ライフサイエンスコーパス: mixed-lineage leukemia

1 sociated with infant acute lymphoblastic and mixed lineage leukemia.

2 s cytogenetics in acute myeloid leukemia and mixed lineage leukemia.

3 an inv(8)(p11q13) from a patient with acute mixed lineage leukemia.

4 ole and is a potential therapeutic target in mixed lineage leukemia.

5 ing response to therapy, of 35 patients with mixed-lineage leukemia.

6 methyltranferases (H3K4MTs) MLL3 and MLL4 in mixed-lineage leukemia.

7 F23, and NUP98-TOP1 physically interact with mixed lineage leukemia 1 (MLL1) and the non-specific let

8 Mixed lineage leukemia 1 (MLL1) is a histone H3 lysine 4

9 The epigenetic activator Mixed lineage leukemia 1 (MLL1) is paramount for embryon

10 We show that the mixed lineage leukemia 1 (MLL1) protein, a histone methy

11 Menin is an essential oncogenic cofactor for mixed lineage leukemia 1 (MLL1)-mediated leukemogenesis

12 ulated by MOZ, mixed lineage leukemia 1, and mixed lineage leukemia 1 cofactor menin.

13 leukemia cell lines harboring the rearranged mixed lineage leukemia 1 gene.

14 of acute leukemias arise from fusion of the mixed lineage leukemia 1 protein (MLL) N terminus to a v

15 oregulators such as histone methylases MLL1 (mixed lineage leukemia 1) and MLL3 and CREB-binding prot

16 The MLL1 (mixed lineage leukemia 1) protein, which is often disrup

17 gnificant overlap in genes regulated by MOZ, mixed lineage leukemia 1, and mixed lineage leukemia 1 c

18 down (KD) of a writer, the methyltransferase mixed-lineage leukemia 1 (Mll1) (n = 26), and an eraser,

19 Here, we show that mixed-lineage leukemia 1 (MLL1) protein is a key determi

20 ity for a truncated, lacZ knock-in allele of mixed-lineage leukemia 1 (Mll1), a histone methyltransfe

21 Ash1l cooperated functionally with mixed-lineage leukemia 1 (Mll1), as combined loss of Ash

22 f the H3K4-specific methyltransferase, Kmt2a/Mixed-lineage leukemia 1 (Mll1), in mouse postnatal fore

23 ultiprotein complex essential for activating mixed-lineage leukemia 1 (MLL1).

24 he histone methyltransferases Set1 and MLL1 (mixed-lineage leukemia 1), leading to histone H3K4 trime

25 The mixed lineage leukemia-1 (MLL1) core complex predominant

26 The mixed lineage leukemia-1 (MLL1) enzyme is a histone H3 l

27 Translocations and amplifications of the mixed lineage leukemia-1 (MLL1) gene are associated with

28 Mixed-lineage leukemia-1 (MLL1) has been shown to direct

29 Lpt) is the N-terminal homolog of mammalian Mixed Lineage Leukemia 2 (MLL2/ALR), a core component of

30 transferases such as enhancer of zeste 2 and mixed lineage leukemia 2, histone demethylases including

31 istone-methyltransferase myeloid/lymphoid or mixed-lineage leukemia 2 (mll2/kmt2b) gene in adult fore

32 ximately 50% reduction in gene dosage of the mixed lineage leukemia 3 (MLL3) gene, located on 7q36.1,

33 The MLL3 (mixed lineage leukemia 3) protein is a member of the hum

34 s identified were all of the subunits of the mixed-lineage leukemia 3 (Mll3) and 4 (Mll4) complexes,

35 The histone H3-lysine-4 methyltransferase mixed-lineage leukemia 3 (MLL3) and its closest homolog,

36 Although PTIP is a unique component of the mixed-lineage leukemia 3 (MLL3)/MLL4 chromatin-modifying

37 deficient in the PTIP component of the MLL3 (mixed-lineage leukemia 3)-MLL4 complex display impaired

38 umonji C family of proteins, associates with mixed-lineage leukemia 3/4 complexes.

39 Mixed-lineage leukemia 4 (MLL4/KMT2D) is a major enhance

40 Mixed-lineage leukemia 4 (MLL4; also called MLL2 and ALR

41 H3.3 is repressed by mixed lineage leukemia 5 (MLL5) in self-renewing GBM cel

42 The human mixed-lineage leukemia 5 (MLL5) protein mediates hematop

43 eptor NKp44 (NKp44L), a novel isoform of the mixed-lineage leukemia-5 protein, as a cellular ligand f

44 lso suppresses proliferation of leukemogenic mixed lineage leukemia-AF9 fusion-protein-transformed my

45 Taspase1, the mixed lineage leukemia and TFIIAalpha-beta cleaving prot

46 mia (ALL), acute myelogenous leukemia (AML), mixed lineage leukemia, and also in therapy AML (t-AML)

47 ragile sites, and breakpoints, including the mixed-lineage leukemia breakpoint cluster region (MLL BC

48 y, although PTIP and PA1 associate with MLL (mixed lineage leukemia) complexes and participate in tra

49 effectively treats aggressive AML, including mixed-lineage leukemia-driven AML, and outperforms stand

50 f conditional transformation by an inducible mixed lineage leukemia-eleven-nineteen leukemia (MLL-ENL

51 A murine retroviral transduction model of mixed lineage leukemia fused to CREB binding protein suc

52 rmined that minimally, the amino terminus of mixed lineage leukemia fused to the bromodomain and hist

53 upport of this idea, we showed recently that mixed lineage leukemia fusion oncoproteins can convert c

54 ses the transcriptional activity of a common mixed-lineage leukemia fusion partner, AF9.

55 The AF1q gene, a mixed-lineage leukemia fusion partner, is highly express

56 ort that hDOT1L interacts with AF10, an MLL (mixed lineage leukemia) fusion partner involved in acute

57 ves as a critical oncogenic cofactor of MLL (mixed lineage leukemia) fusion proteins in acute leukemi

58 in leukemogenesis driven by a subset of MLL (mixed-lineage leukemia) fusion proteins raises the possi

59 ias that harbor translocations involving the mixed lineage leukemia gene (MLL) possess unique biologi

60 Chromosomal translocations affecting mixed lineage leukemia gene (MLL) result in acute leukem

61 Translocations involving the mixed lineage leukemia gene (MLL), the human homolog of

62 The mixed lineage leukemia gene (MLL, also known as HRX, ALL

63 Rearrangements of the mixed lineage leukemia gene MLL are associated with aggr

64 Chromosome translocations involving the mixed lineage leukemia gene MLL are associated with aggr

65 Chromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion prot

66 adults as a result of rearrangements to the mixed-lineage leukemia gene (MLL) located on chromosome

67 atient-derived xenografts (PDX) of pediatric mixed-lineage leukemia gene (MLL)-rearranged ALL were es

68 The mixed-lineage leukemia gene (MLL, ALL1, HRX) encodes a 3

69 ng a chromosomal translocation involving the mixed-lineage leukemia gene (MLL, ALL1, HRX) have a part

70 The Mixed-Lineage Leukemia gene (MLL/HRX/ALL1) encodes a lar

71 The MLL (Mixed Lineage Leukemia) gene is a common target for chro

72 e a drug target for acute leukemia with MLL (mixed lineage leukemia) gene translocations.

73 The MLL (mixed-lineage leukemia) gene is involved in many chromos

74 ene involved in translocations with the MLL (mixed-lineage leukemia) gene, was 631 bp away in a head-

75 to as MLL to denote the gene associated with mixed-lineage leukemia) generate MLL fusion proteins tha

76 MEN1 and its coactivator, the mixed-lineage leukemia histone methyltransferase, are re

77 iginally identified as a fusion partner with mixed-lineage leukemia in a patient with acute myeloid l

78 ize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the path

79 key roles of ERs in the recruitment of these mixed lineage leukemias into the HOXC6 promoter.

80 MLL (mixed-lineage leukemia) is a histone H3 Lys-4 specific m

81 MLL (for mixed-lineage leukemia) is a proto-oncogene that is muta

82 ing translocation t(11;16) (q23;p13.3), MLL (mixed-lineage leukemia) is fused in frame to CBP (CREB b

83 horax family member MLL (myeloid/lymphoid or mixed-lineage leukemia) is presumed to activate Hox expr

84 tool for understanding the biologic basis of mixed lineage leukemia leukemogenesis and for developing

85 One such gene is MLL (myeloid-lymphoid or mixed lineage leukemia) located at chromosome band 11q23

86 5 (WDR5) is a common component of mammalian mixed lineage leukemia methyltransferase family members

87 Mixed lineage leukemia (MLL) and its metazoan Trithorax

88 c-Myb, GATA-3, Menin, and mixed lineage leukemia (MLL) bound to CGRE in human prim

89 e II (TOP2)-mediated DNA cleavage within the mixed lineage leukemia (MLL) breakpoint cluster region (

90 nic fusions of the Trithorax-related protein mixed lineage leukemia (MLL) can initiate aggressive leu

91 allosteric changes that transcription factor mixed lineage leukemia (MLL) causes to the interactions

92 WDR5 is a component of the mixed lineage leukemia (MLL) complex, which methylates l

93 The oncoprotein Ash2L is a component of the mixed lineage leukemia (MLL) family members 1-4, Setd1A,

94 Although misregulation of mixed lineage leukemia (MLL) family proteins has been as

95 in, the MEN1 protein product, interacts with mixed lineage leukemia (MLL) family proteins in a histon

96 Mixed lineage leukemia (MLL) fusion genes arise from chr

97 Identification of the targets of mixed lineage leukemia (MLL) fusion genes will assist in

98 unctions and in leukemogenesis driven by the mixed lineage leukemia (MLL) fusion oncogene MLL-AF9.

99 ough menin acts as an oncogenic cofactor for mixed lineage leukemia (MLL) fusion protein-mediated his

100 polymerase-associated factor complex (PAFc), mixed lineage leukemia (MLL) fusion proteins activate ge

101 unctions as a critical oncogenic cofactor of mixed lineage leukemia (MLL) fusion proteins in the deve

102 The interaction between menin and oncogenic mixed lineage leukemia (MLL) fusion proteins is required

103 Mixed lineage leukemia (MLL) fusion-driven acute leukemi

104 Chromosomal translocations of the mixed lineage leukemia (MLL) gene are a common cause of

105 Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are associated with ag

106 Chromosomal translocations involving the mixed lineage leukemia (MLL) gene are often observed in

107 ith chromosomal translocations involving the mixed lineage leukemia (MLL) gene are usually associated

108 The mixed lineage leukemia (MLL) gene at chromosome band 11q

109 Chromosome translocations involving the mixed lineage leukemia (MLL) gene fuse it in frame with

110 first identified as a fusion partner of the mixed lineage leukemia (MLL) gene in acute myeloid leuke

111 The mixed lineage leukemia (MLL) gene is also frequently inv

112 The Mixed Lineage Leukemia (MLL) gene is commonly involved i

113 A partial nontandem duplication (PNTD) of mixed lineage leukemia (MLL) gene is described in B-cell

114 Translocations of the mixed lineage leukemia (MLL) gene occur in 60% to 80% of

115 en mutated in ALLs with rearrangement of the mixed lineage leukemia (MLL) gene on chromosome 11q23.

116 The mixed lineage leukemia (MLL) gene plays a critical role

117 Chromosomal translocations involving the Mixed Lineage Leukemia (MLL) gene produce chimeric prote

118 of infants with ALL, particularly those with mixed lineage leukemia (MLL) gene rearrangements, is onl

119 Chromosomal translocations disrupting the Mixed lineage leukemia (Mll) gene result in leukemia, wi

120 Chromosomal translocations targeting the mixed lineage leukemia (MLL) gene result in MLL fusion p

121 to be a drug target for acute leukemia with mixed lineage leukemia (MLL) gene translocations.

122 The mixed lineage leukemia (MLL) gene undergoes fusions with

123 kemia (B-ALL) harboring rearrangement of the mixed lineage leukemia (MLL) gene with CD19 CAR-T cells.

124 Chromosomal translocations that fuse the mixed lineage leukemia (MLL) gene with multiple partners

125 L) is characterized by rearrangements of the mixed lineage leukemia (MLL) gene with one of its >50 pa

126 lso interacts with translocation partners of Mixed Lineage Leukemia (MLL) gene, which is commonly tra

127 receptors (ERs) and ER coregulators such as mixed lineage leukemia (MLL) histone methylases (MLL2 an

128 ights into the role of the Trithorax protein mixed lineage leukemia (MLL) in maintaining cancer stem

129 Mixed lineage leukemia (MLL) is a key epigenetic regulat

130 The histone methyltransferase Mixed Lineage Leukemia (MLL) is essential to maintain he

131 Mixed lineage leukemia (MLL) is frequently involved in c

132 A critical unanswered question about mixed lineage leukemia (MLL) is how specific MLL fusion

133 ome translocations, most often involving the mixed lineage leukemia (MLL) locus at 11q23.

134 plex (DotCom), which includes several of the mixed lineage leukemia (MLL) partners in leukemia such a

135 -protein interaction (PPI) between menin and mixed lineage leukemia (MLL) plays a critical role in ac

136 The mixed lineage leukemia (MLL) protein and its Drosophila

137 e Men1 gene product menin interacts with the mixed lineage leukemia (MLL) protein, a histone H3 lysin

138 WD repeat domain 5 (WDR5) and block the WDR5-mixed lineage leukemia (MLL) protein-protein interaction

139 ENL, and AF9, is recruited by HIV-1 Tat and mixed lineage leukemia (MLL) proteins to activate the ex

140 Aven stimulates the mRNA translation of the mixed lineage leukemia (MLL) proto-oncogene in an argini

141 The mixed lineage leukemia (MLL) proto-oncogene is a recurre

142 third plant homeodomain (PHD3) finger of the mixed lineage leukemia (MLL) proto-oncoprotein and a pol

143 Mixed lineage leukemia (MLL) represents a genetically di

144 sents the most common leukemogenic fusion of mixed lineage leukemia (MLL) to a cytoplasmic partner pr

145 ing of activation domains from the c-Myb and mixed lineage leukemia (MLL) transcription factors to th

146 regulator in the expression of HOX genes in mixed lineage leukemia (MLL)-based hematological maligna

147 d the miRNAs are aberrantly overexpressed in mixed lineage leukemia (MLL)-rearranged acute leukemias.

148 regulator CDK6 as a promising new target in mixed lineage leukemia (MLL)-rearranged acute myeloid le

149 hylation (H3K27me3/2) and inhibits growth of mixed lineage leukemia (MLL)-rearranged leukemia cells.

150 ranslocations, that approximately 43% of all mixed lineage leukemia (MLL)-rearranged leukemias are EV

151 the c-Myb/GATA-3 complex contained Menin and mixed lineage leukemia (MLL).

152 , we identify the histone-remodelling enzyme mixed lineage leukemia (MLL)3 as a clock-controlled fact

153 gulated in the pathophysiology of rearranged mixed lineage leukemia (MLL-r).

154 Moreover, UTX associates with mixed-lineage leukemia (MLL) 2/3 complexes, and during r

155 impaired reconstitution of stem cell-derived mixed-lineage leukemia (MLL) AML, which represents an ag

156 isordered transcription factors, such as the mixed-lineage leukemia (MLL) and c-Myb peptides, at isol

157 more, we observed that SALL4 interacted with mixed-lineage leukemia (MLL) and co-occupied the HOXA9 p

158 t multiple MLL-fusion proteins implicated in mixed-lineage leukemia (MLL) associate with AFF4, ELLs,

159 g to a single surface of the KIX domain, the mixed-lineage leukemia (MLL) binding surface.

160 ate maintenance of target gene expression by mixed-lineage leukemia (MLL) chimeras may result from th

161 his targeting strategy does not affect other mixed-lineage leukemia (MLL) family histone methyltransf

162 as the threonine endopeptidase that cleaves mixed-lineage leukemia (MLL) for proper Hox gene express

163 A subgroup of leukemogenic mixed-lineage leukemia (MLL) fusion proteins (MFPs) incl

164 LEDGF associates with mixed-lineage leukemia (MLL) fusion proteins and menin a

165 Mixed-lineage leukemia (MLL) fusion proteins are potent

166 Mixed-lineage leukemia (MLL) fusions are potent oncogene

167 ary acute myelogenous leukemia involving the mixed-lineage leukemia (MLL) gene (11q23) translocations

168 We previously identified a rearrangement of mixed-lineage leukemia (MLL) gene (also known as ALL-1,

169 A fragment of the mixed-lineage leukemia (MLL) gene (Mll, HRX, ALL-1) was

170 hromosomal translocation that juxtaposes the mixed-lineage leukemia (MLL) gene and the AF4 gene.

171 The Mixed-Lineage Leukemia (MLL) gene encodes a Trithorax-re

172 OF REVIEW: Leukemia carrying mutation of the mixed-lineage leukemia (MLL) gene is particularly refrac

173 Chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene occur in primary and t

174 The mixed-lineage leukemia (MLL) gene often fuses with ENL a

175 Chromosomal translocations of the mixed-lineage leukemia (MLL) gene with various partner g

176 t B-ALL is chromosomal rearrangements of the mixed-lineage leukemia (MLL) gene.

177 The mixed-lineage leukemia (MLL) H3K4 methyltransferase prot

178 ost cell factor 1 (HCF1), a component of the mixed-lineage leukemia (MLL) histone methyltransferase c

179 AF4 gene, frequently translocated with mixed-lineage leukemia (MLL) in childhood acute leukemia

180 It is fused to mixed-lineage leukemia (MLL) in leukemia, and missense m

181 Mixed-lineage leukemia (MLL) is a proto-oncogene frequen

182 d Hoxa9, is a feature of leukemias harboring mixed-lineage leukemia (MLL) mutations.

183 t mutations such as FLT3 internal-tandem and mixed-lineage leukemia (MLL) partial-tandem duplications

184 ax binds KIX at the previously characterized mixed-lineage leukemia (MLL) protein interaction surface

185 The Mixed-Lineage Leukemia (MLL) protein is a histone methyl

186 Histone lysine methylation, mediated by mixed-lineage leukemia (MLL) proteins, is now known to b

187 determined that MSI2 directly maintains the mixed-lineage leukemia (MLL) self-renewal program by int

188 The t(4;11)(q21;q23) fuses mixed-lineage leukemia (MLL) to AF4, the most common MLL

189 gements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expre

190 Mixed-lineage leukemia (MLL), an epigenetic regulator, p

191 omal aberrations and abnormalities involving mixed-lineage leukemia (MLL), an upstream regulator of H

192 Mixed-lineage leukemia (MLL)-AF4 fusion arises prenatall

193 Myeloid/lymphoid or mixed-lineage leukemia (MLL)-family genes encode histone

194 t to chromatin as an effective treatment for mixed-lineage leukemia (MLL)-fusion leukemia' by Dawson

195 k the progression of certain cancers such as mixed-lineage leukemia (MLL)-rearranged leukemias.

196 alignancies, including Hodgkin, myeloma, and mixed-lineage leukemia (MLL)-translocated cell lines.

197 In contrast, leukemia driven by mixed-lineage leukemia (MLL, encoded by KMT2A) fusions w

198 Mixed-lineage leukemia (MLL; also known as myeloid/lymph

199 llite markers located at the ATM (D11S2179), mixed-lineage leukemia (MLL; D11S1356), and BCL1 (D11S98

200 They demonstrate that the mixed lineage leukemia (MLL1) gene acts independently fr

201 Mixed Lineage Leukemia (MLL1) translocations encode fusi

202 The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltr

203 ation domain associates with TRRAP/TIP60 and mixed-lineage-leukemia (MLL1/MLL2) SET1-type chromatin-m

204 Mixed lineage leukemias (MLLs) are human histone H3 lysi

205 The human MLL (mixed-lineage leukemia or myeloid-lymphoid leukemia) gen

206 h an aberrant histone methyltransferase, the mixed lineage leukemia partial tandem duplication (MLL-P

207 vation domain of the trithorax group protein mixed lineage leukemia protein (MLL), together with eith

208 th the human transcription factors c-Jun and mixed lineage leukemia protein (MLL).

209 Several lines of evidence suggest that the mixed lineage leukemia protein (MLL, ALL-1, HRX) plays a

210 The mixed lineage leukemia protein MLL1 contains four highly

211 The mixed lineage leukemia protein-1 (MLL1) belongs to the S

212 The mixed lineage leukemia protein-1 (MLL1) catalyzes histon

213 The mixed lineage leukemia protein-1 (MLL1) is a member of t

214 Mixed lineage leukemia protein-1 (MLL1) is a member of t

215 DPY-30), a complex that is part of the MLL1 (mixed lineage leukemia protein-1) core complex but that

216 Here we demonstrate that the mixed-lineage leukemia protein (MLL) complex, a well-kno

217 ith the transcriptional activation domain of mixed-lineage leukemia protein leads to an enhancement o

218 The mixed-lineage leukemia protein MLL1 is a transcriptional

219 lysine 4 (H3K4) methyltransferases including mixed lineage leukemia proteins to regulate homeobox (Ho

220 The MLL (mixed-lineage leukemia) proto-oncogene encodes a histone

221 3 (IGF2BP3) is specifically overexpressed in mixed lineage leukemia-rearranged (MLL-rearranged) B-acu

222 A notable exception is mixed lineage leukemia-rearranged infant ALL, where vene

223 t extremely high levels in ALL patients with mixed lineage leukemia rearrangements or hyperdiploidy a

224 AMLs bearing MLL (mixed lineage leukemia) rearrangements are associated wi

225 The in-frame fusion of mixed lineage leukemia to CREB binding protein has been

226 sented with acute myeloid leukemia, one with mixed-lineage leukemia, two with acute lymphoblastic leu