ライフサイエンスコーパス: model organism

1 xplore virus-host interplay in this powerful model organism.

2 mechanism for cold-induced longevity in this model organism.

3 gic studies require access to the mouse as a model organism.

4 scovery studies that utilize C. elegans as a model organism.

5 infection with the pneumococcus serving as a model organism.

6 O2 nanoparticles using Escherichia coli as a model organism.

7 rritories are organized in the fission yeast model organism.

8 Shewanella oneidensis is used as a model organism.

9 d development has not been investigated in a model organism.

10 hich function as a chemical language in this model organism.

11 in cell death, using Escherichia coli as the model organism.

12 richia coli K-12, the best-studied bacterial model organism.

13 cells and regeneration using M. lignano as a model organism.

14 s protein overexpression in C. merolae-a new model organism.

15 c red alga of increasing importance as a new model organism.

16 xperiments from human, mouse, rat, and other model organisms.

17 ance for the study of nervous systems in non-model organisms.

18 s the manifestations of genetic variation in model organisms.

19 slightly deleterious variants in humans and model organisms.

20 ften lead to inconsistencies across labs and model organisms.

21 abolomic analysis, and functional studies in model organisms.

22 orthologies and/or functional equivalents in model organisms.

23 ell-validated modulator of aging in multiple model organisms.

24 overlooked, even for central metabolites in model organisms.

25 t implications for studying human disease in model organisms.

26 a powerful tool to create mutant alleles in model organisms.

27 of genomic annotation from chordates and key model organisms.

28 lst still providing access to many important model organisms.

29 e essential for cilia biogenesis in multiple model organisms.

30 transcriptomics data for several prokaryotic model organisms.

31 he simplest (and best understood) eukaryotic model organisms.

32 t the organismal level is largely limited to model organisms.

33 forward genetics in even the most tractable model organisms.

34 etwork governing periderm differentiation in model organisms.

35 d with ever increasing precision in multiple model organisms.

36 om the level of single molecules up to small model organisms.

37 daptable for targeting multiple genes across model organisms.

38 R/Cas9-based somatic mutagenesis in emerging model organisms.

39 erence in chromatin organization compared to model organisms.

40 d to efficiently edit the genomes of diverse model organisms.

41 including those from important pathogens and model organisms.

42 s, as anticipated by a large body of work in model organisms.

43 rmation of sensory organs in mammal and fish model organisms.

44 levels cause neurodegeneration in humans and model organisms.

45 interactions, but remain cumbersome in most model organisms.

46 mice, yet surprisingly few overlaps in lower model organisms.

47 nto its underlying genetic causes in diploid model organisms.

48 plying this technology and review its use in model organisms.

49 essential for aspects of mechanosensation in model organisms.

50 es to cell division mechanisms elucidated in model organisms.

51 and delineated biochemically with only a few model organisms.

52 types of data obtained from human samples or model organisms.

53 on research and might be applicable to other model organisms.

54 tions which require predictions for many non-model organisms.

55 covered distinct age-related changes in both model organisms.

56 ng, as the field converges on a few selected model organisms.

57 f sialoglycoproteins from cultured cells and model organisms.

58 que for understanding gene expression in non-model organisms.

59 in bacteria, cell lines and lower eukaryotic model organisms.

60 ing bacteria, and do not conform to those of model organisms.

61 easuring intrinsic functional connections in model organisms [8].

62 Using Francisella novicida as a model organism, a bacterial lipid virulence factor (endo

63 cted to result in changes of the spectrum of model organisms, a reason to open MiTO for species-indep

64 e wealth of information on human homologs in model organisms across numerous databases.

65 To this end, we created MARRVEL (model organism aggregated resources for rare variant exp

66 to image the interior of an ecotoxicological model organism, Americamysis bahia.

67 In the model organism Anabaena sp. strain PCC 7120, the septal

68 tudies on a Cu test pattern, a Daphnia magna model organism and a perlite biocatalyst support materia

69 Large-scale integration of model organism and clinical research data can provide a

70 The method works independently of the model organism and will be useful for colony management

71 the data sets, followed by some of the main model organisms and a growing list of more than 900 dive

72 has made genome editing widely accessible in model organisms and cells.

73 Genetic engineering of model organisms and cultured cells has for decades provi

74 close relatives of Escherichia coli or other model organisms and have eluded culturing and manipulati

75 ion in genetics and has been investigated in model organisms and human cell lines.

76 the molecular mechanisms underlying aging in model organisms and humans.

77 This approach is useful for non-model organisms and in cases of low-coverage data, such

78 ude of physiological benefits with ageing in model organisms and in humans including improvements in

79 ataset represents interaction records for 66 model organisms and represents a 30% increase compared t

80 functional networks for human and six common model organisms and the NetWAS method.

81 rity of NMD factors were first discovered in model organisms and then subsequently identified by homo

82 gap for biologists studying non-traditional model organisms and those without extensive curated reso

83 here we take a classical microprocessor as a model organism, and use our ability to perform arbitrary

84 gene variants, disease-related phenotypes in model organisms, and a bioinformatics platform for thera

85 e-specific and global networks in humans and model organisms, and associated tools, which includes fu

86 aints similar to those identified in vivo in model organisms, and strengthens a framework for neural

87 ply these approaches to a wider range of non-model organisms, and to move from exploratory analyses t

88 cation for three resource types: antibodies, model organisms, and tools (i.e., software and databases

89 However, most of these data are from model organisms, and translation to clinical practice ha

90 recognizing the limitations of traditional "model" organisms, and taxonomic expertise is desperately

91 arative OMICs; gene editing; expanded use of model organisms; and a new single-cell combinatorial ind

92 species are plant pathogens that infect the model organism Arabidopsis thaliana and important crops

93 We used the model organism Arabidopsis thaliana to determine how flo

94 In the model organism Arabidopsis thaliana, SA glucose conjugat

95 tential of easyGWAS with a case study of the model organism Arabidopsis thaliana, using flowering and

96 for the human gene and homologs in the seven model organisms are arranged into a concise output.

97 ing, unprecedented numbers of genes from non-model organisms are available with increasing need for c

98 Studies in model organisms are beginning to identify the genes and

99 Major model organisms are covered by this web service.

100 : Genomes of emerging model organisms are now being sequenced at very low cost

101 As a result, model organisms are used to approximate the physiologica

102 ey to understanding gene function in diploid model organisms, are missing in many polyploid crops.

103 P. putida offer the opportunity to use this model organism as a microbial factory for production of

104 hosphate-limited growth of the Gram-positive model organism Bacillus subtilis 168, WTA is lost from t

105 comprehensive mode-of-action study using the model organism Bacillus subtilis and different assays, i

106 ants, rather than those in the Gram-positive model organism Bacillus subtilis.

107 We used a relatively simple model organism bearing both facultative and constitutive

108 ce of two well characterized axonal mRNAs in model organisms, beta-actin and GAP43, within hESC-neuro

109 We argue that model organism biology would benefit from incorporating

110 Using the model organism Burkholderia thailandensis, we show that

111 n and cell cycling are well-characterized in model organisms, but less is known about these basic asp

112 method to generate hypomorphic mutations in model organisms by targeting translation elongation.

113 ation of the biomechanics of touch using the model organism C. elegans.

114 y-mass spectrometry data from humans and the model organism C. elegans.

115 Nematodes such as the model organism Caenorhabditis elegans produce various ho

116 accessibility changes in a whole animal, the model organism Caenorhabditis elegans, from embryogenesi

117 ual nematodes closely related to the genetic model organism Caenorhabditis elegans.

118 nctional assays in a 1-billion-year diverged model organism can identify pathogenic alleles with sign

119 is relationship in Schmidtea mediterranea, a model organism capable of regenerating any and all of it

120 olytic machinery of the alphaproteobacterial model organism Caulobacter crescentus, with a specific f

121 could be modified to accommodate other small model organisms, cell cultures or tissue slices and the

122 f polar capsules to parasitism, we used as a model organism Ceratonova shasta, which causes lethal di

123 ukaryotic microalgae in particular, like the model organism Chlamydomonas reinhardtii, steer either t

124 ssion and caloric restriction experiments in model organisms confirm the conserved role for RBM6 and

125 omosome sequences is limited to a handful of model organisms, constraining our understanding of Y bio

126 levant species of parasite or host and their model organism counterparts are increasingly apparent.

127 ted as discrete lists within the appropriate Model Organism Database (MOD) so that researchers can re

128 by an authoritative database, for example, a model organism database for each type of resource.

129 of the Hymenoptera Genome Database (HGD), a model organism database for insect species of the order

130 use Genome Database is the primary community model organism database for the laboratory mouse and ser

131 The Zebrafish Model Organism Database is the central resource for zebr

132 TATION is built using tools from the Generic Model Organism Database project, including the biology-a

133 s and are freely distributed through partner model organism databases and meta-databases.

134 y inferences available (e.g. interfaces with model organism databases) were discussed, with several o

135 n from six human genetic databases and seven model organism databases.

136 The model organism Dictyostelium discoideum has greatly faci

137 iatric symptoms, and 3) the possibility that model organisms do not have (and may not be capable of h

138 The model organism Drosophila melanogaster has been at the f

139 ge and quantify the uptake of an AsHC in the model organism Drosophila melanogaster.

140 then used biochemistry, cell biology and the model organism Drosophila to provide insight into the pr

141 odels have been expanded to include an extra model organism (Drosophila melanogaster).

142 Nematostella vectensis serves as a cnidarian model organism due to the availability of laboratory cul

143 CCR has been intensely studied in the model organisms Escherichia coli and Bacillus subtilis b

144 In other vertebrate model organisms, ex vivo assays have been crucial for el

145 edback shapes active locomotion in a genetic model organism exhibiting simple locomotion-the zebrafis

146 containing gene expression measurements for model organisms exposed to hundreds of chemical compound

147 In contrast to Escherichia coli, a model organism for chemotaxis that has 5 chemoreceptors

148 et Gryllus bimaculatus, which is an emerging model organism for functional studies of induction-based

149 establish the Ercc1(/-) mouse as a powerful model organism for health-sustaining interventions, reve

150 ough Saccharomyces cerevisiae is a pervasive model organism for investigating cellular metabolism and

151 nally, we show that Mycobacterium marinum, a model organism for M. tuberculosis, encounters Pi stress

152 wering plant Arabidopsis thaliana is a dicot model organism for research in many aspects of plant bio

153 uable species both as a food source and as a model organism for scientific research.

154 Drosophila melanogaster, a well-established model organism for studies evaluating the molecular and

155 Myxococcus xanthus, a model organism for studies of multicellular behavior in

156 The zebrafish is a popular model organism for studying development and disease, and

157 recent allotetraploid and, thus, is an ideal model organism for studying early changes following poly

158 The honeybee is a model organism for studying learning and memory formatio

159 These results establish zebrafish as a model organism for studying the anxiolytic effects of sc

160 Caulobacter crescentus is a premier model organism for studying the molecular basis of cellu

161 l wasp, Nasonia vitripennis, a rising insect model organism for the study of evolution, development o

162 acterial species, M. xanthus has served as a model organism for the study of multicellular developmen

163 larval and embryonic zebrafish, an important model organism for the study of neuroscience and develop

164 made ball-rolling dung beetles an attractive model organism for the study of the neuroethology behind

165 Proteus mirabilis is a model organism for urease-producing uropathogens.

166 ts the importance of indigenous livestock as model organisms for investigating selection sweeps and g

167 Two model organisms for photobiological studies have taken c

168 e availability of whole-genome sequences and model organisms for the major seaweed groups.

169 f animals, choanoflagellates serve as useful model organisms for understanding the evolution of anima

170 and pathways are known to regulate aging in model organisms, fostering a new crop of anti-aging comp

171 how incorporating biological knowledge from model organisms, functional genomics, and integrative ap

172 ough mice are the most widely used mammalian model organism, genetic studies have suffered from limit

173 By contrast, model organism genetics has excelled at revealing molecu

174 equences from human as well as model and non-model organisms has been used to annotate the human geno

175 tification of mRNAs in distal projections of model organisms has led to the discovery of multiple pro

176 c changes in FFA uptake by the liver in live model organisms has proven difficult.

177 ic toolkit of the Mexican axolotl, a classic model organism, has matured to the point where it is now

178 More recently, advances in non-model organisms have been fuelled by the rapid evolution

179 Alternatively, the GFF files of several model organisms have been pre-loaded so that users only

180 cost of RNA-Seq, an increasing number of non-model organisms have been sequenced.

181 and computational methods used with archaeal model organisms have enabled the mapping and prediction

182 Recent discoveries in model organisms have highlighted roles for the respectiv

183 However, clinical studies and insights from model organisms have identified major roadblocks that no

184 f a few wild tobacco species as experimental model organisms have resulted in growing knowledge about

185 Linkage mapping studies in model organisms have typically focused their efforts in

186 Studies in model organisms have yielded considerable insights into

187 neurons in the ectodermal epithelium of the model organism hydra (a member of the animal phylum Cnid

188 n the body surface during development of the model organism Hydra.

189 fruit fly, Drosophila, a common invertebrate model organism in biological and neurological studies.

190 Despite the extensive use of zebrafish as a model organism in developmental biology and regeneration

191 erns in the microcrustacean Daphnia magna, a model organism in ecotoxicology and risk assessment, exp

192 In this study, we used a model organism in MFCs, Shewanella oneidensis MR-1, and

193 enopus laevis is one of the most widely used model organism in neurobiology.

194 ose producing strains and has been used as a model organism in numerous studies of bacterial cellulos

195 Since its humble start as a model organism in two European laboratories in the 1940s

196 a, or Caenorhabditis elegans have become key model organisms in modern neuroscience.

197 ster group of vertebrates and are recognized model organisms in the field of embryonic development, r

198 s, but for techniques that can be applied to model organisms in which the microbial state of the gut

199 omes to monosomes across other commonly used model organisms, including bacteria, nematodes and fruit

200 chnique for studying the development of many model organisms, including Drosophila.

201 The mechanisms of heart regeneration among model organisms, including neonatal mice, appear remarka

202 titation of intact proteins in three popular model organisms, including prokaryotic and eukaryotic mi

203 AMPK/SNF1 also promotes longevity in several model organisms, including yeast.

204 y studies using commensal E. coli strains as model organisms indicated that formate dehydrogenase and

205 microscopy, in vivo nanoscopy of tissues and model organisms is still not satisfactorily established

206 ead use of GENREs, particularly to study non-model organisms, is the extensive time required to produ

207 rized in mammals but poorly studied in other model organisms like Drosophila.

208 though ILCs have been extensively studied in model organisms, little is known about these "first resp

209 trategies to cover a wide range of different model organisms, locomotion types, and camera properties

210 ring evolutionary changes in the genome of a model organism may have little or no observable impact o

211 ys through which biogenic amines function in model organisms may improve our understanding of dysfunc

212 e in genes that have not been characterized, model organisms may not recapitulate human or veterinary

213 reproduction and development in an estuarine model organism (Menidia beryllina) across multiple gener

214 Using insights derived from simple model organisms, mice, and humans we discuss how these p

215 six existing microRNA finding methods on six model organisms, Mus musculus, Drosophila melanogaste, A

216 lic regulation of the clock in the circadian model organism Neurospora crassa We show that, in a ras2

217 minearum and Colletotrichum graminicola, the model organism Neurospora crassa, the human pathogen Spo

218 g one-dimensional filaments are paradigmatic model organisms of the transition between unicellular an

219 pplication of genomic approaches to 'obscure model organisms' (OMOs), meaning species with no prior g

220 sponse to an emerging health threat in a non-model organism opens the way for mitigation of the epide

221 In model organisms, over 2,000 genes have been shown to mod

222 es, using the shallow-water ecophysiological model organism Palaemon varians.

223 ination, the moss Physcomitrella patens is a model organism particularly suited for reverse genetics,

224 nclude reliance on findings from short-lived model organisms, poor biological understanding of aging,

225 that large-scale studies of gene function in model organisms provide a powerful approach for prioriti

226 edicting growth and gene essentiality in the model organism Pseudomonas aeruginosa UCBPP-PA14.

227 However, the best model organisms remain expensive and time-consuming to u

228 Experiments in model organisms report abundant genetic interactions und

229 ajor determinants of potassium uptake in the model organism Saccharomyces cerevisiae are the Trk1 hig

230 concept, we target the ACT1 promoter of the model organism Saccharomyces cerevisiae using a dCas9-ba

231 s on the growth of the genetically tractable model organism Saccharomyces cerevisiae We used this sys

232 nding of eukaryotic ribosome assembly in the model organism Saccharomyces cerevisiae.

233 a case study, the accumulation of Cu in the model organism Scrippsiella trochoidea resulting from tr

234 beetle, Tribolium castaneum, is an emerging model organism separated from Drosophila by 350 millio

235 Cavefishes have long been used as model organisms showcasing adaptive diversification, but

236 learning mechanism could be searched for in model organisms showing epigenetic inheritance.

237 Our transcriptome collection includes 18 model organisms spanning 10 phyla/subphyla of bacteria a

238 etic and chemical interactions for all major model organism species and humans.

239 curates the biomedical literature for major model organism species, including humans, with a recent

240 Importantly, it curates model organism-specific databases to concurrently displa

241 olecular understanding in the aforementioned model organisms still provides a strong base for dissect

242 and clinical genetics to the utilization of model organism studies.

243 velopmental conditions, especially for a non-model organism such as sunflower, will open new insights

244 e transcriptomes for most species, including model organisms such as Arabidopsis, is a major constrai

245 parable analyses in cells from commonly used model organisms such as rats and mice are lacking.

246 is to introduce that genetic variant into a model organism (such as yeast or mouse) and then to sear

247 ogy to leverage the curated gene pathways of model organisms, such as human, mouse and rat.

248 In some model organisms, such as moths, Drosophila, Caenorhabdit

249 al kinetochores with no apparent homology to model organisms suggests that more than one system for e

250 The photosynthetic model organism Synechocystis sp. PCC 6803 can grow in di

251 As a unicellular model organism, Tetrahymena thermophila is among the fir

252 r variants were predicted with effect in the model organism than in the original organism.

253 The zebrafish is a powerful model organism that enables study of lymphatic vessel de

254 The wasp Nasonia vitripennis is an emerging model organism that exhibits a strong photoperiodic resp

255 s of cellular self-repair by examining a few model organisms that have displayed robust repair capaci

256 Ideas emerging from model and non-model organisms that suggest that sex determination oper

257 stem cells of one of the most commonly used model organisms - the Rattus norvegicus have not been st

258 brain of an important insect pollinator and model organism, the bumblebee (Bombus terrestris).

259 ss Europe of two evolutionary and ecological model organisms, the anther-smut pathogen Microbotryum l

260 iciency, and in all tested cell cultures and model organisms, this decreases mRNA stability and prote

261 Honeybees are typically used as a model organism to investigate insecticide impacts on bee

262 results establish the rat as an alternative model organism to primates for studying attention.

263 sa This bacterium is frequently adopted as a model organism to study bacterial biofilm formation.

264 ish embryos, a transparent and commonly used model organism to study embryonic development.

265 e flatworm Macrostomum lignano is a powerful model organism to study the biology of stem cells in viv

266 rpegnathos establishes this ant species as a model organism to study the complexity of eusociality.

267 demonstrate that D. discoideum is a powerful model organism to study the evolution and conservation o

268 s and Drosophila, we utilised zebrafish as a model organism to study the function of EYS in the retin

269 Drosophila have been used as model organisms to explore both the biophysical mechanis

270 o key issues remain to translate findings in model organisms to future therapies in humans: what is t

271 celerate the translation of discoveries from model organisms to humans.

272 results also show the complexities of using model organisms to investigate genetic variants suspecte

273 elegans is not used as extensively as other model organisms to investigate how natural variation sha

274 the mature MAC genome, making these ciliates model organisms to study the process of somatic genome r

275 embryonic development of the short germband model organism, Tribolium castaneum.

276 Population genetics studies on non-model organisms typically involve sampling few markers f

277 Due to the interest of studying model organism under particular carbon sources, bias of

278 lied to the analysis of biological fluids of model organisms under oxidative stress caused by lead in

279 For model organisms, unlike in cell culture, this is current

280 rhabditis elegans is among the most powerful model organisms used to understand biology.

281 study phenotypic trait variance in tractable model organisms using unbiased mutagenesis screens.

282 To facilitate the development of 2973 as a model organism we developed in this study the genome-sca

283 Using Serratia marcescens as a model organism, we identify here a stage-specific iron-r

284 To see if this is happening in a model organism, we obtained nine different laboratories'

285 Using C. elegans as a model organism, we report the effect of paraquat (PQ)-in

286 roup A Streptococcus (GAS; S. pyogenes) as a model organism, we review the types and regulatory-, phe

287 Here, using Vibrio cholerae as our model organism, we show that during active cell growth,

288 Using Escherichia coli as a model organism, we therefore examined the timing and dyn

289 Contrary to studies in model organisms, we found surprisingly few correlations

290 tudy of infectious disease has been aided by model organisms, which have helped to elucidate molecula

291 netic markers for any species, including non-model organisms, which is revolutionizing ecological, ev

292 resolved genetic information generated from model organisms while allowing for identification of the

293 vere obesity and engineering the variants in model organisms will be needed to explore whether human

294 These results from this model organism with characteristics of animal and plant

295 In addition, zebrafish, a vertebrate model organism with conserved innate immunity, potentiat

296 We here focus on the mouse as a mammalian model organism with genetics, physiology, and behavior t

297 have thus far only been available in simple model organisms with limited relevance to humans.

298 Teleosts have emerged as important model organisms, yet their ancestrally duplicated genome

299 to researchers focused on the crop plant and model organism Zea mays ssp. mays.

300 Among the vertebrate model organisms, zebrafish are superbly suited for rapid