ライフサイエンスコーパス: mitotic spindle

1 ical NuMA-dynein complexes that position the mitotic spindle.

2 so on the subpellicular microtubules and the mitotic spindle.

3 matically impaired Astrin recruitment to the mitotic spindle.

4 cial role in assembly and maintenance of the mitotic spindle.

5 romoting biorientation of chromosomes on the mitotic spindle.

6 SAC silencing entails proper size scaling of mitotic spindle.

7 n adjacent microtubules and form the bipolar mitotic spindle.

8 sembling macromolecular machine known as the mitotic spindle.

9 along astral microtubules to help orient the mitotic spindle.

10 rtex to facilitate planar orientation of the mitotic spindle.

11 ntil the last chromosome has attached to the mitotic spindle.

12 ch sex chromosomes, to separate on the first mitotic spindle.

13 us ends of distinct MT subpopulations in the mitotic spindle.

14 rs that grow out from the poles of the first mitotic spindle.

15 spatial position of a chromosome within the mitotic spindle.

16 ssential for proper formation of the bipolar mitotic spindle.

17 olding into units of manageable size for the mitotic spindle.

18 bule cytoskeleton is reorganized to form the mitotic spindle.

19 sential for the assembly and function of the mitotic spindle.

20 ll chromosomes are correctly attached to the mitotic spindle.

21 rs) or bundles of kinetochore-MTs within the mitotic spindle.

22 bipolar attachments with microtubules of the mitotic spindle.

23 a key role in guiding the orientation of the mitotic spindle.

24 ds until each kinetochore is attached to the mitotic spindle.

25 djacent to the spindle poles and orients the mitotic spindle.

26 until all chromosomes are bioriented on the mitotic spindle.

27 he chromosomes or their biorientation on the mitotic spindle.

28 tubules at cell-cell adhesions to orient the mitotic spindle.

29 med by a self-organized structure called the mitotic spindle.

30 complex classically known for orienting the mitotic spindle.

31 somal separation and proper formation of the mitotic spindle.

32 ter chromosomes are properly attached to the mitotic spindle.

33 not properly attached to microtubules of the mitotic spindle.

34 ring positioned and controlled solely by the mitotic spindle.

35 uitment or centrosome function in organizing mitotic spindles.

36 l microtubule plus end assembly rates within mitotic spindles.

37 tem cells displays randomized orientation of mitotic spindles.

38 le cytoskeletons to position centrosomes and mitotic spindles.

39 es via cenexin a functional asymmetry on all mitotic spindles.

40 lls, play key roles in forming and orienting mitotic spindles.

41 in-X (Myo10) and therefore to associate with mitotic spindles.

42 of morphologically defective and disoriented mitotic spindles.

43 ls that organize interphase microtubules and mitotic spindles.

44 ode positional information that helps orient mitotic spindles.

45 gellum from the cell body, and disruption of mitotic spindles.

46 uch as the nucleus [1, 2], mitochondria [3], mitotic spindle [4, 5], and centrosome [6], exhibit size

47 anical process that requires assembly of the mitotic spindle - a dynamic microtubule-based force-gene

48 FTLD-MAPT in which neurons and glia exhibit mitotic spindle abnormalities, chromosome mis-segregatio

49 However, it is not known whether the mitotic spindle actively maintains a set point tension m

50 Mitotic spindle alignment with the basal or substrate-co

51 In animals, the mitotic spindle aligns with Par complex polarized fate d

52 cell proliferation, planar alignment of the mitotic spindle allows the daughter cells to stay within

53 ance mechanism that ensures alignment of the mitotic spindle along the cell polarity axis.

54 that PCP induction is essential to reorient mitotic spindles along the anterior-posterior axis of el

55 h are mediated by the microtubule (MT)-based mitotic spindle and approximately 200 essential MT-assoc

56 mechanical cues for proper alignment of the mitotic spindle and cell division site.

57 genes encoding proteins that localize to the mitotic spindle and centrosomes have been implicated in

58 n be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, an

59 , which impairs Aurora A localization at the mitotic spindle and induces cell division defects.

60 beta-CTT is critical for the assembly of the mitotic spindle and its elongation during anaphase.

61 or Plk2 in regulating the orientation of the mitotic spindle and maintaining proper cell polarity in

62 During asymmetric cell division, the mitotic spindle and polarized myosin can both determine

63 As nucleators of the mitotic spindle and primary cilium, centrosomes play cru

64 Here, we show that Rab11 localizes to the mitotic spindle and regulates dynein-dependent endosome

65 r, TbNup92 is intimately associated with the mitotic spindle and spindle anchor site but apparently h

66 Rab11 depletion causes misorientation of the mitotic spindle and the plane of cell division.

67 itotic FAs established 3D orientation of the mitotic spindle and the relative positioning of mother a

68 s is regulated by the formation of a bipolar mitotic spindle and the spindle assembly checkpoint, ens

69 required for the assembly of the subsequent mitotic spindle and to phosphorylate a microtubule-assoc

70 tribution and localization of Stu2 along the mitotic spindle and yield defects in spindle morphology

71 Experiments demonstrate allometry of mitotic spindles and a universal scaling relationship be

72 les, leading to the formation of multi-polar mitotic spindles and genomic instability.

73 his study, we show that ADD1 associates with mitotic spindles and is crucial for proper spindle assem

74 during mitosis and localize to centrosomes, mitotic spindles and midbody, and selective inhibition o

75 t nor escape confinement cannot orient their mitotic spindles and more likely undergo apoptosis.

76 2) reveals a function for tropomyosin in the mitotic spindle, and 3) uncovers sequence elements that

77 e degradation of proteins that stabilize the mitotic spindle, and loss or accumulation of such spindl

78 ylation and abrogates EG5 recruitment to the mitotic spindle apparatus, leading to spindle disorganiz

79 Kinetochore fibers (K-fibers) of the mitotic spindle are force-generating units that power ch

80 Mitotic spindles are critical for accurate chromosome se

81 Mitotic spindles are microtubule-based structures, but i

82 In animal cells, mitotic spindles are oriented by the dynein/dynactin mot

83 Mitotic spindles are primarily composed of microtubules

84 exit, ruling out stretching by the elongated mitotic spindle as the cause of breakage.

85 p31(comet), promotes the inactivation of the mitotic (spindle assembly) checkpoint by disassembling t

86 e-organizing centers that facilitate bipolar mitotic spindle assembly and chromosome segregation.

87 tus (NuMA) protein is an essential player in mitotic spindle assembly and maintenance.

88 in that directs nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation.

89 For instance, many mitotic spindle assembly factors are known to be sequest

90 somes, indicating that TL-77 interferes with mitotic spindle assembly in cancer cells.

91 Accurate mitotic spindle assembly is critical for mitotic fidelit

92 for AURKA-dependent, centrosome-independent mitotic spindle assembly is essential for the survival a

93 To identify new mitotic spindle assembly regulators, we isolated 855 mic

94 Mitotic spindle assembly requires the regulated activiti

95 findings unveil a novel function for ADD1 in mitotic spindle assembly through its interaction with My

96 d-bearing attachments to microtubules during mitotic spindle assembly, spindle positioning, and chrom

97 tion ceases simultaneously with intranuclear mitotic spindle assembly.

98 d by Plk1 and SCFbeta-TrCP to promote proper mitotic spindle assembly.

99 ic transport, nuclear envelope formation and mitotic spindle assembly.

100 microtubule motors that function mainly for mitotic spindle assembly.

101 indle matrix has been proposed to facilitate mitotic spindle assembly.

102 correct kinetochore-microtubule attachment, mitotic/spindle-assembly checkpoint, accurate chromosome

103 PLK1 disrupts centrosome separation, causing mitotic spindle asymmetry, merotelic microtubule-kinetoc

104 ides is determined by the orientation of its mitotic spindle at metaphase.

105 chores, ensures accuracy during mitosis: the mitotic spindle attaches randomly to chromosomes and the

106 ically dividing epithelial cells align their mitotic spindle axis with the plane.

107 of cell divisions, which is specified by the mitotic spindle axis.

108 Eg5 establishes the bipolar geometry of the mitotic spindle, but previous work in mammalian cells su

109 B activity causes premature collapse of the mitotic spindle by promoting instability of the spindle

110 a-CTT also regulates force generation in the mitotic spindle by supporting kinesin-5/Cin8 and dampeni

111 all chromosomes are properly attached to the mitotic spindle by the spindle assembly checkpoint (SAC)

112 ion defects strictly depends on a functional mitotic spindle checkpoint as well as on intact microtub

113 In this study, we develop evidence that the mitotic spindle checkpoint molecule BUB1B may offer a pr

114 hts the role of spatiotemporal regulation in mitotic spindle checkpoint signalling and fidelity of ch

115 highlights the role of MK2 in G(2)/M and the mitotic spindle checkpoints, two mechanisms by which MK2

116 leads to morphological defects, disoriented mitotic spindles, chromosome congression defects and del

117 We found that cabazitaxel induced mitotic spindle collapse and multinucleation by targetin

118 e inhibitory complexes are restricted to the mitotic spindle compartment or are diffusible throughout

119 able to diffuse outside the confines of the mitotic spindle compartment.

120 The mitotic spindle consists of microtubules (MTs), which ar

121 The poles of the mitotic spindle contain one old and one young centrosome

122 (mgr), leading to monopolar and disorganized mitotic spindles containing few MTs.

123 Subsequently, mitotic spindle cues establish a Myosin gradient at the

124 chines harbored by eukaryotic cells, such as mitotic spindles, cytoskeletal structures detectable by

125 pression of NUP98 fusion oncoproteins causes mitotic spindle defects and chromosome missegregation, c

126 lls and found that they cause aneuploidy and mitotic spindle defects that then result in apoptosis.

127 ltraviolet irradiation and exhibit nopo-like mitotic spindle defects.

128 The position of the mitotic spindle determines the cleavage plane in animal

129 Correct orientation of the mitotic spindle determines the plane of cellular cleavag

130 The orientation of the mitotic spindle determines the relative size and positio

131 tex of the mitotic cell and we show that the mitotic spindle does not reach equilibrium before chromo

132 Elongation of the mitotic spindle during anaphase B contributes to chromos

133 quired for lumen continuity by orienting the mitotic spindle during cell division.

134 al roles in establishing and maintaining the mitotic spindle during cell division.

135 erface between centromeric chromatin and the mitotic spindle during chromosome segregation.

136 ically modified GR species accumulate at the mitotic spindle during mitosis in a distribution that ov

137 tracked the position and orientation of the mitotic spindle during the first cell division with high

138 Kar9 positions mitotic spindles during budding yeast cell division.

139 nform to tissue organization to orient their mitotic spindles during division and establish new adhes

140 acking software and apply it to characterize mitotic spindle dynamics in the Xenopus laevis embryonic

141 was depleted, centrosome separation and the mitotic spindle dynamics were impaired, resulting in the

142 ors are one of the major players that govern mitotic spindle dynamics.

143 rogression through centrosome separation and mitotic spindle dynamics.

144 show that the lack of Swe1 causes premature mitotic spindle elongation and that high levels of Swe1

145 longation and that high levels of Swe1 block mitotic spindle elongation, indicating that Swe1 inhibit

146 evidence that it is involved in controlling mitotic spindle elongation.

147 dc14 binds and inhibits Swe1 to allow timely mitotic spindle elongation.

148 Centrosomes together with the mitotic spindle ensure the faithful distribution of chro

149 The mitotic spindle ensures the faithful segregation of chro

150 egate into daughter cells, they align at the mitotic spindle equator, a process known as chromosome c

151 CDC2 localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner.

152 orm diverse cellular structures, such as the mitotic spindle for cell division, the backbone of neuro

153 omosome arm must be shorter than half of the mitotic spindle for proper chromosome segregation.

154 t role in many cellular processes, including mitotic spindle formation and cell division.

155 bulin, which is required to prevent abnormal mitotic spindle formation and genome instability.

156 tion of MCAK and HURP, two key regulators of mitotic spindle formation and known substrates of Aurora

157 gets the FOXM1-KIF20A axis to drive abnormal mitotic spindle formation and mitotic catastrophe and th

158 n of mTORC1 kinase, plays a critical role in mitotic spindle formation and subsequent chromosome segr

159 TOG5-microtubule binding maintained mitotic spindle formation as deleting or mutating TOG5 c

160 ged DNA, but also regulates RNA splicing and mitotic spindle formation in its integral capacity as a

161 Mitotic spindle formation is defective in patient-derive

162 the cell nucleus (e.g., DNA replication and mitotic spindle formation).

163 microtubule-associated protein important for mitotic spindle formation.

164 lator that arranges microtubule assembly and mitotic spindle formation.

165 lex accumulates at the centrosome to support mitotic spindle formation.

166 logous possibility that centromeres regulate mitotic spindle formation.

167 sible and active outside the confines of the mitotic spindle from which they are derived.

168 microtubule cross-linker Shortstop (Shot) in mitotic spindle function in Drosophila Shot localizes to

169 Mitotic spindle function is critical for cell division a

170 rates that affect chromosome instability and mitotic spindle function, but the manner by which cellul

171 bule-associated protein that is required for mitotic spindle function.

172 The dogma is that the mitotic spindle governs the assembly and constriction of

173 viding connections between chromatin and the mitotic spindle has not been explored.

174 thods for determining the orientation of the mitotic spindle in complex tissues are needed.

175 origins of diversity in the structure of the mitotic spindle in nematode embryos, at timescales spann

176 -1) is required for precise orientation of a mitotic spindle in response to a Wnt cue.

177 Correct orientation of the mitotic spindle in stem cells underlies organogenesis.

178 The proper positioning of mitotic spindle in the single-cell Caenorhabditis elegan

179 Wnt signals orient mitotic spindles in development, but it remains unclear

180 ge-scale serial electron tomography of whole mitotic spindles in early C. elegans embryos with live-c

181 led to reveal either abnormal centrosomes or mitotic spindles, increased neurogenesis from the neural

182 ed to resolve telomere cohesion and maintain mitotic spindle integrity.

183 The mitotic spindle is a bipolar, microtubule (MT)-based cel

184 The formation of the mitotic spindle is a complex process that requires massi

185 Asymmetric positioning of the mitotic spindle is a fundamental process responsible for

186 The mitotic spindle is a microtubular assembly required for

187 rect bipolar attachment of chromatids to the mitotic spindle is achieved.

188 The formation of a bipolar mitotic spindle is an essential process for the equal se

189 Yet, a mechanistic understanding of how the mitotic spindle is assembled and achieves chromosome seg

190 During cell division, a mitotic spindle is built by the cell and acts to align a

191 The mitotic spindle is composed of dynamic microtubules and

192 oper assembly and orientation of the bipolar mitotic spindle is critical to the fidelity of cell divi

193 Proper length control of the metaphase mitotic spindle is critical to this process and is thoug

194 The mitotic spindle is crucial to achieve segregation of sis

195 The mitotic spindle is defined by its organized, bipolar mas

196 Targeting of Hsp72 to the mitotic spindle is dependent on phosphorylation at Thr-6

197 of CPC proximal to the kinetochore when the mitotic spindle is disrupted.

198 During each cell cycle, the mitotic spindle is efficiently assembled to achieve chro

199 The mechanisms by which the mammalian mitotic spindle is guided to a predefined orientation th

200 Precise positioning of the mitotic spindle is important for specifying the plane of

201 Proper organization of the mitotic spindle is key to genetic stability, but molecul

202 ons of the cortex can thus determine how the mitotic spindle is oriented.

203 The position and orientation of the mitotic spindle is precisely regulated to ensure the acc

204 proper organization of the microtubule-based mitotic spindle is proposed to depend on nanometer-sized

205 Architectural integrity of the mitotic spindle is required for efficient chromosome con

206 The position of the mitotic spindle is tightly controlled in animal cells as

207 The size and position of mitotic spindles is determined by the lengths of their c

208 isolated adherent cells, the orientation of mitotic spindles is sensitive to interphase cell shape a

209 A characteristic feature of mitotic spindles is the congression of chromosomes near

210 only structure linking the two halves of the mitotic spindle, it is under mechanical tension from dyn

211 aphorin ligands fail to correctly orient the mitotic spindle, leading to severe defects in epithelial

212 tubules and caused the formation of abnormal mitotic spindles, leading to mitotic accumulation.

213 e we show that in a range of metazoan phyla, mitotic spindle length decreased with cell size across a

214 localizes at the anterior cortex whereas the mitotic spindle localizes toward the posterior.

215 ns, which contains one of the smallest known mitotic spindles (<1 mum).

216 nesis by coupling juxtamembrane signaling to mitotic spindle machinery.

217 he primary centrosome-associated protein for mitotic spindle maturation.

218 During cell division, a microtubule-based mitotic spindle mediates the faithful segregation of dup

219 TSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover

220 Microtubule turnover varies among different mitotic spindle microtubules, dictated by their spatial

221 These proteins distinguish cortical from mitotic spindle microtubules, even though the assembly o

222 ls exposed to AurkinA mislocalise AURKA from mitotic spindle microtubules.

223 n when a single kinetochore is unattached to mitotic spindle microtubules.

224 with an increase in the proportion of stable mitotic spindle microtubules.

225 ochores connect centromeric nucleosomes with mitotic-spindle microtubules through conserved, cross-in

226 sport at the membrane domain surrounding the mitotic spindle midzone, here named the midzone membrane

227 We found that mHTT caused mitotic spindle misorientation in cultured cells by alte

228 le in the function and dynamic regulation of mitotic spindles, mitotic progression, and chromosome se

229 FOXM1 and KIF20A similarly promotes abnormal mitotic spindle morphology and chromosome alignment, whi

230 genome during vertebrate cell division, the mitotic spindle must attach to a single locus on each ch

231 nscription, whereas Mlp2 associates with the mitotic spindle/NPC in a cell cycle-dependent manner.

232 n kinetochore pushing movements and tripolar mitotic spindles occurred in cells lacking Klp5 but not

233 ed kinesin-14 family have important roles in mitotic spindle organization and chromosome segregation.

234 uch as cell cycle progression, chromatin and mitotic spindle organization may also be regulated throu

235 quired for correct centrosome clustering and mitotic spindle organization.

236 t, cell architecture, and primary cilium and mitotic spindle organization.

237 re of many cells, best known for its role in mitotic spindle organization.

238 in1-ARHGAP21 interactions, Cdc42 activation, mitotic spindle orientation and 3D glandular morphogenes

239 ation of ACD regulators, leading to aberrant mitotic spindle orientation and defects in the generatio

240 Disruptions in polarity and mitotic spindle orientation contribute to the progressio

241 describe multiple distinct functions for the mitotic spindle orientation gene LGN (Gpsm2) in promotin

242 larity in lgl mutants but reveals defects in mitotic spindle orientation in epithelia.

243 y the miR-34/449 family as key regulators of mitotic spindle orientation in the developing cerebral c

244 indicate that miRNA-dependent regulation of mitotic spindle orientation is crucial for cell fate spe

245 e environment, but how those signals control mitotic spindle orientation is not fully understood.

246 Mitotic spindle orientation is used to generate cell fat

247 gnaling as a central regulatory mechanism of mitotic spindle orientation necessary for the alignment

248 Mitotic spindle orientation relies on a complex dialog b

249 All known mechanisms of mitotic spindle orientation rely on astral microtubules.

250 Mitotic spindle orientation requires the precise localiz

251 rafficking of vesicles to the apical domain, mitotic spindle orientation, and midbody position, consi

252 One deletion impairs mitotic spindle orientation, leading to premature cell c

253 y, but not RGP delocalization and randomized mitotic spindle orientation.

254 s a previously unidentified component of the mitotic spindle pole and the centrosome.

255 tained association of each centrosome with a mitotic spindle pole.

256 Instead, MAPKBP1 is recruited to mitotic spindle poles (MSPs) during the early phases of

257 The interaction between centrosomes and mitotic spindle poles is important for efficient spindle

258 ng yeast to mammals, Wts kinase localizes to mitotic spindle poles, a prominent site of Mud localizat

259 dle function in Drosophila Shot localizes to mitotic spindle poles, and its knockdown results in an u

260 d the plus-end tracking protein EB1 controls mitotic spindle positioning by affecting the stability a

261 hways that translate cell polarity cues into mitotic spindle positioning to control the orientation o

262 e interactions with the cell cortex regulate mitotic spindle positioning within the plane of division

263 dditional and direct function of NuMA during mitotic spindle positioning, as well as a reiterative us

264 complex as an astral microtubule mediator of mitotic spindle positioning.

265 chores that are not attached properly to the mitotic spindle produce an inhibitory signal that preven

266 and its binding affinity to centrosomes and mitotic spindles, promoting G2-to-M transition.

267 omatids which depends on correct position of mitotic spindle relative to membrane cortex.

268 issues, multicellular organisms orient their mitotic spindles relative to neighboring cells.

269 Microtubule-based structures such as mitotic spindles scale with cell size, but less is known

270 Mitotic spindles specify cleavage planes in early embryo

271 nterplay between PTEN and EG5 in controlling mitotic spindle structure and chromosome behaviour durin

272 potent microtubule polymerases, critical for mitotic spindle structure and dynamics.

273 on in POC1A caused the formation of abnormal mitotic spindle structure, including supernumerary centr

274 elies on a membranous system surrounding the mitotic spindle that defines an organelle-exclusion zone

275 ensures the alignment of chromosomes on the mitotic spindle that is required for their proper segreg

276 ch may explain why it has the smallest known mitotic spindle that still manifests the classic congres

277 ction of the centrosome, the assembly of the mitotic spindle, the function of the primary cilium and

278 organization of astral microtubules and the mitotic spindle through Rab11-dependent control of spind

279 4-6 pN) and is tightly self-regulated by the mitotic spindle: through adjustments in spindle structur

280 es that couple eukaryotic chromosomes to the mitotic spindle to ensure proper segregation.

281 generators to fine-tune the position of the mitotic spindle to facilitate asymmetric division.

282 binding that optimally positions Stu2 on the mitotic spindle to promote proper spindle structure and

283 In budding yeast, dynein moves the mitotic spindle to the predetermined site of cytokinesis

284 The length of the mitotic spindle varies among different cell types.

285 es, AURKA is allosterically activated on the mitotic spindle via binding to the microtubule-associate

286 ing mitosis, chromosomes are attached to the mitotic spindle via large protein complexes called kinet

287 inase A (AURKA) localizes to centrosomes and mitotic spindles where it mediates mitotic progression a

288 ein best known for its essential role in the mitotic spindle, where it limits the rate at which faste

289 During mitosis, Tm1J localizes to the mitotic spindle, where it promotes chromosome segregatio

290 k6 facilitates association of Hsp72 with the mitotic spindle, where it promotes stable K-fiber assemb

291 -tubule dynamics is achieved in the smallest mitotic spindles, where the noisiness of microtubule ass

292 siRNA stably decreases MT assembly rates in mitotic spindles, whereas depletion of Kif18A stably inc

293 variations in morphology and dynamics of the mitotic spindle, which orchestrates chromosome segregati

294 MTs nucleate from preexisting MTs within the mitotic spindle, which requires the protein TPX2, but th

295 ment of sister chromatid kinetochores to the mitotic spindle with activation of the anaphase-promotin

296 These cells displayed an aberrant mitotic spindle with disorganized, tangle-shaped microtu

297 owever, in contrast to this model, metaphase mitotic spindles with inactive kinesin-14 minus-end-dire

298 ge of MTOCs and contributes to orienting the mitotic spindle within the cell.

299 ations to ensure precise localization of the mitotic spindle, yet compliant enough to allow molecular

300 MAP that promotes MT disassembly within the mitotic spindle, yet its function in regulating MT dynam