ライフサイエンスコーパス: mitogen-activated protein kinase kinase 1

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1 of Ras or a dominant-negative form of MEK1 (mitogen-activated protein kinase kinase 1).

2 rrolo[3,4-c]carbazole-12-p ropanenitrile and mitogen-activated protein kinase kinase 1 2-(2-amino-3-m

3 We further find that modulation of Mitogen Activated Protein Kinase Kinase-1/2 (MAP2K1/2, M

4 sed by pharmacologic and siRNA inhibitors of mitogen-activated protein kinase kinase 1/2 (MEK1/2) and

5 phynylthio)butadiene]-specific inhibitors of mitogen-activated protein kinase kinase 1/2 (MEK1/2) blo

6 ERK1/2), and the combination of SMI-4a and a mitogen-activated protein kinase kinase 1/2 (MEK1/2) inh

7 gonism of PGE2 release was achieved with the mitogen-activated protein kinase kinase 1/2 (MEK1/2) inh

8 between 7-hydroxystaurosporine (UCN-01) and mitogen-activated protein kinase kinase 1/2 (MEK1/2) inh

9 tion that 20S reduction has little effect on mitogen-activated protein kinase kinase 1/2 (MEK1/2) sig

10 , cardiac expression of phospho-Akt, phospho-mitogen-activated protein kinase kinase 1/2 and phospho-

11 Preclinical evaluation of the mitogen-activated protein kinase kinase 1/2 inhibitor se

12 anner, combined exposure to OSU-03012 with a mitogen-activated protein kinase kinase 1/2 inhibitor, p

13 Both Ly294002 and U0126, a mitogen-activated protein kinase kinase 1/2 inhibitor, r

14 ess signaling pathways demonstrated that the mitogen-activated protein kinase kinase 1/2 pathway acti

15 by cytokines and suppressed by inhibition of mitogen-activated protein kinase kinase 1/2, whereas STE

16 The RAF-mitogen-activated protein kinase kinase 1/2-extracellula

17 nd degradation, and subsequent activation of mitogen-activated protein kinase kinase 1/2.

18 al-regulated kinases 1/2 phosphorylation was mitogen-activated protein kinase kinases 1/2 dependent b

19 Use of mitogen-activated protein kinase kinases 1/2 inhibitors

20 human embryonic kidney 293 cells, Raf-1 and mitogen-activated protein kinase kinase 1 activities in

21 osphatase, proteasomal, phospholipase C, and mitogen-activated protein kinase kinase 1 activities.

22 othecin by expression of constitutive active mitogen-activated protein kinase kinase 1, an upstream k

23 ion of BRCA1-induced ERK1/2 activation using mitogen-activated protein kinase kinase 1 and 2 (MEK1/2)

24 ed induction of E-selectin, whereas PD98059 (mitogen-activated protein kinase kinase 1 and 2 inhibito

25 nhibitor of the dual-specificity kinases MEK(mitogen-activated protein kinase kinase) -1 and MEK2 , i

26 The C-terminal region of mitogen-activated protein kinase kinase-1 and 2 (MKK1 an

27 Activation of mitogen-activated protein kinase kinases 1 and 2 (MEK1 a

28 that the hepatocyte growth factor activator, mitogen-activated protein kinase kinase 1, and phosphati

29 The expression of constitutively activated mitogen-activated protein kinase kinase 1 enhanced caspa

30 ant-negative mutant of the ERK1/2 activator, mitogen-activated protein kinase kinase 1, increased the

31 Chemical inhibition of PI-3K and mitogen-activated protein kinase kinase 1 inhibited E(2)

32 y, and the effects of LT were independent of mitogen-activated protein kinase kinase 1 inhibition.

33 ression of the alpha7 integrin or use of the mitogen-activated protein kinase kinase 1 inhibitor U012

34 , although disruption of this pathway by the mitogen-activated protein kinase kinase 1 inhibitor U012

35 PD98059, a mitogen-activated protein kinase kinase 1 inhibitor, als

36 ted and ddPCR confirmed somatic mutations in mitogen activated protein kinase kinase 1 (MAP2K1), the

37 lleles in Ras-like without CAAX 1 (RIT1) and mitogen-activated protein kinase kinase 1 (MAP2K1) and p

38 atment with PD98059, a specific inhibitor of mitogen-activated protein kinase kinase 1 (MAPKK1 (MEK1)

39 n has been linked to its ability to activate mitogen-activated protein kinase kinase 1 (MEK) and mito

40 nhibitor, PD58029, which is specific for the mitogen-activated protein kinase kinase 1 (MEK-1), also

41 constitutively active form of MEKK-1 but not mitogen-activated protein kinase kinase-1 (MEK-1) or TGF

42 Instead, fragmentation depends on cytosolic mitogen-activated protein kinase kinase 1 (MEK1 or MAPKK

43 ion of a constitutively active mutant of the mitogen-activated protein kinase kinase 1 (MEK1(E)), the

44 Conversely, conditional mitogen-activated protein kinase kinase 1 (Mek1) activat

45 Overexpression of V1, V2, or GIT1 activated mitogen-activated protein kinase kinase 1 (MEK1) and ext

46 gulated kinase (ERK)1/2 and Akt and both the mitogen-activated protein kinase kinase 1 (MEK1) and pho

47 where it acts as a metalloprotease to cleave mitogen-activated protein kinase kinase 1 (MEK1) and pos

48 owever, the expression of a kinase-deficient mitogen-activated protein kinase kinase 1 (MEK1) did not

49 The response was blocked by a specific mitogen-activated protein kinase kinase 1 (MEK1) inhibit

50 AK-null cells, constitutively activated (CA) mitogen-activated protein kinase kinase 1 (MEK1) restore

51 us via a signaling pathway in which c-Raf-1, mitogen-activated protein kinase kinase 1 (MEK1), and th

52 Using an activated allele of mitogen-activated protein kinase kinase 1 (MEK1), we sho

53 on of dominant-negative mutants of C-Raf1 or mitogen-activated protein kinase kinase 1 (MEK1).

54 this process requires the cytosolic protein mitogen-activated protein kinase kinase 1 (MEK1).

55 Previous studies have reported that mitogen-activated protein kinase kinase-1 (MEK1) and Cdc

56 Here, we demonstrate that acetylation of the mitogen-activated protein kinase kinase-1 (MEK1) stimula

57 sic pathway of apoptosis, independent of the mitogen-activated protein kinase kinase-1 (MEK1).

58 NF-kappaB-inducing kinase (NIK) and mitogen-activated protein kinase kinase-1 (MEKK-1) were

59 s article, we demonstrate that LPA activates mitogen-activated protein kinase kinase 1 (MEKK1) in a G

60 stimulation of N-Myc and the stress-mediated mitogen-activated-protein kinase kinase 1 (MEKK1) pathwa

61 airway smooth muscle proliferation, with the mitogen-activated protein kinase kinase 1/mitogen-activa

62 efine conditions for nuclear localization of mitogen-activated protein kinase kinase 1 (MKK1) by exam

63 The activation of human mitogen-activated protein kinase kinase 1 (MKK1) is achi

64 Ectopic expression of constitutively active mitogen-activated protein kinase kinase 1 (MKK1) resulte

65 FR with AG1478 or small interfering RNA), or mitogen-activated protein kinase kinase 1 or 2 (MKK1/2 w

66 activating mutation in exon 2 of MEK1 (i.e., mitogen-activated protein kinase kinase 1 or MAP2K1) tha

67 ed by inhibiting HBx stimulation of N-Myc or mitogen-activated-protein kinase kinase 1 using dominant

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