ライフサイエンスコーパス: mode of action

1 approach for Wilson's disease, with a unique mode of action.

2 s a widely used antimalarial without a known mode of action.

3 volvement of envelope-related targets in its mode of action.

4 likely due to their rapid membrane-targeting mode of action.

5 regulatory programs designed around chemical mode of action.

6 tuberculosis strains, indicating a distinct mode of action.

7 creasingly appreciated, as is its intriguing mode of action.

8 stin, we further unraveled their cooperative mode of action.

9 cause of the controversies that underlie its mode of action.

10 ive lack of knowledge of its precise in vivo mode of action.

11 lucocorticoids and plays a key role in their mode of action.

12 itor-binding pocket and maturation inhibitor mode of action.

13 dermatitis and to elucidate possible HOCl's mode of action.

14 erstanding of exosomal composition and their mode of action.

15 sting potential shared transport pathways or mode of action.

16 nslation, further supporting an AMP1-related mode of action.

17 of a 'hit' molecule is identification of its mode of action.

18 nonmalignant T cells, indicating an indirect mode of action.

19 essed in Escherichia coli to determine their mode of action.

20 cleavage, an unanticipated parallel in their mode of action.

21 nique in displaying a marked TRPC6-prevalent mode of action.

22 s, indicating that these drugs have a common mode of action.

23 as identified from L. enzymogenes with a new mode of action.

24 alog, which corresponds to its intracellular mode of action.

25 e provide insights into their metabolism and mode of action.

26 recently developed anthelmintic with a novel mode of action.

27 wild-type tyrosine kinases we clarify their mode of action.

28 and this study sheds light on the underlying mode of action.

29 que cytostatic and cytotoxic effects and its mode of action.

30 resistant strains panel and a potential new mode of action.

31 evelopment of a plant protectant with a dual mode of action.

32 axon outgrowth, consistent with a homotypic mode of action.

33 ch point adenosine, suggesting a competitive mode of action.

34 eads with phenotypically distinct anticancer mode of actions.

35 phoma kinase (ALK) inhibitors with different modes of action.

36 ed that these exhibit different trypanocidal modes of action.

37 ty of these molecules to access two distinct modes of action.

38 istinct maturation inhibitors act by similar modes of action.

39 king their structural features with possible modes of action.

40 VIG) and antiviral agents have complementary modes of action.

41 ng with the components that trigger opposite modes of action.

42 onal distinction between these two different modes of action.

43 acteria, with enhanced potencies and defined modes of action.

44 ng strains that produce antibiotics with new modes of action.

45 ing individual active compounds with precise modes of action.

46 the chemical perturbations and their likely modes of action.

47 vel antibiotics, particularly those with new modes of actions.

48 lyse the reverse of their natural hydrolytic mode of action, allow the attachment of N-glycans to a w

49 Applied to mode-of-action analysis of herbicides, the approach show

50 ing, good safety margin, a potentially novel mode of action and a distinct chemotype support the clin

51 vity with a nM Kd; has a non-ATP competitive mode of action and a novel putative binding site; is wea

52 However, its mode of action and actual enzymatic function in M. tuber

53 n is a member, have a clinically unexploited mode of action and an unusual assembly.

54 porter, and also identify key aspects of the mode of action and binding of two potent inhibitors of V

55 esents the first direct insights into Red1's mode of action and into the mechanism underlying its rol

56 tibiotics for human applications, with novel mode of action and lack of cross-resistance, representin

57 to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have been

58 SM has a highly gene-specific mode of action and preferentially enhances expression of

59 Here, the authors give insights into its mode of action and present the crystal structure of OM b

60 The relatively "nonspecific" mode of action and resistance mechanisms of nitromidazol

61 ycete, and fungal pathogens and has a unique mode of action and structure.

62 However, their mode of action and the intrinsic nature of their gradien

63 types of myelinating glia but that the exact mode of action and the relevance of functional interacti

64 ivity relationship) application, and the EPA Mode of Action and Toxicity (MOAtox) database.

65 However, the mode of action and transcriptional network of nuclear AU

66 ther enhance our understanding of antibiotic mode of action and will enable development of more effec

67 Active compounds showed a bactericidal mode of action, and a mechanistic study suggested the in

68 hese studies provide an understanding of the mode of action, and act as a springboard for continued a

69 enetic screen to investigate the biogenesis, mode of action, and biological function of miRNA-mediate

70 gulator of Q/R site editing, investigate its mode of action, and detect elevated ADAR3 expression in

71 se concerns over BKM120's generally accepted mode of action, and provide a unique mechanistic basis f

72 ndent photoreceptors, their distribution and mode of action, and the structural and photochemical bas

73 molecular framework of miRNA biogenesis and modes of action, and are beginning to elucidate the mech

74 ere, we summarize the known effectors, their modes of action, and RNA targets before surveying the di

75 Due to their unique mode of action, antimicrobial peptides are novel alterna

76 New chemical classes with innovative mode of action are required to prevent a return to the p

77 rms pores, the molecular determinants of its mode of action are significantly different from those re

78 Their respective modes of action are not fully understood and may include

79 Several RNA therapeutics, with diverse modes of action, are being evaluated in large late-stage

80 resented that these novel VDAs have the same mode of action as CA4P and bind reversibly to beta-tubul

81 te) to study toxicokinetics and a neurotoxic mode of action as potential reasons for the deviating fi

82 The adopted mode of action assumed that vaccination, similarly to na

83 orthosteric ligands, implying its allosteric mode of action at the Y4R and evidence for a purely effi

84 plications of five fungicides with different modes of action (azoxystrobin, carbendazim, cyprodinil,

85 rs defined by similar chemical structure and mode of action but divergent toxicities.

86 cellular processes, suggesting a coordinated mode of action but information about potential cross-reg

87 tion RAF inhibitors confirmed their improved mode of action, but also revealed liabilities that allow

88 Thus, general antibiotic modes of action can be identified by profiling the total

89 , and without mechanistic data, an endocrine mode of action cannot be determined.

90 The resulting modes of action demonstrate that rearrangement of an ami

91 ring curiosity into their potentially unique modes of action differing from those acting on water-sol

92 pids were reported, and in most cases, their mode of action differs from that of natural receptors.

93 tituents and provide predictions of compound modes of action directly from primary screening data.

94 ng Staphylococcus aureus and enterococci), a mode of action distinct from that of other agents in cli

95 erve that TALE proteins exhibit two distinct modes of action during the search process-a search state

96 ng gene expression variance via two distinct modes of action-epistasis and destabilization.

97 t to induce autoimmunity, indicating a novel mode of action for BAK1 in immunity control.

98 This represents a rarely observed dual mode of action for drugs.

99 ics screen in Escherichia coli, we uncover a mode of action for DTPs-the disruption of metal homeosta

100 Thus, our work uncovers a mode of action for effector T cells: they abrogate strom

101 Here we report a tumor-suppressive mode of action for growth-differentiation factor 11 (GDF

102 sents an original prodrug design with a dual mode of action for HDAC inhibition.

103 rmation but is insufficient to hypothesize a mode of action for liver tumors in female mice.

104 These data reveal one possible mode of action for mefloquine and demonstrate the vast p

105 lts demonstrate the evolutionarily conserved mode of action for miRNAs, but details of the mechanism

106 in target cells and uncover a potential new mode of action for mutant KRAS in CRC.

107 This study reveals an atypical mode of action for TCF that may apply to other binary de

108 Although the primary mode of action for the protective effect of PrEP is prob

109 xon guidance, confirming a dominant-negative mode of action for these mutations.

110 her ELF3 homologs or possibly an alternative mode of action for this gene in chickpea.

111 present here a detailed study that reveals a mode of action for two P. falciparum choline kinase inhi

112 maize has recently emerged as an alternative mode of action for western corn rootworm (Diabrotica vir

113 The anesthetic mode-of-action for ketamine is mediated primarily throug

114 In this study, we investigate in vivo modes of action for amphomycin and MX-2401 in intact who

115 understanding and potentially comparing the modes of action for clinical treatments and oral-care pr

116 n of topoisomerase, both of which are common modes of action for polycyclic aromatic compounds.

117 Our results reveal new modes of action for TAL effectors, suggesting the possib

118 g distantly related processes and identified modes of action for uncharacterized antibiotics.

119 pseudoparticle entry, suggesting a different mode of action from existing HCV drugs.

120 Their mode of action has not been documented, and immune respo

121 inants of cellular identity, but their exact mode of action has remained unclear.

122 ivity through membrane disruption, its exact mode of action has remained unknown.

123 Its detailed mode of action has, however, remained elusive.

124 es cerevisiae and human tumor cells, but its modes of action have not been fully elucidated.

125 n example of how unrelenting use of a single mode of action herbicide in agricultural weed control dr

126 Due to multiple modes of action, high bioactivity, biorecalcitrance, and

127 This novel antibacterial mode of action holds a low risk to induce bacterial resi

128 Their mode of action, however, remains poorly understood.

129 ators from different kingdoms with unrelated modes of action (i.e. caspases vs metacaspases).

130 ns to date, and reveals many aspects of LLIN mode of action, important for developing the next genera

131 an acr-23, the primary target for monepantel mode of action in C. elegans.

132 While elucidating SFN's mode of action in defense priming, we found that in Arab

133 this study was designed to reinvestigate the mode of action in greater detail.

134 however, little is known about its role and mode of action in liver fibrosis and cancer.

135 es in the kidney associated with its primary mode of action in mammals (prostaglandin-endoperoxide sy

136 widely used in winemaking and brewing, whose mode of action in removing phenolic compounds has not be

137 Additionally, the diversity of chemical mode of action in the global portfolio of marketed antim

138 sides with the eukaryotic ribosome and their modes of action in eukaryotic translation remain largely

139 assessed the relative importance of these 2 modes of action in protection against retinal phototoxic

140 low cost of cobalt complexes and interesting modes of action in the process.

141 ar, we found that fungicides with particular modes of action increased disproportionally in wax withi

142 hat cinaciguat by virtue of its irreversible mode of action is capable of shifting this equilibrium t

143 opment is in chlorophyll re-cycling, and its mode of action is distinct from that of SGR.

144 Elucidating LLIN mode of action is essential to maintain or improve effic

145 Here we show that this mode of action is not a conserved property of type I tox

146 ely sought, but a structural basis for their mode of action is not available.

147 Although their mode of action is often compared to that of mechanical m

148 cochemical properties and for many the exact mode of action is poorly understood, more detailed mecha

149 volved in the inflammatory response, but its mode of action is poorly understood.

150 cycling in heart failure, but its molecular mode of action is poorly understood.

151 auxin-regulated LR formation; however, their mode of action is poorly understood.

152 esignated MpPR-1 proteins, but their precise mode of action is poorly understood.

153 RNA, and protein synthesis, showing that its mode of action is through inhibiting fatty acid synthesi

154 tory responses in vitro and in vivo, but the mode of action is unclear.

155 , their influence remains disputed and their mode of action is unknown.

156 ected during mammalian adaptation, but their mode of action is unknown.

157 is required for telomerase activity, yet its mode of action is unknown.

158 s-generational reproductive fitness, but its mode of action is unknown.

159 ealed that, contrary to popular belief, this mode of action is unlikely to account for their observed

160 t, our knowledge of their specific molecular modes of action is limited to the interaction with few c

161 s differ for different types of endpoints or modes-of-action, lacking a unifying framework.

162 osis, and autophagy, suggesting that a novel mode of action may be operative for this class of rheniu

163 enefits for patients with SMA and, given its mode of action, might be used in combination with other

164 ling unwanted marine pathogens; however, its mode of action (MoA) and significance for the survival o

165 lth for almost four decades, their molecular mode of action (MoA) has in most cases remained elusive.

166 Furthermore, mode of action (MoA) studies revealed that these compoun

167 f substances aggregated based on their toxic Mode of Action (MoA).

168 data were critically reviewed and grouped by mode of action (MoA).

169 These compounds are designed to have mode-of-action (MoA) effects on specific biological path

170 n metal affinity accounted for the different modes of action: Ni(2+) and Cu(2+) uniformly stimulated

171 y interaction encountered when analyzing the mode of action of 5'-fluoro-5'-deoxyadenosine synthase,

172 e aqueous environment, thereby mimicking the mode of action of a natural Diels-Alderase.

173 Here, we investigated the mode of action of a principal bioactive T. arjuna compou

174 The discovery of the mode of action of A2C toxicity could lead to development

175 Our results indicate that the mode of action of allicin is a combination of a decrease

176 However, the precise mode of action of allicin is unknown.

177 uring virion morphogenesis and elucidate the mode of action of ALLINIs.

178 henate kinase Cab1 as models to characterize mode of action of alpha-PanAm and found that alpha-PanAm

179 teria and also provide new insights into the mode of action of antibiotics that target the bacterial

180 Detailed information on the mode of action of antimalarial drugs can be used to impr

181 in the striatum is thought to be the primary mode of action of antipsychotic drugs in alleviating psy

182 pendent route, which is likely to affect the mode of action of antipsychotic drugs.

183 counterion-mediated uptake as the productive mode of action of arginine-rich CPPs.

184 anding of the fundamental differences in the mode of action of bacteriostatic or bactericidal antibio

185 Here, we describe the mode of action of bimagrumab (BYM338), as a human dual-s

186 The most likely mode of action of c2G4 and c4G7 is therefore by inhibiti

187 d in the absence of p53, ER stress-dependent mode of action of citral.

188 The mode of action of compound 30 for targeting COX-2, iNOS,

189 rocesses in human cells, suggesting that the mode of action of CrPV-1A is conserved.

190 n several species, its potential role in the mode of action of Cry2Ab has not been functionally deter

191 This dual mode of action of daclatasvir could explain its efficacy

192 Here we aimed to elucidate the mode of action of DesK by studying the so-called "minima

193 onjugates and LPS and gives insight into the mode of action of dextrin-colistin conjugates.

194 The mode of action of effector proteins in these events is v

195 HLA-B*0801-bound forms, we characterized the mode of action of ERAPs.

196 and serves as a model for understanding the mode of action of eukaryotic cis-PTs.

197 ed, demonstrating that CBMs can modulate the mode of action of LPMOs.

198 ly quantitative to unravel the magnitude and mode of action of many tumor-suppressor genes.

199 The mode of action of methaqualone was further investigated

200 Together, these results establish the mode of action of monepantel in H. contortus and contrib

201 Even though the mode of action of neuropeptides in insects has been vigo

202 racer kinetics can effectively elucidate the mode of action of new lipid-regulating pharmacotherapies

203 The mode of action of NMDAR antagonists seemingly relies on

204 at this approach can be used to identify the mode of action of novel antimalarials, such as the compo

205 This stands in contrast to the mode of action of OV-3 alone, which permeabilizes the me

206 ing progress in elucidating the efficacy and mode of action of OX40- and CD27-targeting mAbs in precl

207 Both the activity and mode of action of PeCsn toward soluble chitosan polymers

208 These findings are shedding light on the mode of action of phytohormones and are opening up a new

209 pathway, represents a core component of the mode of action of pridopidine.

210 new avenue for understanding the underlying mode of action of progranulin in cancer progression, tum

211 investigate the physiological incidence and mode of action of pyoverdine from Pseudomonas fluorescen

212 This study reveals an unprecedented mode of action of pyoverdine in Arabidopsis and demonstr

213 However, the exact mode of action of Red1 remains unclear, although it is k

214 However, the mode of action of RTL2 differs from that of Dcr1.

215 Here, we aimed to unravel the molecular mode of action of SMA copolymers by performing systemati

216 Hence, this study identifies a dual mode of action of SSRIs on bone remodeling and suggests

217 l pathogens; however, the identification and mode of action of T6SS effector proteins that mediate th

218 The mode of action of TCBZ and mechanism(s) underlying paras

219 sought to examine the efficacy, safety, and mode of action of the addition of roflumilast and montel

220 We have begun to dissect the mode of action of the carbonaria transposable element by

221 nd may contribute to an understanding of the mode of action of the highly potent antiviral drugs that

222 In this work, we have revealed the mode of action of the PTC inhibitor madumycin II, an ala

223 The origin, composition and precise mode of action of the ubiquitin coat remain incompletely

224 cellular polypeptides illustrating a unique mode of action of these antibiotics.

225 valuable tools in the future to unravel the mode of action of these biomolecules at the molecular le

226 The mode of action of these compounds is unknown but does no

227 2 inhibitors and provide a rationale for the mode of action of these drugs.

228 of MpPR-1 family members with regard to the mode of action of these proteins during M. perniciosa in

229 s and contribute to our understanding of the mode of action of this anthelmintic.

230 and PI3K provide insights into the selective mode of action of this class of drugs.

231 depressant drugs, consistent with a possible mode of action of this class of drugs.

232 The mode of action of this HDP mimic appears not to involve

233 To better understand the mode of action of this natural product, we synthesized 1

234 red chemical biology strategy to unravel the mode of action of this putative interkingdom signal.

235 To explore the mode of action of this species-specific compound, we con

236 mmune responses and demonstrate differential mode of action of three PI3K inhibitors on IFN-I.

237 level we provide evidence for non-canonical mode of action of Wnt5a and its regulation over genes as

238 lowed building a more detailed model for the mode-of-action of Bac7, and confirming its potential as

239 These data point to species-specific modes of action of BDE-99 on h/mNPC development into the

240 le of directly predicting the identities and modes of action of bioactive constituents for any comple

241 ls, but have also revealed new functions and modes of action of NO in the control and escape of infec

242 lear localization suggests nonclassical GPCR modes of action of the protein that could be relevant fo

243 In summary, our studies describe 2 novel modes of action of ticagrelor, inhibition of platelet EN

244 e use of chemical genomics in characterizing modes of actions of antibiotics and emphasizes the poten

245 xperiments, with the goal of elucidating the modes of actions of the profiled perturbations.

246 gh-throughput application to investigate the modes-of-action of environmental compounds.

247 of Formin FH2 (SMIFH2), after validating its mode of action on a plant formin in vitro, and observed

248 ion whether ivermectin could have additional modes of action on parasitic nematodes.

249 des of enzymes that relate to differences in modes of action or subtle differences within the same su

250 Consistent with this mode of action, peroxide treatment of parental HeLa cell

251 vitro; however, its efficacy in vivo and its mode of action remain unknown.

252 Despite decades of use, the mode of action remains controversial.

253 cating Mycobacterium tuberculosis, but whose mode of action remains enigmatic.

254 in parasitic nematodes, understanding of its mode of action remains incomplete.

255 e lateral surface close to the DNA but their mode of action remains unclear.

256 Additionally, some insights in its mode of action revealed that this compound induced cell

257 a-hematin crystal surfaces by three distinct modes of action: step pinning, kink blocking, and step b

258 Mode of action studies indicate that L-GAELs like the D-

259 esting that such compounds may be useful for mode of action studies on the PORCN O-acyltransferase.

260 Mode of action studies reveal that these compounds activ

261 including contributions to SAR development, mode of action studies, and eventually medicinal chemist

262 Mode-of-action studies demonstrate that 4a, by blocking

263 ge part to the development of drugs, so have mode-of-action studies of these specific immune-targeted

264 l is correct, we carried out a comprehensive mode-of-action study using the model organism Bacillus s

265 were successfully clustered by their shared mode-of-action such as PPARa agonists and COX inhibitors

266 gory includes several candidate termiticidal modes of action such as RNA interference, digestive inhi

267 Mensacarcin's unique mode of action suggests that it may be a useful probe fo

268 that monoenone curcuminoids have a different mode of action than curcumin, rapidly and specifically d

269 The findings identify a site and a mode of action that indicate targets for the treatment o

270 obin and haem fractionation assays suggest a mode of action that results in reduced haemozoin levels

271 ith small variations, a parsimonious vaccine mode of action that was able to reproduce quantitative f

272 are urgently required, especially those with modes of action that have low-resistance potential.

273 entify a repertoire of toxins with different modes of action that improve the utility of entomopathog

274 caldococcus jannaschii (MjAgo) possesses two modes of action: the canonical guide-dependent endonucle

275 Depending on their mode of action, these SPIs can be categorized into serpi

276 Accordingly, neutralizing this second mode of action through co-treatment with the beta-blocke

277 y revealed that IAA and 2,4-D share a common mode of action to elicit downstream physiological respon

278 trine, confirming that HHQs have a different mode of action to other antimalarials drugs for which Pf

279 positive regulators of immunity through two modes of action to fine-tune the timing and amplitude of

280 ly believed that both classes act by similar modes of action to generate aberrant noninfectious parti

281 ein substrates and exhibit distinct cellular modes of action to suppress host responses.

282 all molecule probes having diverse canonical modes-of-action to infer pathways of neuronal cell prote

283 , with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to

284 Because the EDSP was designed to consider mode of action, toxicity pathway and AOP concepts are a

285 o obtain a more comprehensive picture of the mode of action, transcriptomics and proteomics data were

286 tional signatures imply an alteration in the mode of action under combined stresses and limited abili

287 misconception in understanding these agents' modes of action, undermining the development of clinical

288 s no information about compound structure or mode of action until late in the discovery process.

289 Their mode of action was also different, while tyramine caused

290 An endolytic mode of action was observed and studied using gel permea

291 Thus, the mode of action was probably indirect.

292 f potent antimalarial compounds with a novel mode of action was recently identified.

293 The mode of action was tracked using low temperature NMR, UV

294 i-adipogenic natural product whose molecular mode of action was unknown.

295 To probe the mode of action, we performed fluorescence microscopy exp

296 SPR-Cas inhibitors were discovered and their modes of action were elucidated.

297 w that AfIP-1A/1B and mCry3A differ in their mode of action while AfIP-1A/1B and the binary Cry34Ab1/

298 Antibiotics with a novel mode of action will be needed to avoid cross resistance

299 these drugs have immunomodulatory and other modes of action will lead to combination regimens that c

300 e constructs operate via a lipid II-mediated mode of action without causing pore formation.