ライフサイエンスコーパス: mitotically

1 without dividing, whereas small cells divide mitotically.

2 show that caspase-2 is required for deleting mitotically aberrant cells.

3 We recently identified a series of mitotically acting piperazine-based compounds that poten

4 s, an event attributed to phosphorylation by mitotically activated aPKC kinase and thought to promote

5 We also demonstrate that mitotically activated ATM phosphorylates Bub1, a critica

6 ence of keratin 16 at the transition between mitotically active and differentiating cells is recapitu

7 ous derepression occasionally occurs in both mitotically active and differentiating cells.

8 Although these cells are mitotically active and do not morphologically differenti

9 l adhesion molecule) immunoreactive NRPs are mitotically active and electrically immature, and they e

10 The anterior PGCs are very mitotically active and exhibit two division patterns wit

11 ical characterization reveals that the FT is mitotically active and its cells express similar markers

12 f the bulbar conjunctiva near the limbus are mitotically active and yet they are generally immobile i

13 he mammalian forebrain, the subependyma is a mitotically active area that is a source of oligodendroc

14 basonuclin is associated with the nuclei of mitotically active basal cells but not in terminally dif

15 In normal epidermis, a mitotically active basal layer gives rise to terminally

16 Stratified epithelium contains a mitotically active basal layer of cells that cease proli

17 rieved capsules revealed numerous viable and mitotically active BHK cells that continued to secrete h

18 estines were assayed to assess activity in a mitotically active cell type and tissue.

19 a 2 is in a unique position to interact with mitotically active cells (in early retinal development),

20 In the absence of p27(Kip1), mitotically active cells are still observed in the organ

21 Lysates from mitotically active cells did not contain these APC isofo

22 ein-2 showed that the vast majority of these mitotically active cells differentiated into neurons in

23 Mitotically active cells in log growth respond to TNF by

24 n remains elusive, and the function of AR in mitotically active cells is not well understood.

25 an earlier phase of tangential migration of mitotically active cells lays down a widespread periodic

26 ce by positioning the transition zone, where mitotically active cells lose their capacity to divide a

27 ative amacrine cells, nascent cones, and the mitotically active cells of the rod lineage.

28 human ovarian cortical tissue to purify rare mitotically active cells that have a gene expression pro

29 1 was identified as an AR-regulated gene in mitotically active cells that promoted pro-metastatic ph

30 a critical regulator of the transition from mitotically active cells to terminal differentiated neur

31 hymidine analog (EdU), we were able to label mitotically active cells, which revealed that cell proli

32 eak down and dedifferentiate back to single, mitotically active cells.

33 demonstrated that this activity occurred in mitotically active cells.

34 follicular renewal occurs in mammals, and no mitotically active Ddx4-expressing female germline proge

35 rphase and mitosis, only the phosphorylated, mitotically active form of Cdc25 was able to bind Pin1,

36 e women, similar to adult mice, possess rare mitotically active germ cells that can be propagated in

37 hat juvenile and adult mouse ovaries possess mitotically active germ cells that, based on rates of oo

38 While basonuclin RNA expression occurs in mitotically active germ cells, protein was not detected

39 milieu composed of postmitotic neurons, and mitotically active glial and neural progenitor cells.

40 which are quiescent and held in reserve, and mitotically active globose basal cells.

41 epair down-regulation and TNR instability in mitotically active HD cells and offer a proof of princip

42 DNA mutations appears relatively common in a mitotically active human tissue and may provide a method

43 igh degree of silencing is maintained in the mitotically active imaginal cells from mid-embryogenesis

44 Lgr5 marks mitotically active intestinal stem cells (ISCs).

45 Lgr5 marks mitotically active ISCs that exhibit exquisite sensitivi

46 Keratins K5 and K14 are the hallmarks of mitotically active keratinocytes of stratified epithelia

47 ical proliferative zone and appear to become mitotically active late in gestation.

48 pressing tetracycline transactivators in the mitotically active layers of the epidermis, these mice w

49 olongs neural proliferation by maintaining a mitotically active neuroblast.

50 Unlike TFs expressed in mitotically active neuroblasts, these TFs do not regulat

51 in vivo of immature postmitotic neurons and mitotically active neuronal precursor cells.

52 the peripheral margin, Vsx-2 is expressed in mitotically active neuronal progenitors and is downregul

53 d that the primate retinal periphery harbors mitotically active neuroprogenitor cells that increase i

54 The recent purification of mitotically active oocyte progenitor cells, termed femal

55 We found that mitotically active pancreatic progenitor cells in mouse

56 a (NG2 glia) are a uniformly distributed and mitotically active pool of cells in the central nervous

57 These data suggest that there are mitotically active precursors in the mammalian neural cr

58 cluding effects on both neural crest and DRG mitotically active progenitor cells, in addition to poss

59 nteractions among nascent neurons, glia, and mitotically active progenitor cells.

60 s of MARCKS results in ectopic collection of mitotically active radial progenitors away from the vent

61 Nonetheless, only progenitors that are mitotically active respond to LAMP-inducing signals; onl

62 Concurrently, the loss of Math5 causes mitotically active retinal progenitors to undergo aberra

63 We report the generation of mitotically active Rev3L-/- MEFs on a p53-/- genetic bac

64 The decrease in mitotically active SPG11-NPCs was rescued by GSK3 modula

65 rein, we maintained human Sertoli cells in a mitotically active state in vitro, thus enabling transfe

66 A subset of mitotically active SVZ precursor cells gives rise to a p

67 Radial glia are mitotically active throughout neurogenesis, and disappea

68 ends even to the germline, which is the only mitotically active tissue in the adult.

69 dent accumulation of mtDNA mutations in this mitotically active tissue.

70 ghest level of purine biosynthesis occurs in mitotically active tissues of the plant.

71 ntly expressed throughout development in all mitotically active tissues, at lower levels in some post

72 her, these findings delineate AR function in mitotically active tumor cells, thus providing critical

73 t expressed in the neural progenitors of the mitotically active ventricular zone.

74 icts that throughout neurogenesis almost all mitotically active VZ cells and a substantial percentage

75 hat the majority of VZ cells, and nearly all mitotically active VZ cells during neurogenesis, both ha

76 These differentiated Sertoli cells remained mitotically active when cultured in the presence of 10%

77 sal layers of epidermis, but it is absent in mitotically active, basal keratinocytes.

78 e report here that mTECs from adult mice are mitotically active, implying continual turnover, differe

79 The neural crest is a unique population of mitotically active, multipotent progenitors that arise a

80 pancreas, SOX9 expression is restricted to a mitotically active, Notch-responsive subset of PDX1(+) p

81 of a heterogeneous population of cells, some mitotically active, others postmitotic.

82 precursors that, after muscle injury, become mitotically active, proliferate, and fuse together or, t

83 that GFP-positive cells in this region were mitotically active.

84 progression, tumors become vascularized and mitotically active.

85 Ts, are highly vascularized, hemorrhagic and mitotically active.

86 structures and nerves; in addition, they are mitotically active.

87 iated premature differentiation and death of mitotically-active progenitors that express the paired-b

88 Normally, polyploid cells do not divide mitotically after initiating endocycles; hence, little i

89 ain considerable stem cell character as they mitotically amplify prior to differentiation and can be

90 STeS/MMBIR-mediated rearrangements can occur mitotically and can result in duplication or triplicatio

91 s contain exogenous alpha satellite DNA, are mitotically and cytogenetically stable in the absence of

92 Mammalian germ cells divide mitotically and form nests of associated cells just prio

93 wo novel gene functions required to maintain mitotically and meiotically heritable gene silencing ass

94 The weakly expressed Pl' state is mitotically and meiotically stable, yet reversible.

95 ixteen cases of mosaic aneuploidy originated mitotically, and these included four rare trisomies and

96 generated during this process are more sable mitotically, and when reisolated, transform the fungus a

97 TACE (which has alpha-secretase activity) to mitotically arrested adult rat mixed DRG cultures, we de

98 yclosome/anaphase-promoting complex (APC) in mitotically arrested cells but not in interphase cells.

99 Mitotically arrested cells display multipolar spindles a

100 Mitotically arrested cells typically display extensive p

101 cts prepared from logarithmically growing or mitotically arrested cells, we demonstrate that phosphor

102 apoptosis is significantly increased in the mitotically arrested cells.

103 l tails of histone H3 variants purified from mitotically arrested HeLa cells.

104 B, extracted chromosomes were prepared from mitotically-arrested HeLa S3 cells and incubated with re

105 Mitotically blocked cells exhibited aberrant spindles, c

106 ure hair cells after gentamicin treatment in mitotically blocked cultures of the bullfrog saccule.

107 detected in germline micronuclei that divide mitotically but not in somatic macronuclei that divide a

108 eir early radial glial derivatives and their mitotically competent neurogenic daughters.

109 xperiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells reside

110 Thus, the adult human hippocampus contains mitotically competent neuronal progenitors that can be s

111 , the human subcortical white matter harbors mitotically competent progenitor cells, which give rise

112 sufficient for transforming sperm DNA into a mitotically competent pronucleus.

113 unctions in maintaining the pericycle in the mitotically competent state needed for lateral root form

114 es of apoptosis and autophagic cell death in mitotically competent tissues and protein turnover and c

115 that it is the programmed destruction of the mitotically compromised stem cell niche that triggers it

116 erative zone, which includes a population of mitotically cycling cells and cells in meiotic S phase,

117 In mitotically cycling cells, we detect inter-homologue joi

118 hat DHJs are not formed during DSB repair in mitotically cycling cells.

119 Instead, they dedifferentiate back into mitotically cycling germ cells and form rapidly growing

120 d GLP-1 signaling, possibly corresponding to mitotically cycling proliferative zone cells that are di

121 Mitotically dividing cells appear to be less dependent o

122 enorhabditis elegans germline is composed of mitotically dividing cells at the distal end that give r

123 ion, a potential mechanism leading to LOH in mitotically dividing cells is DSB repair involving homol

124 Mitotically dividing cells use a surveillance mechanism,

125 The repE gene is not expressed by mitotically dividing cells, and repE mRNA is first detec

126 es that distinguish it from recombination in mitotically dividing cells, and several of these feature

127 rvations that homologous chromosomes pair in mitotically dividing cells, and that chromosome rearrang

128 though the rec14 transcripts were present in mitotically dividing cells, rec14 mutations had no detec

129 uired for the spindle assembly checkpoint in mitotically dividing cells.

130 We show that SMG-1 mainly acts in mitotically dividing germ cells, and during late embryon

131 We find that mitotically dividing germ cells--including germline stem

132 for the phosphorylation of linker histone in mitotically dividing micronuclei.

133 ects in nuclear divisions were restricted to mitotically dividing micronuclei; macronuclei, which are

134 ls are maintained in an undifferentiated and mitotically dividing state by Notch signaling and the FB

135 In mitotically dividing vertebrate cells, the primary prote

136 Small, mitotically dormant cholangiocytes are activated during

137 ng the course of cholestatic liver diseases, mitotically dormant cholangiocytes proliferate and subse

138 These studies demonstrate that mitotically expanded bone marrow cells can serve as an a

139 moters, which are silenced by methylation or mitotically expressed genes.

140 not in mutants defective in the three known mitotically expressed yeast RecA homologs.

141 Whereas the normally spliced cyclin RNA was mitotically functional, as indicated by its ability to p

142 , Rad51D, XRCC2, and XRCC3) are expressed in mitotically growing cells and are thought to play mediat

143 However, in mitotically growing cells this role can be fulfilled by

144 meras indicate that splicing is prevented in mitotically growing cells via inhibition, in contrast to

145 ransposon Ty1 accumulates to a high level in mitotically growing haploid cells, yet transposition occ

146 We also observed that mitotically growing Ku p70 mutants have an anomalously h

147 In mitotically growing yeast cells, five septin subunits ar

148 DNA molecule (xDNA), was analyzed at rDNA in mitotically growing yeast.

149 Epigenetic expression patterns are mitotically heritable and are stably maintained in adult

150 Although mitotically heritable and stable over time, patterns of

151 ptional memory: repressed genes that exhibit mitotically heritable changes in chromatin structure and

152 Mitotically heritable epigenetic or dynamic chromatin st

153 This mitotically heritable mode of regulation is recently evo

154 known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) ge

155 ion in plant genomes that is meiotically and mitotically heritable, and at times is associated with g

156 omoting cycling and subsequent cell death of mitotically impaired cells.

157 ested in this assay were each able to expand mitotically in concert with the surrounding paraxial mes

158 gates are plated into microdrops seeded with mitotically inactivated feeder cells, and then connected

159 ining the pluripotency of these iPS cells on mitotically inactivated feeder layers prepared from the

160 iopsies were cultured using a combination of mitotically inactivated fibroblasts and Rho-associated p

161 hESCs are conventionally grown on mitotically inactivated mouse embryonic fibroblasts (MEF

162 an be efficiently obtained by cultivation on mitotically inactivated testicular feeders containing CD

163 This included mitotically inactive breast lobular epithelium in additi

164 t meristem of flowering plants is a group of mitotically inactive cells designated the quiescent cent

165 hrough the quiescent center, a population of mitotically inactive cells formerly thought to be undiff

166 en demonstrated to be capable of transducing mitotically inactive cells, including HSCs, and accommod

167 Mitotically inactive feeder layers have been used previo

168 The pathogenic cells were mitotically inactive, but proliferating precursors were

169 These cells are mitotically inactive, differentiated oligodendrocytes an

170 whereupon the buds shrink in size and become mitotically inactive.

171 cell division in the QC, which is generally mitotically inactive.

172 s with reduced EphA4 signaling were rare and mitotically inactive.

173 In conclusion, we found that mitotically incompetent ocular tissue cells contain adul

174 cs can be defined as all the meiotically and mitotically inherited changes in gene expression that ar

175 s, and this chromatin-related memory must be mitotically inherited to maintain cell identity through

176 expression pattern is stably maintained and mitotically inherited.

177 cle formation in skin reconstitution assays, mitotically inhibited cells readily contribute to DP.

178 nick end labeling positive, and they can be mitotically labeled by sustained rather than acute bromo

179 Adenomas appeared to be relatively mitotically old populations, pocketed with occasional ne

180 ations, suggesting that they were relatively mitotically old populations.

181 The mitotically phosphorylated MEK1, upon partial proteolysi

182 retic mobility shifts, we have identified 20 mitotically phosphorylated proteins from Xenopus embryos

183 ody MPM-2 recognizes a significant subset of mitotically phosphorylated S/TP motifs; however, the req

184 The mitotically preserved processing complexes may be essent

185 Some of these mitotically produced cells began to differentiate into h

186 ns has important functions in cytokinesis in mitotically proliferating cells.

187 proliferate and then differentiate to become mitotically quiescent adipocytes.

188 We showed that the mitotically quiescent cells were very significantly more

189 ot meristem has a centrally located group of mitotically quiescent cells, to which current models ass

190 xposure stimulates cellular proliferation in mitotically quiescent cells.

191 CD4+ T cells but significantly decreased in mitotically quiescent cells.

192 For in vitro analysis, mitotically quiescent chondrocytes were exposed to incre

193 and their progenitors with both dividing and mitotically quiescent endothelial cells in restricted re

194 population called satellite cells, which are mitotically quiescent in mature muscle, but can be activ

195 Although mitotically quiescent in mature muscle, satellite cells

196 iated marker negligibly expressed in normal, mitotically quiescent neural tissues.

197 Because the liver is essentially a mitotically quiescent organ, tamoxifen-DNA adduction in

198 for primitive HPCs, persists in culture in a mitotically quiescent state due to their cytokine-nonres

199 an prostate cancer cell lines, we identified mitotically quiescent subpopulations (<1%), which we com

200 The normally mitotically quiescent supporting cells proliferated afte

201 ca-1(+)lin(-) engrafting cell as one that is mitotically quiescent, CD43(+), CD49e(+), CD11a(-), CD49

202 ration shows that the placodal epithelium is mitotically quiescent, with few phosphohistone H3-positi

203 m all cells in the basilar papilla, which is mitotically quiescent.

204 rare mononucleate muscle precursor cells are mitotically quiescent.

205 of cells in an epithelium that is otherwise mitotically quiescent.

206 nase inhibitor p27(Kip1), and are presumably mitotically quiescent.

207 surfaces through trans-oligomerization in a mitotically regulated manner.

208 ties required to bind surfaces together in a mitotically regulated manner.

209 necessary for initiating the division of all mitotically regulated neuroblasts in the brain lobes.

210 ratus during mitosis implicated GRASP65 as a mitotically regulated stacking factor.

211 NA necessary for ribosome biogenesis, is not mitotically regulated.

212 ization and trans-oligomerization but is not mitotically regulated.

213 mitosis originated the hypothesis that such mitotically retained molecular signatures could provide

214 Mitotically selected CHO cells were incubated without tr

215 ering by causing a repression of FLC that is mitotically stable after return to warm growing conditio

216 ble in both the prion and the nonprion form, mitotically stable but meiotically unstable, and cured b

217 Results from deletion analysis of mitotically stable chromosome rearrangements and from a

218 es on stable dicentric chromosomes, and also mitotically stable chromosomes lacking alpha-satellite D

219 e 22 with no detectable CENP-B motifs formed mitotically stable HACs in the absence of drug selection

220 e association of Ring1b and ubH2A with Xi is mitotically stable in non-differentiated TS cells.

221 e active kinetochore protein CENP-E and were mitotically stable in the absence of selection for at le

222 pigenetic phenomenon in the sense that it is mitotically stable in the spring after the inducing sign

223 als, numerous autosomal genes are subject to mitotically stable monoallelic expression (MAE), includi

224 Although artificial chromosomes are mitotically stable over many months in culture, when we

225 ess by which a long period of cold induces a mitotically stable state that leads to accelerated flowe

226 esults in "resetting" of the variegated, but mitotically stable, defects.

227 nducibly convert circular DNA molecules into mitotically stable, linear chromosomes replete with func

228 jority of or all cells analyzed and appeared mitotically stable, thereby indicating the presence of a

229 nspose into random rDNA repeat units and are mitotically stable.

230 Through tandem mass spectrometry analysis of mitotically SUMOylated PARP1, we identified a residue wi

231 When mitotically synchronized cells were treated with the Cdk

232 Analysis of BrdU incorporation in mitotically synchronized HeLa cells suggested that cells

233 h a stem cell population continues to divide mitotically throughout life; hence the cell cycles of th

234 Germ cells can divide mitotically to replenish germline tissue or meiotically

235 contribute to epigenetic functions that are mitotically transmitted by Runx2 in osteoblastic cells.

236 This array is mitotically unstable and can be lost to produce a clone

237 the URA3 negative selectable marker becomes mitotically unstable and is lost at high frequency by di

238 lasmic infection (cytoduction), but which is mitotically unstable in non-selective conditions.

239 ific histone variant CENPA and the HSA17 was mitotically unstable, or alternatively, the centromere w

240 are represented as circular elements and are mitotically unstable.

241 e to reform functional CEN chromatin and was mitotically unstable.

242 , but the prions formed by this variant were mitotically very unstable.

243 Male germ cells arrest mitotically, while female germ cells directly enter meio