ライフサイエンスコーパス: mitotic checkpoint

1 f MCC, necessary for the inactivation of the mitotic checkpoint.

2 Depletion of Shp2 compromised the mitotic checkpoint.

3 ent of its previously identified role in the mitotic checkpoint.

4 polymerization with nocodazole, activate the mitotic checkpoint.

5 wed a marked defect in the activation of the mitotic checkpoint.

6 lls that undergo prolonged activation of the mitotic checkpoint.

7 is directly due to a delay in satisfying the mitotic checkpoint.

8 these attachments and the activation of the mitotic checkpoint.

9 nstability after prolonged activation of the mitotic checkpoint.

10 microtubules is insufficient to satisfy the mitotic checkpoint.

11 Cdc20 mutant that cannot be inhibited by the mitotic checkpoint.

12 between Taxol concentration, the DM, and the mitotic checkpoint.

13 N-APC mutant of egg extracts inactivates the mitotic checkpoint.

14 microtubule-targeting agents that invoke the mitotic checkpoint.

15 rora B, contributes to the activation of the mitotic checkpoint.

16 site and has even been suggested to act in a mitotic checkpoint.

17 Q2 normally functions to antagonize an early mitotic checkpoint.

18 s renders its degradation insensitive to the mitotic checkpoint.

19 t centrosome equivalent) duplication and the mitotic checkpoint.

20 mutation in Mps1, a kinase required for the mitotic checkpoint.

21 l, overlapping, and cooperating roles in the mitotic checkpoint.

22 inhibitor nocodazole, indicating an impaired mitotic checkpoint.

23 d in the mRNA export pathway and Bub3 in the mitotic checkpoint.

24 with Ptpn11 GOF mutations show a compromised mitotic checkpoint.

25 the spindle assembly checkpoint and the post-mitotic checkpoint.

26 ressor and transcription factor, WT1, in the mitotic checkpoint.

27 tachments and triggers the engagement of the mitotic checkpoint.

28 pports CPC localization to chromatin and the mitotic checkpoint.

29 a novel, p53-independent role for ARF in the mitotic checkpoint.

30 s1 function abrogates the SPOC but not other mitotic checkpoints.

31 ells by suppressing Src activity at G(1) and mitotic checkpoints.

32 ability and seems to be monitored by several mitotic checkpoints.

33 ore often than control cells and displayed a mitotic checkpoint abnormality with production of polypl

34 The mitotic checkpoint activated by loss of survivin is medi

35 tance of the MAD2 alphaC helix in modulating mitotic checkpoint activation and silencing.

36 Upon mitotic checkpoint activation, S. pombe Dma1 concentrate

37 fertile, and overtly normal despite weakened mitotic checkpoint activity and high percentages of aneu

38 ed from Zbtb4(-/-) mice exhibited diminished mitotic checkpoint activity, increased mitotic defects,

39 The mitotic checkpoint acts to maintain chromosome content b

40 The mitotic checkpoint (also known as the spindle assembly c

41 s chromosome segregation during mitosis, the mitotic checkpoint (also known as the spindle assembly c

42 The mitotic checkpoint, also known as the spindle assembly c

43 BubR1 kinase is essential for the mitotic checkpoint and also for kinetochores to establis

44 We have used extracts that replicate the mitotic checkpoint and anaphase release to identify diff

45 findings identify WT1 as a regulator of the mitotic checkpoint and chromosomal stability.

46 et al. (2014) describe an adhesion-dependent mitotic checkpoint and identify DEPDC1B as the factor re

47 In contrast, the abrogation of mitotic checkpoint and increased cell death were blocked

48 gregation during mitosis is monitored by the mitotic checkpoint and is dependent upon DNA methylation

49 We found that USP44 regulated the mitotic checkpoint and prevented chromosome lagging.

50 phosphorylation site that is involved in the mitotic checkpoint and that CHK2 contributes to chromoso

51 nd organism viability and relies on both the mitotic checkpoint and the machinery that corrects kinet

52 Here, we demonstrate that defects in the mitotic checkpoint and the mitotic exit network can supp

53 onomously replicating DNA viruses must evade mitotic checkpoints and actively partition their genomes

54 lymerization and dynamics and thereby induce mitotic checkpoints and apoptosis.

55 a defect in a network of genes that regulate mitotic checkpoints and chromosomal organization and seg

56 codes a protein kinase that is essential for mitotic checkpoints and the DNA damage response.

57 totic checkpoint gene expression, a weakened mitotic checkpoint, and an increased frequency of laggin

58 rain of Bub1b(H/H) mice, which have a faulty mitotic checkpoint, and Ercc1(-/Delta7) mice, defective

59 1 and Bub1, contributes to abrogation of the mitotic checkpoint, and induces cancer cell death.

60 ecific circumstances, is not detected by the mitotic checkpoint, and induces lagging chromosomes in a

61 east, APC:Cdc20 and its inhibitor MCC at the mitotic checkpoint, and PP2A:B55 and its inhibitor, alph

62 ells by suppressing Src activity at G(1) and mitotic checkpoints, and consequently delaying cell cycl

63 ons of genes involved in cell cycle control, mitotic checkpoints, and DNA repair were identified.

64 ells by suppressing Src activity at G(1) and mitotic checkpoints, and in the intrinsic apoptotic and

65 ed genes, including TP53, ARID1A, and ARID2, mitotic checkpoint anomalies distinguish the C1 subtype

66 By activating the mitotic checkpoint, anti-microtubule drugs such as nocod

67 did not result from S-phase, DNA damage, or mitotic checkpoints, apoptosis, or stress response pathw

68 port that blocking membrane traffic causes a mitotic checkpoint arrest via Wee1-dependent inhibitory

69 tively active Pkc1 can drive cells through a mitotic checkpoint arrest, which suggests that Pkc1-depe

70 is required to prevent cytokinesis during a mitotic checkpoint arrest.

71 s, is a key mechanism that incapacitates the mitotic checkpoint at anaphase.

72 MT attachment stability independently of the mitotic checkpoint because k-MT attachments are unaltere

73 n replication is independent of both DNA and mitotic checkpoints because mutations in other checkpoin

74 tely 40 nM) during chronic activation of the mitotic checkpoint but disappears during mitotic exit at

75 Cdc14, in turn, inactivates the mitotic checkpoint by dephosphorylating Sli15(INCENP), a

76 PICH contributes to the mitotic checkpoint by recruiting Mad2 to kinetochores an

77 gation errors independent of its role in the mitotic checkpoint by regulating centrosome separation,

78 ur suppressors safeguard the fidelity of the mitotic checkpoint by transcriptional regulation of gene

79 These data suggest that functional mitotic checkpoints can play a role in the formation of

80 When the checkpoint is active, a Mitotic Checkpoint Complex (MCC) assembles and inhibits

81 The mitotic checkpoint complex (MCC) consisting of BubR1, Bu

82 checkpoint and enhance the production of the mitotic checkpoint complex (MCC) consisting of BubR1, Bu

83 ling ultimately enhances the assembly of the mitotic checkpoint complex (MCC) consisting of BubR1-Bub

84 The mitotic checkpoint complex (MCC) coordinates proper chro

85 When the checkpoint is turned on, the mitotic checkpoint complex (MCC) inhibits the ubiquitin

86 The mitotic checkpoint complex (MCC) is formed from two sub-

87 ng complex/cyclosome (APC/C) and many of the mitotic checkpoint complex (MCC) proteins.

88 hat binds Cdc20, BubR1, and Bub3 to form the mitotic checkpoint complex (MCC), a potent inhibitor of

89 When the checkpoint is activated, the mitotic checkpoint complex (MCC), assembled from BUBR1,

90 t TIF1gamma is also a component of the APC/C-mitotic checkpoint complex (MCC), but is not required fo

91 When this checkpoint is active, a mitotic checkpoint complex (MCC), composed of the checkp

92 tical for assembly and function of the human mitotic checkpoint complex (MCC), the SAC effector.

93 APC/C is inhibited by the Mitotic Checkpoint Complex (MCC), which assembles when t

94 bR1) then bind and inhibit Cdc20 to form the mitotic checkpoint complex (MCC), which binds and inhibi

95 It catalyzes the production of the Mitotic Checkpoint Complex (MCC), which inhibits Cdc20 t

96 C-Mad2-Cdc20 is incorporated into the mitotic checkpoint complex (MCC), which inhibits the ana

97 rrectly attached to the spindle generate the mitotic checkpoint complex (MCC), which inhibits the ana

98 attached kinetochores, the SAC generates the mitotic checkpoint complex (MCC), which inhibits the APC

99 turned on, it promotes the formation of the mitotic checkpoint complex (MCC), which inhibits the ubi

100 The SAC is imposed by the mitotic checkpoint complex (MCC), whose assembly is cata

101 ndle checkpoint proteins, in the form of the mitotic checkpoint complex (MCC), with the APC/C. apc14D

102 ation of genes that encode components of the mitotic checkpoint complex (MCC).

103 ts association to Mad3 and Cdc20 to form the mitotic checkpoint complex (MCC).

104 checkpoint inhibitor of APC/C(Cdc20) is the mitotic checkpoint complex (MCC).

105 -activator, CDC20, into a complex called the mitotic checkpoint complex (MCC).

106 le assembly) checkpoint by disassembling the mitotic checkpoint complex (MCC).

107 oteins, Mad2 and BubR1, to Cdc20 forming the mitotic checkpoint complex (MCC).

108 change in Mad2 [10-12], and formation of the mitotic checkpoint complex (MCC: Cdc20-Mad3-Mad2 [13-15]

109 y coactivator subunits, phosphorylation, the mitotic checkpoint complex and interphase early mitotic

110 ation, scaffolds formation of a higher-order mitotic checkpoint complex at kinetochores.

111 hed by disrupting the proper assembly of the mitotic checkpoint complex at the level of the Cdc20-Bub

112 r kinetochore localization of the inhibitory mitotic checkpoint complex components, Mad2 and Cdc20, a

113 We also show that the integrity of the human mitotic checkpoint complex depends on the specific recog

114 d2 and Cdc20, and for the maintenance of the mitotic checkpoint complex integrity.

115 er Bub3-stimulated event generates the final mitotic checkpoint complex of Bub3-BubR1-Cdc20 that sele

116 phosphorylated and is further inhibited by a mitotic checkpoint complex until all chromosomes are bio

117 Checkpoint signaling produces the "mitotic checkpoint complex" (MCC), which prevents anapha

118 ins Bub3 and BubR1 are key components of the mitotic checkpoint complex, an essential part of the mol

119 ence of the effector for the checkpoint, the mitotic checkpoint complex, and its association and inhi

120 -derived "wait anaphase" signal known as the mitotic checkpoint complex.

121 with Nup358 depletion further suggests that mitotic checkpoint complexes may remain active at nonkin

122 silencing was induced by an accumulation of mitotic checkpoint complexes.

123 conformational conversion and disassembly of mitotic checkpoint complexes.

124 Reduced expression of the mitotic checkpoint component Mad1 causes aneuploidy and

125 whereas synthesis of proteins including the mitotic checkpoint component MAD2L1 was negatively regul

126 NP-E(+/-) mice by reducing levels of another mitotic checkpoint component, Mad2, is now shown to resu

127 , Bub1, and a portion of Mad2, all essential mitotic-checkpoint components, are stably bound elements

128 It has been implicated in mitotic checkpoint control, as an active kinase at unatt

129 s, and a microtubule-independent function in mitotic checkpoint control.

130 1 reversed the cytokinesis delay but not the mitotic checkpoint defect in Pim-1 overexpressing cells.

131 ub3 results in a similar phenotype involving mitotic checkpoint defects and chromosome missegregation

132 Finally, we show that mice with mitotic checkpoint defects are more susceptible to dimet

133 raploidization, centrosome amplification and mitotic checkpoint defects.

134 ergent evolution of fast-growing clones with mitotic checkpoint defects.

135 ic strategy involving abrogation of the G2/M mitotic checkpoint defense of tumor cells toward lethal

136 In response to unattached kinetochores, the mitotic checkpoint delays anaphase onset by inhibiting t

137 d components that catalyze generation of the mitotic checkpoint-derived "stop anaphase" inhibitor.

138 ct upstream or downstream of RAD53 or in the mitotic checkpoint do not exhibit these phenotypes.

139 The mitotic checkpoint ensures correct chromosome segregatio

140 As a sensitive signaling system, the mitotic checkpoint ensures faithful chromosome segregati

141 The mitotic checkpoint ensures that chromosomes are divided

142 We identify the mitotic checkpoint factor BubR1 as a direct PIDDosome in

143 nstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fi

144 e of this motif results in dependence on the mitotic checkpoint for viability.

145 narily conserved mechanism that prevents the mitotic checkpoint from reengaging when tension between

146 Mad2 is essential for mitotic checkpoint function and is frequently overexpres

147 ediating oriented cell division and faithful mitotic checkpoint function in the renal epithelium, emp

148 hich include defects in chromosome cohesion, mitotic checkpoint function, centrosome copy number, kin

149 cell division site, E3 ligase activity, and mitotic checkpoint function.

150 is, thereby reconciling divergent models for mitotic checkpoint function.

151 , microtubule binding and stabilization, and mitotic checkpoint function.

152 to investigate the role of Lis1/dynactin in mitotic checkpoint function.

153 a critical regulator of Mad2 translation and mitotic checkpoint function.

154 d role for ARF in chromosome segregation and mitotic checkpoint function.

155 red N-terminal 80 amino acid tail domain and mitotic-checkpoint function is dependent on the CH domai

156 of aging-associated phenotypes in mice with mitotic checkpoint gene defects is linked to cellular se

157 binucleated cells in parallel with aberrant mitotic checkpoint gene expression, a weakened mitotic c

158 omosome instability by overexpression of the mitotic checkpoint gene Mad2 in mice does not affect the

159 However, mutated or altered expression of mitotic checkpoint genes accounts for a minor proportion

160 ce that are double haploinsufficient for the mitotic checkpoint genes Bub3 and Rae1 but not in mice t

161 on to generating aneuploidy, manipulation of mitotic checkpoint genes can have unexpected interphase

162 h faster than normal mice, but whether other mitotic checkpoint genes function to prevent the early o

163 y support a conserved cross-species role for mitotic checkpoint genes in genetic stability and epithe

164 ions of Mad1 that do not directly affect the mitotic checkpoint have remained largely undefined.

165 le of chromosomal instability as a result of mitotic checkpoint hyperactivation in the initiation of

166 Hec1 in an inducible mouse model results in mitotic checkpoint hyperactivation.

167 cohesion at anaphase onset would engage the mitotic checkpoint if this was not prevented by concomit

168 es but not chromosome bridges, indicative of mitotic checkpoint impairment.

169 in hMPS1 and found that it can abrogate the mitotic checkpoint in a dominant negative manner.

170 rference technology restored the function of mitotic checkpoint in core-expressing cells.

171 o the kinetochore and cannot reestablish the mitotic checkpoint in hMps1-depleted cells.

172 itotic control genes and induces loss of the mitotic checkpoint in nontransformed preleukemic thymocy

173 During mitosis, the SAC initiates a mitotic checkpoint in response to chromosomes with kinet

174 alizes to centromeres where it activates the mitotic checkpoint in response to inappropriate inter-ki

175 pe breakdown to anaphase, and an override of mitotic checkpoints induced by spindle poisons.

176 le activity, histone deacetylase inhibition, mitotic checkpoint inhibition, and targeting of DNA repl

177 d to Cdc20 that is then converted to a final mitotic checkpoint inhibitor with Cdc20 bound to BubR1.

178 espectively, to facilitate production of the mitotic checkpoint inhibitor.

179 The mitotic checkpoint is a cellular safeguard that prevents

180 The mitotic checkpoint is a mechanism that arrests the progr

181 ed until mitotic cell cycle arrest, when the mitotic checkpoint is activated and apoptosis is trigger

182 The mitotic checkpoint is an important mechanism that preven

183 When the mitotic checkpoint is extinguished, both APC/C-bound and

184 bility (CIN) phenotype, in which a defective mitotic checkpoint is implicated.

185 We conclude that the mitotic checkpoint is not essential for viability per se

186 contain aneuploid cells, indicating that the mitotic checkpoint is permissive to the proliferation of

187 Thus, the mitotic checkpoint is produced by a cascade of two catal

188 The mitotic checkpoint is the major cell cycle checkpoint ac

189 The mitotic checkpoint is the major cell cycle control mecha

190 s or the kinetochore/centromere promotes the mitotic checkpoint, it is insufficient for a robust mito

191 Chk1, a mitotic checkpoint kinase and a client of Hsp90, was deg

192 Mice overexpressing the mitotic checkpoint kinase gene BubR1 live longer, wherea

193 rt that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces aneuploidy

194 In this paper, we show that the mitotic checkpoint kinase MPS1 contains an N-terminal lo

195 With several inhibitors of the mitotic checkpoint kinase MPS1 in preclinical developmen

196 al inhibitors to analyze the function of the mitotic checkpoint kinase Mps1.

197 Human Mps1 (hMps1) is a mitotic checkpoint kinase responsible for sensing the un

198 Aurora B is a mitotic checkpoint kinase that plays a pivotal role in t

199 the interaction of a kinetochore-associated mitotic checkpoint kinase, BubR1, with two microtubule p

200 ion of the Mad2 gene, hyperactivation of the mitotic checkpoint leads to aneuploidy in vitro and is s

201 ular stress response to an antiapoptotic and mitotic checkpoint maintained by survivin.

202 The mitotic checkpoint maintains genomic stability by blocki

203 The mitotic checkpoint maintains genomic stability by ensuri

204 aspase activity is required for a functional mitotic checkpoint (MC) and mitotic slippage.

205 with the H4K20me1 levels, suggesting a novel mitotic checkpoint mechanism.

206 e dynamic polymers with central roles in the mitotic checkpoint, mitotic spindle assembly, and chromo

207 -microtubule attachment, chromatid cohesion, mitotic checkpoint monitoring or cytokinesis.

208 The mitotic checkpoint monitors kinetochore-microtubule atta

209 The mitotic checkpoint monitors the attachment of kinetochor

210 nsion between sister chromatids, but why the mitotic checkpoint now remains silent is poorly understo

211 The mitotic checkpoint (or spindle assembly checkpoint) is a

212 generated as a result of deregulation of the mitotic checkpoint pathway, a frequent characteristic of

213 The mitotic checkpoint plays an important role in preventing

214 ition of Mps-1 resulted in abrogation of the mitotic checkpoint, premature progression through mitosi

215 The mitotic checkpoint prevents advance to anaphase prior to

216 In particular, it is unclear why the mitotic checkpoint prevents the anaphase-promoting compl

217 The mitotic checkpoint prevents the onset of anaphase before

218 APC mutant in mammalian cells with an intact mitotic checkpoint produces premature anaphase onset wit

219 of miR-28-5p function restored Mad2 levels, mitotic checkpoint proficiency, and chromosomal stabilit

220 driving TGFbeta1-induced DNA replication and mitotic checkpoint progression.

221 Zeste white 10 (ZW10) is a mitotic checkpoint protein and the anchor for cytoplasmi

222 The mitotic checkpoint protein Bub1 is essential for embryog

223 The physiological role of the mitotic checkpoint protein Bub1 is unknown.

224 Mice that have small amounts of the mitotic checkpoint protein BubR1 age much faster than no

225 APC(Cdh1) coincides with the release of the mitotic checkpoint protein BubR1 from Cdc20-activated AP

226 A series of diverse mouse models for the mitotic checkpoint protein BubR1 has provided evidence f

227 Expression of the mitotic checkpoint protein Chfr is lost in 20-50% of pri

228 of Rab6 relative to Zeste White 10 (ZW10), a mitotic checkpoint protein implicated in Golgi/endoplasm

229 hese results reveal an unexpected role for a mitotic checkpoint protein in secretion, adhesion, and m

230 We show that the mitotic checkpoint protein Mad2 is a direct E2F target a

231 Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome miss

232 This was dependent on the mitotic checkpoint protein Mad2.

233 nabled in part by aberrant expression of the mitotic checkpoint protein Mad2.

234 Daxx interacts with mitotic checkpoint protein RAS-association domain family

235 ization and phosphorylation of BubR1, a core mitotic checkpoint protein that is also critical for chr

236 o link the control of the stability of a key mitotic checkpoint protein to caspase activation, a regu

237 ing gene (PTTG), also known as securin, is a mitotic checkpoint protein which inhibits sister chromat

238 BubR1 is an essential mitotic checkpoint protein with multiple functional doma

239 finger domains (CHFR), a recently identified mitotic checkpoint protein, plays an important role in m

240 PC fragments (N-APC) with Mad2, an essential mitotic checkpoint protein, providing a direct molecular

241 Our studies of Cdc20, an important mitotic checkpoint protein, throughout the cell cycle de

242 As a consequence, mitotic checkpoint proteins accumulate at anaphase kinet

243 Current theories suggest that mitotic checkpoint proteins are essential for proper cel

244 or paclitaxel (Taxol) reduced levels of the mitotic checkpoint proteins BubR1 and Bub1.

245 of a functional balance between AuroraA and mitotic checkpoint proteins is essential for the proper

246 Kinetochore (KT) localization of mitotic checkpoint proteins is essential for their funct

247 ole or paclitaxel (Taxol) and is mediated by mitotic checkpoint proteins that include BubR1.

248 We used purified subcomplexes of mitotic checkpoint proteins to examine these problems.

249 slocation caused the untimely recruitment of mitotic checkpoint proteins to kinetochores at anaphase

250 n through its recruitment to kinetochores of mitotic checkpoint proteins, formation of interphase and

251 otic abnormalities and altered expression of mitotic checkpoint proteins.

252 produce 'twinkling', demonstrating cycles of mitotic checkpoint reactivation and silencing and a cruc

253 What prevents mitotic checkpoint reactivation when sister centromeres

254 Furthermore, the mitotic checkpoint remains functional after deletion of

255 ere localization of the kinesin MCAK and the mitotic checkpoint response to taxol.

256 ated depletion of DOT1A appears to disrupt a mitotic checkpoint, resulting in premature progression t

257 function as the key receptor responsible for mitotic checkpoint signal transduction after interaction

258 ting it as an essential amplifier of a basal mitotic checkpoint signal.

259 y integrates attachment error correction and mitotic checkpoint signaling by controlling the localiza

260 Impaired mitotic checkpoint signaling can both promote and suppre

261 nd chromosomal instability through weakening mitotic checkpoint signaling caused by mislocalization o

262 Thus, suppression of mitotic checkpoint signaling is invariably lethal as the

263 apture at the kinetochore is translated into mitotic checkpoint signaling remains largely unknown.

264 er responsible for silencing BubR1-dependent mitotic checkpoint signaling through its capture at kine

265 These latter kinetochores generate mitotic checkpoint signaling when unattached, recruiting

266 f kinetochore proteins, centromere-generated mitotic checkpoint signaling, chromosome segregation, an

267 tant roles in normal mitotic progression and mitotic checkpoint signaling, co-purifies with this comp

268 kinase Mps1, long known to be the 'boss' in mitotic checkpoint signaling, phosphorylates multiple pr

269 (Mps1/TTK) is a protein kinase essential in mitotic checkpoint signaling, preventing anaphase until

270 roposed a role for microtubule nucleation in mitotic checkpoint signaling.

271 t Ser-610 and Tyr-634 also contribute to the mitotic checkpoint signaling.

272 ins (NTD and CTD) of MAD1 also contribute to mitotic checkpoint signaling.

273 PS1 kinase, providing critical insights into mitotic checkpoint signaling.

274 dual mechanisms through which Bub3 promotes mitotic checkpoint signaling.

275 urvival despite continued centromere-derived mitotic checkpoint signalling.

276 thus sequentially integrates DNA damage and mitotic checkpoint signals to decide cell fate in respon

277 merization and MAD2 binding to p31(comet), a mitotic checkpoint silencing protein.

278 We suggest that premature mitotic checkpoint silencing triggered by TRIP13 overexp

279 ce with TRIP13 abolished p31(comet)-mediated mitotic checkpoint silencing.

280 reported that TRIP13 AAA-ATPase binds to the mitotic checkpoint-silencing protein p31(comet).

281 These results suggest that TRIP13 is a novel mitotic checkpoint-silencing protein.

282 Here we show that Cdk1 inactivation disables mitotic checkpoint surveillance at anaphase onset in hum

283 The mitotic checkpoint system delays anaphase until all chro

284 The mitotic checkpoint system prevents premature separation

285 ontributes to the inhibition of APC/C by the mitotic checkpoint system.

286 The mitotic checkpoint targets Cdc20, the specificity factor

287 lian SNM1 has been shown to be required in a mitotic checkpoint that causes arrest of cells in propha

288 etochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway

289 e localization of MPS1 and essential for the mitotic checkpoint, the predominant kinetochore binding

290 A compromised mitotic checkpoint, the primary mechanism for ensuring t

291 Premature anaphase onset is prevented by the mitotic checkpoint through production of a "wait anaphas

292 a suggest that HCV infection may inhibit the mitotic checkpoint to induce polyploidy, which likely co

293 inetochores is important for a full-strength mitotic checkpoint to prevent single chromosome loss.

294 otic cells employ a suite of replication and mitotic checkpoints to ensure the accurate transmission

295 ogates the engagement and maintenance of the mitotic checkpoint upon microtubule depolymerization.

296 system from Xenopus eggs that reproduces the mitotic checkpoint, we show that MCC can be assembled in

297 axel-treated cells in mitosis, we envision a mitotic checkpoint wherein p53-dependent activation of S

298 hores are also the signal generators for the mitotic checkpoint, which arrests mitosis until all kine

299 hat is important for the control of an early mitotic checkpoint, which delays entry into metaphase in

300 hat tumor evolution selects for a permissive mitotic checkpoint, which may promote survival despite c