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1 logenetic origins (the nucleus, plastid, and mitochondrion).
2 s of E. coli to anticipate challenges to its mitochondrion.
3 th poorly defined function in the eukaryotic mitochondrion.
4 n T-tubules and ultimately surrounding every mitochondrion.
5 parate pathways, one of which resides in the mitochondrion.
6 ty, and recruits Parkin to the dysfunctional mitochondrion.
7 e lipoylated proteins reside in the parasite mitochondrion.
8 sion and degradation of the damaged daughter mitochondrion.
9 main (TMD) that localizes the protein to the mitochondrion.
10 inkage map spanning all 12 autosomes and the mitochondrion.
11 etic state or to the respective size of each mitochondrion.
12 acid complexes at the inner membrane of the mitochondrion.
13 nsertion/deletion RNA editing process in its mitochondrion.
14 the main ADP/ATP carrier in the trypanosome mitochondrion.
15 F(1)-ATP synthase, for ATP production in the mitochondrion.
16 d in tRNA binding and translocation into the mitochondrion.
17 ry increase in oxidative phosphorylation per mitochondrion.
18 zation of all but one of the subunits to the mitochondrion.
19 ctive DNA methyltransferases targeted to the mitochondrion.
20 rfamily that is localized exclusively to the mitochondrion.
21 ased oxidative and nitrosative damage to the mitochondrion.
22 at the dNTP pool asymmetry arises within the mitochondrion.
23 r genes whose products are imported into the mitochondrion.
24 lyadenylation facilitates translation in the mitochondrion.
25 ane potential, as a GrB substrate within the mitochondrion.
26 ignalling, TgMSH-1 localizes to the parasite mitochondrion.
27 al termination and ribosome recycling in the mitochondrion.
28 or NCX-9 in handling calcium exchange at the mitochondrion.
29 ensive model of Fe/S protein assembly in the mitochondrion.
30 ion of redox marker genes of the cytosol and mitochondrion.
31 and limited repair mechanisms present in the mitochondrion.
32 in silico role of glycolytic enzymes in the mitochondrion.
33 s across the two membranes that surround the mitochondrion.
34 trated that the SLO3-GFP is localized to the mitochondrion.
35 ondrion of Plasmodium falciparum and a human mitochondrion.
36 oxygen species stress generated by a (proto) mitochondrion.
37 dox homeostasis are intimately linked in the mitochondrion.
39 ction of the genome revealed an average size mitochondrion (459,678 nt) with relatively little repeti
40 artners--the plastid (a cyanobacterium), the mitochondrion (a proteobacterium), and its host (an arch
41 , we have targeted cytosolic proteins to the mitochondrion, a poly(A) specific 3' exoribonuclease, mt
44 orms a productive signaling complex with the mitochondrion-anchored MAVS protein, resulting in nuclea
48 e Drp1, which assembles in a ring around the mitochondrion and appears to constrict both outer and in
49 taining import substrates are taken into the mitochondrion and are used as templates for damage drive
51 etabolite analysis to define the role of the mitochondrion and cellular heme in the chemical and mole
52 ionase, whereas its catabolism occurs in the mitochondrion and couples to the energy-yielding electro
53 -1 cells resulted in its accumulation in the mitochondrion and downregulation of functional ATP6 prot
54 p1 mediates fission, and interaction between mitochondrion and endoplasmic reticulum (ER) enhances fi
56 fied TbPSD as type I PS decarboxylase in the mitochondrion and found that it is processed proteolytic
57 ryotes, the traditional relationship between mitochondrion and host has been subverted in E. cuniculi
58 has been shown to function primarily at the mitochondrion and is an important regulator of neuronal
59 se 1, LipL1, has been shown to reside in the mitochondrion and it catalyses the lipoylation of the H-
60 veal that PtdEtn is produced in the parasite mitochondrion and parasitophorous vacuole by decarboxyla
62 lant species, that MSH1 functions within the mitochondrion and plastid to influence organellar genome
63 e need to transport intermediates out of the mitochondrion and reducing the loss of intermediates to
64 namics and inextricably link the fate of the mitochondrion and that of the host eukaryote, as exempli
66 one arm buried in the inner membrane of the mitochondrion and the orthogonal arm protruding about 10
67 first to demonstrate GrB activity within the mitochondrion and to identify Hax-1 cleavage as a novel
68 ation, translocates to the nucleus or to the mitochondrion and triggers two complementary antiviral r
69 bacterial endosymbiont that gave rise to the mitochondrion and was the source of the mitochondrial ge
70 oteins are regulated by microRNAs inside the mitochondrion and whether subcellular spatial location o
71 n cell compartments, favoring the cytoplasm, mitochondrion, and endoplasmic reticulum at the expense
72 OM64, and AtTPR7 reside in the chloroplast, mitochondrion, and endoplasmic reticulum of Arabidopsis
76 es of orthologous proteins representing both mitochondrion- and plastid-encoded proteomes across stre
77 y Ca(2+), which were confirmed in the intact mitochondrion as well as cellular and in vivo systems.
79 presence of lower glycolysis pathways in the mitochondrion, as well as differences between P. tricorn
81 cal flow was used in combination with single mitochondrion assay of mitochondrial thiol redox status
82 um ATP synthase is localized to the parasite mitochondrion, assembled as a large dimeric complex, and
84 ntial and may in concert with the identified mitochondrion-associated apoptosis inducing factor (AIFM
85 racil auxotrophy by genetically deleting the mitochondrion-associated DHODH of T. gondii (TgDHODH) fa
86 iral NS3/4A protease cleavage of MAVS on the mitochondrion-associated endoplasmic reticulum (ER) memb
87 e interface between the mitochondria and the mitochondrion-associated endoplasmic reticulum (ER) memb
88 ty of 3betaHSD2 and its association with the mitochondrion-associated ER membrane (MAM) and mitochond
90 intracellular ATP content, and expression of mitochondrion-associated genes were decreased by overexp
91 ntracellular ATP content, and transcripts of mitochondrion-associated genes were prevented by blockad
92 NA and levels of transcripts and proteins of mitochondrion-associated genes, increased ectopic fat ac
93 ducing factor (AIF) and AMID (AIF-homologous mitochondrion-associated inducer of death) are flavoprot
95 itochondrial destabilization, generating the mitochondrion-associated ligands that activate the NLRP3
96 ioesterase superfamily member 2 (Them2) is a mitochondrion-associated long-chain fatty acyl coenzyme
97 m the endoplasmic reticulum (ER) through the mitochondrion-associated membrane compartment to the mit
98 e physically linked to mitochondria known as mitochondrion-associated membranes (MAM), and to mitocho
99 fected cells, UL37 proteins traffic into the mitochondrion-associated membranes (MAM), the site of co
100 from the endoplasmic reticulum (ER) through mitochondrion-associated membranes (MAMs) to the outer m
102 cal changes in mitochondria, myofibrils, and mitochondrion-associated membranes in skeletal and cardi
105 The nature of the host that acquired the mitochondrion at the eukaryote origin is an important mi
108 subsequent degradation of the dysfunctional mitochondrion before it causes activation of cell death.
109 lidation of protein function predictions for mitochondrion biogenesis in Saccharomyces cerevisiae.
110 editing at the cob-908 site is necessary for mitochondrion biogenesis, cell division, and plant growt
111 vidence for Fancd2 as a crucial regulator of mitochondrion biosynthesis, and of a molecular link betw
112 e enzymes were localized to the cytoplasm or mitochondrion, but most were dually localized to both ce
113 The probe is targeted to the matrix of the mitochondrion by an alkyltriphenylphosphonium lipophilic
114 D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXD
116 ge between the endoplasmic reticulum and the mitochondrion, by increasing interaction with a macromol
118 es are clear: the number of MCU channels per mitochondrion can be calculated, and MCU probability is
120 al for ongoing viability through the female, mitochondrion-carrying line of sexual reproduction in P.
121 s from our and other groups suggest that the mitochondrion-centred hypometabolism is a key feature of
123 In the pathogenic bloodstream stage, the mitochondrion consumes ATP to maintain an energized stat
124 owth conditions, Vps13 localizes to endosome-mitochondrion contacts and to the nuclear-vacuole juncti
125 er, rather than being degraded by lysosomes, mitochondrion-containing autophagosomes are released fro
126 sible evolutionary sequence giving rise to a mitochondrion-containing eukaryotic cell from an endosym
128 distributed between three compartments: the mitochondrion, cytosol, and apicoplast, a plastid acquir
129 ated the crucial role of plastid-cytosol and mitochondrion-cytosol malate transporters in recycling t
131 Moreover, hypoxia failed to activate AMPK in mitochondrion-deficient rho(0)-A549 cells, suggesting th
132 lux distribution for lower glycolysis in the mitochondrion depended on which transporters for TCA cyc
133 ts as a positive feedback loop involving the mitochondrion-dependent activation of caspases, independ
140 we observed that cell-cell contact induces a mitochondrion-dependent increase in intracellular calciu
141 al location signal sequence, which undergoes mitochondrion-dependent posttranslational cleavage.
142 lin caused oxidative stress, and blockade of mitochondrion-derived oxidative stress by overexpression
144 eta but not PDGFRalpha, reduced the level of mitochondrion-derived reactive oxygen species, which are
148 mbly factors impinging the biogenesis of the mitochondrion-encoded catalytic core subunit 2 (COX2) re
149 itiates with synthesis and maturation of the mitochondrion-encoded Cox1 subunit prior to the addition
150 iquely possesses heterologous, nucleus-, and mitochondrion-encoded cytochrome c maturase systems.
151 membrane protein, mediates the insertion of mitochondrion-encoded precursors into the inner mitochon
155 encoded by the maternally inherited parasite mitochondrion, even outcrossing with wild-type strains c
156 ted from healthy components in an individual mitochondrion, followed by mitochondrial fission and deg
157 nduced silencing complex constituents in the mitochondrion for functional mitomiR translational regul
159 oenzyme shift that diverts pyruvate into the mitochondrion for the final steps of glucose oxidation.
162 irulence by protecting the parasites against mitochondrion-generated oxidative stress and by initiati
164 , imports about a thousand proteins into the mitochondrion; however, the mitochondrial protein import
170 Cardiolipin, a phospholipid specific to the mitochondrion, interacts with the small electron transfe
171 ecifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrio
184 onditions, carbohydrate oxidation inside the mitochondrion is the primary energy source for cellular
185 in quality control of matrix proteins of the mitochondrion is well characterized and until recently t
186 cell and number of mitochondrial genomes per mitochondrion, is an indirect biomarker of mitochondrial
188 Fe trafficking away from the cytosol to the mitochondrion, leading to a cytosolic Fe deficiency.
189 neous redox signals in neurons at the single mitochondrion level where transients of glutathione oxid
192 lles, known as hydrogenosomes, mitosomes, or mitochondrion-like organelles, are typically reduced, bo
193 n UL37 exon 1 (pUL37x1), also known as viral mitochondrion-localized inhibitor of apoptosis (vMIA), s
194 protein (pUL37x1), which is the potent viral mitochondrion-localized inhibitor of apoptosis (vMIA), t
195 -1 was strongly enhanced by depletion of the mitochondrion-localized, GSH-dependent persulfide oxygen
199 uttles between the chloroplast, cytosol, and mitochondrion may play a significant role at low light l
201 previously showed that MVC infection induces mitochondrion-mediated apoptosis and G(2)/M-phase arrest
203 lts demonstrate that MVC infection induces a mitochondrion-mediated apoptosis that is dependent on th
207 allele, might also lead to the peroxisome-to-mitochondrion mistargeting of AGT, a suggestion that has
208 consumption (V(O2)) was first assessed in a mitochondrion model, and then in the integrated cardiac
209 dox misbalance does not significantly affect mitochondrion morphology or the activity of respiratory
210 m the host cell to the extracellular matrix, mitochondrion morphology radically changes, resulting in
212 of CRMP5 expression at later stages enhanced mitochondrion numbers in cultured neurons, suggesting th
215 insertion/deletion RNA editing in the single mitochondrion of kinetoplastids, an ancient lineage of e
216 2 plasmids from bacteria, the apicoplast and mitochondrion of Plasmodium falciparum and a human mitoc
218 r type I nitroreductase (NTR) located in the mitochondrion of trypanosomatids and, at the same time,
223 les in the phloem, such as plastid, vacuole, mitochondrion, or endoplasmic reticulum, interact with s
224 ge in the fluorescent state of an individual mitochondrion, "oscillation" to refer to a localized cha
225 y identified regions of coupling between the mitochondrion outer membrane and the parasite pellicle,
226 vators of SIRT1 (resveratrol or SRT1720) and mitochondrion oxidation consumption rate and immunoblot
230 hanges in net pro-apoptotic signaling at the mitochondrion ("priming") induced by chemotherapeutic ag
231 It has been shown that DNA repair in the mitochondrion proceeds through both short- and long-patc
232 tion and suggest a free radical-sensitive ER-mitochondrion-Rac1.GTP pathway in the regulation of dend
235 of mtDNA, ATP production, and expression of mitochondrion-related genes was largely prevented by inh
236 n is a negative transcriptional regulator of mitochondrion-related nuclear genes and genes encoding s
237 myclobutanil, the expression of five of six mitochondrion-related nuclear genes was down-regulated.
239 No examples of examined eukaryotes lacking a mitochondrion-related organelle exist, implying that the
240 olutionary continuum that includes anaerobic mitochondrion-related organelles (MROs), such as hydroge
242 tis ISC system function within its anaerobic mitochondrion-related organelles and can functionally re
243 strategy to label the acidic contents of the mitochondrion relies on the use of the membrane-permeabl
245 cking of CFTR from intracellular vesicles in mitochondrion rich cells to the plasma membrane in the g
251 s TWINKLE, SSBP1, and TFAM, all of which are mitochondrion-specific DNA effectors and are known to fu
254 Our results support the hypothesis that the mitochondrion-specific lipid cardiolipin functions as a
255 s (i.e. the BCL2 homology 3 ligand cBID, the mitochondrion-specific lipid cardiolipin, and membrane g
257 d co-localization of PNKP and NEIL2 with the mitochondrion-specific protein cytochrome c oxidase subu
261 glutathione, and the regulation of ROS as a mitochondrion-STAT3-dependent pathway in Ras-transformed
262 e: a majority of axon fragments containing a mitochondrion survive axotomy, whereas those lacking mit
263 d Hep G2 cell lines expressing predominantly mitochondrion-targeted (Mt(++)) CYP2E1 and livers from a
264 emerged as the prototype of a novel class of mitochondrion-targeted agents that deplete cardiolipin a
265 uro-2A cells stably expressing predominantly mitochondrion-targeted CYP2D6 were more sensitive to MPT
269 FOXO-mediated transcriptional activation of mitochondrion-targeted nuclear genes in concert with red
270 c approach, we characterized the role of the mitochondrion-targeted PPR78 protein in nad5 mature mRNA
271 t of innate immunity and supports the use of mitochondrion-targeted ROS scavengers as potential adjuv
273 ris(4-methoxyphenyl)phosphonium) is a better mitochondrion-targeting molecule than TPP and 3mTPP (tri
274 in the parasite, one of which resides in the mitochondrion (TgPEPCKmt), whereas the other protein is
277 nt mitochondrial depolarizations in a single mitochondrion that occur in a nonperiodic manner, simula
278 . tricornutum predicts that reactions in the mitochondrion that supply glycerate may support TAG synt
279 ition to preventing transfer of DNA from the mitochondrion to the nucleus, VPS13 suppresses mitophagy
280 nction, thereby influencing the fate of each mitochondrion, to be either destined for a subsequent fu
283 skeletal muscle and liver cells, uptake per mitochondrion varies in magnitude but total uptake per c
284 othelial nitric-oxide synthase (eNOS) to the mitochondrion via a mechanism that requires protein nitr
288 tofluorescence, the metabolic status of each mitochondrion was analyzed following addition of a respi
289 is well characterized and until recently the mitochondrion was considered a 'ubiquitination-free' org
291 hese results indicate that the origin of the mitochondrion was not a prerequisite for genome-size exp
293 ipid droplets (LDs) in direct contact with a mitochondrion was reduced, and the average distance betw
294 e its yeast counterpart, is localized to the mitochondrion where it adopts an extremely protease-resi
295 r eukaryotes Trypanosoma brucei has a single mitochondrion whose single-unit genome is physically con
297 on and increased translocation of Hk1 to the mitochondrion with corresponding heightened ATP synthase
298 th efficient trafficking of (18)F-FTO to the mitochondrion with subsequent metabolism to protein-boun
299 D projection image was captured of a similar mitochondrion with the aid of strongly scattering Au ref
300 cess to "colorize" detailed EM images of the mitochondrion with the position of labeled proteins.
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