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1 ambiguous whether the signal is exclusively mitogenic.
2 lagen-activated NPY-rich platelets were more mitogenic (~2-fold vs. ~1.6-fold increase) for human mic
4 ia converts the myogenic action of IGFs into mitogenic action by differentially regulating multiple s
5 rb14 as a physiological repressor of insulin mitogenic action in the liver and further supports that
6 retinoic acid, correlated with sustained pro-mitogenic action of PACAP beyond the developmental switc
9 or tyrosine kinases (RTKs) and/or downstream mitogenic activation is almost ubiquitous; thus tailored
10 phatidic acid (PA) is a critical mediator of mitogenic activation of mammalian target of rapamycin co
12 poR that cannot be ubiquitinated has reduced mitogenic activities and ability to stimulate the STAT5,
13 activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF
14 ying EGF mutants with significantly enhanced mitogenic activity at low concentrations compared to tha
16 the increase in tumor engraftment and serum mitogenic activity in mice pretreated with a chemotherap
17 val of mice after partial hepatectomy, FGF19 mitogenic activity is associated with liver carcinoma.
18 and protein assays, we further show that the mitogenic activity of TWEAK on primary astrocytes requir
20 endent of its protease activity, FXII exerts mitogenic activity with implications for angiogenesis.
21 ations as well as macrophage recruitment and mitogenic activity, and a decrease in UVB-induced apopto
22 stigating factors that limit YAP's postnatal mitogenic activity, we found that the CM-enriched TEAD1
24 s with the capacity to withstand an aberrant mitogenic activity, with a profound impact on the geneti
30 yses revealed that a variety of antioxidant, mitogenic, acute phase genes were up-regulated in the li
35 receptor substrates 1 and 2 (IRS1/2) mediate mitogenic and antiapoptotic signaling from insulin-like
36 y as a C-terminal fragment homologous to the mitogenic and bactericidal region in human lacritin, sug
37 syndecan-1 binding is necessary for lacritin mitogenic and cytoprotective activities, TGM2 cross-link
38 sic 1-10 nM dose optimum, the same domain is mitogenic and cytoprotective for epithelia via a syndeca
39 ERalpha-mediated gene expression involved in mitogenic and developmental processes in MCF7 breast can
40 scaffold proteins that interact with various mitogenic and developmental signals, the genetic role of
43 hedgehog (HH) pathway is well known for its mitogenic and morphogenic functions during development,
46 ayers and growth factors alone, we sustained mitogenic and osteogenic signals with these growth facto
51 ine-threonine kinase, has been implicated in mitogenic and survival control, and it is markedly overe
52 s studies, we find that E-peptide signaling, mitogenic, and motogenic effects are dependent upon IGF-
53 renal ischemia-reperfusion injury, mainly by mitogenic, angiogenic, and anti-inflammatory mechanisms.
54 ture of murine CD3epsilon complexed with the mitogenic anti-CD3epsilon antibody 2C11 enabled the firs
57 ased upregulation of the CSF1R-dependent pro-mitogenic cascade, correlating with disease severity.
59 rs (GEFs) of the Dbl family are activated by mitogenic cell surface receptors and activate the Rho fa
62 these data suggest mTOR signaling-dependent, mitogenic conditioning of AECII is a determinant of host
64 rexpression of Dsg2 increased EV release and mitogenic content including epidermal growth factor rece
67 between in vivo and in vitro studies on the mitogenic effect of estrogen and raises questions regard
69 endent of keratinocyte proliferation and the mitogenic effect of FGF signalling, which are only requi
73 the WNT signaling pathway is known to have a mitogenic effect on cells, but relatively little is know
74 l properties against 11 human pathogens, and mitogenic effect on hamster spleen lymphocytes were also
76 tumors and cell lines, leading to a similar mitogenic effect through activation of the MAP kinase pa
78 y smooth muscle cell proliferation, and this mitogenic effect was greatly pronounced in PAH-pulmonary
81 ese findings provide evidence that insulin's mitogenic effects are mediated by a subpopulation of IRs
83 three members of the MAPK family mediate the mitogenic effects of catecholoestradiols in the endothel
89 n of direct from indirect and motogenic from mitogenic effects of genes and molecules affecting wound
90 ration, and clinical trials that exploit the mitogenic effects of IL-7 have achieved success in treat
96 se BPA exerted c-Myc-dependent genotoxic and mitogenic effects on ERalpha-negative mammary cells.
97 producing IL-22 and IL-17, which have direct mitogenic effects on hepatocytes and promote a regenerat
98 Neuregulin1 (Nrg1), previously shown to have mitogenic effects on mammalian cardiomyocytes, is sharpl
100 iferation, we investigated whether insulin's mitogenic effects result from activation of Ca(2+)-signa
101 olypeptide hormones with potent anabolic and mitogenic effects that regulate cell growth and differen
104 ough E-cadherin, which prevents secretion of mitogenic epidermal growth factors (EGFs) by repressing
107 s strains have genes encoding IgA proteases, mitogenic factor deoxyribonucleases, nickel/cobalt uptak
109 wth factor (EGF) is a potent chemotactic and mitogenic factor for epidermal keratinocytes, and these
112 moattractant protein-1 and hypoxia-inducible mitogenic factor, in the murine model of hypoxic pulmona
113 ng inducer of the myelinating phenotype, and mitogenic factors activating receptor tyrosine kinases (
114 ascades lead to the downstream production of mitogenic factors and the proliferation of neighboring s
116 f fenestrations and expression of growth and mitogenic factors, leading to proliferative changes and
118 Serotonin (5-hydroxytryptamine, 5-HT) is mitogenic for several cell types including pulmonary art
120 sults show FOXM1 to be a key mediator of the mitogenic functions of ERalpha and estrogen in breast ca
125 lation of which is stimulated in response to mitogenic, growth, and nutritional stimuli, and proteins
126 We demonstrate in this study that this is a mitogenic human B cell response that occurs independentl
127 insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the
128 subthreshold TCR signaling in the context of mitogenic IL-2 signals, thereby rendering CD8 T cells ex
129 lls, suggesting that integration of multiple mitogenic inputs may alter the minimal requirement for T
131 mechanism responsible for the generation of mitogenic IR-A and provides a novel interplay between IR
132 ntrol of ENaC activity and the activation of mitogenic kinase pathways; (b) provide evidence for a Cy
133 s a proximal target for EET-activated ERK1/2 mitogenic kinases, (c) characterize a mechanistic common
134 ed by activation of Sestrin2, which impaired mitogenic mammalian target of rapamycin (mTOR) signaling
136 tor through early endosomes are accelerated, mitogenic MAPK-ERK1/2 signals are rapidly terminated, an
138 ur data demonstrate that IL-1 functions as a mitogenic mediator of encephalitogenic Th17 cells rather
140 tant roles of the TNF-alpha ligand Eiger and mitogenic molecules in mediating these interactions duri
141 atocyte growth factor, Met signaling confers mitogenic, morphogenic, and motogenic activity to variou
143 ) SCLC cells, an increased expression of the mitogenic neuropeptide receptors for gastrin-releasing p
146 axon guidance; 2) some very highly expressed mitogenic pathway genes (e.g., Map2k1, Igf1r, Rara, Runx
147 rectly link a well-established developmental mitogenic pathway with a key tumor suppressor and contri
148 eraction with monocytes to activate distinct mitogenic pathways in T(reg) but not effector T cells.
150 by converting a transcriptional repressor of mitogenic pathways into a transcriptional activator.
151 tion 5a (Stat5a), factors that influence key mitogenic pathways that regulate normal mammary gland de
153 of adrenomedullin (Adm, gene; AM, protein)-a mitogenic peptide hormone required for normal cardiovasc
154 for producing active endothelin-1 (ET-1), a mitogenic peptide implicated in the aetiology of a numbe
158 tion of furin reduces IRA maturation and its mitogenic potential without altering the insulin effects
160 al mediator of FGF19 action on metabolic and mitogenic programs; thus, the involvement of mTORC1 in F
164 reased hepatocyte proliferation; however, no mitogenic response in hepatocytes to T3 was evident in t
165 demonstrate that neuronal activity elicits a mitogenic response of neural progenitor cells and OPCs,
166 ily of Ca(2+)-regulated PDEs, also induced a mitogenic response to AVP in NHK cells, similar to the e
167 We have identified T3-induced hepatocyte mitogenic response to be mediated by PKA-dependent beta-
169 y reflect the requirement for an exceptional mitogenic response to growth factor signalling in the af
170 re rapid VEGFR2 clustering and a more potent mitogenic response triggered by VEGF-A in respect to gre
174 weakly acting phytoestrogen that mimics the mitogenic responses produced by E2 in an ERalpha-depende
176 cholinergic neurons, revealing an important mitogenic role for the planarian hh signaling molecule i
178 rn of events given the pathway's established mitogenic role, and they show that Hedgehog pathway atte
181 phingolipids ceramide and sphingosine to the mitogenic S1P, thereby determining the susceptibility of
182 port that the ER-transiting and functionally mitogenic secreted proenzyme (pCatD) form of cathepsin D
184 regulated in CF SMGs and that this sustained mitogenic signal alters properties of the SMG progenitor
185 Previously, we found that PACAP was an anti-mitogenic signal from embryonic day 13.5 (E13.5) onward
190 kinase impaired ERBB3 (HER3) create a potent mitogenic signal, but the phosphorylation of ERBB2 in th
191 gulated and extended the transduction of the mitogenic signal, whereas silencing of LNK produced the
193 broblasts function cooperatively to activate mitogenic signaling activities and to induce their trans
194 , we propose that cilia decapitation induces mitogenic signaling and constitutes a molecular link bet
195 Cav-1 may provide a mechanism for regulating mitogenic signaling and modulating the cell-surface pres
199 c transcription factor, blocked Ras-mediated mitogenic signaling at the level of MEK through the dire
200 cell proliferation by induction of paracrine mitogenic signaling between heterogeneous malignant cell
204 nockdown or small-molecule targeting reduced mitogenic signaling in non-small cell lung cancer cell l
208 expression activates PI3K, a key node in the mitogenic signaling network known to promote malignancie
209 hinery is a major recipient of the principal mitogenic signaling networks involving Raf-ERK1/2 and ph
210 wever, understanding the compound effects of mitogenic signaling on the translation apparatus and on
211 ry of knowledge for beta-cell researchers on mitogenic signaling pathways and to emphasize how little
212 findings show that an important activity of mitogenic signaling pathways is to inactivate the growth
213 increased hHSC proliferation through several mitogenic signaling pathways such as EGFR, PI3K and p38.
214 d translocation but also from alterations in mitogenic signaling pathways that affect Myc levels thro
215 nduces hHSC fibrogenic activity via multiple mitogenic signaling pathways, and is upregulated in muri
218 cell proliferation, tissue growth, and many mitogenic signaling pathways; we investigated its role i
219 Taken together, these results indicate that mitogenic signaling regulates the miRNA effector machine
221 cellular desmosomal adhesion, Dsg2 regulates mitogenic signaling that may promote cancer development
222 ling, contraction, intracellular Ca(2+), and mitogenic signaling were determined in vivo and in vitro
223 uce the maturation of IRA and its associated mitogenic signaling without altering the signals emanati
225 pletion reduces smooth muscle proliferation, mitogenic signaling, and extracellular matrix deposition
226 nic demonstrated RTK blockade, inhibition of mitogenic signaling, and proapoptotic signal induction i
227 in receptor, allowing aberrant activation of mitogenic signaling, promotes aberrant splicing and expr
228 ermal growth factor receptor (EGFR)-mediated mitogenic signaling, promoting tumor cell survival throu
236 R activity prevented angiotensin II-mediated mitogenic signalling and profibrogenic gene expression.
237 r's association with endosomes is prolonged, mitogenic signals (ERK 1/2, Src, and STAT5) are amplifie
240 hai or Galphas, Akt signaling is suppressed, mitogenic signals are enhanced due to delayed transit ti
241 and implicate tumor-associated DCs and their mitogenic signals as auspicious therapeutic targets.
242 77-eGFP, c-Myc protein expression integrates mitogenic signals downstream of both IL-2 and the TCR, y
244 vels allows effective integration of diverse mitogenic signals in ISCs to adapt their proliferative a
246 alpha(q) and its coupled receptors transduce mitogenic signals is still unclear because of the comple
250 to permeate neurofibroma tissue, mediate key mitogenic signals that contribute to vascular ingrowth,
251 r cells, as well as to normal cells, sending mitogenic signals that greatly enhance tumor growth.
252 plex) is poised to be activated by extrinsic mitogenic signals that impinge upon p27 at the earliest
253 tal for oncogenic signaling as it integrates mitogenic signals to amplify production of pro-growth an
254 mature myometrial or leiomyoma cells to send mitogenic signals to neighboring tissue stem cells in re
255 clin D-dependent kinases sense a plethora of mitogenic signals to orchestrate specific transcriptiona
257 We show that Activin directly inhibits the mitogenic sonic hedgehog pathway in a Gli3-dependent man
263 -associated HIV-1 RNA was detected following mitogenic stimulation of peripheral blood CD4(+) T cells
266 e protein complexes that can be activated by mitogenic stimulation to repress mitogen-stimulated targ
272 and temporarily dissociated from mTORC1 upon mitogenic stimulation, suggesting a mechanism underlying
284 f cord blood mononuclear cells to innate and mitogenic stimuli (P = .0009), with an average 1.7- to 2
285 nt phosphorylation of Ser-247 was induced by mitogenic stimuli and required prior phosphorylation of
286 lar B lymphocytes were expanded by providing mitogenic stimuli and then challenged with KSHV-specific
292 hese conditions, hPSC-CMs were refractory to mitogenic stimuli, and we found that key proliferation p
296 irus 8 (HHV-8) is believed to contribute via mitogenic, survival, and angiogenic activities to HHV-8-
297 nd cytokine secretion after stimulation with mitogenic, TLR, and T-cell stimuli by cytometric bead ar
298 ing growth factor-beta1 (TGF-beta1), LRG1 is mitogenic to endothelial cells and promotes angiogenesis
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