ライフサイエンスコーパス: modern human

1 Neanderthal but belonged to an anatomically modern human.

2 ter group of Denisovans after diverging from modern humans.

3 iting our knowledge of these predecessors of modern humans.

4 al selection against Neanderthal variants in modern humans.

5 ese inhibitors predispose to two scourges of modern humans.

6 ity (bone strength relative to body size) in modern humans.

7 portant for the study of dispersal routes of modern humans.

8 nd lacking traits typical of Neandertals and modern humans.

9 ted that D. folliculorum origins may predate modern humans.

10 ing the evolutionary history of anatomically modern humans.

11 ing it was amplified during the evolution of modern humans.

12 le from those of Late Pleistocene and recent modern humans.

13 elationship between Pleistocene hominins and modern humans.

14 history took place before the appearance of modern humans.

15 t apes and humans, long before the advent of modern humans.

16 sence of fully behaviorally and anatomically modern humans.

17 eloped before or as a result of contact with modern humans.

18 he same configuration that occurs modally in modern humans.

19 ogression of Y chromosomes into anatomically modern humans.

20 ol, lissoir, previously only associated with modern humans.

21 o the generation of adaptive variation among modern humans.

22 e for cultural diffusion from Neandertals to modern humans.

23 hominins (human ancestors) and anatomically modern humans.

24 e evidence for the symbolic culture of early modern humans.

25 hat might have followed FOXP2 adaptations in modern humans.

26 wth spurt no longer confers any advantage in modern humans.

27 es in these early hominin taxa compared with modern humans.

28 tter is most likely produced by anatomically modern humans.

29 d materials required to sustain hyper-dense, modern humans.

30 still limited in their endurance compared to modern humans.

31 otion that East Africa was the birthplace of modern humans.

32 r functional or structural traits typical of modern humans.

33 haping genotypic and phenotypic variation in modern humans.

34 dispersal, i.e., a single major diffusion of modern humans across Eurasia and Australasia [3-5]; and

35 The spread of modern humans across the globe has led to genetic adapta

36 act of large herbivores on ecosystems before modern human activities is an open question in ecology a

37 icrobial communities that interact most with modern human activities.

38 biotic resistance genes has been enhanced by modern human activity and its influence on the environme

39 In particular, at least some Neanderthal-modern human admixture must postdate the separation of t

40 Neandertal and modern human adults differ in skeletal features of the c

41 e list of substitutions that became fixed in modern humans after their separation from the ancestors

42 pression differences between Neanderthal and modern human alleles, indicating pervasive cis-regulator

43 , fossil evidence suggests that anatomically modern humans (AMH) and various archaic forms coexisted

44 Genetic evidence for anatomically modern humans (AMH) out of Africa before 75 thousand yea

45 ic event since the emergence of anatomically modern humans (AMH).

46 mains generally associated with anatomically modern humans (AMHs) and evidence of a probable Neandert

47 pped with the earliest incoming anatomically modern humans (AMHs) in Eurasia are key questions in pal

48 nd largely extinct expansion of anatomically modern humans (AMHs) out of Africa.

49 tinctly different from those of anatomically modern humans (AMHs), despite the close relationship bet

50 f Neandertals and the spread of anatomically modern humans (AMHs).

51 the population divergence of Neandertals and modern human ancestors, and it refutes alternative scena

52 y dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the

53 on of a key shared derived characteristic of modern human and Neandertal hand morphology and suggests

54 limb epiphyses (long bone articular ends) in modern humans and chimpanzees and in fossil hominins att

55 covery of interbreeding between anatomically modern humans and extinct hominins; the development of a

56 clavicle lengths, along with those of early modern humans and latitudinally diverse recent humans, w

57 not remained stable even since the origin of modern humans and might have changed numerous times duri

58 d material with early or recent anatomically modern humans and more primitive neurocranial and endocr

59 Thus, the history of admixture between modern humans and Neandertals is most likely more comple

60 Middle to Upper Palaeolithic interface, both modern humans and Neanderthals contemporaneously inhabit

61 spanning chimpanzees, ancient hominids, and modern humans and reveals new aspects of MEI biology in

62 gressed fragments in the genome sequences of modern humans and to determine whether positive selectio

63 rphology that is shared with Neandertals and modern humans, and considered adaptive for intensified m

64 h before and after divergence of non-African modern humans, and Neandertals were a source of adaptive

65 have shown that Neanderthals interbred with modern humans, and that non-Africans today are the produ

66 genetically diverged from other anatomically modern humans, and they likely experienced strong select

67 he large brain and small postcanine teeth of modern humans are among our most distinctive features, a

68 Modern humans are characterized by a highly specialized

69 Modern humans are characterized by specialized hand morp

70 skeletal differences between Neandertals and modern humans are largely established by the time of bir

71 s of the divergence between Neanderthals and modern humans are underestimated; or (iii) phenotypic di

72 haracteristics and cognitive capabilities of modern humans are well-documented, less is known about h

73 urignacian assemblages--demonstrably made by modern humans--are commonly used as proxies for the pres

74 Interglacial (132,000-110,000 y B.P., before modern human arrival) than in the early Holocene (10,000

75 Modern humans arrived in Europe ~45,000 years ago, but l

76 There is a consensus that modern humans arrived in the Americas 15,000-20,000 y ag

77 rtals show behaviors similar to those of the modern humans arriving into Europe, including the use of

78 stage for later refinements that manifest in modern humans as language-based conversational turn-taki

79 il hominins and highlight the value of using modern humans as models for inferring the limits of homi

80 n addition to using MELT to discover MEIs in modern humans as part of the 1000 Genomes Project, we al

81 sites and demonstrates that the presence of modern humans associated with Upper Paleolithic toolkits

82 K222 exists in modern humans at multiple loci spread across the pericen

83 ome have speculated that the demise of early modern humans at that time was due in part to a dramatic

84 t elements fell within the expected range of modern humans at this age.

85 er deciduous incisor from Riparo Bombrini is modern human, based on its morphology.

86 by 41,000 calendar years before the present, modern humans bearing Protoaurignacian culture spread in

87 sophisticated manual abilities, yet much of modern human behavior evolved very recently.

88 ly implies that innovational pulses of early modern human behaviour were climatically influenced and

89 therosclerosis is thought to be a disease of modern human beings and related to contemporary lifestyl

90 The latter assume that modern humans benefited from some selective advantage ov

91 eference genome is part of the foundation of modern human biology and a monumental scientific achieve

92 ousand years old, therefore the emergence of modern human biology is commonly placed at around 200 th

93 Nevertheless, natural selection persists in modern humans, both as differential mortality and as dif

94 s the possibility that phenotypic changes in modern human brains and behavior may have been mediated

95 Comparisons of modern human brains with those of chimpanzees provide an

96 ltiple interactions between Neanderthals and modern humans, but there is currently little genetic evi

97 e European population, it may have arisen in modern humans by admixture with Neanderthals in Europe.

98 have discovered that HK2 viruses produced in modern humans can package HK2 sequences and transmit the

99 ruda fossil is significant for the spread of modern humans carrying the IUP into Europe and suggests

100 ns of development, implying that a prolonged modern human childhood evolved quite recently.

101 However, some modern humans climb tall trees routinely in pursuit of h

102 Southern Italy, have demonstrated that early modern humans collected and processed various plants.

103 e Neanderthal genome with genomes of several modern humans concluded that Neanderthals made a small (

104 n Siberia to isolate its endogenous DNA from modern human contaminants and show that the reconstructe

105 As modern humans continue to live under extended periods of

106 t into the complexity and diversification of modern human culture during a key period in the global d

107 Modern human dispersal into Europe is thought to have oc

108 As modern humans dispersed from Africa throughout the world

109 How modern humans dispersed into Eurasia and Australasia, in

110 n important for understanding the origins of modern human diversity.

111 n skeletons is the presence of contaminating modern human DNA molecules in many fossil samples and la

112 Neanderthal-derived variants that survive in modern human DNA; however, the neural implications of th

113 During bipedal walking, modern humans dorsiflex their forefoot at the metatarsop

114 Many Neanderthal sequences survive in modern humans due to ancient hybridization, providing an

115 They coexisted with modern humans during part of this time.

116 aracterized by a series of founder events as modern humans expanded into multiple continents.

117 g in favourable environmental conditions for modern human expansion.

118 tantially to later people or represent early modern human expansions into Eurasia that left no surviv

119 between growth in tooth root length and the modern human extended period of childhood.

120 , show extensive bone deposition, whereas in modern humans extensive osteoclastic bone resorption is

121 t not with modern humans suggesting that the modern human face is developmentally derived.

122 Huesos (SH) and different from the retracted modern human face.

123 Modern human faces are distinct from those of the Neande

124 It is relevant to debates about when modern humans first dispersed out of Africa and when the

125 ens of thousands of years after anatomically modern humans first left Africa and thousands of years a

126 eolithic toolkits in the Levant predates all modern human fossils from Europe.

127 those of the age of the oldest anatomically modern human fossils.

128 we analyse DNA from a 37,000-42,000-year-old modern human from Pestera cu Oase, Romania.

129 We investigated ancestry of 3,528 modern humans from 163 samples.

130 was determined by the repeated migration of modern humans from Africa into Eurasia.

131 Levantine corridor hypothesis suggests that modern humans from Africa spread into Europe via the Lev

132 y that the initial dispersal of anatomically modern humans from Africa to southern Asia occurred befo

133 ta support a coastally oriented dispersal of modern humans from eastern Africa to southern Asia appro

134 The timing of a migration reversal of modern humans from Eurasia into North Africa is suggeste

135 o, one of the oldest fossils of anatomically modern humans from Europe.

136 patterns of social behavior that distinguish modern humans from other living primates likely played s

137 iological characteristics that differentiate modern humans from other primates.

138 In such a scenario, modern human genetic and phenotypic variation was primar

139 nderthal ancestry, has been deleterious on a modern human genetic background, as reflected by its dep

140 decreased fertility in males when moved to a modern human genetic background.

141 ur knowledge this is the oldest anatomically modern human genome reported to date.

142 genome and an expanded set of high-coverage modern human genome sequences.

143 s the persistence of its risk alleles in the modern human genome.

144 with the evolution of RV-C and helped shape modern human genomes against the virus-susceptible, albe

145 ed archaic hominin sequence that survives in modern human genomes and what these genomic excavations

146 Many modern human genomes retain DNA inherited from interbree

147 d (3) the introgression of ancient MEIs into modern human genomes.

148 make a direct comparison between archaic and modern human genomes.

149 and Bacteroides, the dominant genera in the modern human gut microbiome.

150 st 45,000 years before present, anatomically modern humans had spread across Eurasia [1-3], but it is

151 the possible relationship with anatomically modern humans has captured our imagination and stimulate

152 Throughout history, the population size of modern humans has varied considerably due to changes in

153 the extinct Neanderthal and Denisovan, while modern humans have at least 100 K111 proviruses spread a

154 tal sequences that persist in the genomes of modern humans have been identified in Eurasians, compara

155 Here, we test the hypotheses that (i) recent modern humans have low trabecular density throughout the

156 Results show that only recent modern humans have low trabecular density throughout the

157 Recent analyses of de novo DNA mutations in modern humans have suggested a nuclear substitution rate

158 ebate about the Neanderthals' replacement by modern humans highlight the role of environmental pressu

159 nvestigated genetic differentiation of early modern humans, human admixture and migration events, and

160 ibular shape variation in fossil Homo and in modern human hunter-gatherer populations.

161 as related to the colonization of Eurasia by modern human hunter-gatherers, who competed with wolves

162 n spite of this, however, there have been no modern human imaging studies of its acute effects on the

163 strating an early appearance of behaviorally modern humans in a medium-cold steppe-type environment w

164 a population that diverged early from other modern humans in Africa contributed genetically to the a

165 probably predate the arrival of anatomically modern humans in Eastern Europe.

166 ity of interbreeding between Neandertals and modern humans in Eurasia.

167 Whereas there is no evidence of the earliest modern humans in Europe contributing to the genetic comp

168 Hence, the behavior of the first modern humans in Europe is still unknown.

169 ed the relationship between Neanderthals and modern humans in greater detail by applying two compleme

170 However, the H. naledi foot differs from modern humans in having more curved proximal pedal phala

171 ges in the genetic structure of anatomically modern humans in recent millennia.

172 n resonance dating of mammalian teeth, place modern humans in Sumatra between 73 and 63 ka.

173 different from most other early anatomically modern humans in the Levant.

174 Given the role of modern humans in the world-wide decimations of megafauna

175 he debate about the timing of the arrival of modern humans in western Europe and the demise of Neande

176 Most modern humans, in contrast, concentrate in large cities

177 andertal lineages that persist in the DNA of modern humans, in whole-genome sequences from 379 Europe

178 ples from 51 deciduous teeth of 12 different modern human individuals of known dietary histories, as

179 he present, containing multiple anatomically modern human individuals.

180 stantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is c

181 om body parts of endemic animals, suggesting modern humans integrated exotic faunas and other novel r

182 ient hominin lineage most closely related to modern humans, interbred with ancestors of present-day h

183 Based on genetic evidence the dispersal of modern humans into Eurasia started less than 55 ka ago.

184 shortly after the expansion of anatomically modern humans into Europe and from the ancestors of Neol

185 tween HBV phylogeny and genetic diversity of modern humans, investigated the timescale of global HBV

186 tions has been used to distinguish them from modern humans, invoked to account for other aspects of t

187 model of admixture between Neanderthals and modern humans is necessary to account for the different

188 The first settlement of Europe by modern humans is thought to have occurred between 50,000

189 After these losses and in the presence of modern humans, large herbivores generally were less abun

190 e possible cause-effect relationship of this modern human-like (MHL) hand anatomy, its associated gri

191 dually along a single morphocline, achieving modern human-like configuration and function within the

192 The H. naledi foot is predominantly modern human-like in morphology and inferred function, w

193 rints provide the oldest direct evidence for modern human-like weight transfer and confirm the presen

194 or and pigmentation have changed more on the modern human lineage.

195 Modern humans live in an "exploded" network with unusual

196 erectus, consistent with the shift toward a modern human locomotor anatomy, or more recently in conc

197 sequence of a approximately 45,000-year-old modern human male from Siberia.

198 0 and 42,900 cal B.P. and the IUP-associated modern human maxilla known as "Ethelruda" before approxi

199 zation is not easy for physical reasons, and modern humans may be exceptional.

200 pact on our ancestors, and furthermore, that modern humans may have already expanded beyond Africa by

201 , for example the appearance of behaviorally modern humans, may be unwarranted.

202 The antiquity of Neanderthal gene flow into modern humans means that genomic regions that derive fro

203 nderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near Ea

204 Both modern humans (MHs) and Neanderthals successfully settle

205 obiota and converge along an axis toward the modern human microbiome.

206 As modern humans migrated out of Africa, they encountered m

207 es are consistent with the major prehistoric modern human migrations.

208 in human ancient DNA suggested that an early modern human mitochondrial lineage emerged in Asia and t

209 the temporal and spatial complexity of early modern human morphological variability.

210 Modern humans moving into Asia met Neandertals, Denisova

211 the last common ancestor of Neanderthals and modern humans ([N-MH]LCA).

212 years after documented interbreeding between modern humans, Neandertals and Denisovans, that we see m

213 Analyses of the genetic relationships among modern humans, Neanderthals and Denisovans have suggeste

214 ed a rich history of admixture between early modern humans, Neanderthals, and Denisovans, and has all

215 However, the timing of peak root velocity in modern humans occurs earlier than expected and coincides

216 event in human evolution is the expansion of modern humans of African origin across Eurasia between 6

217 verlap between Neanderthals and anatomically modern humans of more than 5,000 years.

218 d after 50 kyr ago--potentially encountering modern humans on Flores or other hominins dispersing thr

219 ecreate the evolutionary pathway between two modern human oncogenes, Src and Abl, by reconstructing t

220 Here we studied three ORF1 proteins: a modern human one (111p), its resuscitated primate ancest

221 d nonsynonymous mutations faster than either modern humans or Neanderthals.

222 nd whether they have the potential to infect modern humans or other primates.

223 Previously, only large-brained modern humans or their close relatives had been demonstr

224 y a significant role in language function in modern humans, originally evolved to support domain-gene

225 Modern humans originated in Africa, but where exactly?

226 neage emerged in Asia and that the theory of modern human origins could no longer be considered solel

227 The serial founder model of modern human origins predicts that the phylogeny of ance

228 t hominids has reshaped our understanding of modern human origins.

229 iled description of the complex dispersal of modern humans out of Africa and their population expansi

230 played an important role in the dispersal of modern humans out of Africa but the Karnataka state, whi

231 val of humans in Australia, the dispersal of modern humans out of Africa, and the subsequent interact

232 archaeological evidence for the expansion of modern humans out of Africa, with initial occupation at

233 nd environmental context of the dispersal of modern humans out of Africa.

234 that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago.

235 Anatomically modern humans overlapped and mated with Neandertals such

236 Modern humans overlapped in time and space with other ho

237 ent and modern viruses have implications for modern human pandemics from viral reservoirs and for hum

238 d different bipedal push-off kinematics than modern humans, perhaps resulting in a less efficient for

239 e expression that contribute to variation in modern human phenotypes.

240 ysis is of several genomic samples from each modern human population considered, we are able to docum

241 polymorphisms and cranial shape variables of modern human populations from Africa and Asia.

242 ent of "archaic" Neanderthal by anatomically modern human populations in other regions of western Eur

243 stant parental relatedness that is common in modern human populations is less well understood.

244 The predominantly African origin of all modern human populations is well established, but the ro

245 from Neanderthals/Denisovans to non-African modern human populations through gene flow.

246 n of biological affinities between worldwide modern human populations, derived independently from den

247 ntly different mean values in various recent modern human populations, favoring a scenario of fast ev

248 nd evolved over thousands of years alongside modern human populations.

249 red among Neanderthals, Denisovans and early modern humans, possibly including gene flow into Denisov

250 hal remains, suggesting that Neanderthal and modern human presence overlapped in Europe for some mill

251 archaic admixture influences disease risk in modern humans, provide hypotheses about the effects of h

252 at H. floresiensis survived until long after modern humans reached Australia by ~50 kyr ago.

253 gastropod Phorcus turbinatus associated with modern human remains and IUP and EUP stone tools from Ks

254 In Europe, modern human remains of this time period are scarce and

255 (EUP) Upper Paleolithic sequence containing modern human remains, has played an important part in th

256 Modern humans replaced Neandertals approximately 40,000

257 Anatomically modern humans replaced Neanderthals in Europe around 40,

258 The Pleistocene global dispersal of modern humans required the transit of arid and semiarid

259 is more derived than any other anatomically modern humans, resembling middle-to-late Late Pleistocen

260 a subfamily acts as an endogenous mutagen in modern humans, reshaping both somatic and germline genom

261 rived from Neanderthals, more than any other modern human sequenced to date.

262 s divergence from orthologous chimpanzee and modern human sequences and find strong support for a mod

263 us, the low trabecular density of the recent modern human skeleton evolved late in our evolutionary h

264 Many interactions in modern human societies are among strangers.

265 have a profound impact on the functioning of modern human societies, but effects on economic activity

266 distant strangers that are characteristic of modern human societies.

267 me sequences from ten securely dated ancient modern humans spanning 40,000 years as calibration point

268 d intrinsic causes, with research focused on modern human-specific models to understand disease pathw

269 Moreover, at present, Manot 1 is the only modern human specimen to provide evidence that during th

270 different conclusions regarding how and when modern humans spread out of Africa and into the rest of

271 vention by Neandertals or an indication that modern humans started influencing European Neandertals m

272 Australopithecus and early Homo but not with modern humans suggesting that the modern human face is d

273 tal Y we describe has never been observed in modern humans suggests that the lineage is most likely e

274 the Neanderthal mitochondrial DNA (mtDNA) to modern humans than Denisovans has recently been suggeste

275 Fixed in modern humans, the deletion is also in archaic human gen

276 e inter-species dynamics of Neanderthals and modern humans, the eventual replacement of the Neanderth

277 as the main place of origin for anatomically modern humans, their dispersal pattern out of the contin

278 However, in species of Homo, including modern humans, there is a tight link between tooth propo

279 of similar objects in Europe by anatomically modern humans, they could also be evidence for cultural

280 Considered exclusive to modern humans, this behavior has been used to argue in f

281 ing that Neanderthal alleles may have helped modern humans to adapt to non-African environments.

282 ed that in at least a few anatomical regions modern humans today appear to have relatively low trabec

283 mane contains ancient mitochondrial DNA of a modern human type.

284 Here we infer early demographic histories of modern humans using whole-genome sequences of five Khois

285 mixture between Neandertals and anatomically modern humans, we analyzed patterns of introgressed sequ

286 Using the opponens muscles from a sample of modern humans, we tested the hypothesis that aspects of

287 Notably, although fully modern humans were already present in southern China at

288 the ancestral lineage common to archaic and modern humans, whereas genes involved in behavior and pi

289 r and subsequent mixture of Neanderthals and modern humans - which, on genetic evidence, is considere

290 people could be closely related to the first modern humans who later successfully colonized Europe.

291 The genetic diversity of the first modern humans who spread into Europe during the Late Ple

292 indeed an additional ecological barrier for modern humans, who could only enter Europe when the demi

293 the Neanderthals' demise to competition with modern humans, who occupied the same ecological niche.

294 f Africa, and the subsequent interactions of modern humans with Neanderthals and Denisovans.

295 sub-Saharan African origin for anatomically modern humans with subsequent migrations out of Africa.

296 ions outside Africa to be colonized by fully modern humans, with archaeological evidence for human pr

297 nt common ancestor (TMRCA) of Neandertal and modern human Y chromosomes is approximately 588 thousand

298 in-coding differences between Neandertal and modern human Y chromosomes, including potentially damagi

299 ces the Neandertal lineage as an outgroup to modern human Y chromosomes-including A00, the highly div

300 onger than the TMRCA of A00 and other extant modern human Y-chromosome lineages.