mitochondrially targeted Ca(2+) probe (MityCam) and thes

197 Furthermore, a mitochondrially targeted catalase transgene suppresses B

198 Neurons were cotransfected with a mitochondrially targeted cyan fluorescent protein and an

199 We therefore designed and synthesized a new mitochondrially targeted CypD inhibitor, JW47, using a q

200 oscopy with either hydroethidine (HE) or its mitochondrially targeted derivative Mito-HE (MitoSOX Red

201 ensional reconstruction of fluorescence from mitochondrially targeted DsRed1 or calcein.

202 These data support the view that mitochondrially targeted electron acceptors and SOD mimi

203 e of cultured hippocampal neurons expressing mitochondrially targeted enhanced yellow fluorescent pro

204 in primary cultures of rat forebrain using a mitochondrially targeted enhanced yellow fluorescent pro

205 itional knockout strategy, we incorporated a mitochondrially targeted fluorescent reporter to facilit

206 two non-AUG, to produce distinct plastid and mitochondrially targeted forms of the protein.

207 Using adenoviral infection, a ratiometric mitochondrially targeted Forster resonance energy transf

208 COX4 translation was studied here using a mitochondrially targeted green fluorescence protein (mtG

209 red using hydroethidium and signals from the mitochondrially targeted hydroethidine, was increased in

210 Using the mitochondrially targeted inverse pericam indicator Mityc

211 PINK1 is a mitochondrially targeted kinase that regulates multiple

212 We transgenically expressed mitochondrially targeted miniSOG (mito-miniSOG) in Caeno

213 We have developed the first cell-permeable, mitochondrially targeted modulators of the PKCdelta-dF(1

214 Overexpression of the mitochondrially targeted MPG dramatically increased the

215 However, it was unknown whether mitochondrially targeted p53 has suppressor activities i

216 n chromosome 2L that united a portion of the mitochondrially targeted peptide CG12264 with a segment

217 In contrast, the cell-permeable, mitochondrially targeted PKCdelta-dF(1)F(0) facilitator

218 th 10 nm extracellular concentrations of the mitochondrially targeted PKCdelta-dF(1)F(0) interaction

219 ve-strand RNA synthesis, multiple domains of mitochondrially targeted protein A cooperate to selectiv

220 unia restorer of fertility gene product is a mitochondrially targeted protein that is almost entirely

221 A mitochondrially targeted PstI degraded mtDNA harboring P

222 Using a mitochondrially targeted ratiometric sensor (Ro-GFP) in

223 id anti-inflammatory agent, and XJB-5-131, a mitochondrially targeted reactive oxygen species scaveng

224 assay of mitochondrial thiol redox status by mitochondrially targeted redox-sensitive green fluoresce

225 mtDNA by developing a mouse model in which a mitochondrially targeted restriction endonuclease (PstI)

226 se specific mtDNA haplotypes by expressing a mitochondrially targeted restriction endonuclease, ApaLI

227 Using a genetic scheme that expresses a mitochondrially targeted restriction enzyme to induce ti

228 PTEN-induced putative kinase 1 (PINK1) is a mitochondrially targeted serine-threonine kinase, which

229 re discussed in the context of processing of mitochondrially targeted SODs.

230 These findings suggest that early mitochondrially targeted therapeutic interventions may b

231 ividually or simultaneously substituted with mitochondrially targeted transmembrane sequences.

232 This study suggests that mitochondrially targeted variant 3 CYP2C8 may contribute

233 Mitochondrially targeted vitamin E (MitoVit E), a chemic

234 The first step describes how to construct mitochondrially targeted ZFPs (mtZFPs) so that they are

235 Use of the mitochondrially targeted zinc finger-nuclease (mtZFN) re

236 otes were injected with mRNA encoding either mitochondrially-targeted catalase, which quenches mitoch

237 against hypoxic injury by a cell-permeable, mitochondrially-targeted deltaPKC-d subunit of F1Fo ATPa

238 Treatments of cells with lipoate and with mitochondrially-targeted lipoate were unsuccessful at co

239 ed mRNAs (RIP-seq) identified mRNAs encoding mitochondrially-targeted proteins.

240 Matrix Ca(2+) levels measured by X-rhod-1 or mitochondrially-targeted ratiometric biosensor 4mtD3cpv,

241 We show that mitochondrially-targeted SOD1 localizes to the IMS, wher

242 COX VIII-3 protein is mitochondrially-targeted, as shown by a fluorescent COX

243 To determine if stress affects mitochondrially transcribed mRNA (mtRNA) expression, we

244 ondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that ar

245 To examine these consequences, mitochondrially transformed cells (cybrids) were created

246 All detectable mtDNA in the mitochondrially transformed cells contained the patholog

247 Activated JNK, and cytosolic and mitochondrially-translocated Bax were increased in P4 bu

248 Mitochondrially transmitted diseases are no exception.

249 a minor histocompatibility Ag composed of a mitochondrially transmitted factor (MTF) and the RT1.Aa