ライフサイエンスコーパス: model of

1 f wild-type and Df(16)A(+/-) mice, an animal model of 22q11.2 deletion syndrome, one of the most comm

2 Finally, computational modeling of 25 missense mutations of CYP11B1 revealed th

3 eneration, we have used the Cln3 (-/-) mouse model of a juvenile form of NCL.

4 In a computational model of a local RT network featuring slow Cl(-) extrusi

5 We present an atomic model of a substrate-bound inner mitochondrial membrane

6 nhanced allergic responses in an OVA-induced model of AAD.

7 cellular and molecular mechanisms in a mouse model of ACD.

8 These data indicate that in this model of acute, neutrophil-dependent glomerulonephritis,

9 INSR attenuated clinical symptoms in animal models of acute graft-versus-host disease and multiple s

10 In our studies of mouse models of acute leukemia, we used high-resolution micros

11 on of canola oil on the phenotype of a mouse model of AD that develops both plaques and tangles (3xTg

12 receptor agonist bexarotene in an aggressive model of AD.

13 e absence of BACE1 S-palmitoylation in mouse models of AD amyloidosis.

14 ional skin and blood, more complex biomarker models of AD are needed.

15 These venerable hypotheses persist in models of aesthetic processing [3-7] but have never been

16 a significantly improved survival in a mouse model of aGVHD while retaining graft-versus-leukemia eff

17 Using a mouse model of allergic airway inflammation, we found that ado

18 Here, we demonstrate, using murine models of allogeneic BMT, that type 2 innate lymphoid ce

19 was low, microglial proliferation in a mouse model of Alzheimer's beta-amyloidosis was increased thre

20 tide (FAD) in fresh brain samples of a mouse model of Alzheimer's disease (AD).

21 hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

22 rong support to crystallographically derived models of aminoglycoside-ribosome interactions.

23 Further, in a mouse model of AMR, in which C57BL/6.

24 In an animal model of anti-TNF-resistant intestinal inflammation, gen

25 Studies in experimental models of anti-MPO GN suggest that, after ANCA-induced n

26 tructure in a maternal Ube3a knock-out mouse model of AS.

27 ients who lost weight, glycemia, homeostasis model of assessment of insulin resistance, serum ferriti

28 tistatin in two well-established preclinical models of atherosclerosis, and the molecular and cellula

29 K9 hypomethylation and a translational mouse model of AUD showed that alcohol exposure leads to PCSK9

30 ct of granzyme A deficiency in the NOD mouse model of autoimmune diabetes.

31 latory arm of the immune response in animals models of autoimmunity and Th17-skewing human cell cultu

32 cally prone and experimentally induced mouse models of autoimmunity, increased serum levels of IgM an

33 irectly investigate GFAP turnover in a mouse model of AxD that is heterozygous for a disease-causing

34 Using a mouse model of bacterial sepsis, we found that the numbers of

35 Current models of bacterial homologous recombination (HR) posit

36 In a mouse model of basal ErbB2 receptor tyrosine kinase 2 (ErbB2)-

37 o test this hypothesis, we exploited a mouse model of beta-thalassemia intermedia, Th3/(+) We observe

38 Computational models of betaS fibril structures indicate that key glut

39 y model, and to a higher degree, the pathway model of biological ET partly capture the predicted rate

40 oint for further steps of data analytics and modeling of biological dynamics.

41 One of the main tasks in the analysis of models of biomolecular networks is to characterize the d

42 llular intoxication and pathology in a mouse model of botulism.

43 In an ex vivo human model of BP, normal human skin cryosections were incubat

44 We have developed mathematic models of brain activity that allow for accurate predict

45 be a milestone for instructing computational models of brain function.

46 n the U(VI) oxidation state) in a plant cell model of Brassica napus.

47 ent slows tumor progression in an aggressive model of breast cancer.

48 ional tissue culture to build an organotypic model of bronchial dysplasia.

49 tly suppresses neurotoxicity in a Drosophila model of C9orf72 ALS.

50 ation and locomotor deficits in a Drosophila model of C9ORF72-related disease.

51 Using an explicit model of Ca2+, CaM, and seven highly-expressed hippocamp

52 technology to create scarless isogenic cell models of cancer variants in 1 month.

53 best studied in the tumor context in animal models of cancer.

54 FLT) uptake and tissue distribution in mouse models of cancer.

55 ut may also provide speculative insight into models of care that attenuate the weekend effect.

56 We adapted a mouse model of CAUTI to investigate how catheterization increa

57 vascular deficits in chronic and acute mouse models of CCM3 loss in vivo, significantly reducing lesi

58 he cerebellar cortex, as required by forward models of cerebellar control.

59 Our findings strongly support an active model of chaperonin-mediated protein folding, where part

60 hannel Nav1.7 are increased in a preclinical model of chemotherapy-induced peripheral neuropathy (CIP

61 Novel mouse models of Chlamydia, Haemophilus influenzae, influenza,

62 ktail of three virulent phages in two animal models of cholera pathogenesis (infant mouse and rabbit

63 BCR-ABL fusion protein kinase-induced mouse model of chronic myeloid leukemia (CML).

64 otrophic cardiac transplantation in a murine model of chronic rejection.

65 Disease-specific, time-updated modeling of clinical data for several uveitides suggests

66 duces spontaneous immunopathology in a mouse model of CNS inflammation.

67 flammatory and neuroprotective properties in models of CNS injury.

68 state 4 (STEAP4) was highly induced in mouse models of colitis and in IBD patients.

69 By combining models of commensal colonization in antibiotic-treated a

70 , iFoldNMR, for rapid and accurate structure modeling of complex RNAs.

71 Here, we analyzed a Xenopus model of conversion of melanocytes to a metastatic-like

72 6, and able to recover function in an animal model of corneal epithelial dysfunction after surgical t

73 ax model responses into an existing spectral model of depth-integrated, daily production will enable

74 tudies using DBA2/J and Nos3 (eNos) KO mouse models of diabetes, TEPP-46 treatment reversed metabolic

75 and protein quality control, we used a mouse model of dilated cardiomyopathy driven by cardiac restri

76 ostmortem brains, cultured cells, and animal models of disease that support the idea that alpha-synuc

77 The canonical model of DNA replication describes a highly-processive a

78 l and a new severe acute hypoxia (SAH) mouse model of DWMI activates the initial step of the ISR.

79 sed three-dimensional, multiscale, in-silico model of dynamically coupled angiogenic tumour growth is

80 llustrate, we show how hierarchical Bayesian models of ecological diffusion can be implemented for la

81 DelPhiForce web server enables modeling of electrostatic forces on individual atoms, re

82 namic measurements, we established a kinetic model of Ena/VASP-mediated actin filament elongation.

83 Finally, using a model of endotoxemia, we present examples of the way in

84 rid between "enhanceosome" and "smorgasbord" models of enhancer function, in which elements cooperate

85 se results are consistent with the morpheein model of enzyme hysteresis, in which substrate binding i

86 tro whole-blood assays and an in vivo baboon model of Escherichia coli sepsis.

87 reduce the severity of paralysis in a mouse model of EV-D68 infection: (1) human intravenous immunog

88 Animal models of exercise-induced pain have been developed and

89 e present a data-driven decision-theoretical model of feeding in Caenorhabditis elegans Our central a

90 We developed a multiscale model of fibrinolysis that includes the main chemical re

91 Using a mouse model of foodborne L. monocytogenes infection, a reduced

92 ung and adult Fmr1 knock-out mice, the mouse model of fragile X syndrome (FXS).

93 ensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I imbalance t

94 dominance deficits in Grn+/- mice, an animal model of frontotemporal dementia due to GRN mutations.

95 Animal models of FSHD are hindered by incomplete knowledge rega

96 In animal models of FXS and of ASD, GABA-B agonists have improved

97 This model of gene regulation raises the intriguing notion th

98 to efficiently generate personalized in vivo models of genetic renal diseases bearing patient-specifi

99 Based on these observations, a model of GenK catalysis is proposed wherein free rotatio

100 In intracranial mouse xenograft models of glioblastoma, inhibiting Wnt5a activity blocke

101 We used genetically engineered mouse models of glioma and quantitative metabolomics to invest

102 cognized as key contributors in early animal models of GN, at a time when the prevailing view conside

103 This mechanism has served as the predominant model of GR-mediated transrepression of inflammatory gen

104 ouse endothelial-derived EOMA cell line as a model of HE, we explored the regulatory effect of platel

105 en shown to control joint bleeding in animal models of hemophilia.

106 a rapidly progressing SIV/pigtailed macaque model of HIV to examine enteropathy and microbial transl

107 Developing in vitro models of HIV-1 latency that recapitulate the characteri

108 iological results have motivated theoretical models of how the brain selects actions, regulates movem

109 nclusion, the FAH(-/-) pig is a large-animal model of HT1 with clinical characteristics that resemble

110 We established a mouse xenograft model of human acute myeloid leukemia (AML) that enabled

111 A reproducible neuronal model of human origin would facilitate studies of HSV an

112 per-tumor-cell uptake in a mouse orthotopic model of human triple-negative breast cancer.

113 ress this challenge through the analysis and modelling of human brain voltage activity recorded simul

114 In cell models of human breast cancer or in a cyclin D1-deficien

115 of cardiopharyngeal phenotypes in zebrafish models of human congenital disorders.

116 -pair precision, which allows novel in vitro models of human disease to be generated-e.g., in pluripo

117 ce for their efficacy in cellular and animal models of human inflammatory disease and in some human c

118 peutically effective against mouse xenograft models of human leukemia.

119 Here, we developed 3D cell-line-based models of human syncytiotrophoblasts, cells that lie in

120 In mouse xenograft models of human TNBC, administration of C1572 suppressed

121 (PARAFAC) analysis supported a two-component model of humic-like and nonhumic-like dissolved organic

122 ve aggregate-clearing activity in a cellular model of Huntington's disease, and induce autophagy in v

123 erception, or production of song, functional models of HVC activity may need revision to account for

124 molecule inhibitor MS-444 in AOM/DSS mice, a model of IBD and inflammatory colon cancer, augmented DS

125 interval, and remain unexplained by previous models of ice age adjustment or other local (for example

126 y inflammation was assessed by using in vivo models of IL-13-induced lung pathology and in vitro cult

127 theoretical considerations and experimental models of immune responses in vitro and in vivo to quant

128 decrease in GAS fitness in a humanized mouse model of impetigo; the DeltafbaA mutant also exhibited d

129 ly inhibit P. aeruginosa infection in murine model of implant-associated infection.

130 Using a mouse model of inducible SOX2, which is broadly expressed in o

131 med our results in a Friend virus retroviral model of infection in mice.

132 d immune cell infiltration in an intradermal model of infection yet still elicited protective immunit

133 s well as a discussion of the current animal models of infection.

134 In the lipopolysaccharide model of inflammation, RVX-297 reduced proinflammatory m

135 he contrary, 1F11 showed efficacy in several models of inflammation yet was less potent at inhibiting

136 ally delete C5aR2 expression in experimental models of inflammation.

137 eutrophil recruitment and are protected in 2 models of inflammatory arthritis.

138 SCFA are protective in various animal models of inflammatory disease.

139 analyze urine samples collected from rodent models of inflammatory glomerulonephritis (GN) as well a

140 Studies in preclinical models of influenza virus infections have shown that ant

141 nalyses and suggests an enzyme isomerization model of inhibition.

142 These results expand the model of insulin-stimulated glucose uptake in skeletal m

143 ormal motion associated with the switchblade model of integrin activation, where the development of t

144 vity and are consistent with drift-diffusion models of interval timing.

145 tive prohemorrhagic effect of NAC in a mouse model of intracranial hemorrhage induced by in situ coll

146 Flow cytometric assessment and mathematical modeling of intraerythrocytic parasite development revea

147 l, dendrimer nanoparticle (DNAC), in a mouse model of intrauterine inflammation.

148 In a mouse lung model of KRas(G12D)-driven adenomas, we find that co-act

149 plasticity in cognitive networks and inform models of language reorganization.

150 ne density by 30-40% in the Rpe65(-/-) mouse model of Leber congenital amaurosis and reduced the numb

151 tumor types, and in a genome-scale metabolic model of leukemia.

152 Various mouse models of liver regeneration after extended partial hepa

153 ing of LmnaH222P/H222P mouse, a small animal model of LMNA cardiomyopathy, suggested decreased WNT/be

154 Based on these results, we propose a revised model of long-patch BER and a new key regulation point f

155 ation in multiple immunocompetent orthotopic models of lung cancer.

156 A hallmark of autoimmunity in murine models of lupus is the formation of germinal centers (GC

157 In a murine model of lymphoid-specific EZH2 deficiency we found that

158 ther support female pig-tailed macaques as a model of M. genitalium infection, persistence, and immun

159 From an earlier study, we had structural models of M.tb at a proteome scale from which a set of 1

160 Accurate atomic modeling of macromolecular structures into cryo-electron

161 In a sparsely connected model of MCs and GCs, we found first that interglomerula

162 Here, we design and analyze a model of mechanotransduction where each tip link attache

163 n inducible RAF-driven, autochthonous murine model of melanoma incorporating a fluorescent reporter a

164 IGNIFICANCE STATEMENT Recent neurobiological models of memory have argued that large-scale neural osc

165 rature (SM/ST) can significantly improve the modeling of mesoscale deep convection is tested over the

166 Thus, we propose a model of MET complex assembly where Tomt and the Tmcs in

167 s to constrain fluxes through a genome-scale model of metabolism, Population flux balance analysis (P

168 s of detailed experiments and finite element modeling of metal micro-droplet motion associated with m

169 oncogenic KRAS in CRC, we engineered a mouse model of metastatic CRC that harbors an inducible oncoge

170 Conditional deletion of Mof in a mouse model of MLL-AF9-driven leukemogenesis reduced tumor bur

171 In an in vitro and cell-based model of MMP-dependent breast cancer cellular invasivene

172 We used a murine model of MS, experimental autoimmune encephalomyelitis (

173 eviously developed dimer-scale computational model of MT dynamics.

174 pproach to infer data-driven dynamic network models of multi-organ gene regulatory influences.

175 To test function of CLEC12A in an animal model of multiple sclerosis (MS), we administered blocki

176 lomyelitis, which is the most-studied animal model of multiple sclerosis.

177 vity for (177)Lu-PSMA-617 RLT in a syngeneic model of murine prostate cancer.

178 in mice and conferred protection in a murine model of Mycobacterium tuberculosis infection.

179 ultaneous (18)F-FDG PET/MR scans of a canine model of myocardial infarct and was demonstrated in a hu

180 erfusion reduces infarct size in rat and pig models of myocardial infarction.

181 he TGFbeta pathway, we first generated mouse models of neoplastic disease with TGFbeta receptor defic

182 Here, we show that modeling of neural sound representations in terms of fre

183 Creating and running realistic models of neural networks has hitherto been a task for c

184 ex influences dendritic morphogenesis in two models of neurodevelopment in a region-specific manner h

185 rooms extracts on high-fat diet (HFD) animal model of non-alcoholic steatohepatitis (NASH).

186 An EL4 mouse model of non-Hodgkin lymphoma and a B16 mouse model of s

187 KD developed in a clinically relevant murine model of nonischemic hypertrophic CHF, transverse aortic

188 heir neural responses are accounted for by a model of numerosity coding that has been used to explain

189 and thus compatible with the food addiction model of obesity.

190 and cell death in RGCs, including in a mouse model of optic nerve injury, and show that the same path

191 This paper uses a formal model of optimal policing to explore how society might r

192 scaling factors derived from this literature model of organic cation sorption, along with phenyltrime

193 Here, using a rat model of osmotic demyelination, we showed that rapid cor

194 d Methods A state-transition microsimulation model of osteoporosis for postmenopausal women aged 55 y

195 combined these analytical tools with in vivo models of osteotomy healing and implant osseointegration

196 elium and abrogate angiogenesis in the mouse models of oxygen-induced retinopathy and laser-induced c

197 An agent-based stochastic simulation model of P. falciparum transmission was used to investig

198 root ganglia, spinal slices, and in a mouse model of pain induced by NaV1.7 activation, Pn3a alone d

199 ere validated in both primary and metastatic models of pancreatic cancer.

200 eneration of dopaminergic neurons in a mouse model of Parkinson's disease using 1-methyl-4-phenyl-1,2

201 In the paraquat-induced model of Parkinsonism, this nigro-vagal pathway was comp

202 whether this pathway is compromised in a rat model of Parkinsonism.

203 patients with breast cancer and to outline a model of pathologic response, considering pathologic com

204 uating sleep and breathing patterns on mouse models of pathophysiology.

205 Here we use an engineered organotypic model of perfused microvessels to show that activation o

206 w injection of complete Freund's adjuvant, a model of peripheral inflammatory pain.

207 detectors from computer vision with a recent model of peripheral pooling regions found at the V1 laye

208 r, recent work in the murine norovirus (MNV) model of persistent infection demonstrates that innate i

209 Modeling of phenotypes for multilocus genotype classes i

210 on by monocular deprivation is the canonical model of plasticity confined to a critical period.

211 dence was also investigated with a dynamical model of poliovirus transmission to observe prevalence a

212 esence of internal friction, and theoretical models of polymer dynamics provide a framework for inter

213 To address this, we propose a model of population growth that includes a new formulati

214 ction (FOI) between districts, we compared 6 models of population movement (adjacency, gravity, radia

215 Most models of population spread are based on one sex, or inc

216 city that radically differs from traditional models of postsynaptic plasticity.

217 ly, our results imply that OSCAR is a robust model of prion diseases that offers a promising platform

218 ASP to form tetramers and provide an amended model of processive VASP-mediated actin assembly in clus

219 scence in vitro Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to ma

220 and to fix likely errors in user supplied 3D models of proteins via successive rounds of refinement.

221 Based on synergy in preclinical models of PTCL, we initiated a phase 1 study of pralatre

222 s studies of SiC and Si, are analyzed with a model of radiation damage formation which accounts for t

223 luorescently labeled and injected into a rat model of radiation-induced lung injury via endotracheal

224 We conclude that the current model of radical-pair magnetoreception is unable to expl

225 Accordingly, we present an alternative model of relative force of infection that better capture

226 In a transgenic mouse model of resectable PDAC, we investigated the coordinate

227 anistic experiments were designed in a mouse model of resuscitated hemorrhagic shock and tissue traum

228 Models of retinal and choroidal angiogenesis, including

229 In mouse models of retroviral AML transplantation, as well as in

230 To generate a multidimensional predictive model of risk factors for iatrogenic withdrawal syndrome

231 of this parameter in biologically plausible models of saccade initiation.

232 On the one hand, models of scale-dependent feedbacks, whereby plants faci

233 evel states emerged naturally from a generic model of self-organizing groups composed of individuals

234 survival in the cecal ligation and puncture model of sepsis in adult female outbred mice.

235 nonclassical monocytes is consistent with a model of sequential transition.

236 ficantly reduced renal allograft injury in a model of severe antibody-mediated damage in highly sensi

237 We use a mathematical model of smallholders' fields to determine the effect of

238 Most conceptual and mathematical models of soil vapor intrusion assume that the transport

239 asurements from mice of either sex to inform modeling of sparse and filopodia-bearing mossy fibers, f

240 METHODS AND We combined a model of specific antibody deficiency, B cell-specific C

241 eport the generation of induced neuron-based model of sporadic Alzheimer's disease in mice and humans

242 A three-dimensional structure (3D) model of Ss-RIOK-2 was generated using the Chaetomium th

243 peutically effective in a preclinical murine model of steatosis-associated liver cancer.

244 the continuously growing mouse incisor as a model of stem cell-based tissue renewal, we found that t

245 In a model of sterile inflammation utilizing TLR4 ligation fo

246 lso involved in producing reinstatement in a model of stress-induced relapse to drug taking.

247 odel of non-Hodgkin lymphoma and a B16 mouse model of subcutaneous melanoma are used to extract a sna

248 Two murine models of synucleinopathy (a Gaucher-related synucleinop

249 els and protection from mortality in a mouse model of systemic inflammatory response syndrome.

250 Mouse models of T. cruzi infection have been used to study hea

251 st-spiking inhibitory interneurons, in a rat model of TBI as well as in brains of human epileptic pat

252 at, when news coverage is uniform, efficient modeling of temporal topic trends using time-series regr

253 Here we develop mathematical models of Tfh cells in germinal centers to explicitly de

254 i-experimental instrumental variables probit model of the association correlation of ECT administrati

255 ted and validated a predictive computational model of the cardiac mechano-signaling network in order

256 bining these structures we built a molecular model of the coat.

257 terials is critical to developing a physical model of the cytoskeleton and designing biomimetic activ

258 ning of the AD phenotype in a relevant mouse model of the disease.

259 k describes a suite of algorithms by which a model of the environment, in the form of a state transit

260 Here, we report an atomistic model of the excited state ensemble of a stabilized muta

261 We develop a mathematical model of the function of the 1,2-propanediol utilization

262 rns, we constructed a large-scale 3D network model of the granular layer.

263 physiologically based pharmacokinetic (PBPK) model of the human cardiovascular system was incorporate

264 This pioneering work has made a new model of the human intestine available and has begun mak

265 le transmission function by using a physical model of the image formation under partial spatial coher

266 lective activity against MDA-MB-453 cells, a model of the luminal androgen receptor (LAR) subtype of

267 ns are validated in a spiking neural network model of the OB-PC pathway that satisfies the many const

268 ate a multilayer computational biomechanical model of the organism and accurately derive its material

269 ATPase superfamily; (iv) a molecular docking model of the pentamer is compatible with the location of

270 grees ) using a residue-level coarse-grained model of the ribosome.

271 We then propose a neural model of the self as an emerging property of interaction

272 Methods 2 and 3 estimate R by fitting a model of the spread of infection to data on the sizes an

273 n the marked sexual dimorphism observed in a model of the transition to chronic pain, hyperalgesic pr

274 sed differences between conditions by linear modeling of the data.

275 Computational modelling of the heart tube during development reveals t

276 Modelling of the temperature dependence of the DBMP-bind

277 determinants of pattern separation we built models of the cerebellar input layer with spatially corr

278 transcriptomics data and to build predictive models of the gene regulatory networks that drive the se

279 Continuum elastic models of the membrane have been widely used to study pr

280 These findings challenge current models of the occupation of the Tibetan Plateau.

281 containing phospholipid vesicles, serving as models of the OMM, is investigated to probe cytochrome c

282 In two structural models of the perfluoroarylated product, distinct intera

283 ray scattering and ensemble modeling yielded models of the PHn-PHc fragment that indicate it is in eq

284 critical re-evaluation of prevailing uplift models of the plateau and their temporal relationships w

285 IGNIFICANCE STATEMENT Reinforcement learning models of the ventral striatum (VS) often assume that it

286 creation of genetically accurate preclinical models of these disorders.

287 We study in three different models of this system how these two seemingly conflictin

288 opy to deliver, in atomic detail, structural models of three key PANS: the hexasome (H2A.H2B).(H3.H4)

289 sticizer into a simple but widely applicable model of tip growth.

290 In an immunocompetent model of TNBC in which Eo771/MUC1-C cells were engrafted

291 Modeling of transcriptional regulatory networks (TRNs) h

292 The structure supports a 'conveyor belt' model of translocation in which ATP binding allows a Vps

293 We use a reaction-diffusion equation based model of tumour growth to investigate how the invasion f

294 as well as maintain normoglycemia in a mouse model of type 1 diabetes.

295 visited this hypothesis using the NOD murine model of type 1 diabetes.

296 he renal tubular epithelial cells of a mouse model of unilateral ureteral obstruction (UUO) and relat

297 of prematurity, we developed a composite rat model of UPI and oxygen-fluctuations and removed prematu

298 For three example models of varying size, we show that for large numbers o

299 s in a static quenching FRET experiment: the model of Veatch and Stryer, derived in 1977, and the kin

300 f newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis.