ライフサイエンスコーパス: mixed lymphocyte reaction

1 ect alloresponse (cell-mediated lympholysis, mixed lymphocyte reaction).

2 c tolerance did not develop clinically or in mixed lymphocyte reaction.

3 by autologous non-T cells in the autologous mixed lymphocyte reaction.

4 nd proliferation capacity was measured using mixed lymphocyte reaction.

5 eaction and tolerance by skin grafts and the mixed lymphocyte reaction.

6 to be functionally active by inhibition of a mixed lymphocyte reaction.

7 ifically peptide-primed syngeneic T cells in mixed lymphocyte reaction.

8 ulated T-cell proliferation in an autologous mixed lymphocyte reaction.

9 r the known function of IL-16 to inhibit the mixed lymphocyte reaction.

10 to modulate the CD3 complex and inhibit the mixed lymphocyte reaction.

11 us, significantly reduced proliferation in a mixed lymphocyte reaction.

12 ific tolerance upon stimulation in a one-way mixed lymphocyte reaction.

13 interferon gamma production in an allogeneic mixed lymphocyte reaction.

14 vitro, and assayed for capacity to suppress mixed lymphocyte reaction.

15 liferation was present on days 5 to 9 of the mixed lymphocyte reaction.

16 ressive activity on cytokine production in a mixed lymphocyte reaction.

17 a triggering in T cells during an allogeneic mixed lymphocyte reaction.

18 their allogeneic potential, as indicated in mixed lymphocyte reaction.

19 ction and T-cell proliferation in an in vivo mixed lymphocyte reaction.

20 al and can costimulate allogeneic cells in a mixed lymphocyte reaction.

21 ability to support T-cell proliferation in a mixed-lymphocyte reaction.

22 o stimulate allogeneic CD4(+) T cells in the mixed-lymphocyte reaction.

23 type-1 T-cell response induced in allogeneic mixed-lymphocyte reaction.

24 y to induce a regulatory T-cell phenotype in mixed lymphocyte reactions.

25 s and naive recipient-matched stimulators in mixed lymphocyte reactions.

26 T DC for stimulating T-cell proliferation in mixed lymphocyte reactions.

27 Ab to CD28 and can mount an alloresponse in mixed lymphocyte reactions.

28 specifically nonresponsive to donor cells in mixed lymphocyte reactions.

29 lial/T cell reaction but not of conventional mixed lymphocyte reactions.

30 une regulatory) macrophages were measured in mixed lymphocyte reactions.

31 effects of rIL-16 on T cell proliferation in mixed lymphocyte reactions.

32 ts ability to inhibit proliferation in human mixed lymphocyte reactions.

33 ell responsiveness of the host using one-way mixed lymphocyte reactions.

34 kine that potently inhibits alloresponses in mixed lymphocyte reactions.

35 ent ability to suppress T-cell activation in mixed lymphocyte reactions.

36 5(+)/CD4(+)CD25(-) T cells were evaluated in mixed lymphocyte reactions.

37 ell proliferation and cytokine production in mixed lymphocyte reactions.

38 cells on the immune system was evaluated in mixed lymphocyte reactions.

39 tion, and T cell proliferation in autologous mixed lymphocyte reactions.

40 lyzed for their ability to elicit allogeneic mixed-lymphocyte reactions.

41 geneic cytotoxic T lymphocytes (58%) and the mixed lymphocyte reaction (36%); CTLA4Ig was more effect

42 us postconversion sera on Treg generation in mixed lymphocyte reactions; (4) peripheral blood nonspec

43 emonstrated by significant depression of the mixed lymphocyte reaction (690+/-119 vs. 3850+/-148 cpm,

44 specially in the ICLP (alpha>13) and two-way mixed lymphocyte reaction (alpha>40) assays.

45 The autologous mixed lymphocyte reaction also indicated a trend towards

46 Both pre- and postconversion sera inhibited mixed lymphocyte reactions, although only TAC sera suppr

47 y T cell activity was assessed by autologous mixed lymphocyte reaction (AMLR), an in vitro assay for

48 tudies, in addition to functional allogeneic mixed lymphocyte reaction and accessory-cell dependent m

49 Lewis anti-hamster mixed lymphocyte reaction and cell-mediated lympholysis

50 s determined by various parameters including mixed lymphocyte reaction and cytotoxic T lymphocyte ass

51 lity complex (MHC) antigens as measured by a mixed lymphocyte reaction and cytotoxic T-cell assay.

52 In vitro assays (mixed lymphocyte reaction and ELISPOT) revealed donor-sp

53 iferation and interferon-gamma production in mixed lymphocyte reaction and enzyme-linked immunospot a

54 mice, as well as didemnin M, tested for the mixed lymphocyte reaction and graft vs host reaction in

55 d increased levels of IFN-gamma and IL-17 in mixed lymphocyte reaction and in the graft.

56 r allogeneic antigen stimulation in both the mixed lymphocyte reaction and in the skin explant assay.

57 Suppression was assayed in vitro by mixed lymphocyte reaction and in vivo by targeting cardi

58 with 381 also stimulated a higher autologous mixed lymphocyte reaction and induced a Th1-type respons

59 s showed enhanced functional activity in the mixed lymphocyte reaction and induced T cells to secrete

60 Donor-specific tolerance was assessed with mixed lymphocyte reaction and INF-gamma ELISPOT before (

61 alloreactivity in the host was confirmed by mixed lymphocyte reaction and skin grafting.

62 ontrol levels of proliferation in allogeneic mixed lymphocyte reactions and a type 1 (IFN-gamma) cyto

63 -mPGPtide, inhibited T-cell proliferation in mixed lymphocyte reactions and blocked activation of bot

64 ia cells are highly effective stimulators in mixed lymphocyte reactions and can induce generation of

65 T lymphocytes could be detected on day 2 of mixed lymphocyte reactions and continued to increase in

66 atch induces the expression of granzyme B in mixed lymphocyte reactions and in a model of graft-versu

67 eDCs were functional in mixed lymphocyte reactions and produced tumor necrosis f

68 tely 16 weeks posttransplant for analysis of mixed lymphocyte reactions and spectratyping of human CD

69 ro anti-donor responsiveness was assessed by mixed-lymphocyte reaction and cell-mediated lympholysis

70 Mixed-lymphocyte reactions and delayed-type hypersensiti

71 otypes and clonality, cytokine production in mixed lymphocyte reaction, and characterization of intra

72 to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, and increases the survival of

73 to mitogens and Ags, tolerance to donor in a mixed lymphocyte reaction, and normal Ab titers after te

74 They responded in an autologous mixed lymphocyte reaction, and T cell clones isolated fr

75 profiling, cytokine assays, flow cytometry, mixed lymphocyte reaction, and T-cell proliferation assa

76 s controlling specific immune responses, the mixed lymphocyte reaction, and the structure of Ia antig

77 tant role in primary alloresponses, e.g., in mixed lymphocyte reactions, and organ transplantation.

78 tudies, including cell-mediated lympholysis, mixed lymphocyte reactions, and peptide proliferation as

79 Using mixed lymphocyte reactions as a model of alloimmunizatio

80 T lymphocyte lytic activity were assessed by mixed lymphocyte reaction assay and 51 Chromium release

81 e porcine hematopoietic donor as measured by mixed lymphocyte reaction assay and skin grafting.

82 Mixed lymphocyte reaction assay demonstrated tolerance t

83 -cell costimulatory activity, as measured by mixed lymphocyte reaction assay, was lower in patients,

84 Cs) to assess VEC proliferation or used in a mixed lymphocyte reaction assay.

85 oregulatory activity were assessed through a mixed lymphocyte reaction assay.

86 Mixed lymphocyte reaction assays in both groups revealed

87 ymphocyte proliferation correlated well with mixed lymphocyte reaction assays using purified protein.

88 a role of iNKT cells in regulating aGVHD, in mixed lymphocyte reaction assays, CD4(-) iNKT cells effe

89 ocytes from men and women as well as two-way mixed lymphocyte reaction assays.

90 nked immunospot, intracellular cytokine, and mixed lymphocyte reaction assays.

91 ayed different allostimulation capability in mixed lymphocyte reaction assays.

92 days after cessation of the treatment and by mixed lymphocyte reaction at 100 days.

93 ysis, electron microscopy, and an allogeneic mixed lymphocyte reaction at day 14.

94 48 hr, however, the T cells from the primary mixed lymphocyte reaction began producing IFN-gamma, con

95 HLA-G, TGF-beta, and IL-10) were tested on a mixed lymphocyte reaction between antigen-presenting cel

96 ng T cells in both autologous and allogeneic mixed lymphocyte reactions but less efficient at present

97 Both agents effectively inhibited rhesus mixed lymphocyte reactions, but the combination was 100

98 Induction of an in vivo autologous mixed lymphocyte reaction by caspase-modified self-Ags p

99 Stimulation of cells in mixed lymphocyte reactions by wild-type DCs was suppress

100 unoconjugate pretreated donors inhibited the mixed lymphocyte reaction completely without the use of

101 In vitro investigation of baboon anti-pig mixed lymphocyte reaction confirmed that only the indire

102 % CD4/RT1a, 9.28% CD8/RT1a) transplants, and mixed lymphocyte reaction confirmed tolerance in recipie

103 duction and proliferation were assessed in a mixed lymphocyte reaction containing FK734, human T cell

104 CD40:CD40L costimulatory pathway in primary mixed lymphocyte reaction cultures resulted in profound

105 ed and control animals were added to one-way mixed lymphocyte reaction cultures.

106 cytotoxic-T-lymphocyte generation in primary mixed lymphocyte reaction cultures.

107 Cellular immune responses were monitored by mixed lymphocyte reaction, cytometric analysis of graft-

108 aluated ex vivo by enzyme-linked immunospot, mixed lymphocytes reaction, cytotoxic T lymphocyte, and

109 Mixed lymphocyte reaction demonstrated in vitro donor-sp

110 Mixed lymphocyte reactions demonstrated that CD4+CD25- T

111 Mixed lymphocyte reactions demonstrated that T-cells fro

112 ed using fluorescence-activated cell sorter, mixed lymphocyte reaction, enzyme-linked immunospot, sig

113 In mixed lymphocyte reactions, EPO induced a dose-dependent

114 In mixed lymphocyte reaction experiments designed to simula

115 orphology, flow cytometry for phenotype, and mixed lymphocyte reaction for allostimulatory function.

116 Mixed lymphocyte reaction for donor-specific tolerance i

117 ma at the time of neonatal priming recovered mixed lymphocyte reaction hypoproliferation and restored

118 nued insulin independence and donor-specific mixed lymphocyte reaction hyporeactivity.

119 fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT is capable o

120 tivated by allogeneic monocytes in a primary mixed lymphocyte reaction in the presence of exogenous i

121 he ability to suppress phytohemagglutinin or mixed lymphocyte reaction-induced splenocyte proliferati

122 hibit DPPIV in cell culture and in the human mixed lymphocyte reaction is demonstrated.

123 owed donor-specific nonresponsiveness in the mixed lymphocyte reaction, lack of antidonor IgG antibod

124 A TR2-Fc fusion protein inhibited a mixed lymphocyte reaction-mediated proliferation suggest

125 y for at least 1 month, and then islets from mixed lymphocyte reaction mismatched primates were infus

126 nd bone were heterotopically transplanted to mixed lymphocyte reaction-mismatched Cynomolgus macaques

127 nsplantation from blood group compatible but mixed lymphocyte reaction-mismatched donors.

128 renal aortic segments were exchanged between mixed lymphocyte reaction-mismatched, blood group-compat

129 ic responder cells taking part in allogeneic mixed lymphocyte reaction (MLR) and cell-mediated lympho

130 o antidonor responsiveness was determined by mixed lymphocyte reaction (MLR) and cell-mediated lympho

131 c analysis and functionally as modulators in mixed lymphocyte reaction (MLR) and cell-mediated lympho

132 e was assessed by skin grafting, and also by mixed lymphocyte reaction (MLR) and cell-mediated lympho

133 Regulatory mechanisms were assessed by mixed lymphocyte reaction (MLR) and cell-mediated lympho

134 ty was assessed by in vitro assays including mixed lymphocyte reaction (MLR) and flow cytometry to de

135 cells stimulate naive T cells in the primary mixed lymphocyte reaction (MLR) and induce MC38 tumor-sp

136 ravenous immunoglobulin [IVIG]) inhibits the mixed lymphocyte reaction (MLR) and induces apoptosis pr

137 Mixed lymphocyte reaction (MLR) and skin grafting assess

138 vity of the didemnins was determined using a mixed lymphocyte reaction (MLR) assay.

139 phocytic reactivity and cytokine analysis of mixed lymphocyte reaction (MLR) culture supernatants by

140 flow cytometric cell sorting approach after mixed lymphocyte reaction (MLR) culture, we have found t

141 proliferation in dendritic cell-driven allo-mixed lymphocyte reaction (MLR) cultures by more than 90

142 shows that blockade of B7/CD28 in anergizing mixed lymphocyte reaction (MLR) cultures of peripheral b

143 rowth factor (TGF)-beta treatment of primary mixed lymphocyte reaction (MLR) cultures resulted in sec

144 inst cell surface determinants, treatment of mixed lymphocyte reaction (MLR) cultures with interleuki

145 micro-cell-mediated lympholysis (m-CML) and mixed lymphocyte reaction (MLR) in recipients with quies

146 h irradiated allogenic stimulator cells in a mixed lymphocyte reaction (MLR) in the presence of solub

147 rmined by standard skin grafting in vivo and mixed lymphocyte reaction (MLR) in vitro.

148 The allogeneic mixed lymphocyte reaction (MLR) is a complex in vitro as

149 The demonstration that stimulation in the mixed lymphocyte reaction (MLR) mapped to the same regio

150 Thirty-nine cynomolgus monkeys received mixed lymphocyte reaction (MLR) mismatched unilateral lu

151 tors) in cell-mediated lympholysis (CML) and mixed lymphocyte reaction (MLR) responses of normal peri

152 DC activation and mixed lymphocyte reaction (MLR) studies were performed t

153 noantibodies of these isotypes and displayed mixed lymphocyte reaction (MLR) tolerance to donor pig m

154 ctivated cell sorting analysis of cells from mixed lymphocyte reaction (MLR) treated with MEDI-507 re

155 dard skin grafting, flow cytometry (FC), and mixed lymphocyte reaction (MLR) were used to assess effi

156 SPTs undergo less proliferation in a mixed lymphocyte reaction (MLR) when compared with unpul

157 , blocked binding of ICAM-1, and inhibited a mixed lymphocyte reaction (MLR) with potency significant

158 nisms of tolerance, we examined in vitro the mixed lymphocyte reaction (MLR), cell-mediated lymphocyt

159 APC function, assessed using an allogeneic mixed lymphocyte reaction (MLR), demonstrated equivalent

160 Histology, mixed lymphocyte reaction (MLR), skin grafting, and flow

161 Using mixed lymphocyte reaction (MLR), the effect of atorvasta

162 Proliferation and mixed lymphocyte reaction (MLR)-based assays were used t

163 Our results show that primary mixed lymphocyte reaction (MLR)-derived CTLs from granzy

164 CD8+ cells were tested for veto activity by mixed lymphocyte reaction (MLR)-induced cell-mediated ly

165 while having no effect on the CD4-dependent mixed lymphocyte reaction (MLR).

166 +) and YFP(-)) was evaluated in an allogenic mixed lymphocyte reaction (MLR).

167 ased CTLA-4 was functionally inhibitory in a mixed lymphocyte reaction (MLR).

168 T lymphocytes (CTLs) that are generated in a mixed lymphocyte reaction (MLR).

169 GTKO, GTKO/CD46 pigs and human was tested by mixed lymphocyte reaction (MLR).

170 , and IL-13 by T cells, in the course of the mixed lymphocyte reaction (MLR).

171 Furthermore, mixed lymphocyte reactions (MLR) against self antigens w

172 f BEL on human regulatory T cells (Tregs) in mixed lymphocyte reactions (MLR) alone and in combinatio

173 Mixed lymphocyte reactions (MLR) and cell-mediated lymph

174 Antagonistic antibody blocked mixed lymphocyte reactions (MLR) in a dose-dependent man

175 Mixed lymphocyte reactions (MLR) using peripheral blood

176 -derived T cell line and replicate, anti-DR1 mixed lymphocyte reactions (MLR), established from an un

177 to the CD31 domain 6 and inhibits the human mixed-lymphocyte reaction (MLR) in a specific and dose-d

178 mulated autologous and allogeneic T cells by mixed-lymphocyte reaction (MLR).

179 presenting cells able to induce the primary (mixed lymphocyte reaction [MLR]) and secondary (recall r

180 ester-labeled CD4+CD25 high FOXP3+ cells in mixed lymphocyte reactions (MLRs) ("the Treg MLR"), with

181 with more than 95% suppression of allogeneic mixed lymphocyte reactions (MLRs) (29 of 30 donors).

182 cytokine production during donor-antipatient mixed lymphocyte reactions (MLRs) and acute graft-versus

183 tion with host PBMCs, as assessed in primary mixed lymphocyte reactions (MLRs).

184 n preventing T cell function using a one-way mixed lymphocyte reaction model for bone marrow transpla

185 d used either as stimulator cells in one-way mixed lymphocyte reaction or transplanted into naive Bal

186 fusion protein did not affect the allogeneic mixed lymphocyte reaction, our data indicate that TNFRSF

187 ers to peripheral blood mononuclear cells in mixed lymphocyte reactions (P<0.001).

188 te acute rejection had marked suppression of mixed lymphocyte reaction proliferation to intact donor

189 from the spleen of P5-primed rats had a high mixed lymphocyte reaction proliferative response to P5 p

190 ociated with a significant reduction in host mixed lymphocyte reaction reactivity and is correlated i

191 Analysis of selective mixed lymphocyte reaction responses to DR or DQ antigens

192 Anti-donor mixed lymphocyte reaction responses were positive in the

193 Cytotoxic antibodies, secondary mixed lymphocyte reaction responses, cytotoxic T cells,

194 esulted in normal cytotoxic T lymphocyte and mixed lymphocyte reaction responses, showing that clonal

195 In vitro mixed lymphocyte reactions revealed modulation of the re

196 Moreover, mixed lymphocyte reactions revealed that exposure of CD3

197 Mixed lymphocyte reaction showed nonspecific suppression

198 ferent T-cell receptor (Tcr) ligand systems: mixed lymphocyte reactions, stimulation of Tcr transgeni

199 Skin grafts and mixed lymphocyte reaction studies showed no durable tole

200 6 cells was induced by culture in allogeneic mixed lymphocyte reaction supernatant, an effect largely

201 Cytokine profile of mixed lymphocyte reaction supernatants of T cells obtain

202 Finally, we show that in an in vitro mixed lymphocyte reaction system using human T cells, th

203 ed DC were capable of inducing an allogeneic mixed lymphocyte reaction, they did so to a significantl

204 activity, skew T(H)1 responses in allogeneic mixed lymphocyte reactions through reduction of IL-4 and

205 ) demonstrated evidence of immune deviation; mixed lymphocyte reaction to ACI stimulator cells was vi

206 for more than 4 hr were able to inhibit the mixed lymphocyte reaction to almost background levels, b

207 The chimeric animal was less responsive by mixed lymphocyte reaction to pig-specific stimulators th

208 mmunizing peptides, as well as having strong mixed lymphocyte reactions to donor cells prior to trans

209 These approaches include mixed lymphocyte reactions, trans-vivo delayed-type hype

210 ctor P3 (FOXP3) T-regulatory (Treg) cells in mixed lymphocyte reaction (Treg MLR) and now report addi

211 e short-lived and elicited potent allogeneic mixed-lymphocyte reactions typical of DCs.

212 ory molecules both in vivo and in vitro, and mixed lymphocyte reaction using alloantigen-primed Mac-1

213 Donor-specific mixed lymphocyte reaction was generally preserved.

214 ever, evidence of sensitization in antidonor mixed lymphocyte reaction was observed in seven of eight

215 Previously, the mixed lymphocyte reaction was used as standard to detect

216 ions that LFA3TIP inhibits baboon allogeneic mixed lymphocyte reactions, we gave baboon recipients of

217 analysis of peripheral blood lymphocytes and mixed lymphocyte reaction were performed before transpla

218 Primary one-way mixed lymphocyte reactions were established, and the exp

219 Mixed lymphocyte reactions were performed combining enri

220 Mixed lymphocyte reactions were performed in naive gld,

221 In syngeneic mixed-lymphocyte reactions with BALB/c splenocytes, A20

222 ch combining a classical in vitro assay, the mixed lymphocyte reaction, with deep T cell receptor seq

223 ne costimulatory blockade was tested in xeno-mixed lymphocyte reactions (XMLRs) and in natural killer