ライフサイエンスコーパス: mitotic chromosome

1 lls, a fraction of separase localizes to the mitotic chromosome.

2 ts with spindle checkpoint signaling on each mitotic chromosome.

3 ET in spatial proximity to and far away from mitotic chromosomes.

4 tubule attachments formed at kinetochores of mitotic chromosomes.

5 l LANA binds TR DNA and also associates with mitotic chromosomes.

6 mentally increasing the levels of cohesin on mitotic chromosomes.

7 on of the kinase to the centromere region of mitotic chromosomes.

8 e it has never been observed directly within mitotic chromosomes.

9 mately 4,000 proteins identified in isolated mitotic chromosomes.

10 vent resulted in the removal of PR-Set7 from mitotic chromosomes.

11 ith gene promoters packaged within condensed mitotic chromosomes.

12 een lasers are used to induce alterations in mitotic chromosomes.

13 n-mediated compaction to fold chromatin into mitotic chromosomes.

14 topological organization of chromatin inside mitotic chromosomes.

15 constraints on chromatin, ATP alone relaxes mitotic chromosomes.

16 processes occur only in the vicinity of the mitotic chromosomes.

17 al chromatin polymers, megabase domains, and mitotic chromosomes.

18 and increased SRp20 and ASF/SF2 retention on mitotic chromosomes.

19 transcription, and the assembly of condensed mitotic chromosomes.

20 ecessary and sufficient for interaction with mitotic chromosomes.

21 lex is a major constituent of interphase and mitotic chromosomes.

22 l imaging indicated that they are present in mitotic chromosomes.

23 rotein targets the short arms of acrocentric mitotic chromosomes.

24 a novel interaction with specific regions of mitotic chromosomes.

25 f-associates to specifically bind TR DNA and mitotic chromosomes.

26 Widerborst subunit led to scattering of all mitotic chromosomes.

27 rus type 1 E2 and viral genomes to host cell mitotic chromosomes.

28 8 decorated the inter-chromatid axial DNA on mitotic chromosomes.

29 viruses (HPV) for anchoring viral genomes to mitotic chromosomes.

30 s appear to bind to more specific regions of mitotic chromosomes.

31 tion is insufficient for E2 association with mitotic chromosomes.

32 illomavirus type 1 links the viral genome to mitotic chromosomes.

33 lR1 significantly reduced E2 localization to mitotic chromosomes.

34 tion with LANA and the KSHV episomes on host mitotic chromosomes.

35 is interaction to efficiently associate with mitotic chromosomes.

36 e arms as well as the centromeric regions of mitotic chromosomes.

37 n (LANA) mediates viral genome attachment to mitotic chromosomes.

38 and correspondingly does not associate with mitotic chromosomes.

39 teins AKAP95 and HA95, which are targeted to mitotic chromosomes.

40 he BPV1 E2 protein has been shown to bind to mitotic chromosomes.

41 DNA, either HPV-16 or -31, is displaced from mitotic chromosomes.

42 cient for association of the E2 protein with mitotic chromosomes.

43 osomal genomes by tethering them to cellular mitotic chromosomes.

44 mediate the association between BPV1 E2 and mitotic chromosomes.

45 uorescence on both spread and directly fixed mitotic chromosomes.

46 e tested for their ability to associate with mitotic chromosomes.

47 ll as to the motions of organelles including mitotic chromosomes.

48 ompetent in these functions were attached to mitotic chromosomes.

49 nus of p12 is required for tethering to host mitotic chromosomes.

50 ture of the interaction of this complex with mitotic chromosomes.

51 ochore proteins CENP-A, CENP-C, and NDC80 to mitotic chromosomes.

52 TFs we tested are significantly enriched on mitotic chromosomes.

53 s ratio is a critical determinant in shaping mitotic chromosomes.

54 independent and cooperative roles in folding mitotic chromosomes.

55 e that alters the ratio of condensin I:II on mitotic chromosomes.

56 d from the TGN, followed by association with mitotic chromosomes.

57 ions in homeodomain lose the ability to bind mitotic chromosomes.

58 tion and axial contraction to properly shape mitotic chromosomes.

59 P-D3 acts to limit condensin II binding onto mitotic chromosomes.

60 nsin II play non-redundant roles controlling mitotic chromosomes.

61 ensin complex plays a key role in organizing mitotic chromosomes.

62 n complex, a key component of interphase and mitotic chromosomes.

63 ic chromosomes, Cbx2 overwhelmingly binds to mitotic chromosomes.

64 nd Cbx2 is needed to recruit PRC1 complex to mitotic chromosomes.

65 s no effect on the immobilization of Cbx2 on mitotic chromosomes.

66 G2 and M-phase is truly required for shaping mitotic chromosomes.

67 ther Cbx-family proteins dynamically bind to mitotic chromosomes.

68 proteins had weaker association to condensed mitotic chromosomes.

69 to 120- and 300- to 700-nanometer fibers and mitotic chromosomes.

70 ammalian cells reduces RCC1 association with mitotic chromosomes.

71 region did not independently associate with mitotic chromosomes.

72 itosis and is necessary for the formation of mitotic chromosomes.

73 egions of the domain that mediate binding to mitotic chromosomes, a panel of mutations has been gener

74 Duplicated mitotic chromosomes aligned at the metaphase plate maint

75 Astrin/SKAP complex plays important roles in mitotic chromosome alignment and centrosome integrity, b

76 hronic inhibition of DRP1, causes defects in mitotic chromosome alignment and S-phase entry character

77 ave roles in interphase nuclear positioning, mitotic chromosome alignment, and nuclear migration duri

78 nanoscopic imaging of interphase nuclei and mitotic chromosomes, allowing a quantitative analysis of

79 d identified bromodomain protein Brd4 as the mitotic chromosome anchor for the bovine papillomavirus

80 nted microtubules (MTs) self-organize around mitotic chromosomes and assemble anastral spindles.

81 on of chromatin in mitosis that form compact mitotic chromosomes and ensure the fidelity of chromosom

82 The ZmSGO1 protein is not found on mitotic chromosomes and has no obvious mitotic function.

83 The spatial organization of mitotic chromosomes and how condensin shapes chromatin a

84 we found that PICH is modified by SUMO2/3 on mitotic chromosomes and in vitro.

85 PIAS family members in its capacity to bind mitotic chromosomes and recruit Ubc9 onto chromatin.

86 t topoisomerase II is the major component of mitotic chromosomes and remain attached to the chromosom

87 r loading the papillomavirus E2 protein onto mitotic chromosomes and represents a kinetochore-indepen

88 dividing cells are noncovalent passengers on mitotic chromosomes and require specific viral-encoded a

89 nstable interactions between kinetochores of mitotic chromosomes and spindle microtubules.

90 protein for the carboxyl terminus of LANA on mitotic chromosomes and suggest distinct functional role

91 fold for the efficient assembly of condensed mitotic chromosomes and that tethering of chromosomal ar

92 act sequentially to initiate the assembly of mitotic chromosomes and that their specialized distribut

93 n domain is crucial for its interaction with mitotic chromosomes and that this association can be mod

94 the molecular mechanism of PAX3s loading on mitotic chromosomes and the importance of this localizat

95 nal LANA binds histones H2A/H2B to attach to mitotic chromosomes, and C-terminal LANA binds TR DNA an

96 ckles, constitutive heterochromatin domains, mitotic chromosomes, and extrachromosomal regions of mit

97 in tethering LANA/viral episomes to the host mitotic chromosomes, and LANA chromosome-binding sites a

98 m both HPV and animal papillomavirus bind to mitotic chromosomes, and there are variations in the spe

99 of transcription, contributes to cytological mitotic chromosome appearance or 'condensation'.

100 Linker histone H1 is required for mitotic chromosome architecture in Xenopus laevis egg ex

101 enhances the ability of somatic H1 to rescue mitotic chromosome architecture.

102 opically folded "chromatin network" model of mitotic chromosome architecture.

103 he condensin complex is a key determinant of mitotic chromosome architecture.

104 Mitotic chromosomes are among the most recognizable stru

105 Kinetochores of mitotic chromosomes are coupled to spindle microtubules

106 Mitotic chromosomes are hypercondensed in length, but di

107 rotein complexes that play a central role in mitotic chromosome assembly and segregation.

108 Mitotic chromosome assembly remains a big mystery in bio

109 lation of centromere, kinetochore, and other mitotic chromosome-associated proteins is essential for

110 by electrophoretic mobility shift assay, and mitotic chromosome association, indicating that distinct

111 f the transactivation domain responsible for mitotic chromosome association.

112 is interaction is epigenetically retained on mitotic chromosomes at nucleolar organizing regions.

113 8 family member Kif18A is essential to align mitotic chromosomes at the spindle equator during cell d

114 ase, results in a dramatic shortening of the mitotic chromosome axis, and leads to abnormal INCENP lo

115 Cdk1 controls many aspects of mitotic chromosome behavior and spindle microtubule (MT)

116 d Sbf "antiphosphatase" resulted in aberrant mitotic chromosome behavior.

117 Mitotic chromosome binding activity was found to correla

118 The mutated E2 proteins were assessed for mitotic chromosome binding and, in addition, transcripti

119 residues within this motif are required for mitotic chromosome binding.

120 iate self-interaction, completely eliminated mitotic chromosome binding.

121 tion and found markedly different extents of mitotic chromosome binding.

122 factor FoxA1 exhibits the greatest extent of mitotic chromosome binding.

123 nal amino acid sequences that are similar to mitotic chromosome-binding sequences in the transcriptio

124 er transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable ge

125 DNA and to interact with Brd4 and mammalian mitotic chromosomes but did not require its replication

126 PARP1 was robustly conjugated to SUMO-2/3 on mitotic chromosomes but not on interphase chromatin.

127 to KSHV LANA, mLANA broadly associated with mitotic chromosomes but relocalized to concentrated dots

128 thesized to guide directional instability of mitotic chromosomes, but a direct link has never been es

129 functional within Arabidopsis centromeres of mitotic chromosomes, but cannot be loaded onto centromer

130 3 serine 10 phosphorylation is a hallmark of mitotic chromosomes, but its full function remains to be

131 matin, are released from hyperphosphorylated mitotic chromosomes, but reassociate with chromatin late

132 lian bromodomain protein Brd4 interacts with mitotic chromosomes by binding to acetylated histone H3

133 aintained in dividing cells by attachment to mitotic chromosomes by means of the E2 protein.

134 nodepletion of Nap1 decreased H1M binding to mitotic chromosomes by nearly 50%, reduced H1M dynamics

135 topoisomerase IIalpha contributed to shaping mitotic chromosomes by promoting the shortening of the c

136 or the regulation of TopoIIalpha activity on mitotic chromosomes by SUMOylation.

137 o the nuclear periphery, (b) condensation of mitotic chromosomes, (c) nucleolar morphology, and (d) t

138 Here, we report that mitotic chromosomes can acquire DNA breaks during both p

139 ibit variable capacities of association with mitotic chromosomes, Cbx2 overwhelmingly binds to mitoti

140 , which we term 3D-CLEM, to model the entire mitotic chromosome complement at ultra-structural resolu

141 hat is associated with a subsequent delay in mitotic chromosome condensation (DMC).

142 ing (DRT) that is associated with a delay in mitotic chromosome condensation (DMC).

143 ease mechanism for microcephaly, implicating mitotic chromosome condensation as a key process ensurin

144 Remarkably, defective mitotic chromosome condensation by a condensin mutation,

145 taining delay in replication timing/delay in mitotic chromosome condensation chromosomes frequently d

146 ls with delay in replication timing/delay in mitotic chromosome condensation chromosomes that persist

147 ls with delay in replication timing/delay in mitotic chromosome condensation display chromosomal inst

148 omosome conformation capture (Hi-C) to study mitotic chromosome condensation in the fission yeast Sch

149 ng that delay in replication timing/delay in mitotic chromosome condensation is associated with aneup

150 Mitotic chromosome condensation is chiefly driven by the

151 The mechanism of mitotic chromosome condensation is poorly understood, bu

152 es with delay in replication timing/delay in mitotic chromosome condensation participate in frequent

153 hat the delay in replication timing/delay in mitotic chromosome condensation phenotype occurs predomi

154 ith the delay in replication timing/delay in mitotic chromosome condensation phenotype, and that the

155 Mitotic chromosome condensation, sister chromatid cohesi

156 ed for a poorly understood cellular function-mitotic chromosome condensation-and experimentally valid

157 condensin action and to propose a model for mitotic chromosome condensation.

158 at G(2)/M, massive DNA damage, and improper mitotic chromosome condensation.

159 , cessation of transcription is coupled with mitotic chromosome condensation.

160 n that may be the consequence of problems in mitotic chromosome condensation.

161 on timing that is associated with a delay in mitotic chromosome condensation.

162 isplays delay in replication timing/delay in mitotic chromosome condensation.

163 sruption with pharmacological agents and for mitotic chromosome congression.

164 l loss of CENP-A protein resulted in shorter mitotic chromosomes, consistent with a role in setting c

165 ore than 33% of the protein mass of isolated mitotic chromosomes determined by quantitative proteomic

166 tid cohesion, a key architectural feature of mitotic chromosomes, display surprising flexibility.

167 ation is pivotal for accurate segregation of mitotic chromosomes during cell division.

168 K1 as a key regulator of NE architecture and mitotic chromosome dynamics in mammalian cells.

169 protein and BPV1 genomes are associated with mitotic chromosomes; E2 links the genomes to cellular ch

170 opoisomerase (topo) II is observed to reduce mitotic chromosome elastic stiffness.

171 of diffuse interphase chromatin into stable mitotic chromosomes enables the segregation of replicate

172 Topo-II localized to the perimeter of mitotic chromosomes, excluded from the centromere region

173 e-replication complex assembly by binding to mitotic chromosomes, followed by gradual removal from ch

174 e the tethering of viral genomes to the host mitotic chromosomes for persistence of viral episomes in

175 Mitotic chromosome formation involves a relatively minor

176 Together, our data challenge the view that mitotic chromosome formation is an invariant process dur

177 hether topo IIbeta makes any contribution to mitotic chromosome formation.

178 ogy and structure of both the interphase and mitotic chromosomes from effective energy landscapes con

179 e protein have been used to distinguish real mitotic chromosome functions of topo IIalpha from its mo

180 These observations argue that budding yeast mitotic chromosomes have an intrinsic, geometric bias to

181 ions by tethering papillomavirus episomes to mitotic chromosomes; however, the mechanism remains unre

182 ach, they assayed the protein composition of mitotic chromosomes, identifying 4029 associated protein

183 y placing a high RanGTP concentration on the mitotic chromosome in mammalian cells.

184 all maintained the ability to associate with mitotic chromosomes in a wild-type fashion and to bind T

185 As expected, the LANA mutants bound mitotic chromosomes in a wild-type pattern and also boun

186 in concentrates at the kinetochore region of mitotic chromosomes in animals to accelerate spindle mic

187 4-CTD expression released the viral DNA from mitotic chromosomes in BPV-1 transformed cells.

188 ive patch mutants concentrated to dots along mitotic chromosomes in cells containing episomes, simila

189 e the E2 protein tethers the viral genome to mitotic chromosomes in complex with the cellular bromodo

190 irus E2 protein tethers the viral genomes to mitotic chromosomes in dividing cells through binding to

191 serves to tether E2 and the viral genomes to mitotic chromosomes in dividing cells, thus ensuring vir

192 for binding of the C-terminal half of Nod to mitotic chromosomes in embryos.

193 Our findings indicate that mitotic chromosomes in general and ribosomal genes in pa

194 hromatid resolution and cohesin release from mitotic chromosomes in human cells and Xenopus egg extra

195 on in vitro, it is largely excluded from the mitotic chromosomes in KSHV-uninfected cells and is part

196 membrane ruffles, intracellular vesicles and mitotic chromosomes in live cells, the microscope curren

197 is necessary for RCC1 to generate RanGTP on mitotic chromosomes in mammalian cells, which in turn is

198 FISH) probes that could differentially label mitotic chromosomes in root tip preparations.

199 ones and has been observed to diffusely coat mitotic chromosomes in several cell types.

200 racting proteins are also found localized to mitotic chromosomes in the presence of Z.

201 nscriptional regulatory microenvironments in mitotic chromosomes in which the genes bookmarked for re

202 eins bind to pericentromeric regions of host mitotic chromosomes, including the ribosomal DNA loci.

203 of papillomavirus E2 proteins associate with mitotic chromosomes independently of Brd4 binding.

204 xCep57 inhibition on isolated mitotic chromosomes inhibits kinetochore-microtubule bin

205 s, E2-mediated tethering of viral genomes to mitotic chromosomes is a common strategy of papillomavir

206 The presence of mitotic chromosomes is additionally required and involve

207 We find that RNA associated with mitotic chromosomes is concentrated at pericentric heter

208 The size of mitotic chromosomes is coordinated with cell size in a m

209 The recruitment of Cbx2 to mitotic chromosomes is independent of PRC1 or PRC2, and

210 Deposition onto mitotic chromosomes is L2-mediated.

211 equired to convert interphase chromatin into mitotic chromosomes is limited.

212 in was not required for binding to condensed mitotic chromosomes, its deletion subtly affected the nu

213 across the genome and the proper assembly of mitotic chromosomes, leading to severe defects in chromo

214 Mutant PAX3 proteins that lose mitotic chromosome localization block cell proliferation

215 itotic progression, mitotic orientation, and mitotic chromosome localization in cortical progenitors

216 spore colonies had very high frequencies of mitotic chromosome loss, resulting in genetically divers

217 The association between Z and mitotic chromosomes may lead to the sequestering of Z-in

218 Mitotic chromosome misalignment and micronuclei formatio

219 mal expansion of the primary constriction of mitotic chromosomes, mislocalization and destabilization

220 ts that integrate inputs from DSB repair and mitotic chromosome morphogenesis into the complete meiot

221 Mammalian mitotic chromosome morphogenesis was analyzed by 4D live

222 r determinants in shaping the characteristic mitotic chromosome morphology.

223 Mitotic chromosome motions are driven by microtubules (M

224 ell division is associated with disorganized mitotic chromosome movements and chromosome loss.

225 d-bearing microtubule attachments that drive mitotic chromosome movements.

226 ins that could dimerize were able to bind to mitotic chromosomes much more efficiently than monomeric

227 Mitotic chromosomes must be organised into a highly orde

228 In eukaryotes, many latent viruses attach to mitotic chromosomes noncovalently for effective partitio

229 , the causes and consequences of spontaneous mitotic chromosome nondisjunction in human cells are not

230 cell cycle-dependent genome organization and mitotic chromosome organization to support faithful chro

231 are essential protein complexes critical for mitotic chromosome organization.

232 eviously, we showed that Ki-67 organizes the mitotic chromosome periphery and recruits protein phosph

233 kinetochore microtubule dynamics to control mitotic chromosome positioning.

234 ty of chromatin-constraining elements in the mitotic chromosome, providing evidence consistent with a

235 revious study that identified Brd4 as the E2 mitotic chromosome receptor to show that Brd4-CTD expres

236 Moreover, loading of PAX3 on mitotic chromosomes requires arginine methylation, which

237 The initial binding of Orc1 to mitotic chromosomes requires C-terminal amino acid seque

238 Further analysis of mitotic chromosomes revealed that PICH localized to the

239 A proteomic analysis of mitotic chromosome scaffolds led to the identification o

240 Mitotic chromosomes segregate at the ends of shortening

241 ogramming, sequential cleavage divisions and mitotic chromosome segregation and embryonic genome acti

242 ther expand Mps1's significance for faithful mitotic chromosome segregation and emphasize the importa

243 tin at centromeres, together with defects in mitotic chromosome segregation and telomere clustering.

244 kinetochore-dependent mechanisms that drive mitotic chromosome segregation are well understood, in o

245 ) resulted in virtually identical defects in mitotic chromosome segregation characterized by a failur

246 Accurate mitotic chromosome segregation depends on the formation

247 ments, both of which can be facilitated by a mitotic chromosome segregation error to produce a micron

248 Here we show that treatment with IR leads to mitotic chromosome segregation errors in vivo and long-l

249 e we identify a mechanism by which errors in mitotic chromosome segregation generate DNA breaks via t

250 Mitotic chromosome segregation is facilitated by the coh

251 Mitotic chromosome segregation requires that kinetochore

252 contribute to sister chromatid cohesion and mitotic chromosome segregation through splicing of soror

253 It is now known that IAPs are involved in mitotic chromosome segregation, cellular morphogenesis,

254 These include chromatin remodeling, mitotic chromosome segregation, protein homeostasis, and

255 egg extracts and plays an essential role in mitotic chromosome segregation.

256 rucial roles in homologous recombination and mitotic chromosome segregation.

257 but is dispensable for cytokinesis following mitotic chromosome segregation.

258 , TLK-1 and AIR-2 cooperate to ensure proper mitotic chromosome segregation.

259 ponse, DNA repair, chromatin regulation, and mitotic chromosome segregation.

260 st to the random association of BPV1 E2 with mitotic chromosomes, several of these proteins appear to

261 element families were used as FISH probes on mitotic chromosome spreads from a "trispecies" hybrid co

262 We demonstrated by immunostaining of mitotic chromosome spreads of preimplantation embryos th

263 Despite many decades of study, mitotic chromosome structure and composition remain poor

264 Mitotic chromosome structure and pathways of mitotic con

265 Current models of mitotic chromosome structure are based largely on the ex

266 elopment and provide evidence that defective mitotic chromosome structure can promote tumorigenesis.

267 Mitotic chromosome structure is pivotal to cell division

268 The limited amount of structural data on mitotic chromosome structure makes it impossible to dist

269 is study identifies an activity critical for mitotic chromosome structure that is inactivated by Repo

270 he role of condensin I in the maintenance of mitotic chromosome structure with unprecedented temporal

271 previous studies of effects of nucleases on mitotic chromosome structure, indicate that mild proteol

272 with a topoisomerase II mutant, defective in mitotic chromosome structure, is also due to the retenti

273 hromatid disentanglement, and maintenance of mitotic chromosome structure.

274 ies that a select set of TFs remain bound on mitotic chromosomes suggest a potential mechanism for ma

275 tone H3, causes retention of HP1 proteins on mitotic chromosomes, suggesting that H3 serine 10 phosph

276 of PARP1 alter the accumulation of PARP1 on mitotic chromosomes, suggesting that SUMOylation regulat

277 While many nuclear factors dissociate from mitotic chromosomes, the observation that certain nuclea

278 e geometrically uniform folding of eukaryote mitotic chromosomes, through extrusion of pre-programmed

279 Brd4 associates with mitotic chromosomes throughout mitosis and demonstrates

280 nomes to daughter cells by tethering them to mitotic chromosomes, thus ensuring equal distribution an

281 rus E2 protein tethers viral genomes to host mitotic chromosomes to ensure genome maintenance.

282 tein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term main

283 al papillomaviruses link the viral genome to mitotic chromosomes to ensure retention and the efficien

284 ein that tethers terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence in di

285 A) tethers viral terminal repeat (TR) DNA to mitotic chromosomes to mediate episome persistence.

286 LANA also simultaneously binds to TR DNA and mitotic chromosomes to mediate the segregation of episom

287 -terminal regions of LANA tether episomes to mitotic chromosomes to segregate episomes to progeny cel

288 rogate the colocalization of E2 with Brd4 on mitotic chromosomes, to block association of the viral e

289 n addition forms numerous foci/aggregates on mitotic chromosomes upon DNA damage.

290 Here, we found that PAX3 loads on mitotic chromosomes using its homeodomain.

291 ine papillomavirus type 1 is tethered to the mitotic chromosomes via the cellular protein Brd4.

292 lar pattern of E2 and Brd4 colocalization on mitotic chromosomes was observed in CV-1 cells, whereas

293 Within the condensed mitotic chromosomes we find that Runx2 is retained in la

294 in, which tethers the viral episomes to host mitotic chromosomes, we examined whether KSHV LANA inter

295 Mitotic chromosomes were one of the first cell biologica

296 nd in highly proliferative cells showed that mitotic chromosomes were surrounded by steep Ran guanosi

297 ex is recruited to the kinetochore region of mitotic chromosomes, where it initiates spindle checkpoi

298 l18, and Phc1 proteins become immobilized at mitotic chromosomes, whereas other Cbx-family proteins d

299 nus of Cbx2 is needed for its recruitment to mitotic chromosomes, whereas the C-terminus is required

300 LANA binds histones H2A and H2B to attach to mitotic chromosomes, while the C-terminal region binds T