ライフサイエンスコーパス: model wherein

1 Collectively, the current results suggest a model wherein 14-3-3varepsilon binds to Ser12-phosphoryl

2 We propose a model wherein 25OH activation of OSBP promotes the bindi

3 to maintain genomic stability and point to a model wherein 53BP1 and H2AX cooperate to repress resect

4 on full-length LYS7, suggest an alternative model wherein a dimer of LYS7 interacts with a dimer of

5 , Chaudhuri et al. (2015) present a cortical model wherein a hierarchy of timescales arises from loca

6 Overall, we propose a model wherein a modest effect on RNA splicing is suffici

7 These data support a model wherein a network of MIT and MIT-like domain inter

8 n period of 8.7 years were consistent with a model wherein a normal plateau phase of variable length

9 tence and concomitant immunity, suggesting a model wherein a parasite reservoir repopulates itself in

10 In conclusion, our data support a model wherein a pre-TfH wave of IL-4 secreted by interfo

11 We propose a model wherein a Ran-mediated vesicular fusion step is re

12 uction in DNA-binding affinity and support a model wherein a single cell cycle-dependent Ser/Thr kina

13 Overall, our data are consistent with a model wherein a single molecule of bezlotoxumab neutrali

14 present evidence in support of the 'sliding model' wherein a RecA filament diffuses along a dsDNA tr

15 We propose a working model, wherein a cycle of H2B ubiquitination/deubiquitin

16 y analyzed using equilibrium receptor gating models, wherein a postulated class of equivalent etomida

17 nowledge of drug availability, and support a model wherein aberrant circuitry linking dorsolateral pr

18 d precursor protein processing and support a model wherein Abeta production is amplified by plaque-in

19 Altogether, our results support a model wherein Ac1PIM2, a major form of PIMs produced by

20 These data suggest a model wherein activated Fus3p is recruited back to the c

21 Our results are consistent with a model wherein active Ded1 promotes translation but inact

22 We propose a working model wherein after lysosomal hydrolysis of LDL-choleste

23 ; here we construct, to our knowledge, a new model wherein airway narrowing and closure dynamics are

24 ar localization of these proteins suggests a model wherein alginate is modified at the polymer level

25 This led to a model wherein Alt 2 and the phylogenetically conserved A

26 nditioned taste aversion learning in the rat model, wherein animals associate a novel taste with visc

27 and chronic rejection, we developed a murine model wherein anti-MHC class I Abs or control (C1.18.4/a

28 en-CD3 above basal levels, consistent with a model wherein antigenic engagement induces maximum PRS e

29 These data suggest a model wherein APC controls enterocyte differentiation by

30 Our findings imply a model wherein APC controls intestinal cell fating throug

31 These findings support a model wherein Apc serves a dual role in regulating Wnt a

32 ves a P35-insensitive caspase and supports a model wherein apical and effector caspases function thro

33 The data are consistent with a model wherein apoA-V(1-146) alpha-helices circumscribe t

34 Together, these results support a model wherein aptamers suppress viral replication by cum

35 Our studies are consistent with a model wherein ARC3 directly inhibits Z-ring assembly in

36 In summary, our data support a model wherein As(2)O(3) increases rAAV transduction both

37 results of this study are consistent with a model wherein ATP binding regulates the anti-inflammator

38 This is consistent with a model wherein ATP may first bind to Mlh1, resulting in e

39 asive front of human CRCs supports a revised model wherein Axin2 acts as a potent tumor promoter in v

40 These data are consistent with a model wherein basal transient sumoylation of the NH2-ter

41 rrently relevant stimulus, consistent with a model wherein behavioral relevance modulates the impact

42 ell described by a simplified shrinking core model wherein binding equilibration is much more rapid t

43 These data support a model wherein binding of a catalytic ion to a precatalyt

44 We propose a model wherein binding of Rev dimers to MTs at their ends

45 In a biotic biofilm model, wherein biofilms form on cultured airway cells, t

46 tions are consistent with the predictions of models wherein blinking is controlled by diffusion of th

47 stream of E2F1; this was confirmed in murine models, wherein Brm loss induced E2F1 deregulation in a

48 These findings support the model wherein c-Myc promotes cell growth and transformat

49 These data support a model wherein C75 of the genomic HDV ribozyme acts as a

50 From these results, we propose a model wherein caffeine abrogates the G(2)/M checkpoint b

51 Together these data support a model wherein calcium-induced MMP-9 expression is differ

52 We present a model wherein cAMP induces a membrane apolipoprotein rec

53 These findings suggest a model wherein carcinogenesis in BRCA2 mutation carriers

54 ophages is only routinely observed in animal models wherein CD4 T cells are almost entirely depleted.

55 These studies support a model wherein cell-matrix engagement regulates the funct

56 on and structure that is not replicated by a model wherein cells receive random feedforward inputs.

57 We propose a model wherein chronic stress results in glucocorticoid r

58 These findings support a model wherein CIITA inhibits MMP-9 expression by binding

59 Mutational analyses of SNAP190 support a model wherein CK2 phosphorylation triggers an allosteric

60 reveals that (1) gating is best described by models wherein closed and open states communicate via a

61 Overall, our study puts forth a model wherein combined actions of Set1 and Jhd2 via modu

62 Our data support a model wherein conformational changes in SF3b1 promote U2

63 These findings support the model wherein cooperative interactions among intrinsic s

64 led a binding mode similar to that initially modeled wherein covalent attachment of the nucleophilic

65 Our results suggest a model wherein CP-31398-mediated stabilization of p53 may

66 chanisms for increasing torque and supported models wherein critical interactions occur atop the C ri

67 These results suggest a model wherein CSL-dependent Notch signaling confers prot

68 Collectively, our data support a model wherein cyclin D1 has a mitogenic (CDK4-dependent)

69 toplasm of cells, which is consistent with a model wherein cytosolic APOBEC3G packages into assemblin

70 ogether, these results are consistent with a model wherein DDX1 acts as an RNA chaperone, remodeling

71 the stem II structural transition leads to a model wherein DDX1 can act as an RNA chaperone, folding

72 Our data support a model wherein deregulation of cyclin D1 nuclear export m

73 an extension of the conformational selection model, wherein different substrates select different sta

74 that regulates pDC development, supporting a model wherein differentiation into pDCs represents a pri

75 was recently challenged with an alternative model wherein disrupting RubisCO activity prevents photo

76 This effect is consistent with a model wherein distal polyanionic surfaces of the nanocag

77 We describe a working model wherein distinct classes of transcription factors

78 onal and apoptotic; thus, our data support a model wherein division-linked generation of T(DIM) contr

79 The results support a model wherein dNTP elevation is needed to facilitate non

80 Based on our results, we propose a model wherein E4-ORF1 binding to Dlg1 triggers the resul

81 These findings led us to propose a model wherein each LXXLL motif has an additive effect, a

82 Our data are consistent with a model wherein early resistance to B. malayi is mediated

83 Our results support a model wherein efficient electron propagation can explain

84 Taken together, our data support a model wherein EGF promotes Tcf/Lef transcriptional activ

85 These data suggest a model wherein either Gsalpha or forskolin enhances assoc

86 Furthermore, we describe a new model wherein EMT induced by TGFbeta requires translatio

87 Our data support a model wherein epicardial-derived pericytes populate the

88 The combined data suggest a model wherein epigenetic and genetic elements cooperativ

89 Together, these studies support a model wherein episodic Blimp-1-mediated plasma cell diff

90 on or function of the U6 snRNA, supporting a model wherein excess Lsm1 reduces the availability of th

91 The data also suggest a model wherein factors implicated in aging (for example,

92 These results advance a new model wherein Fn polymerization serves as a structural s

93 We present a model wherein FoxO degradation is a component of a stabi

94 We propose a model wherein fras1 prompts late-p1 formation and thereb

95 ses of these mutant forms of Tor1p support a model wherein functional interactions between the FRB an

96 provide strong support for a GAL gene switch model wherein Gal80 rapidly dissociates from Gal4 throug

97 Gal3p proteins provides strong support for a model wherein galactose causes an alteration in Gal3p th

98 these findings serve as the foundation for a model wherein GDNF and CGRP interact in a paracrine mann

99 at the restrictive temperature, we propose a model wherein Gfd1 serves as a bridging factor between G

100 Our results are consistent with a model wherein GINS trades places with Sld3 at a replicat

101 Here, we describe a somatic mouse model wherein H3.3(K27M) and Trp53 loss alone are suffic

102 ProHA x TRAMP mice), as well as an analogous model wherein HA is expressed in normal tissues as a mod

103 CD81 and claudin-1 endocytosis, supporting a model wherein HCV stimulates receptor trafficking to pro

104 We propose a model wherein heparin exerts this effect by providing a

105 The data support a model wherein HIV-1 entry occurs in three stages: recept

106 Furthermore, they support a model wherein hr-mediated transactivation by IE1 involve

107 These results support a model wherein Hsp90 interacts predominantly with the cyt

108 Our results suggest a model wherein hSWI/SNF-directed nucleosome movement away

109 To develop an in vivo model wherein human hematopoiesis occurs, we transplante

110 The results are interpreted in terms of a model wherein HypA controls the flow of nickel traffic i

111 These data support a model wherein IE1 oligomerizes prior to DNA binding to f

112 These findings support a model wherein IE1 oligomerizes within the cytosol as a p

113 Our results support a model wherein IL-7 transduces a replicative signal to no

114 Collectively, these data support a model wherein IL12Rbeta1DeltaTM is a secreted product of

115 iving biofilm formation in vivo We propose a model wherein impaired cellular respiration stimulates S

116 We propose a model wherein imprinting defects at chromosome 11p13 may

117 in vivo and in vitro, were consistent with a model wherein improved C-helix "leucine zipper" interact

118 These findings invoke a model wherein incomplete DNA synthesis during S phase le

119 -syn in the presence of Ca(2+), we propose a model wherein initial lipid interaction occurs via the N

120 These data are compatible with a model wherein interaction of MDA-9/syntenin with c-Src p

121 Our results suggest a model wherein interactions among TFAP2A, CITED2, and p30

122 These findings support a model wherein interactions between transcription factors

123 These findings support a model wherein interoceptive processing in the mid-insula

124 in support of this hypothesis, and propose a model wherein IRE1 surveys the integrity of the ER, acti

125 veral lines of evidence combine to support a model wherein it acts to maintain barrel structure while

126 We propose a Kv4.3 gating model wherein KChIP2 isoforms accelerate recovery, slow

127 Our data support a model wherein KLCs promote activation of kinesin-1 for c

128 Together, these data support a model wherein KLK5-mediated PAR-2 activation regulates t

129 We describe a murine model wherein leukocytes interacting with inflamed micro

130 suppressed murine colitis in an experimental model wherein lipopolysaccharide is known to play an imp

131 In a xenograft model wherein, live renal cancer cells were implanted un

132 These results support a model wherein LT from RORgammat(+) cells orchestrates th

133 isms and three-dimensional (3D) cell culture models wherein mammalian epithelial cells undergo morpho

134 Together these data support a model wherein matrix-induced clustering ofalpha3beta1 in

135 We proposed a model wherein mechanical loading, i.e. stretch, stimulat

136 isoforms and provide further evidence for a model wherein membrane potential promotes charged CQ tra

137 The data suggest a model wherein Metnase promotes integration of exogenous

138 e established an immune-mediated TRALI mouse model, wherein mice with cognate antigen were challenged

139 Wine grapes present a unique biogeography model, wherein microbial biodiversity patterns across vi

140 We posit a model wherein microRNAs are critical for downregulation

141 Together, these data were consistent with a model wherein MKL1 transduces signals from the cytoskele

142 Our combined data support a model wherein modest alterations in B cell-intrinsic, BC

143 These findings support a novel model wherein modulation of the Treg response as a resul

144 s result can be explained by a reinforcement model wherein movement errors influence decision-making,

145 Our data support a model wherein MSL2 and MSL3 control plastid size, shape,

146 were interpreted using a cooperative binding model wherein multiple non-covalent interactions create

147 erns were more consistent with a crypt niche model wherein multiple stem cells were present and repla

148 Taken together, these data support a model wherein Munc18c transiently switches from associat

149 These findings support a model wherein mutant DISC1 leads to SR degradation via d

150 Our studies suggest a molecular model wherein mutually antagonistic intermolecular compe

151 This mechanism differs from the standard model wherein nascent C3b generated in the fluid phase a

152 Collectively, our results support a model wherein non-stem cancer cells have the potential t

153 These results support a model wherein Notch signaling in bone marrow normally ac

154 ogether, these studies suggest a heterotypic model wherein Notch signaling in vSMCs provides early in

155 These data are consistent with a model wherein Notch signaling represses SMC differentiat

156 Based on these results we propose a model wherein nuclear accumulation of the cyclin E/Cdk2/

157 We propose a model wherein Nup159 and Gle1-IP(6) regulate Dbp5 cycles

158 e examined by using generalized linear mixed modeling wherein observations were nested for each radio

159 Further analysis supported a model wherein one monomer of TRN-SR2 is bound to one mon

160 Our findings suggest a new model wherein Op-IAP3 interacts directly with SfIAP to m

161 The present results are discussed within a model wherein oscillators influence one another in a pha

162 Together, these findings suggest a model wherein Pak1 regulation of cyclin D1 expression mi

163 Our data are consistent with a model wherein PfCRT catalyzes electrochemically downhill

164 These results reinforce a model wherein phosphorylation of specific residues of BR

165 Our data support a model wherein PilW, PilX, and PilY1, in addition to thei

166 Altogether, our data suggest a model wherein PL is a prodrug whose intracellular hydrol

167 ed a similarity-based reinforcement learning model wherein prediction errors generalize across simila

168 Here we describe a maternal SLE mouse model wherein pregnant dams harbored DNA-specific, NMDAR

169 The T. brucei data fit a model wherein processing factors assemble at the 5'ETS s

170 Our data suggest a coordination model wherein PrP(C) vesicles maintain a stable populati

171 cell migration [15, 16], our data support a model wherein PTB-domain-containing adaptor proteins reg

172 d of rgd2-R;pve1-M2 double mutants suggest a model wherein PVE1 functions downstream of RGD2 in a pat

173 We present a model wherein Rad51 helps recruit Sgs1-Top3 to sites of

174 We present a unified model wherein Rad54 acts as an hDNA pump that drives D l

175 Our results are consistent with a model wherein rbf represses synthesis of icaR, which in

176 Allosteric models wherein receptor binding shifts the equilibrium t

177 State-performance correlations support a model wherein reconsolidation of hippocampus-dependent f

178 We propose a distinctive model wherein RecQ melts dsDNA internally to initiate un

179 Our data support a spatiotemporal model wherein recruitment of AMPK in association with co

180 These findings suggest a model wherein recruitment of CD4 to the IS allows its ph

181 The results presented support a model wherein regulation of the binding of UBF to Rb and

182 Our results are most consistent with a model wherein Rel homodimers or heterodimers must bind D

183 We discuss a model wherein repair of a double-strand gap requires mul

184 , this has led us to propose a "looped belt" model, wherein residues 133-146 comprise a flexible loop

185 Data support the elicitor-receptor model wherein resistant plants contain receptors for pat

186 dependent, an observation consistent with a model wherein Rev self-association acts to transiently m

187 Combined, these results suggest a model wherein Rev-associated nuclear export signals coop

188 ial epidermal identity occurs and suggests a model wherein RGD2 is required to coordinate dorsiventra

189 A model wherein S170 phosphorylation functions as part of

190 Taken together, our results support a model wherein Ser(138) phosphorylation sensitizes IRP1/c

191 are consistent with a 'differential fusion' model wherein sexual selection reduces rates of fusion a

192 We suggest a model wherein sheathing bases and parallel veins are bot

193 Our data support a model wherein silent information regulator 4 tethers the

194 aluated in nude mouse ascites or solid tumor models, wherein SK-OV-3 cells were administered i.p. or

195 We propose a model wherein Sld2 blocks the interaction between GINS a

196 In summary, these results suggest a novel model wherein SNP-modulated RNA splicing modulates CD33

197 the strength of interference and suggested a model wherein some crossovers experience interference wh

198 We propose a model wherein specific DNMT-histone methyltransferase ne

199 involved in this response, and we proposed a model wherein SREBP-1c and carbohydrate response factor

200 These results are discussed in terms of a model wherein SRP and NAC regulate each others' activity

201 Data presented support a model wherein SrrAB-dependent biofilm formation occurs i

202 clinical strategy in a stringent preclinical model, wherein standard-of-care chemotherapy is followed

203 Based on our findings, we propose a model wherein STIM1-mediated store-operated calcium entr

204 ole cells as well as cell-free systems fit a model wherein stimulus-induced acetyltransferase activat

205 We conclude by proposing a model wherein stochasticity in the nuclear location of t

206 l data, the structure supports a mechanistic model wherein subunit H inhibits ATPase activity by stab

207 We propose a model wherein SufT, and by extension the DUF59, is essen

208 These new data support a model wherein Tcf3-mediated control of Nanog levels allo

209 vidence, we propose the Piggyback-the-Winner model wherein temperate dynamics become increasingly imp

210 We propose a model wherein the 4E-T/4EHP interaction engenders a clos

211 These data suggest a model wherein the active site of LCAT is shielded from s

212 Taken together, these data support a model wherein the alpha-helices in the receptor-binding

213 Taken together, these data suggest a new model wherein the antiapoptotic function of IAP requires

214 We propose an evolutionary model wherein the appearance of the most active enzyme i

215 The combined results support a model wherein the beta-hairpin PG-1 peptide acts as an a

216 etic and biochemical evidence corroborates a model wherein the biosynthesis and translocation of DAT

217 Such observations led to the long-standing model wherein the Calvin cycle is necessary during photo

218 Altogether, our experimental data suggest a model wherein the catalytic site is essentially preforme

219 fore and after RYGB are in accordance with a model wherein the cerebral extracellular 5-HT level modu

220 CM proteins onto chromatin, which supports a model wherein the composite action of multiple G1 CDK co

221 our previous experimental data, we propose a model wherein the conformational transitions are importa

222 , Renno-Costa et al. introduce a theoretical model wherein the convergence of the medial and lateral

223 To account for these findings, we propose a model wherein the covalent attachment of ubiquitin to su

224 These results are consistent with a model wherein the cytokinin/WUS pathway and retrograde s

225 Our findings support a model wherein the degron is exposed when SMN is monomeri

226 To this end, we developed a transgenic mouse model wherein the firefly luciferase gene expression was

227 Altogether, our experimental data support a model wherein the flexibility and conformational transit

228 These findings support a model wherein the immunomodulatory capacity of F. tulare

229 Collectively, our data support a model wherein the in vivo role of VitD3 during TB is not

230 Results are accommodated by a model wherein the Mg(2+)-free pKa observed for WT arises

231 These data support a new model wherein the N-terminal domain is required to media

232 ntify such a region in SOCS36E and propose a model wherein the N-terminal of SOCS36E blocks access to

233 This suggests a model wherein the neocentromere represents a primordial

234 The results were most consistent with a model wherein the non-ion-paired C1(2+*) excited state t

235 r transport velocities are consistent with a model wherein the normal stepping behavior of the myosin

236 st cell transcription factors and suggests a model wherein the orderly sequence of virus-mediated cha

237 n these observations, we develop a summative model wherein the P-body assembly phenotype of a given m

238 These data are consistent with a new model wherein the P35 reactive site loop participates in

239 The results support a model wherein the PFC is critical for top-down intrahemi

240 Based on prior studies, we proposed a model wherein the poliovirus RNA-dependent RNA polymeras

241 previously known role of ppGpp and support a model wherein the ppGpp-dependent redistribution of RNA

242 Together our data support a model wherein the production of type I interferons drive

243 We propose a model wherein the recruitment of ZFP-1/DOT-1.1 and depos

244 Our data lead to a model wherein the replication complex can be assembled w

245 The data suggest a model wherein the requirement for Npl3p defines the mRNA

246 These data provide a model wherein the respiratory epithelium responds to hyp

247 Taken together our results suggest a model wherein the retraction of the spectrin-actin cytos

248 We propose a model wherein the right-handed ((+) solenoidal) wrapping

249 We discuss a model wherein the SA signaling pathway and plasmodesmata

250 Based on these findings, we propose a model wherein the unique physiology of ROS-low LSCs prov

251 r data support a two-site gp120-CCR5 binding model wherein the V3 crown and stem interact with distin

252 phorylated CTD peptides is consistent with a model wherein the WW domain positions Ess1 to catalyze i

253 Our findings are consistent with a model, wherein the 5-HT4R density adjusts to changes in

254 A kinetic model, wherein the secondary structure of the nascent RN

255 ntegrative structure and a bipartite binding model, wherein the TAR central loop engages the CycT1 TR

256 by the ENA image does not conform to current models, wherein the heliosphere resembles a cometlike fi

257 Ps in miRNA-mediated silencing and support a model wherein they enable miRNA-binding sites by looping

258 ilJ and the PilJ demethylase ChpB, support a model wherein this chemotaxis cluster participates in th

259 ll lymphomas, we developed a murine lymphoma model wherein three potential rejection antigens, human

260 in the context of a translational checkpoint model wherein TIA and eIF2 are functional antagonists of

261 ato do not regulate each other, we propose a model wherein tll expression restricts the ability of ce

262 These data support a model wherein TLR responses in FM B cells are tightly re

263 The results are consistent with a model wherein TM can directly and reversibly down-regula

264 Our results fortify a model wherein toxicity of mutant spastin proteins, espec

265 embrane protein gp210, our results support a model wherein transport of integral proteins to the INM

266 les in the release-ready state and support a model wherein tryptophan-mediated protein-lipid interact

267 epigenetic function for eHsp90 and support a model wherein tumor eHsp90 functions as a rheostat for E

268 Thus, the data support a model wherein tumor Treg cells sustain and amplify their

269 Here we propose and test a "proximity model" wherein two females that vary in their relative a

270 A model wherein TyrR, IHF, and CRP collaborate to regulate

271 These findings are best explained by a model wherein UAG codons may have ambiguous meaning and

272 Our findings support a conceptual model wherein variable climatic conditions dominate rece

273 so observed for W45A and W45S in the cardiac model, wherein W45F is normal.

274 mer tubulation was exaggerated, supporting a model wherein WASH links retromer-mediated cargo contain

275 We present a molecular model wherein Xrcc2 is important to preserve or restore

276 gand binding domain, we propose an alternate model wherein Y537F mutation favors an "open" pocket con

277 We propose a model wherein Yps and Orb bind competitively to oskar mR

278 Our data suggest a model wherein ZC3H3 interfaces between the polyadenylati