ライフサイエンスコーパス: mitotic exit

1 nism of SAC inactivation required for timely mitotic exit.

2 wl with a phosphomimetic S883E mutant blocks mitotic exit.

3 erior to the furrow to ensure properly timed mitotic exit.

4 domain of ectopic furrowing when forced into mitotic exit.

5 ited a delay in mitotic entry and an earlier mitotic exit.

6 pling moesin-dependent cell shape changes to mitotic exit.

7 es Cdk1 phosphorylation and is important for mitotic exit.

8 On the other hand, nuclear Cdc55 prevents mitotic exit.

9 ient Mcm proteins loading on chromatin after mitotic exit.

10 et and regulates chromosome structure during mitotic exit.

11 the major mitotic regulator Cdk1/Cyclin B or mitotic exit.

12 osome segregation with spindle breakdown and mitotic exit.

13 h plays important roles in mitotic entry and mitotic exit.

14 Cdc14a nor Cdc14b seems to be essential for mitotic exit.

15 vents of nuclear envelope reformation during mitotic exit.

16 Zds1/Zds2 inhibit Cdc55-PP2A function during mitotic exit.

17 anaphase, an event closely coordinated with mitotic exit.

18 nuclear envelope integrity during anaphase B/mitotic exit.

19 Thus p31(comet) is required for timely mitotic exit.

20 educes the length of mitosis and accelerates mitotic exit.

21 signals are diluted, resulting in premature mitotic exit.

22 vation of Cdc25C and PLK1, leading to faster mitotic exit.

23 on and is then progressively degraded during mitotic exit.

24 ase reverses Cdk1 phosphorylation to promote mitotic exit.

25 lerates transcription reactivation following mitotic exit.

26 t other phosphatase(s) are also required for mitotic exit.

27 r known mechanism that turns off Cdk1 during mitotic exit.

28 metaphase to allow timely anaphase onset and mitotic exit.

29 mitotic progression and coordinate efficient mitotic exit.

30 served in interphase is reestablished during mitotic exit.

31 migrated to the spindle equator, leading to mitotic exit.

32 contribute to timely Cdc14 activation during mitotic exit.

33 speeding progression through G1/S as well as mitotic exit.

34 on of Chk1 activity with UCN-01 also reduced mitotic exit.

35 cessing complex componentl(2)NC136during the mitotic exit.

36 required for sister-chromatid separation or mitotic exit.

37 ulture cells, high in mitosis and low during mitotic exit.

38 icrotubule-cortex interactions with Lte1 and mitotic exit.

39 B, thus promoting the onset of anaphase and mitotic exit.

40 Ki-67 and RepoMan have key roles during mitotic exit.

41 , suggesting a role of securin in preventing mitotic exit.

42 on of separase and the onset of anaphase and mitotic exit.

43 ly of Cdc5, a Polo-like kinase essential for mitotic exit.

44 s, and appears to be involved in controlling mitotic exit.

45 nly transiently present at centromeres after mitotic exit.

46 during mitosis and rapidly eliminated during mitotic exit.

47 strates and assigned their temporal order in mitotic exit.

48 n of Bub1 by APC/C(Cdh1) is not required for mitotic exit.

49 ion in coordinating nuclear segregation with mitotic exit.

50 the precursors for TAG, in the mutant during mitotic exit.

51 affold to which dispersed Nups return during mitotic exit.

52 ion, and incomplete cytokinesis upon delayed mitotic exit.

53 g in mitosis and dropping drastically during mitotic exit.

54 ng yeast associates with kinases involved in mitotic exit.

55 re-sensitive mutants that display defects in mitotic exit.

56 both Clb2p and Clb4p must be degraded before mitotic exit.

57 ependent of the known negative regulators of mitotic exit.

58 important mechanism of Cdk1p inhibition and mitotic exit.

59 nase with anaphase onset, a prerequisite for mitotic exit.

60 e show that Cdc55 is a negative regulator of mitotic exit.

61 ulated, peaking at G2/M and declining before mitotic exit.

62 ting complex/cyclosome (APC) is critical for mitotic exit.

63 to direct NE recruitment of ESCRT-III during mitotic exit.

64 mapping of transcription during mitosis and mitotic exit.

65 death or senescence is often triggered after mitotic exit.

66 ase that controls chromosome segregation and mitotic exit.

67 activation and other events occurring during mitotic exit.

68 tosis and shuttles to the midzone spindle at mitotic exit.

69 ity must subsequently be restored to promote mitotic exit.

70 B1, thereby causing inactivation of Cdk1 and mitotic exit.

71 loading of CENP-A to the centromere prior to mitotic exit.

72 promoting complex/cyclosome (APC/C) controls mitotic exit.

73 ved by a proteasome-dependent process during mitotic exit.

74 n of attachment monitoring mechanisms during mitotic exit.

75 tes cyclin-dependent kinase 1 (Cdk1) causing mitotic exit.

76 lerated cyclin B1 degradation during induced mitotic exit.

77 osomes, thereby enhancing anaphase onset and mitotic exit.

78 ant, but not wild-type PTEN, caused enhanced mitotic exit.

79 s silenced during mitosis and reactivated at mitotic exit.

80 after mitotic entry and before commitment to mitotic exit.

81 ition checkpoint (SPOC) component to inhibit mitotic exit.

82 ant accumulation of chromatin PTEN, delaying mitotic exit.

83 This creates two cyclin B thresholds during mitotic exit.

84 oval of SS18 and its replacement by CREST at mitotic exit.

85 enable gene expression reestablishment upon mitotic exit.

86 d coordinated daughter cell spreading during mitotic exit.

87 sembly upon mitotic entry and disassembly at mitotic exit.

88 n the reforming nuclear envelope (NE) during mitotic exit [2, 3].

89 budding yeast to prevent anaphase entry and mitotic exit, allowing cells more time to repair damaged

90 Here, we show that mitotic exit also activates pathways that catalyze inhib

91 in HEK293 cells causes cell cycle arrest at mitotic exit and apoptotic cell death.

92 tingly, up-regulation of PPP1R3B facilitates mitotic exit and blocks mitotic entry.

93 y of checkpoint inhibitor compounds to drive mitotic exit and cause cells to flatten onto the substra

94 disengagement at anaphase is independent of mitotic exit and Cdk2/cyclin E activity, but requires th

95 er of Cdk substrate dephosphorylation during mitotic exit and contribute to roles in other cellular p

96 sphatases play a conserved role in promoting mitotic exit and cytokinesis by dephosphorylating substr

97 Cdc14 is a phosphatase that controls mitotic exit and cytokinesis in budding yeast.

98 d to regulate DNA damage repair, whereas the mitotic exit and cytokinesis rely on another phosphatase

99 Completion of mitotic exit and cytokinesis requires the inactivation o

100 me segregation and/or spindle integrity with mitotic exit and cytokinesis via regulation of chromosom

101 ivision requires strict coordination between mitotic exit and cytokinesis.

102 y APC/C(Cdh1) participates in the control of mitotic exit and cytokinesis.

103 in B, Cdk inhibitors will nonetheless induce mitotic exit and cytokinesis.

104 central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis.

105 nsition and during anaphase but drops during mitotic exit and cytokinesis.

106 al regulation of microtubule function during mitotic exit and cytokinesis.

107 arase blocked centriole disengagement during mitotic exit and delayed assembly of new centrioles duri

108 on of cyclin destruction and interferes with mitotic exit and DNA replication.

109 ization of DELLAs, which are responsible for mitotic exit and earlier onset of endoreduplication.

110 ssembly machinery in an inactive state until mitotic exit and entry into G1, at which time new CENP-A

111 o pulse-label transcripts during mitosis and mitotic exit and found that many genes exhibit transcrip

112 complex/cyclosome (APC/C) and contributes to mitotic exit and G1 maintenance by facilitating the poly

113 uitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-c

114 APC/C(Cdh1) becomes active during mitotic exit and has essential targets in G1 phase.

115 During mitotic exit and interphase, the mitochondrial network r

116 he cohesin complex binds to chromatin during mitotic exit and is converted to a functional form durin

117 rtially prevented kinetochore disassembly at mitotic exit and led to chromosome segregation defects i

118 Mitotic exit and onset of endoreduplication do not corre

119 tion of mitotic progression: it both induces mitotic exit and prevents polarized growth during mitoti

120 machinery, our data support its dual role in mitotic exit and promotion of NHEJ repair in yeast and m

121 factors and centrosome-based regulations in mitotic exit and SPOC control.

122 is a physiological substrate of APC/C during mitotic exit and that a tight regulation of the CKAP2 pr

123 Here we show that Bub1 is degraded during mitotic exit and that degradation of Bub1 is mediated by

124 ols the degradation of substrate proteins at mitotic exit and throughout the G1 phase.

125 ephosphorylates threonine-161 of CDC2 during mitotic exit and we visualize CDC2(pThr-161) at kinetoch

126 RPA2 kinase) also were severely defective in mitotic exit and were unable to support RPA hyperphospho

127 nique dual inhibition profile targeting TTK (mitotic exit) and CLK2 (mRNA splicing).

128 -B is associated with aneuploidy, incomplete mitotic exit, and cell death.

129 cycle processes, including spindle assembly, mitotic exit, and cytokinesis, but the full range of its

130 ion of mitotic entry, spindle pole assembly, mitotic exit, and cytokinesis.

131 tion, mitotic entry, chromosome segregation, mitotic exit, and cytokinesis.

132 crotubule array or ectopic furrows following mitotic exit, and recruitment of Aurora B kinase, male g

133 operate to precisely position the CPC during mitotic exit, and that these pathways converge to ensure

134 s exposed to microtubule poisons facilitated mitotic exit, and this activity required MOB1A.

135 potential mechanisms whereby RACK1 regulates mitotic exit are identified: suppression of Src-mediated

136 Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin liga

137 the mitotic checkpoint but disappears during mitotic exit at a rate of 31 pM/s.

138 ome deposition occurs in early G1 just after mitotic exit at the time when the CENP-A deposition mach

139 After mitotic exit, BAF53a is replaced by BAF53b, and BAF45a b

140 es not seem to result simply from a delay in mitotic exit, because overexpression of a nondegradable

141 Mitotic exit becomes irreversible only after longer peri

142 C(C) (dh1) ubiquitin ligase mainly regulates mitotic exit but is also implicated in the DNA damage-in

143 destruction of many APC/C substrates during mitotic exit but strongly and specifically stabilize Aur

144 dent kinase (Cdk), is thought to bring about mitotic exit, but how temporal ordering of mitotic exit

145 destruction schedule of cyclin types guides mitotic exit by affecting both Cdk1 and APC/C, whose act

146 cluding Mad2, and the other to inhibition of mitotic exit by Bub2.

147 Cdc14p mediates mitotic exit by dephosphorylating Cdk1p substrates and p

148 Rad53 prevents mitotic exit by inhibiting the MEN pathway, whereas the

149 However, precocious mitotic exit by mitotic slippage limits the cytotoxicity

150 Cdc20 through kinetochores also accelerates mitotic exit by promoting its dephosphorylation by kinet

151 ally inhibit APC/C-dependent proteolysis and mitotic exit by simultaneously disrupting two protein-pr

152 tiates the metaphase-anaphase transition and mitotic exit by targeting proteins such as securin and c

153 during G(2)/M and is dephosphorylated during mitotic exit by the phosphatase Cdc14A.

154 cyclosome (APC/C) that triggers anaphase and mitotic exit by ubiquitylating securin and cyclin B1.

155 On mitotic exit, centrosomes disassemble producing interpha

156 and its inhibitor, alpha-endosulfine, at the mitotic-exit checkpoint.

157 ities have each been independently linked to mitotic exit control in other eukaryotes.

158 four particularly intriguing features of the mitotic-exit control system and attempt to examine these

159 ty stems in part from the attempt to explain mitotic-exit control using concepts from traditional top

160 These defects are distinct from the mitotic-exit defects caused by stabilization of the mito

161 The DNA damage-induced mitotic exit delay correlates with the inhibition of Cdh

162 loidy and aneuploidy, spindle defects, and a mitotic exit delay.

163 this reversibility decreases with time after mitotic exit despite the continued presence of the cycli

164 Here, we report the presence of a mitotic exit DNA damage checkpoint in mammalian cells.

165 are all delivered to the division site upon mitotic exit even when the AMR is absent.

166 t mitotic exit, but how temporal ordering of mitotic exit events is achieved is poorly understood.

167 ion of Cdk substrates involved in sequential mitotic exit events occurs with ordered timing.

168 body (SPB, centrosome equivalent) to control mitotic exit events.

169 totic budding yeast cells efficiently drives mitotic exit events.

170 formation of an asymmetric Sfi1 filament at mitotic exit followed by Mps1-dependent assembly of a Sp

171 e its importance for temporal control during mitotic exit, how B55 substrates are recognized and diff

172 Failure to down-regulate Cdc42 during mitotic exit impairs the normal localization of key cyto

173 und that EYA1 is efficiently degraded during mitotic exit in a Cdh1-dependent manner and that these t

174 inated by APC/C in vitro and degraded during mitotic exit in a Cdh1-dependent manner in vivo.

175 loss of microtubules from the neck leads to mitotic exit in a majority of checkpoint-activated cells

176 phase of the cell cycle and drop rapidly at mitotic exit in an APC/C- and KEN-box-dependent fashion.

177 events during anaphase and is essential for mitotic exit in budding yeast.

178 he Cdc14 phosphatase, which is essential for mitotic exit in budding yeast.

179 w us to present a new quantitative model for mitotic exit in budding yeast.

180 Cell cycle checkpoints can delay mitotic exit in budding yeast.

181 The phosphatase Cdc14 is required for mitotic exit in budding yeast.

182 Mitotic exit in Chk2-deficient cells correlates with red

183 Mitotic exit in neurons is accompanied by an essential s

184 spindle position checkpoint (SPOC) inhibits mitotic exit in response to mispositioned spindles.

185 cts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae Surprisingly, h

186 ect mitotic spindle position before allowing mitotic exit in the budding yeast Saccharomyces cerevisi

187 (SIN) serves to coordinate cytokinesis with mitotic exit in the fission yeast Schizosaccharomyces po

188 signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe, an

189 Exit from meiosis I is distinct from mitotic exit, in that replication origins are not licens

190 thaliana) and found that stress causes early mitotic exit, in which cells end their mitotic division

191 uces cytokinesis and other normal aspects of mitotic exit, including cyclin B degradation.

192 but have been observed in cells defective in mitotic exit, including the semidominant cdc5-ad mutatio

193 atase required for nucleolar segregation and mitotic exit, inhibits transcription of yeast ribosomal

194 and that the removal of this modification at mitotic exit is a key regulatory event that controls the

195 Because blocking mitotic exit is an effective approach for inducing tumou

196 the budding yeast Saccharomyces cerevisiae, mitotic exit is controlled by the FEAR (for "Cdc-fourtee

197 To prevent genome instability, mitotic exit is delayed until all chromosomes are proper

198 In Saccharomyces cerevisiae, mitotic exit is driven by a protein phosphatase, Cdc14,

199 We determined that this premature mitotic exit is due to defects in spindle assembly check

200 lipids to neutral lipids for storage during mitotic exit is important for proper execution of cytoki

201 gs demonstrate that the unidirectionality of mitotic exit is not the consequence of proteolysis but o

202 associate with segregated kinetochores when mitotic exit is prevented by expression of nondegradable

203 Therefore, temporal order during mitotic exit is promoted by the metazoan BEG pathway.

204 osphatase to kinase ratio over the course of mitotic exit is read out by Cdk substrates that respond

205 The ability of apcin to block mitotic exit is synergistically amplified by co-addition

206 me that counteracts Cdk during budding yeast mitotic exit is the Cdc14 phosphatase.

207 Here, we report that Dbf2, a conserved mitotic exit kinase, localizes to the division site afte

208 ntify Zds1 and Zds2 as new components of the mitotic exit machinery, involved in activation of the Cd

209 A role of LATS1 in mitotic exit may explain its previously described abilit

210 east, three interdigitated pathways regulate mitotic exit (ME): mitotic cyclin-cyclin-dependent kinas

211 aled that these filaments exhibit a delay in mitotic exit mediated by the checkpoint protein Bub2.

212 During mitotic exit, missegregated chromosomes can recruit thei

213 GSY2 and HAP1, and the mediating TF Hap1; a mitotic exit module featuring four cis-linked genes, AMN

214 have shown that Cdc7-Dbf4 also regulates the mitotic exit network (MEN) and monopolar homolog orienta

215 osis conserved signaling pathways termed the mitotic exit network (MEN) and the septation initiation

216 Release of the mitotic exit network (MEN) component, Cdc14p, from the n

217 eolytic function of separase (Esp1); and the mitotic exit network (MEN) driven by interaction between

218 such signal transduction pathway called the mitotic exit network (MEN) governs the transition from m

219 The mitotic exit network (MEN) in S. cerevisiae and its homo

220 The Saccharomyces cerevisiae mitotic exit network (MEN) is a conserved signaling netw

221 The mitotic exit network (MEN) is an essential GTPase signal

222 r "Cdc-fourteen early anaphase release") and mitotic exit network (MEN) pathways.

223 s-like GTPase signaling cascade known as the mitotic exit network (MEN) promotes exit from mitosis.

224 In budding yeast, the Mitotic Exit Network (MEN) releases Cdc14 phosphatase fr

225 The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate c

226 ding yeast, a signaling network known as the mitotic exit network (MEN) triggers exit from mitosis.

227 with mispositioned nuclei by inhibiting the mitotic exit network (MEN), a GTPase signaling cascade t

228 e position and regulates the activity of the mitotic exit network (MEN), a GTPase signaling pathway t

229 The mitotic exit network (MEN), a protein kinase cascade und

230 This checkpoint works by inhibiting the mitotic exit network (MEN), a signaling cascade initiate

231 position and, in budding yeast, inhibits the mitotic exit network (MEN), a signaling pathway that pro

232 Components of the mitotic exit network (MEN), a signaling pathway that tri

233 rtment, cells arrest in anaphase because the mitotic exit network (MEN), an essential Ras-like GTPase

234 his order is ensured in budding yeast by the mitotic exit network (MEN), where Cdc14p dephosphorylate

235 es cerevisiae, Cdc5 kinase is a component of mitotic exit network (MEN), which inactivates cyclin-dep

236 eolus, but successful anaphase activates the mitotic exit network (MEN), which triggers dispersal of

237 d that slowing spindle elongation delays the mitotic exit network (MEN)-dependent release of Cdc14, t

238 Cbk1 cannot phosphorylate Ace2 until after mitotic exit network (MEN)-initiated release of the phos

239 regulator of mitotic exit, sitting atop the mitotic exit network (MEN).

240 14 phosphatase, the ultimate effector of the mitotic exit network (MEN).

241 m mitosis by restraining the activity of the mitotic exit network (MEN).

242 s the Bub2-Bfa1 complex, an inhibitor of the mitotic exit network (MEN).

243 prevent exit from mitosis by inhibiting the mitotic exit network (MEN).

244 Both the mitotic exit network and fourteen early anaphase release

245 acts either downstream or independent of the mitotic exit network kinase Cdc15.

246 The mitotic exit network protein Dbf2p binds to SWI5 and CLB

247 of Bfa1, contributing to activation of the "mitotic exit network" that sustains Cdc14 as Cdk activit

248 FEAR (Cdc14 early anaphase release) and MEN (mitotic exit network) activate phosphatase Cdc14 by prom

249 mutants affecting cyclin degradation and the mitotic exit network, we found that targeted secretion,

250 ing activity of the Saccharomyces cerevisiae mitotic exit network.

251 ion, requires cyclin degradation but not the mitotic exit network.

252 In some cells, however, mitotic exit occurred in the presence of pole-associated

253 HM site phosphorylation prior to mitotic exit occurs in response to activation of the FEA

254 cificity phosphatase plays a key role in the mitotic exit of budding yeast cells.

255 position checkpoint (SPOC) therefore delays mitotic exit of cells with a mispositioned spindle.

256 Nearing mitotic exit of neural progenitors, miR-9* and miR-124 r

257 tokinesis, but this is not due to a delay in mitotic exit or assembly of the contractile ring.

258 Mitotic exit pathways are responsible for the inactivati

259 exus between the DNA damage response and the mitotic exit pathways during cell-cycle progression to p

260 the enzyme that removes O-GlcNAc, induces a mitotic exit phenotype accompanied by a delay in mitotic

261 hese findings not only show how two distinct mitotic exit phosphatases are recruited to their substra

262 Here we show how Ki-67 and RepoMan form mitotic exit phosphatases by recruiting PP1, how they di

263 After CDK1-CyclinB inactivation upon mitotic exit, PLK4 can bind and phosphorylate STIL in G1

264 During mitotic exit, PP1-dependent dephosphorylation of Gwl Ser

265 ivision site with the septin complex and, as mitotic exit progresses, moves to the actomyosin ring (A

266 dition, analysis of spc72 cells shows that a mitotic-exit-promoting dominant signal, which is trigger

267 In mitotic exit, proteins that were highly phosphorylated a

268 Conversely, mitotic exit requires Cdk1 inactivation and reversal of

269 is, whereas Ser-157 dephosphorylation during mitotic exit restores IRP2 RNA-binding activity and repr

270 Closure of this fenestra during anaphase B/mitotic exit returns the cytoplasmic component to the cy

271 ike protein and is the critical regulator of mitotic exit, sitting atop the mitotic exit network (MEN

272 nd Cdc25 that controls the abruptness of the mitotic exit switch.

273 However, if after mitotic exit, the Cdk1 inhibitor is washed free from cel

274 After forced mitotic exit, the cytoskeleton of monopolar mitotic cell

275 cause Cdk1 activity is at its minimum at the mitotic exit, the ratio of Cdk1/PP1alpha activity change

276 cyclin proteolysis to the irreversibility of mitotic exit, the transition from high mitotic Cdk activ

277 During mitotic exit, they reestablish these adhesions and at th

278 At mitotic exit, this rigid cortex must be dismantled to al

279 icating that yeast cells negatively regulate mitotic exit through two distinct pathways in response t

280 yclosome (APC/C) promotes anaphase onset and mitotic exit through ubiquitinating securin and cyclin B

281 mation of the actomyosin contractile ring at mitotic exit, through the local activation of RhoA.

282 tic spindle, segregation of chromosomes, and mitotic exit, thus protecting cells against genetic inst

283 lation in the absence of 14-3-3sigma impairs mitotic exit to generate binucleate cells and provides a

284 We use phosphoproteome analysis of mitotic exit to identify Cdk targets that are dephosphor

285 nal the spindle assembly checkpoint to delay mitotic exit until all chromosomes are attached.

286 the spindle position checkpoint (SPC) delays mitotic exit until the mitotic spindle moves into the ne

287 ositioning errors, relay a signal to inhibit mitotic exit until the spindle is appropriately position

288 for the spindle position checkpoint to delay mitotic exit until the spindle is positioned correctly.

289 associated surveillance mechanism that halts mitotic exit upon spindle mis-orientation.

290 that Cdc14 coordinates cell separation with mitotic exit via FEAR-initiated phosphorylation of the C

291 linkages on the same substrates added during mitotic exit were Cdh1-independent.

292 t of the vertebrate nervous system occurs at mitotic exit when cells lose multipotency and begin to d

293 hosphorylates Aurora B-serine 331 to prevent mitotic exit when most kinetochores are unattached.

294 nteracting machines on chromosomes, restrain mitotic exit when not attached to spindle microtubules b

295 le drugs, Ska3-depleted cells exhibit slower mitotic exit when the spindle checkpoint is silenced by

296 Here we test this hypothesis for mitotic exit, which is regulated by degradation of the c

297 hibition of Aurora kinases, causing abnormal mitotic exit with formation of single cells with aberran

298 n of the MAD2-CDC20 complex, and accelerated mitotic exit with SAC override in the presence of spindl

299 de-induced giant cells revealed a failure in mitotic exit, with the appearance of multinucleated cell

300 ivation allows normal nuclear reassembly and mitotic exit without DNA segregation.