ライフサイエンスコーパス: model where

1 ntal lineFe(IV)-O-Fe(IV)(OH)(L)2](ClO4)3 (4) models (where, L = tris(3,5-dimethyl-4-methoxypyridyl-2-

2 tudy, using the Hsp90/Aha1 macrocomplex as a model (where Hsp denotes a heat shock protein), we optim

3 A model where H2O2 mediates the negative regulation of pla

4 A model where power-law fluctuations of the alpha envelope

5 A model where two Tom40 pores act in concert as a dimeric

6 ed Hsc70-synapsin associations, advocating a model where Hsc70 activity dynamically clusters cytosoli

7 bomian gland (MG) formation is employed as a model where Dkk4 and its Wnt targets are expressed.

8 nctional module in CarD activity and built a model where each module contributes to stabilizing RNAP-

9 pe Ic supernovae, but can be reproduced by a model where extra energy is injected by a strongly magne

10 open-complex formation can be explained by a model where, at saturating concentrations of CarD, the r

11 Building on these findings, we develop a model where increased inhibitory tone on dopamine neuron

12 We develop a model where organisms perform 'leaky' functions that pro

13 Based on this evidence, we envisage a model where this homeostatic circuit maintains a constan

14 We established a model where the TCR repertoire of normal polyclonal Treg

15 Our data favor a model where the high diversity of the Treg TCR provides

16 In a model where black and white MSM have identical care outc

17 In a model where both neuronal populations were connected bi-

18 by a person's own genotype, as expected in a model where one's height determines the choice of mate h

19 e function for CNS-specific CD8 T-cells in a model where the antigen is exogenously administered in v

20 Together, our data indicate a model where an alteration at position 420 causes a subtl

21 However, calibration of a model where a behaviour depends on an intervention intro

22 In support of a model where PIP3-driven P-REX1 promotes both PI3K/AKT an

23 he findings into consideration, we present a model where Nab2/ZC3H14 interacts with spliceosome compo

24 We propose a model where ABCG26-exported polyketides traffic from tap

25 with data from lower organisms, we propose a model where age-dependent down-regulation of protein tra

26 We propose a model where ASE requires genetic variability in cis, a d

27 We propose a model where bunyaviruses activate Wnt-responsive genes t

28 We propose a model where cigarette smoke exposure increases miR-31 ex

29 Together, we propose a model where coordination of LKB1 farnesylation and kinas

30 From these results, we propose a model where direct coupling of ATP hydrolysis and confor

31 s issue, Twelvetrees et al. (2016) propose a model where dynein is transported by direct-but transien

32 Based on these observations we propose a model where in the hydrated state the organized rod stru

33 We propose a model where interactions between FGF18 in the distal lim

34 specification by FGF signaling and propose a model where interactions between NANOG, GATA6, and the F

35 from this and previous studies, we propose a model where KEG mediates the ubiquitination and subseque

36 hibitory effects on ASIC1a, and we propose a model where mambalgin-2 traps the channel in a closed co

37 We propose a model where positive and negative regulatory influences

38 d on our experimental evidence, we propose a model where RepC nicking activity is passive and depende

39 data and pull-down experiments, we propose a model where ST8SiaIV recognizes and docks on an acidic s

40 Overall, we propose a model where TgISPs recruit protein partners to the IMC t

41 We propose a model where the +2 base pair regulates the efficiency of

42 We propose a model where the C terminus of TF modulates the palmitoyl

43 We propose a model where the core planar polarity proteins Celsr1 and

44 We propose a model where the ligase organizes all steps during NHEJ w

45 We propose a model where the silencing proteins AGO4, IDN2 and DRM2 b

46 On the basis of these findings we propose a model where, in the presence of ethylene, the EIN2 C ter

47 We have previously proposed a model where subcomplexes of vRNA are exported from the n

48 s and DNA footprinting experiments suggest a model where a PC4 dimer accommodates the DNA with one mo

49 Together, our results suggest a model where exocyst mediated vesicle trafficking facilit

50 Our findings suggest a model where innate immune cells discriminate fungal micr

51 Our results suggest a model where multiple alpha-actinin/Z-repeat interactions

52 Our results suggest a model where NRT1.1/AtNPF6.3 and a phospholipase C activi

53 mediating DNA damage responses and suggest a model where p53 binding to the DAD limits HDAC3 interact

54 On the basis of these results we suggest a model where salt decreases the free-energy barrier for A

55 Our data suggest a model where SynEtr1 inhibits downstream signaling and et

56 Our data suggest a model where the G allele enables enhanced activities of

57 level in living cells; our results suggest a model where the motor domain restricts dynamics via a me

58 Together, these findings suggest a model where the profilaggrin N-terminus uses calcium-dep

59 , biophysical and biochemical data suggest a model where transition from the 'initiation' state into

60 ontaining canonical TATA boxes, suggesting a model where transcription initiation at promoters by RNA

61 Tentatively, this evidence suggests a model where an elevation in striatal D2/3 receptor avail

62 This suggests a model where key interactions at the vertex and edges are

63 This investigation suggests a model where LtgD produces PG monomers in such a way that

64 This suggests a model where the checkpoint functions as a feedback mecha

65 This suggests a model where the DELLA1-mediated GA signaling interplays

66 wledge of PRMT crystal structures suggests a model where the size of two distinct subregions in the a

67 Collectively, our data support a model where a late-acting cis-regulatory up-regulation o

68 Our data support a model where adding AMPA receptors is sufficient to activ

69 Our in vitro and in vivo data support a model where an oxidized dNTPs pool together with aberran

70 These data support a model where Arabidopsis CRKs are synthesized upon pathog

71 These data support a model where Asna1 ensures retrograde transport and, henc

72 Our data support a model where Bcd influences chromatin structure to gain a

73 Our data support a model where both an increased expression of Galphaq-coup

74 Our data support a model where clonal epigenetic reprogramming towards redu

75 Overall, our data support a model where Dar, a GSH S-conjugate, is processed at the

76 Collectively, our results support a model where ERalpha signals activate MeA neurons to stim

77 ical and molecular biology results support a model where ETR1 and ETR2 are indirectly affecting the e

78 n contributes to FXS pathology and support a model where FMRP, by controlling the translation of Dgkk

79 llectively, results presented here support a model where GSK3beta regulates signaling by controlling

80 Our data support a model where H2A.Z in gene bodies has a strong repressive

81 Taken together, our data support a model where IcsA and N-WASP form a tight complex releasi

82 Our data support a model where Kip3 directly suppresses spindle microtubule

83 Our data support a model where KZNF gene expansion limits the activity of n

84 Our findings support a model where low-dose IL-2 selectively activates Tregs to

85 These data support a model where mutations are prevalent in germinal center c

86 In conclusion, our data support a model where NCC is constitutively cycled to the plasma m

87 Our data support a model where nutrition is a key environmental factor infl

88 Taken together these data support a model where PDHK4 regulates KRAS signalling and its tumo

89 These results support a model where Pil1-Lsp1 heterodimers are the minimal eisos

90 The results support a model where Pol iota occasionally accesses the replicati

91 In summary, our data support a model where Rab5a-positive vesicles, likely through inte

92 Our data support a model where rapid accumulation of serial forces on TCR-p

93 Our results support a model where residues in these positions determine specif

94 In a resting cell, our results support a model where RhoA is constantly cycling between activatio

95 Our observations support a model where specificity is generated through conformatio

96 Together, these findings support a model where spontaneous control of HCV such as sometimes

97 Taken together, our data support a model where TCR-induced phosphorylation of Dlg1 Y222 is

98 Our data support a model where the balance of activating and inhibitory rec

99 Our data support a model where the density of shared RNA binding sites arou

100 Altogether, these results support a model where the eVP30-eNP interaction plays a critical r

101 These results support a model where the Mre11 RBD and linker domain act as an au

102 The results support a model where the pseudokinase domain regulates activation

103 The data support a model where the shape and size of tendon is determined b

104 ide affinity and release rates, supporting a model where G5 loop movement promotes nucleotide release

105 A core of these interactions supports a model where specificity can be enhanced by a rigid molec

106 ises from the Swa2 TPR domain and supports a model where Swa2 acts through Hsp70, most likely to prov

107 A thermodynamic analysis supports a model where the N terminus is folded around the Zn(2+) i

108 This study lends further support to a model where DNA breaks are generated by multiple random

109 These results lead to a model where protein and small-molecule ligands synergist

110 This points to a model where the in vivo influence on protein behavior is

111 with the OOA dispersal, particularly under a model where deleterious mutations are recessive.

112 Under a model where selection is inversely related to dominance,

113 Our findings will be discussed using a model where bacterial RNase P cleavage proceeds through

114 e changes with age and are consistent with a model where a relationship between cell cycle progressio

115 Results are quantitatively consistent with a model where CAi catalyses local H+ ion delivery to the N

116 We explain these results with a model where different allosteric mechanisms in the CNBD

117 These results are consistent with a model where direct interaction between HmpF and the T4P

118 These data are consistent with a model where filoviral VP35 proteins are the major suppre

119 These results are compatible with a model where gene expression levels are modulated by the

120 ecovered in under an hour, consistent with a model where loop extrusion is rapid.

121 Together, our data are consistent with a model where MICOS, mitochondrial lipids and respiratory

122 Our data are compatible with a model where multiple mRNA closed-loop complexes form wit

123 Consistent with a model where RNA-binding proteins modulate the PDCD4 tran

124 Results are consistent with a model where SFPQ*NONO promotes sequence-independent pair

125 together, our results are consistent with a model where Tec kinases (Btk, Tec, Bmx) are required for

126 Our data are consistent with a model where the CNS shapes intrathecal immune responses

127 laser light scattering are consistent with a model where the DNA undergoes a conformational change to

128 at these results quantitatively agree with a model where the dynamics is governed by the competition

129 on of structural states is consistent with a model where the increased activity results from an incre

130 The findings are consistent with a model where the N terminus acts as a lever to support am

131 etion was measured in a murine thigh abscess model, where similar levels of SEl-K accumulation were n

132 These data lead to a signal activation model, where Arrow is required to localize Dsh to the me

133 ta were interpreted in view of an allosteric model, where pore opening is intrinsically independent b

134 However, new data suggest an alternative model where THEMIS enhances TCR signaling enabling thymo

135 P2D6-humanized (Tg-CYP2D6) mice as an animal model where hepatic CYP2D6 expression is increased durin

136 ant enhancement to the rhesus macaque animal model where both the clinical utility and biological rol

137 but reveals attenuated effects in the animal model where adiposity is reduced naturally independent o

138 Studies in animal models where a single copy of the syntenic 16p11.2 regio

139 upport viral replication in vivo, the animal models where macrophage-mediated replication of SIV is t

140 ribed in human muscular dystrophy and animal models, where it is thought to relate to the progressive

141 tients with metabolic syndrome and in animal models, where CCG is impaired.

142 These data support an assembly model where staged binding events cooperate to yield hig

143 These findings support an RPA-based model where dissociation and re-association of individua

144 e quantitatively characterized by a Bayesian model where agents ignore expectancy violations that do

145 ession, while others support a bidimensional model where symptoms segregate into distress (depression

146 enerated 2 chimeric BM transplantation (BMT) models where both young green fluorescent protein (GFP)-

147 seen in a long-term estrogen-deprived breast model, where significant downregulation of ERalpha prote

148 and that co-occurrence is well explained by models where specific mental disorders are understood as

149 immunity in prostate inflammation and cancer models, where the loss of CAT2 results in enhanced antit

150 We establish a RAS mutant cancer cell model where the autophagy gene ATG5 is dispensable in A5

151 we established a mouse subcutaneous chamber model, where a mixture of four oral pathogens commonly a

152 ion-and-action model, and an embodied choice model where the action feeds back into the decision maki

153 ke a traditional international collaboration model, where individual-level patient DNA are physically

154 compulsive participants using computational models, where these enable a segregation between metacog

155 Our results lead to a conceptual model where Tau stabilizes the MT lattice by strengtheni

156 The results allow us to propose a consistent model where changes in the overall protein dynamics rath

157 n status in a human myoblast differentiation model, where myoblasts were cultured in low-serum medium

158 l to a targeted, hypothesis-driven discovery model where the chemical features and biological functio

159 oach can be extended to other animal disease models where macrophages are implicated and has potentia

160 ee text] under the edit and Hamming distance models, where w is the size of the computer word; as suc

161 ian framework for specifying diversification models-where rates are constant, vary continuously, or c

162 We propose a population dynamical model where immunity can be both acquired and lost.

163 we examine this idea with an ecoevolutionary model where microbes make multiple secretions, which can

164 ingful integration of viruses into ecosystem models where they act as key players in nutrient cycling

165 -effect models were used, and random-effects models where significant heterogeneity was present.

166 re we introduce an atomistic electrodynamics model where the traditional description of nanoparticles

167 Our findings support an emerging model where both ribosomal and messenger RNAs are princi

168 ures allows us to construct a semi-empirical model where protocells are able to reproduce and undergo

169 However, chemical reaction (master equation) models where the transcriptional transactivator and prom

170 he recently proposed stochastic evolutionary model where payoff only weakly drives evolution and indi

171 We have developed an experimental model where genetically identical, co-housed Drosophila

172 This is one of very few models where autoimmune thyroid disease and hypothyroidi

173 epends critically on the heterozygosity, for models where frequencies are widely dispersed, such as f

174 Here we examine a general model where population growth can be induced or accelera

175 he transition density function for a general model where the effective population size, selection coe

176 ans is directly mirrored in a murine genetic model, where inbred mouse strains are differentially sus

177 this research into a 'ventrodorsal gradient' model, where frontal cortex engagement along this axis d

178 h cancer is associated with a directed graph model where nodes are anatomical locations where a metas

179 face-bound kinetics, and we propose a growth model where initiation occurs at nanoparticle corners.

180 mat composition resulted in a revised growth model where coccoid cyanobacteria predominate in mat com

181 ed by in vivo studies in a rat wound healing model where shock wave treatment induced proliferation a

182 on spontaneous activity patterns: a Hebbian model, where coincident activity in neighboring populati

183 data) is an integrated Bayesian hierarchical model where: (i) cell-specific normalisation constants a

184 roposed procedure is based on a hierarchical model, where a structure-based prior distribution is des

185 etion of Adora2b to ALI, utilizing a two-hit model where intratracheal LPS treatment is followed by i

186 formulation of the classic sleep homeostasis model, where homeostatic pressure rises exclusively in T

187 We propose a homeostatic model where C. albicans disease pressure is balanced by

188 connections between them; and a homeostatic model, where connections are homeostatically regulated t

189 We propose a hypothetical model where ripening/senescence induced a redox homeosta

190 bservations were corroborated in the implant model, where there was decreased dissemination from an h

191 ch an mGlu3 NAM has demonstrated efficacy in models where prior efficacy had previously been noted wi

192 rpretation of mitochondrial perturbations in models where APP is overexpressed, and a potential role

193 atures of the observed AMO are reproduced in models where the ocean heat transport is prescribed and

194 racy of patterning-both in space and time-in models where readout is provided not by the morphogen co

195 many variants functions through independent model, where the pleiotropic variants directly affect lu

196 ttenuated for virulence in a mouse infection model, where it elicits decreased inflammation in the lu

197 so demonstrated in the deep-tissue infection model, where Hu-1.4/1.1 bound to SEB in vivo and decreas

198 so tested in a mouse peritoneal inflammation model, where they caused a reduction in neutrophil infil

199 n a variety of (brain and peripheral) injury models where COX-2 levels correlate with disease progres

200 individual channels, we found that a kinetic model where apoCaM associates with channels before their

201 We introduce an Eulerian-Lagrangian model where hemodynamics is solved on a fixed Eulerian g

202 les integration of basecalling into a larger model where other parameters can be incorporated, such a

203 In the LGMD model, where different doses of vector were used, MYOM3

204 In contrast to linear models where translation is largely limited by initiatio

205 used an experimental murine tail lymphedema model where sustained fluid stasis was generated on disr

206 ratory experiments we propose a mathematical model where the c-di-GMP network is analogous to a machi

207 are then input to a mechanistic mathematical model, where mechanical regulation of BMP-2 production m

208 ies have been studied in simple mathematical models where genotypes are represented as binary sequenc

209 t by a AAA+ ATPase and suggest a mechanistic model where IstB binding and subsequent DNA bending prim

210 These observations support a mechanistic model where the C-terminal amphipathic helix is stabiliz

211 Our results thus support a mechanochemical model where a chemosensory system measures the mechanica

212 yme kinetics into constraint-based metabolic models, where kinetics have usually been ignored or over

213 a spatially explicit zero-sum metacommunity model where species have an elevation-dependent fitness

214 ecific Wwox(hep-/-) and total Wwox(-/-) mice models, where we found decreased ApoA-I and Abca1 levels

215 issue, we have been able to generate a mouse model where B cells specifically express a dominant-nega

216 ificantly alter CD8 T cell memory in a mouse model where CD8 T cell epitopes are clearly defined.

217 e after experimental stroke, even in a mouse model where CNS antigen-specific autoreactive T-cell res

218 Using a mouse model where encephalopathy of prematurity is induced by

219 We have studied a mouse model where Lamin B1 level are increased in oligodendroc

220 Here we have developed a mouse model where light improves cognitive function, which pro

221 ME and thyroid cancer progression in a mouse model where thyroid-specific expression of oncogenic BRA

222 primarily in young animals, we used a mouse model where weanling mice, but not adult mice, develop n

223 keletal muscle-specific Cpt1b knockout mouse model where the inhibition of mitochondrial fatty acid o

224 Here, we present a novel mouse model where the presence of a single autoreactive B cell

225 inst P. falciparum in the in vivo SCID mouse model where the efficacy was found to be more consistent

226 To address this, we used a transgenic mouse model where Lamin B1 overexpression is targeted to oligo

227 Using the GT-tg bigenic mouse model, where brain-selective Tat expression is induced b

228 ct-derived cell lines and in a new DMD mouse model, where expression of the truncated isoform protect

229 Utilizing the Emu-myc mouse model, where Myc is overexpressed specifically in B cell

230 Herein, we use a novel transgenic mouse model, where doxycycline-induced overexpression of vascu

231 e turned to the DO11.10 TCR transgenic mouse model, where OVA is recognized in the context of H-2(d),

232 Knockdown mouse models, where gene dosages can be modulated, provide val

233 cortex and compare it to a recurrent network model, where connectivity can be precisely measured and

234 ents a challenge to existing spiking network models, where typically each neuron is at most bistable.

235 Data support a new model where an LGP2-MDA5 oligomer shuttles NS3 to the mi

236 Thus, we propose a new model where disruption of Nedd4-2 interaction elevates h

237 Our measurements are described by a new model where the Poisson ratio drives transverse motion,

238 correlations is predicted by a normalization model where MT units sum V1 inputs that are passed throu

239 In the present study, we used a novel model where T cells derived from two independent TCR tra

240 these proteins follows a seeding-nucleation model, where a misfolded aggregate or 'seed' promotes th

241 articular injections of lubricin in a rat OA model where the inhibition of systemic inflammatory sign

242 fectious burden, and compared the results of models where pathogen overdispersion either was or was n

243 for proof of concept studies in a variety of models where EP2 activation is playing a deleterious rol

244 unrelated individuals based on an orthogonal model where the estimate of hSNP(2) is independent of th

245 accuracy and the associated variance in our model where a decision boundary is learned in a supervis

246 re consistent with a simple and parsimonious model where twin resemblance is solely due to additive g

247 hese effects were also observed in a passive model where all the non-synaptic voltage-gated conductan

248 heoretical framework of a two state two path model, where two slip bonds are coupled forming a double

249 These findings support a pathogenesis model where cross-reactive antibodies wane from higher-t

250 cal model based on existing network pathways/models, where each node can be interrogated by computati

251 sults suggest a supportive versus permissive model, where patterns of coordinated activity, rather th

252 ced into a target engagement pharmacodynamic model where it exhibited robust reversal of histamine-in

253 Here, we propose a phosphoswitch model, where two competing phosphorylation sites determi

254 bed by a wormlike chain force law, a polymer model where persistence length is the only adjustable pa

255 lts were fitted to a second-order polynomial model where regression analysis and analysis of variance

256 Here we develop a stochastic population model where beneficial drivers engage in a tug-of-war wi

257 ctivation, and present a minimal, predictive model where clustering receptors leads to their collecti

258 size several recent findings into a proposed model where the transcription of lncRNAs can serve as gu

259 analysis in support of a previously proposed model where APOBEC activity is the underlying process th

260 s which one is behaviorally manifest: a race model, where action selection and execution are closely

261 table in spinal tap biofluid from an ALS rat model, where its levels change as disease progresses, su

262 good agreement with a translocation ratchet model where binding of chaperones in the periplasm biase

263 nalysis of these data suggests a recruitment model, where bound ribosomes facilitate binding of the s

264 species, such replacement leads to a reduced model, where fast species are eliminated.

265 with shared characteristics; and meta-region models where inter-region transmission is expressed as a

266 gh two modelling approaches: parallel-region models, where epidemics in different regions are assumed

267 RG investigation of hole binding in the same model, where a novel pairing-glue scheme beyond the BCS

268 trategy that has been proposed is the "scout model" where cells comprising a fraction of the dormant

269 atomic structure, we propose a local seeding model where the kinked GGA motifs in the stem region of

270 inders of keeping their target with a simple model where a polymer composed by hard spheres interacts

271 Our results suggest a simple model where backbone modifications and Schiff base subst

272 rotein calmodulin and explain it in a simple model where mechanical unfolding and ligand binding occu

273 Such is the case, for example, in a simple model where overlapping particles are each given a small

274 To explain this behavior we propose a simple model, where fibrils come in two forms, one built entire

275 Fungi are simple models, where compatibility is based on the recognition

276 s studies have mainly focused on very simple models, where the receptive fields of neurons were essen

277 theory calculations of an enzyme active site model, where the optimized Cu(I) and (II) structures wer

278 ogical or medical studies: learning a sparse model, where only a subset of a large number of possible

279 mages is estimated by first using stochastic modelling where the locations of clusters in the images

280 the PSD and are consistent with a structural model where MAGUKs, corresponding to membrane-associated

281 We construct stage- and age-structured models (where stage is mass) of a roe deer population, w

282 These observations support models where task goals interact with sensory inputs via

283 ons, our measurements support a syngergistic model where these interactions are inhibited in the abse

284 These findings revisit the model where neovascularization is considered to happen c

285 Our results are consistent with the model where strand separation by the helicase unpairs th

286 This model, where stem cell behavior can be monitored in vivo

287 in free and HAP-adsorbed SN15 are fitted to models where the side chains are assumed to exchange bet

288 based gap filling approach, we applied it to models where essential pathways were removed, finding th

289 In a Hy10 antibody transgenic model where anergic B cells respond to a biophysically d

290 vity are predicted by a concerted transition model where the binding of each GABAergic drug additivel

291 principally studied in the 4T1 mammary tumor model, where silencing of Twist in vitro has been shown

292 3-producing cells was detected only in tumor models where IL-23 neutralization was therapeutic.

293 nted for by a formal single-level tunnelling model where the temperature dependence relies on the the

294 We therefore propose an updated model where MinE is brought to the membrane through inte

295 oscillations in mouse CA1, using an in vitro model where brief epochs of rhythmic activity were evoke

296 ogical and genetic studies support a working model where rapsyn, a classic scaffold protein, serves a

297 se in the estrogen-dependent MCF-7 xenograft model, where this effect was accompanied by a dose-depen

298 ndidates involved in flowering using a yeast model, where prion attributes are well defined and readi

299 In contrast to the zebrafish model, where activation of gp130/Jak/Stat is sufficient

300 ation conforms to the classic "tension zone" model, where alleles are lost via reduced hybrid viabili