ライフサイエンスコーパス: model in which

1 Our data support a new model in which a (1) O2 retrograde signal, generated by

2 Based on these results, we propose a model in which a conformational change in BTN3A1 is a ke

3 anisms, we have developed a primary neuronal model in which a longitudinal survival analysis can be p

4 lation to O-O cleavage in HCOs, supporting a model in which a peroxo intermediate serves as the activ

5 13 as a regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination axis d

6 a novel regulator of DNA repair and reveal a model in which a phosphorylation-deubiquitination cascad

7 To test this hypothesis, we created a mouse model in which a portion of the sciatic nerve from one h

8 ontribution is reflected in the 'sigma hole' model in which a positive patch on E attracts the nucleo

9 These data support a model in which a single neuronal stem cell can produce a

10 nt work in bacteria has suggested an 'adder' model, in which a cell increments its size by a constant

11 belling measurements reinforce this biphasic model, in which a crossover from uniform lateral growth

12 A "notch-drives-growth" model, in which a diffusible morphogen produced at each

13 These findings support a supervised learning model in which activation of the US representation guide

14 Together, our results support a model in which acute inflammation after injury initiates

15 Our work supports a model in which AdamTS-A anchors cells in place and prese

16 We explore a model in which all interactions between the packed conte

17 We discuss a model in which an "epigenetic addiction" to the HJURP ch

18 These findings support a model in which an AGO2 phosphorylation cycle stimulated

19 is mechanism, we developed a Drosophila SCA5 model in which an equivalent mutant Drosophila beta-spec

20 Together, this work supports a model in which an extrinsic signal triggers an intrinsic

21 Our results describe a model in which an organelle is partitioned asymmetricall

22 ctural proteins for enhancers and supports a model in which animal genomes use the nuclear pore as an

23 eratinocytes and in well-characterized mouse models in which antitumor efficacy has been shown; inhib

24 , we propose a universal eight-state kinetic model in which any degree of coupling is realized and H(

25 Together, the data support a model in which AP-1 family members contribute to Sox9 ac

26 Together, these findings suggest a model in which App promotes Dachs activity by simultaneo

27 ter OCs are well described by a quantitative model in which approximately 1.0 kcal/mol of scrunching

28 with HslV in their degradation, supporting a model in which ATP hydrolysis and linked mechanical func

29 Taken together, these data support a model in which autophagosomes were directed to the LDs v

30 These data support a model in which B1 and VRK2 share additional substrates i

31 nterstitial fibrosis, we established a mouse model in which Bax and Bak, two critical genes in the in

32 We propose a model in which beta-monoacylglycerols, or a derivative t

33 Our results support a model in which biological outcomes of caspase activation

34 These data are consistent with a model in which bivalent recruitment of a GADS/SLP-76 com

35 results were used to construct a statistical model in which bouton addition, elimination, and size ch

36 In a HCC/hepatocyte co-culture model, in which cancerous and healthy cells share the sa

37 sistent with a recently proposed theoretical model in which CAPE depends on the influence of convecti

38 Our data suggest a novel mechanism and model in which CAV1 phosphorylation facilitates CAV1 sca

39 Our data are consistent with a model in which CCL27 drives baseline recruitment of HSV-

40 We propose a model in which CD138 expression on fully mature ASCs pro

41 These data support a model in which CD8(+) T cells upon activation create the

42 Our results support a model in which Cdk-counteracting phosphatases contribute

43 Here, we used a 3D epithelial morphogenesis model in which cells were cultured in biochemically and

44 Our data support a model in which central command circuits recruit individu

45 An advection-dispersion model, in which chemotaxis was represented explicitly as

46 Rather, our measurements support a model in which collision with a trailing ribosome causes

47 ting preproteins, which is consistent with a model in which conformational changes induced by dimer-m

48 nally, single-molecule experiments support a model in which conformational sampling between the open

49 best explained in a two-level normalization model in which consciousness affects only the first leve

50 be explained with a two-level normalization model, in which consciousness affects only the first lev

51 Our results suggest an evolutionary model in which contemporary subgroups of the superfamily

52 Our work supports a model in which context-specific modulation of transcript

53 We propose a hierarchical regulatory model in which core promoters define broad windows of op

54 d a conditional-by-inversion (Notch2(COIN) ) model in which Cre recombination generates a Notch2(Delt

55 Together, our data support a model in which DACH1 stimulates coronary artery growth b

56 cross the genome, and we therefore propose a model in which decompaction of boundary-insulator-interb

57 Results lend further support for models in which deficits in microglial, endothelial (blo

58 The preponderance of evidence supports a model in which DNA polymerase epsilon (Pol epsilon) carr

59 ene expression and mutant analyses support a model in which DnaA and Rok cooperate to repress transcr

60 es have been attributed to a charge-transfer model in which donor-acceptor complexes play a primary r

61 N gene expression in the shoot, leading to a model in which dorsoventral genes coordinate to regulate

62 We propose a model in which during re-synthesis of resected DNA, the

63 of Nip100/p150(glued) Our results support a model in which dynein destabilizes its microtubule subst

64 We propose a model in which dysfunction of the translational stress r

65 lung structure, we implemented a mechanistic model in which each unit has individual pressures and sp

66 opmental contexts, the range of experimental models in which each of the steps can be examined in det

67 The data support a model in which EAP deficits lead to poor functional outc

68 The findings in these index cases support a model in which early development of occult hippocampal h

69 nt source of BMP6 in the liver and support a model in which EC BMP6 has paracrine actions on hepatocy

70 e results enabled us to propose a structural model in which Ecm29 intrudes on the interaction between

71 This relationship fits a computational model in which eIF4G is at the core of a multi-component

72 ctivity has been described by a hierarchical model in which elements of Hippo pathway are under the c

73 sed two distinct post-status epilepticus rat models, in which epilepsy was induced with injections of

74 Based on these findings, we propose a model in which ER Ca(2+) depletion promotes the activati

75 Here, we generated mouse models in which ERK/MAPK signaling was completely abolis

76 tive recycling endosomes (REs), suggesting a model in which F and M trafficking pathways converge at

77 Our data support a model in which FAK Y397 autophosphorylation is required

78 r, our findings support a novel "outside-in" model in which fatty acid availability sets cell envelop

79 Taken together, these data support a model in which FGFs, possibly from axons, activate FGFR2

80 We propose a model in which flagellar stators are disengaged and sequ

81 phenotypes and modeling support an assembly model in which flexible E153-R210 links mediate capsomer

82 Using a transgenic mouse model in which FlnA is selectively depleted in myeloid c

83 applied force, supporting a mechanosensitive model in which forces stabilize vinculin's active confor

84 novic et al. describe an elegant biophysical model in which friction between lipids and BAR-domain pr

85 important measure and are consistent with a model in which FUT2 rs601338 influences holoHC by alteri

86 d a bilateral ischemia-reperfusion AKI mouse model, in which gallein attenuated renal dysfunction, ti

87 We provide a model in which GCAP1 and GCAP2 do not share a single bin

88 From these data, we offer a model in which GDU1 activates LOG2 to stimulate amino ac

89 is is often tested with a "diathesis-stress" model, in which genes confer excess vulnerability.

90 Together, these data support an emerging model in which genome folding and misfolding is critical

91 am of Draper in AD model flies, supporting a model in which glia engulf and destroy Abeta peptides to

92 These results support a model in which GpsB negatively regulates peripheral PG s

93 suggest a molecular mechanism underlying our model, in which gradient levels regulate the switch betw

94 molecular complex studied, we could exclude models in which GreB is selectively recruited to backtra

95 Together, the data suggest a model in which growth rate and cell size are mechanistic

96 Accordingly, we propose a "leaky gate" model in which Grp(+) neurons transmit both itch and wea

97 Our results thus suggest a model in which H. pylori employs ImaA to regulate intera

98 Our data support a model in which H2S exerts its cytoprotective effect on I

99 Together our data suggest a model in which high mTORC1 activity promotes proliferati

100 In multivariable models in which highest and lowest quartiles of dietary

101 s the experimental framework used in climate modeling, in which historical climate simulations serve

102 indings and the work of others, we propose a model in which HIV replication is favored by the intrace

103 and disease using a well-established murine model in which HSV-1 reactivation was induced from laten

104 Using a well-established murine model, in which HSV-1 reactivation in latently infected

105 Our findings argue for a novel model in which human B cells promote specific T-cell pro

106 Our data suggest a model in which hydrophobic residues on TM3 and TM7 form

107 Here we develop several mouse models in which hypothalamic stem/progenitor cells that

108 control under hypoxia and are supported by a model in which hypoxia-induced changes to cotranscriptio

109 Both cell types are explained by a model in which ILDs are computed within separate frequen

110 We propose a model in which IncV acts as one of the primary tethers t

111 ors, we characterized a new transgenic mouse model in which inducible ablation of SCIN is achieved wi

112 These findings support a model in which information flow from SL to SP cells and

113 Our findings support a model in which initial inhomogeneities in inputs are amp

114 rizes, milestone payments, or insurance-like models in which innovation is rewarded with a fixed seri

115 Our results support a model in which inter-chromosomal microtubules of the cen

116 We suggest a model in which interaction of KinG with SHR allows for t

117 hanism, and instead support a flexible stalk model in which interhead strain rotates the rings throug

118 These data are consistent with a model in which IQGAP1 cleavage is regulated by acetylati

119 was extended to a patient-derived xenograft model, in which jetPEI tumor accumulation was reduced fo

120 seen in suPAR-associated proteinuric animal models, in which kidney damage is caused not by local po

121 s of these experiments are consistent with a model in which kinase-mediated phosphorylation within th

122 We thus propose a model in which kinetochores mature through Ska complex r

123 with previous studies, these data support a model in which L. donovani amastigotes readily salvage o

124 Our findings support a model in which Ldo proteins modulate the activity of the

125 Our data support a model in which LDs provide a lipid buffering system that

126 edge can enrich "next-generation" vegetation models in which leaf temperature and water use during ph

127 nd other results suggest a positive feedback model in which LET-99 localizes to the presumptive cleav

128 We propose a new model in which Lfng-mediated Notch signaling enables dir

129 res of P- and E-selectin suggest a two-state model in which ligand binding to the lectin domain close

130 ell described by the band anticrossing (BAC) model in which localized nitrogen states interact with t

131 Together, the findings support a model in which low early-life n-6/n-3 ratios remodel adi

132 Our results support a model in which LsERF1 acts through the promotion of gibb

133 Moreover, our results support a lock-and-key model in which LYR proteins associate with acyl-ACP as a

134 nse, and our findings collectively support a model in which m(6)A RNA serves as a beacon for the sele

135 Thus, we present a model in which macrophage/tumor cell contact allows for

136 may be widely applied to in vitro cell-based models in which matrix protein deposition reflects the u

137 Our findings support a model in which Mcp1 and Vps13 work as functional effecto

138 We have previously described a mouse model in which mDPP4 was replaced with hDPP4 such that h

139 We analyze a model in which metabolite concentrations, production reg

140 ogically and genetically in transgenic mouse models in which microglia and systemic monocytes were se

141 ploration of OncoPPi led to a new biological model in which MKK3 operates by two distinct mechanisms

142 Our results point to a model in which MLCK and ROCK regulate peripheral and cen

143 liday junction resolvase and support a novel model in which Mlh1-Mlh3 is loaded onto DNA to form an a

144 Based on these data we propose a mechanistic model in which Mms1 binds to specific G-rich/G4 motif lo

145 cular levels, consistent with a motor-clutch model in which motors and clutches are both increased.

146 These findings support a model in which mouse MX1 interacts with the incoming inf

147 re important for shape control and support a model in which MreB organizes the cell wall growth machi

148 dies, the solution structural data lead to a model, in which Mtalpha(521-540) comes in close proximit

149 These data are consistent with a model in which MtMOT1.3 is responsible for introducing m

150 Our work supports a model in which multiple surfaces of Ska1 interact with d

151 We propose a model in which multiple Vps4 hexamers (four or more) dra

152 Our results support a model in which MW deteriorates performance in the task a

153 Taken together, our findings support a model in which neighboring binding sites interact compet

154 her, the results outline a disease-avoidance model in which neural mechanisms involved in the detecti

155 We propose a model in which NK-cell education prevents or delays down

156 Our results support a model in which NMC is dependent on ectopic NUT-mediated

157 e behavioral results fully consistent with a model in which nonspatial features are bound exclusively

158 eration during endocytosis in yeast, using a model in which NPFs form a ring around the endocytic sit

159 observations are potentially explained by a model in which obesity influences the iatrogenic injury

160 Based on our results, we propose a model in which otoferlin acts as a calcium-sensitive sca

161 Taken together, our study suggests a model in which overexpression of wild-type PDGFRA associ

162 We propose a model in which PARP3 suppresses G4 DNA and facilitates D

163 se results are quantitatively explained by a model in which partially dissociated bound proteins are

164 Physicians should consider a stepped-care model in which patients may begin with relatively nonint

165 Here we present a model in which patterning in both the blastoderm and ger

166 In contrast to other transplant models in which PD-L1 generally shows protective functio

167 Together, this work provides support for a model in which PEP87 disrupts HA function by displacing

168 The results support a model in which perceptual filling-in is aided by differe

169 ly, our investigations are consistent with a model in which PhoPQ-dependent Mg(2+) homeostasis protec

170 Together, these data support a model in which physiological levels of Ca(2+) may result

171 s a robust role in neutrophils and propose a model in which PIKfyve modulates phagosome maturation th

172 These data support a model in which PlrS senses conditions present in the LRT

173 nd microtubule regulation, consistent with a model in which PMS-dependent microtubule polymerization

174 We propose a model in which Polo-like kinases recognize crossover des

175 Our data support a model in which polyQ peptides containing strong beta-hai

176 Our results suggest a model in which PRDM9-bound hotspot DNA is brought to the

177 Together, our findings support a model in which PrgU proteins represent a novel class of

178 lar explanation is the 'conformational wave' model, in which protofilaments pull on the kinetochore a

179 ned with previous work, these data support a model in which RDN1 arabinosylates MtCLE12, and this mod

180 substrate binding, and support a structural model in which rearrangement of a flexible loop upon bin

181 the preclinical level using different animal models in which relapse to drug seeking is assessed afte

182 Our findings support a model in which repression of activin signaling by FST en

183 sky behavior was captured by a computational model in which reward prompts an adaptive update to the

184 Studies in brain slices have led to a model in which rhythmic synchronized spiking (phasic fir

185 Our data support a model in which RNA editing is executed via multiple path

186 Our results are consistent with a model in which RNAPII is dissociated after the dual inci

187 These findings are consistent with a model in which RVs, as persistent MPs, prevent fusion be

188 uthal directions, in contrast to the classic models in which S varies only with the distance from the

189 We present a model in which sheath formation depends on the coordinat

190 ose an extension of a simple and influential model in which shifts in rnoise can simultaneously enhan

191 Our data support a model in which simultaneous interactions between the mic

192 Together, our findings support a model in which sliding helicase-loading intermediates in

193 Altogether, our data support a model in which small neutral hydrophobic residues facili

194 These data support a model in which SMC complexes function by processively en

195 cids, a hypothesis consistent with a general model in which some modern biochemical systems retain la

196 Collectively, our analyses suggest a model in which some proteins evicted from chromatin and

197 On the other hand, neutral models, in which species do not interact and diversity i

198 We propose a model in which specification to the DC lineage is driven

199 We propose here a new version of the current model in which spin-selective recombination of the radic

200 These results support a model in which Src-family kinase binding induces conform

201 We propose a model in which stiffening of the damaged ends by the rep

202 behavioral level can be captured by a simple model in which stimulus and mask interact nonlinearly at

203 Together, our results support a model in which stimulus-evoked exocytosis in retinal rib

204 These data support a model in which stressed mitochondria generate an oxidize

205 Overall, these results support a model in which structured RNA negatively regulates the p

206 We propose a dynamic model in which sucrose acts via IR60b to activate a circ

207 Together, our data suggest a model in which sustained FGF signaling acts to suppress

208 These findings support a relay model in which Sxl in neurons and Sxl in local tissues a

209 cted in vivo data are most consistent with a model in which synthesis and degradation are both increa

210 We propose a new model in which TAFs function as reinitiation factors, ac

211 Our findings support a model in which TFAM first recruits POLRMT to the promote

212 Based on our data, we propose a model in which TH acting through TRalpha1 and TRbeta1, r

213 thematically modeled using a logistic growth model in which the Abeta carrying capacity is heterogene

214 These results support a model in which the AE3 Cl(-)/HCO3(-) exchanger, coupled

215 We propose a model in which the Astrin-SKAP complex acts together wit

216 We propose a model in which the C-terminus of ATP8A2 consists of an a

217 e findings, we propose a sequential assembly model in which the CcoQ subunit is required for the earl

218 We propose a model in which the central regulatory region promotes AS

219 fit to a minimal three-step 'bind-open-lock' model in which the clamp loader binds a closed clamp, th

220 Pase to be arrested in state 2, we propose a model in which the conformational mismatch between free

221 for simulated CAPE extremes using a climate model in which the convective entrainment rate is varied

222 Our data suggest a model in which the CTD serves primarily to anchor Tim44

223 Our data support a model in which the daughter centriole promotes ciliogene

224 a molecular regulator of PMW, and propose a model in which the Drosophila nervous system integrates

225 Our results support a model in which the E. coli clamp loader actively opens t

226 oss all families in which it segregates to a model in which the effect of a SNP can vary across famil

227 Here, we have generated an ACH mouse model in which the endogenous mouse Fgfr3 gene was repla

228 We propose a unifying model in which the erythroid transcriptional program wor

229 Here, we present a model in which the ETV1 promoter is used to specifically

230 Taken together, our findings support a model in which the evolution of the bipolar mating syste

231 Our findings support a model in which the folate receptor interacts with cell a

232 Using a genetic mouse model in which the gene encoding the GR is selectively d

233 Our results reveal a model in which the GtCCR2 retinylidene SB chromophore ra

234 cted a multivariate Cox proportional hazards model in which the impact of each covariate was adjusted

235 These results support a model in which the interaction of RyR with CaM is nonuni

236 rcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression

237 We propose a model in which the local variance in tension between jun

238 A variety of data support a model in which the loss of K(+) ions from the selectivit

239 Our data suggest a model in which the majority of NK cells in the human lun

240 These data support a model in which the MBD2/3 methylation-dependent function

241 ial damage, we knocked out Parkin in a mouse model in which the mitochondrial DNA is damaged in dopam

242 We propose a model in which the modification state of the transcripti

243 tionalized in a vibrationally adiabatic (VA) model in which the motion of the H3O(+) ion in the crown

244 In contrast, in a mouse gut colonization model in which the natural microbiota is unperturbed, th

245 describe the characterization of a new mouse model in which the parts of two host factors that are es

246 Altogether, we propose a model in which the positive and negative energy reporter

247 Our data suggest a model in which the POTRA domains serve as a binding site

248 We propose a bipartite interaction model in which the previously identified high-affinity i

249 Here, we describe a predator-prey model in which the prey population growth depends on a p

250 Such a transition state supports a model in which the rate-limiting step of the hybridizati

251 In most conditions, a model in which the recent history of past samples determ

252 s in vivo Combined, these findings support a model in which the SCCRO, substrate, and substrate adapt

253 est, to our knowledge, a novel hairpin-hinge model in which the signal peptide hairpin unhinges durin

254 Instead, we present a mechanistic model in which the spatiotemporal dynamics of GapR are p

255 Here, we used a mouse knock-out model in which the transduction component used to discri

256 Together, our experiments support a model in which the transition from sedentary to light ac

257 to mass spectrometry (HDX-MS) we rule out a model in which the two forms are in rapid equilibrium.

258 ate type and concentration affords a kinetic model in which the two S = 1/2 intermediates exist in a

259 r different chemical states of CcO support a model in which the volume and hydration level of the cav

260 We propose a model, in which the activity of HUWE1 underlies conforma

261 Here we used a novel rat model, in which the availability of a mutually exclusive

262 We present a game-theoretic model, in which the best strategic choice for the victim

263 ES has used the total body iron stores (TBI) model, in which the log ratio of sTfR to SF is assessed.

264 Notably, 'shuttling' models in which the BMP distribution is modulated by a C

265 rast material-enhanced five-dimensional XCAT models, in which the fifth dimension represents the dyna

266 tioned before it binds Notch and (2) pulling models, in which the ligand must be endocytosed after it

267 r this unusual requirement are (1) recycling models, in which the ligand must be endocytosed to be mo

268 n through these subpopulations, supporting a model in which these three states correspond to consecut

269 specific regions of the alternative refined models in which they are most interested e.g. key intera

270 y an improved generation of galaxy-formation models, in which they form rapidly at z approximately 3-

271 Taken together, these results support a model in which this IDR of Med13 plays a key role in con

272 sses many features that make it an excellent model in which to investigate tubulogenesis, but the cel

273 indings point to the zebrafish as a valuable model in which to study cancer cell homing to the hemato

274 Here we use Caenorhabditis elegans as a model in which to study RIBEs, and identify the cysteine

275 d suggest that zebrafish will provide a good model in which to study the development and refinement o

276 e cells and thus provide a potential in vivo model in which to study the pathogenesis of nephrotic sy

277 astic carcinomas, and a new disease relevant model in which to test new treatment strategies.

278 It provides a useful model in which to test the specificity of in vivo bindin

279 pendent human disease and provide an in vivo model in which to test therapeutic candidates targeting

280 tment for AADC deficiency and few truly good models in which to investigate disease mechanisms or dev

281 e of gastric disease, there are few adequate models in which to study the fundus epithelium of the hu

282 Our results support a model in which TOPBP1(Dpb11) plays a conserved role in m

283 , these results suggest an LTM consolidation model in which transient neural activities of early labi

284 icient Caenorhabditis elegans and supports a model in which translesion synthesis polymerases perform

285 We propose a model in which TraR mimics the effects of DksA and ppGpp

286 On the basis of these findings, we propose a model in which Treg cell responses at peripheral sites c

287 Using two different mouse models in which Tsc1 is deleted by Cre expression in oli

288 iced isoform, our data are consistent with a model in which unproductive splicing complexes assembled

289 Our results are consistent with a model in which, upon the onset of heat stress, translati

290 This leads to a model in which Vpu monomers, Vpu homooligomers, and Vpu-

291 hese findings support an ADAMTS13 activation model in which VWF D4-CK engages the TSP8-CUB2 domains,

292 Here we show that in a mouse model in which we deleted two of titin's C-zone super-re

293 Here, we describe a mouse model in which we inactivated Cic by selectively disabli

294 lished allergic airway inflammation and in a model in which we neutralized IFN-gamma during HDM chall

295 We validated our results in a xenograft model in which we observed an increase in survival time

296 We developed a needle- and antibiotic-free model in which we readily induced S. aureus colonisation

297 Mig-6 in P4 resistance, we generated a mouse model in which we specifically ablated Mig-6 in uterine

298 In models in which we controlled for time-varying income, w

299 e model using time-averaged DAS28 among 1000 models in which we randomly picked up one-time DAS28.

300 Together, our results support a model in which YY1 acts as an architectural protein to c