ライフサイエンスコーパス: mitotic index

1 hymidine incorporation, PCNA expression, and mitotic index).

2 transplanted into normal mice showed reduced mitotic index.

3 e highest in proliferating tissues with high mitotic index.

4 RB and a concomitant decrease in the cardiac mitotic index.

5 zed with higher levels in tissues with a low mitotic index.

6 blast-like cells in the hemolymph with high mitotic index.

7 mised spindle architecture and increased the mitotic index.

8 , and this prolongation leads to an elevated mitotic index.

9 oes not result in a temporal increase in the mitotic index.

10 d treatment with TPA+ATRA also decreased the mitotic index.

11 epatocyte proliferation, as monitored by the mitotic index.

12 d by fluorescence-activated cell sorting and mitotic index.

13 the percentage of cycling myocytes and their mitotic index.

14 her two mutants, other than slightly reduced mitotic indexes.

15 s rates at 24 hours, proliferation rates and mitotic index 24 hours after growth stimulation, and the

16 cohorts showed marked increases in the skin mitotic index after dosing.

17 ith Ad5IkappaB but not Ad5LacZ decreased the mitotic index after partial hepatectomy.

18 rican Americans after adjusting for baseline mitotic index, age, gender, and pack-years of smoking [a

19 tasis (P = 0.0331), but only marginally with mitotic index, AJCC stage, nodal metastasis, or blood va

20 ording to age, sex, tumor location and size, mitotic index, American Society of Anesthesiology score,

21 d in G2 phase arrest, which was confirmed by mitotic index analysis.

22 rrelated with increased histologic grade and mitotic index and a decreased disease-free interval (DFI

23 ograft growth, with a concurrent decrease in mitotic index and a significant increase in apoptosis.

24 cle arrest at G(2), as demonstrated by a low mitotic index and Cdc2 activity.

25 etion of Gravin correlates with an increased mitotic index and disorganization of seminiferous tubule

26 The mitotic index and doubling time for LLCPK-1alpha were no

27 n-dependent differences in blastemal length, mitotic index and expression of the Fgf target genes mkp

28 Mitotic index and grade were associated with both ploidy

29 In addition, a lower mitotic index and lower mitotic cyclin-dependent kinase

30 Genetic interaction maps based on mitotic index and nuclear size grouped candidates into k

31 eration, as assessed by a scoring method for mitotic index and proliferating nuclear cell antigen sta

32 table Neurog3 protein, has a relatively high mitotic index and prolonged epithelial residency.

33 8 hours did not increase significantly their mitotic index and protected the cells from the cytotoxic

34 r increased abundance contributes to the low mitotic index and protection of genomic integrity in cel

35 ease DNA synthesis (BrdU, S phase), mitosis (mitotic index and regenerated liver weight, M phase), an

36 or the knockdown of Cdc25A remedies the high mitotic index and rescues the premature differentiation

37 , consequently resulting in reduction of the mitotic index and significant inhibition of tumor growth

38 ated birds exhibited a decreased endothelial mitotic index and substantially diminished neuronal recr

39 Cell multiplication, mitotic index and telomerase increased but did not compe

40 roblasts from null mutants reveals a reduced mitotic index and the presence of polyploid cells.

41 ressive breast tumors, i.e., those with high mitotic index and the so-called triple-negative breast t

42 e, RB-fed pigs had significantly lower ileal mitotic index and villus width, and significantly increa

43 icular cells of these mice, they had a lower mitotic index and were not transformed.

44 regenerative response was assessed by PCNA, mitotic index, and BrdU labeling.

45 ured retinal size, cell density, cell death, mitotic index, and cell birth index.

46 py increased mouse survival, decreased tumor mitotic index, and decreased tumor microvessel density,

47 l or missing imaginal discs, greatly reduced mitotic index, and fragmented and abnormally condensed c

48 NR increased DNA synthesis, mitotic index, and mass restoration in the regenerating

49 phase, bromodeoxy uridine [BrdU] = S phase, mitotic index, and regenerated liver weight = M phase).

50 Sex, histology, ulceration, mitotic index, and SN basin location were not predictive

51 cytes was assessed by MCM5 labeling, myocyte mitotic index, and telomerase function.

52 grade, cathepsin-D, Ki-67, S-phase fraction, mitotic index, and vascular invasion showed a significan

53 grade, cathepsin-D, Ki-67, S-phase fraction, mitotic index, and vascular invasion showed a significan

54 e more perfused, exhibited a two-fold higher mitotic index, and were more highly positive for insulin

55 The mitotic index, as assessed by MIB-1 staining, was consis

56 Cell cycle analysis and the mitotic index assay showed that following DNA damage ind

57 BrdU staining, which was used to a calculate mitotic index at several times postoperatively.

58 of keratinocyte differentiation markers, or mitotic index attributed to p53 loss.

59 thymidine incorporation into hepatic DNA and mitotic index by immunochemical detection of Ki67) and 4

60 thymidine incorporation into hepatic DNA and mitotic index by immunochemical detection of Ki67) and a

61 Mitotic index changes substantiate these interpretations

62 tion doubling time and a 2-fold reduction in mitotic index compared with controls.

63 tutively in some human cancer cell lines and mitotic index correlates with cell cannibalism in primar

64 r (prod) gene of Drosophila causes decreased mitotic index, defects of anaphase chromatid separation,

65 MIB-1, BrDu labeling, and mitotic index-derived proliferation data were highly cor

66 , including accelerated growth rates, higher mitotic index, enhanced invasiveness, increased motility

67 of Bub3, Mad2, or Mps1 resulted in a lowered mitotic index, errors in chromosome segregation (includi

68 e in programmed cell death and a decrease in mitotic index, especially in the region of the distal ti

69 AEtr cells had a reduced mitotic index following nocodazole treatment, suggesting

70 due to a defect in proliferation, since the mitotic index for transgenic and wild-type glands was si

71 results were correlated with tumor Ki-67 and mitotic index, from in vitro assays of the tumor tissue.

72 csp mutant embryos have an increased mitotic index, have highly disorganized mitotic spindles

73 the observed phenotypes including a reduced mitotic index, high frequency of aneuploidy and persiste

74 that it correlates with an expression-based mitotic index in cancer tissue.

75 the survival curve; (ii) measurement of the mitotic index in cells collected after treatment with co

76 al patterning defects without decreasing the mitotic index in dorsal domains.

77 immunochemical detection of Ki67) and 40 h (mitotic index in HE sections) after partial hepatectomy.

78 munochemical detection of Ki67) and at 32 h (mitotic index in HE sections) in the control group of ra

79 hymidine incorporation into hepatic DNA, the mitotic index in hematoxylin-eosin (HE) sections and by

80 ]pyrene are smaller in size and have a lower mitotic index in MIF-KO mice relative to their WT counte

81 erexpressing cells showed a reduction in the mitotic index in the presence of a spindle poison and fa

82 Compared with cell culture, the peak mitotic index in tumors exposed to Ptx was lower and the

83 sed dosage of the same loci caused a reduced mitotic index in vitro.

84 T3 with small interference RNA increases the mitotic index, in particular, the number of cells in pro

85 is elevated in tissues and cells with a high mitotic index, including cancer cells.

86 is elevated in tissues and cells with a high mitotic index, including cancer cells.

87 The CSC mitotic index increased 29-fold in acute and 14-fold in

88 The mean vascular density and mitotic index increased from stage 2 to stage 3 metastas

89 g cell nuclear antigen (PCNA) expression and mitotic index increased substantially in 50% but not 30%

90 tion fatty animals showed an increase in the mitotic index indicating a delay of regeneration in stea

91 bryos also had an increased endothelial cell mitotic index, indicating that aberrant endothelial cell

92 Mitotic index is an important component of histologic gr

93 mall intestine, colon/rectum, or other), and mitotic index (<5 or > or =5 mitoses per 50 high-power f

94 that cause microtubules to disassemble, the mitotic index (MI) progressively increases as the cells

95 A mitotic index (MI) was calculated as the percentage of n

96 ized by immunocytochemical staining, and the mitotic index (MI) was determined between postnatal day

97 We used gene expression profiling, mitotic index (MI), and quantification of tumor infiltra

98 carcinomas and did not correlate simply with mitotic index, modified Dukes' stage, or tumor size.

99 ssion caused by LPS and increased hepatocyte mitotic index, nuclear cyclin D1 translocation, and phos

100 TP53 mutations (44% vs 15%, P<.001), higher mitotic index (odds ratio [OR], 11.0; 95% confidence int

101 n after injury and an elevated cardiomyocyte mitotic index of 10-20% for the MRL compared with 1-3% f

102 n vitro growth characteristics and increased mitotic index of 94-A/K embryos, and molecular structura

103 crease in thymidine incorporation and in the mitotic index of aphidicolin synchronized cells.

104 ventral region of the hippocampus while the mitotic index of NSCs in the dorsal portion of the hippo

105 , mainly due to the low in vivo and in vitro mitotic index of plasma cells.

106 Yet, the mitotic index of precancerous cells and the observable l

107 The proliferation rate and mitotic index of the grafted cells were higher on BL tha

108 Conversely, the mitotic index of the p.Q434del epidermis was significant

109 ino-mediated depletion of Wee2 increases the mitotic index of the paraxial mesoderm and this results

110 Thus, the low mitotic index of the paraxial mesoderm plays an essentia

111 f the amides caused a marked increase in the mitotic index of treated cells, indicating that tubulin

112 of myocytes into the cell cycle resulted in mitotic indexes of 0.08 percent and 0.03 percent, respec

113 at more closely associated with outcome than mitotic index or in vitro BrDu data.

114 t predictors of DFS were proliferation rate (mitotic index or MIB-1) and tumor grade.

115 with features such as large tumor size, high mitotic index, or tumor rupture may also be at higher ri

116 itive association with tumor size (P =.002), mitotic index (P <.0001), histologic grade (P <.0001), a

117 ion, 3.6%), which was highly correlated with mitotic index (P = .0001).

118 Within the first 5 years of follow-up, mitotic index (P =.004), grade (P =.004), ploidy (P =.00

119 eries of open operative resection, the tumor mitotic index predicts local recurrence.

120 significantly reduced regenerative capacity (mitotic index, proliferating cell nuclear antigen, and r

121 compared with lean Zucker rats (PCNA, BrdU, mitotic index, regenerated liver weight) at days 1 and 2

122 3(TA.LO) progenitors, with a doubling of its mitotic index relative to normal Neurog3 expression, sug

123 The mitotic index remained unaltered in vivo, whereas the ap

124 we found that these tumors exhibited a high mitotic index, resembling poorly differentiated (PD)-Pan

125 crease in mitotic cells, but within 24 h the mitotic index returned to baseline.

126 ion of cells with 4 n DNA content, increased mitotic index, separated centrosomes, elevated histone H

127 Measurements of DNA synthesis and mitotic index showed modest effects of Myc to increase l

128 Precystic collecting ducts had an increased mitotic index, suggesting that cell proliferation may dr

129 cause it generates endothelium with a higher mitotic index than endothelium derived from local source

130 in diameter, more invasive, and had a higher mitotic index than tumors in p53+/+ and p53+/- mice.

131 ological examination indicated a decrease in mitotic index that paralleled the changes in T1rho.

132 e undergoing mitosis was determined, and the mitotic index (the ratio of the number of nuclei undergo

133 es, as deduced from the number of cells, the mitotic index, the amount of apoptosis and the expressio

134 RKIP depletion causes decreases in the mitotic index, the number of metaphase cells, and traver

135 mitotic RPCs during development, causing the mitotic index to increase markedly over time compared wi

136 Patient age, tumor size, mitotic index, tumor ulceration, and necrosis were stati

137 lleviates the reduction in CDC2 activity and mitotic index upon exposure to DNA damage.

138 After 2 weeks in Gln- medium, the mitotic index was 0.3% and the [3H]TdR-labeling index (1

139 Furthermore, the mitotic index was elevated in neural folds and hindgut o

140 The effect of mitotic index was largely a result of the difference bet

141 ial cells by day 8, and the endothelial cell mitotic index was significantly elevated before day 8.

142 12 days after cholestasis induction and the mitotic index was very high upon cholestasis in p38alpha

143 Du labeling index, MIB-1 immunolabeling, and mitotic index were also associated with shortened diseas

144 , growth pattern, mean vascular density, and mitotic index were determined with the aid of immunohist

145 red, their growth rate, apoptosis level, and mitotic index were not affected by the loss of p21, sugg

146 es (Nottingham Combined Histologic Grade and mitotic index) were performed on paraffin-embedded tissu

147 MEK inhibition reverses the reduction in the mitotic index, whereas hyperactivation of Raf mimics the

148 st, tcf3 gene knockdown results in a reduced mitotic index without affecting dorsal patterning.