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1 PTX) paradoxically cause G1 arrest (without mitotic arrest).
2 of 468 cells pretreated with EpoB (to induce mitotic arrest).
3 chromosome attachment failures, which led to mitotic arrest.
4 s initiate meiosis and male germ cells enter mitotic arrest.
5 f Mad2 with its binding partners and thereby mitotic arrest.
6 n in the current model describing fate after mitotic arrest.
7 ion and caused cellular microtubule loss and mitotic arrest.
8 ate the checkpoint after a defined period of mitotic arrest.
9 ltinucleated rather than dying directly from mitotic arrest.
10 les and metaphase plate formation and causes mitotic arrest.
11 -) HCT116 cells is frequently accompanied by mitotic arrest.
12 guishes between normal mitosis and prolonged mitotic arrest.
13 uppression results in monopolar spindles and mitotic arrest.
14 ng cancer cells in the apoptotic response to mitotic arrest.
15 formation of aberrant mitotic spindles, and mitotic arrest.
16 locking centrosome maturation and leading to mitotic arrest.
17 mma-tubulin at the centrosomes, rescuing the mitotic arrest.
18 osis in some cell lines at similar levels of mitotic arrest.
19 (PTX) and other microtubule inhibitors cause mitotic arrest.
20 and results in microtubule stabilization and mitotic arrest.
21 in human lens epithelial cells resulted in a mitotic arrest.
22 paclitaxel-induced microtubule bundling and mitotic arrest.
23 delayed at cell separation upon release from mitotic arrest.
24 proteins rescues the Chk1 depletion-induced mitotic arrest.
25 20 and induces a spindle-checkpoint-mediated mitotic arrest.
26 r, partial depletion of CCT or Plk1 leads to mitotic arrest.
27 0 or LIS1 cause distinct spindle defects and mitotic arrest.
28 cells by CA-4-P is associated with prolonged mitotic arrest.
29 ation of FoxM1 and its target genes preceded mitotic arrest.
30 Blockade of APC activity causes mitotic arrest.
31 nes and increased the population of cells in mitotic arrest.
32 telomeric poly(ADP-ribose) polymerase caused mitotic arrest.
33 s exhibit both proliferative defect(s) and a mitotic arrest.
34 g S or G2-M phases underwent death following mitotic arrest.
35 gen tails with human fibroblasts induce G(1) mitotic arrest.
36 sMAD1R558 in binding hsMAD2 and in enforcing mitotic arrest.
37 ure to increase cyclin D1, all indicative of mitotic arrest.
38 and dose-dependent manner, correlating with mitotic arrest.
39 d for mitotic cell cycle factors, leading to mitotic arrest.
40 spindle checkpoint re-activation and lethal mitotic arrest.
41 ta link AR degradation via ubiquitination to mitotic arrest.
42 ing AR into PC3-M cells confers 2-ME-induced mitotic arrest.
43 the apoptosis and adaptation pathways during mitotic arrest.
44 checkpoint, it is insufficient for a robust mitotic arrest.
45 ate a robust checkpoint signal and prolonged mitotic arrest.
46 thesis and caused incomplete proteolysis and mitotic arrest.
47 rations of epothilone B, one that induced no mitotic arrest (0.2 nM, 20 h), one that induced one-thir
48 r ability to recover from nocodazole-induced mitotic arrest: a large fraction of +/- cells failed to
49 ecific conditional lethality associated with mitotic arrest, aberrant spindle structures, and chromos
50 congression, and their disruption results in mitotic arrest accompanied by multiple spindle aberratio
51 affect liver regeneration but caused limited mitotic arrest, accumulation of abnormal mitotic figures
53 codynamic experiments demonstrated prolonged mitotic arrest after oral administration of 12c to tumor
54 ces early cell cycle progression followed by mitotic arrest, an event that almost certainly reflects
55 v1 xenografts in mice with docetaxel induced mitotic arrest and a decrease in PSA expression in tumor
56 wn of Aurora A impaired cell growth, induced mitotic arrest and aberrant nuclear division leading to
57 nd inhibits tumor cell proliferation through mitotic arrest and accumulation of monopolar spindles.
58 Paclitaxel stabilizes microtubules, causing mitotic arrest and activating the spindle assembly check
61 ive cell-cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kina
62 by lentivirus-based RNA interference led to mitotic arrest and apoptosis in cancer cells, whereas no
63 rovide novel insights into the mechanisms of mitotic arrest and apoptosis induced by microtubule-targ
64 might provide a molecular basis for linking mitotic arrest and apoptosis of fibroblasts by C1q tails
66 tubule destabilizing agent, led to increased mitotic arrest and apoptosis, consistent with spindle de
71 Like Dma1, CK1 accumulates at SPBs during a mitotic arrest and associates stably with SPB components
75 although it was insufficient to override the mitotic arrest and cell death caused by RABL6A loss.
76 eover, S12 alters spindle formation, causing mitotic arrest and cell death, and inhibits tumor growth
85 get the microtubule cytoskeleton, leading to mitotic arrest and cell death; however, their clinical e
87 tured cells, depletion of the protein causes mitotic arrest and complete failure of sister chromatid
88 chanism is independent of paclitaxel-induced mitotic arrest and could provide an alternative mechanis
91 and kidney defects in heterozygotes and with mitotic arrest and embryonic lethality in homozygotes.
92 Accordingly, p53(-/-) cells exhibit reduced mitotic arrest and enhanced polyploidy upon survivin abl
93 by Cdk1 is required for checkpoint-mediated mitotic arrest and for recruitment of Plx1 and the check
95 nt inhibitor of KSP, CK0106023, which causes mitotic arrest and growth inhibition in several human tu
96 tion of this protein in vivo causes an early mitotic arrest and increased cytotoxicity when cells are
97 death occurs in premetaphase stage following mitotic arrest and is not a consequence of general toxic
99 e outcome consistent with dual mechanisms of mitotic arrest and mitotic slippage induced by antimitot
101 In mice, ablation of Aurora A results in mitotic arrest and pre-implantation lethality, preventin
104 ntrations of paclitaxel are too low to cause mitotic arrest and result in multipolar divisions instea
105 l imaging of treated cells demonstrated that mitotic arrest and segregation abnormalities lead to cel
106 ncreased the ratio of cells that died during mitotic arrest and sensitized cancer cells to mitotic po
109 delayed progression into nocodazole-induced mitotic arrest and was confirmed by a lack of BrdUrd inc
110 tosis induction by AITC depended entirely on mitotic arrest and was mediated via Bcl-2 phosphorylatio
111 ominantly acting cell cycle regulator causes mitotic arrest and, thereby, inviability of male hybrid
112 akinetochore stretch, a checkpoint-dependent mitotic arrest, and accumulation of microtubule attachme
113 d proteasome-dependent survivin degradation, mitotic arrest, and apoptosis, and it blocked the growth
114 Taxanes induce microtubule stabilization, mitotic arrest, and apoptotic cell death, but recent dat
115 y for MT morphology, chromatin condensation, mitotic arrest, and cellular toxicity to identify region
116 cell-cycle progression, increased apoptosis, mitotic arrest, and chemosensitivity, and cooperated wit
117 k model describing cell death control during mitotic arrest, and constrained the model using experime
118 ression prolonged mitosis, caused occasional mitotic arrest, and decreased mitotic spindle movements.
119 govern neural progenitor lineage commitment, mitotic arrest, and differentiation into functional prog
122 p between the excitation light intensity and mitotic arrest, and the frequency of mitotic arrest is d
123 assemble K11 linkages in cells released from mitotic arrest, and these are proposed to constitute an
124 d that Plk1 depletion preferentially induced mitotic arrest, aneuploidy, and reduced cell survival in
125 lities that include increased DNA synthesis, mitotic arrest, appearance of convoluted nuclei with dec
126 targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but can
128 low nanomolar range and caused apoptosis and mitotic arrest as measured in a high content nuclear mor
130 ed defective chromosome alignment and severe mitotic arrest associated with increased Mad1/Mad2 signa
133 hibited a biphasic dose-response curve, with mitotic arrest at low drug concentrations (100 nM nocoda
135 ells expressing kinase-inactive Nek6 reveals mitotic arrest at the metaphase stage prior to cells ent
136 er and the tumor cells survived longer after mitotic arrest, becoming multinucleated rather than dyin
142 ine (MCF-10A) was markedly more resistant to mitotic arrest by WA compared with breast cancer cells.
143 chromatid cohesion defects and the resulting mitotic arrest caused by Naa50 depletion, indicating tha
145 ed in noninfected cells, E4orf3 overcame the mitotic arrest caused by the degradation-resistant R42A
146 spase-2 and suggest that under conditions of mitotic arrest, cdk1-cyclin B1 activity must be overcome
147 of p34(cdc2) activity by purvalanol A caused mitotic-arrested cells to rapidly exit mitosis, suggesti
148 n improper Plk1 recruitment to kinetochores, mitotic arrest, chromosome missegregation, and apoptosis
150 apoptosis, suggesting that Cdk activation at mitotic arrest could induce subsequent MCL-1 degradation
151 onents of the spindle checkpoint include the mitotic arrest defective (MAD) genes MAD1-3, and the bud
158 nclude up-regulation/induction of cyclin D1, mitotic arrest deficient (MAD)1, p21, growth arrest and
163 t is the conformational conversion of "open" mitotic arrest deficient 2 (O-MAD2) into "closed" MAD2 (
165 association studies have identified MAD1L1 (mitotic arrest deficient-like 1) as a susceptibility gen
166 by modulating several targets including MAD2 mitotic arrest deficient-like 1, MAD2L1, a component of
167 udding uninhibited by benzimidazole (Bub) 1, mitotic arrest-deficient (Mad) 1, and Mad2 proteins prom
171 the extent of Thr-602 phosphorylation during mitotic arrest dependent on the mechanism of the arresti
172 evailing model suggests that cell fate after mitotic arrest depends on two independent and competing
173 cer cell lines to undergo nocodazole-induced mitotic arrest despite intact mitotic checkpoint protein
174 ed microtubule dynamics, and the duration of mitotic arrest dictates the probability, but not the tim
175 pre-mRNA at the restrictive temperature, the mitotic arrest does not appear to result from a failure
176 transient during mitosis to sustained during mitotic arrest, dramatically increases the extent of Bcl
180 ddition, potent and novel agents that induce mitotic arrest either by directly interfering with tubul
181 In contrast, cells made polyploid without mitotic arrest exhibited neither significant structural
184 l of survivin by RNA interference produces a mitotic arrest followed by re-entry into the cell cycle
186 os perturbs the progression of cell cycle by mitotic arrest, followed by apoptotic cell death associa
187 reatment caused spindle assembly defects and mitotic arrest, followed by slippage from mitotic arrest
188 -orientation, and while the SAC can maintain mitotic arrest for extended periods, moderate delays in
191 At the same time, deliberate induction of mitotic arrest has proved clinically useful, as antimito
192 tion of anti-apoptotic Bcl-2 proteins during mitotic arrest; however, it remains unclear how this mec
194 M, 20 h), one that induced one-third maximal mitotic arrest (IC(33,) 2 nM, 20 h), and one that induce
196 uman fibroblasts, DNA breaks occurred during mitotic arrest in a p53-independent manner, but p53 was
200 capacity of the SAH domain is important for mitotic arrest in conditions of suppressed microtubule d
203 -E17.5, many mutant germ cells fail to enter mitotic arrest in G0 and do not downregulate the pluripo
208 ted, strongly suggesting that DND1 regulates mitotic arrest in male germ cells through translational
210 Our results suggest that maintenance of mitotic arrest in pregranulosa cells may preclude upregu
211 , an endogenous estrogen metabolite, induces mitotic arrest in prostate cancer cells involving activa
212 on of MT dynamics is critical to maintaining mitotic arrest in response to mispositioned spindles.
214 1 in slippage-resistant HT29 or by enforcing mitotic arrest in slippage-prone DLD-1 cells, evokes a s
216 identify a Cdc28 domain necessary for proper mitotic arrest in the face of kinetochore defects or mic
218 is whether cells complete mitosis or sustain mitotic arrest in the presence of unaligned chromosomes.
219 hat cells are unable to maintain a prolonged mitotic arrest in the presence of unaligned chromosomes.
222 accompanies paclitaxel-induced, SAC-mediated mitotic arrest, independent of p53 integrity or signalin
224 f metaphase chromosome alignment and induced mitotic arrest, indicating that tight binding of CENP-E
229 dependent kinase 1 (CDK1)/cyclin B catalyzes mitotic-arrest-induced Bcl-x(L)/Bcl-2 phosphorylation.
234 ity and mitotic arrest, and the frequency of mitotic arrest is dependent on the presence of an IFP th
235 ought to test the hypothesis that fate after mitotic arrest is dictated by the robustness of Cdk1/cyc
239 efficiency of both chromosome alignment and mitotic arrest, likely through displacement of endogenou
240 ssembly; as such, inhibition of Eg5 leads to mitotic arrest making it a potential anticancer target.
241 ase cells, suggesting that As(2)O(3)-induced mitotic arrest may be a requirement for the activation o
245 with human U2OS cells revealed that 1 causes mitotic arrest, micronucleus induction, centrosome ampli
246 analogues cause mitotic spindle disruption, mitotic arrest, microtubule depolymerization, and inhibi
247 We observed aberrant exit of gonocytes from mitotic arrest, migration toward cord periphery, and pre
249 sequences, including a temperature-sensitive mitotic arrest mutant, map to a beta-sheet region of the
253 ormal cells in the G1 phase while inducing a mitotic arrest of tumor cells resulting in selective kil
254 ex with Mad2, which is required for imposing mitotic arrest on cells in which the spindle assembly is
256 urora A inhibition that act independently of mitotic arrest or slippage, were assessed in the tumor b
261 n of any one of these proteins abolishes the mitotic arrest provoked by depolymerizing microtubules o
263 s (high content screening), we find that the mitotic arrest response shows relatively little variatio
265 at human cells in crisis undergo spontaneous mitotic arrest, resulting in death during mitosis or in
266 is pathway wherein chromosome fusions induce mitotic arrest, resulting in mitotic telomere deprotecti
267 do accumulate Mcd1/Scc1 at centromeres upon mitotic arrest, suggesting that the cyclin-dependent mec
272 t nucleus also undergoes remodeling during a mitotic arrest; the NE continues to expand despite the p
274 ic exit and prevents polarized growth during mitotic arrest, thereby coupling cell cycle progression
276 r cells did not progress through Ptx-induced mitotic arrest, tumor significantly regressed in the mod
278 that HR22C16-A1 induces cell death following mitotic arrest via the intrinsic apoptotic pathway.
280 ited growth of normal lung fibroblast cells, mitotic arrest was more pronounced in the colon cancer c
281 ontrast to results with 2D culture, observed mitotic arrest was relatively low, suggesting involvemen
282 of Bcl-2 proteins in apoptosis induced after mitotic arrest, we investigated the subcellular location
283 ences the rate and extent of apoptosis after mitotic arrest, we screened a kinase-enriched small inte
285 er(216) phosphorylation of Cdc25C as well as mitotic arrest were significantly attenuated by knockdow
286 s of acute leukemia cells have an attenuated mitotic arrest when decatenation is inhibited and that i
287 as an activity in mature oocytes that caused mitotic arrest when injected into dividing embryos.
288 chromatid exchange but fail to maintain the mitotic arrest when SAC is activated and exhibit a broad
289 aclitaxel has long been recognized to induce mitotic arrest, which leads to cell death in a subset of
290 as aborted cell division without a prolonged mitotic arrest, which ultimately resulted in cell death.
291 mammalian cells can eventually overcome the mitotic arrest while the checkpoint is still activated.
292 ibroblasts causes impaired mitotic entry and mitotic arrest with a profound defect in bipolar spindle
296 wild-type or a non-degradable CKAP2 led to a mitotic arrest with monopolar spindles containing highly
297 HeLa cells inhibits cell growth and induces mitotic arrest with multiple mitotic defects, which subs
298 utations in Cdc48 and its adaptor Ubx4 cause mitotic arrest with sustained Clb2 and Cdc20 proteins th
299 g slippage and the outcome of taxane-induced mitotic arrest, with potential implications for cancer t
300 (2)-M arrest, cells escaped from a prolonged mitotic arrest without cell division, resulting in tetra
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