ライフサイエンスコーパス: modest effect

1 decreases in cholesterol levels have only a modest effect.

2 ilar treatments with deoxygedunin had only a modest effect.

3 y relatively few genomic regions of small to modest effect.

4 les for diabetic retinopathy appear to be of modest effect.

5 use, the findings suggest that it only has a modest effect.

6 ot and a PPARbeta/delta activator had only a modest effect.

7 he bud neck-associated septin proteins has a modest effect.

8 ing the contribution of multiple variants of modest effect.

9 r treatment of the KB1050 biofilm had only a modest effect.

10 (interleukin 28R [IL-28R]) or IL-10R2, had a modest effect.

11 nitude of the average improvement suggests a modest effect.

12 er, but rather was due to the lack of even a modest effect.

13 control) effects, whereas CO2 and N only had modest effects.

14 as agents administered individually had only modest effects.

15 es; brassinosteroid and gibberellin had only modest effects.

16 oving O(2) from the templating base had more modest effects.

17 large sample size requirements for detecting modest effects.

18 a shortened side chain for Leu-531 had only modest effects.

19 ositions -4, -9, and -11 for M-MuLV had more modest effects.

20 d to preserve the helical structure had more modest effects.

21 beta cell in adult mice reportedly has more modest effects.

22 valent mutations at the NBD1 socket had only modest effects.

23 dels, whereas loss of Akt1 or Akt2 have more modest effects.

24 We show here that loss of a c-Myb allele had modest effects (20%-28% decrease) on colony formation of

25 ected that risk involves multiple genes with modest effects acting independently or interacting.

26 redominant role played by common variants of modest effect and the diversity of biological mechanisms

27 verse outcomes, whereas Kineret exerted only modest effects and no benefit for gestation length, neon

28 risk variants likely to include hundreds of modest effects and possibly thousands of very small effe

29 Rep52 has modest effects, and Rep40 exerts no significant effect o

30 o confer disease susceptibility, with only a modest effect at each locus.

31 t of extracted soy isoflavones, except for a modest effect at the femoral neck.

32 to investigate the presence of common allele modest effects at autosomal and chromosome X variants th

33 clic beta-sheets 1a and 1b only exhibit more modest effects at equimolar or greater concentrations.

34 Interventions that have even quite modest effects at the individual level could drastically

35 ured children and their parents have shown a modest effect, but additional research is needed to refi

36 prove adherence rates have demonstrated only modest effects, but lessons from these initial intervent

37 Most medical interventions have modest effects, but occasionally some clinical trials ma

38 s exist to identify susceptibility loci with modest effect by meta-analyzing together multiple studie

39 nd showed higher GSH than HSC(control), with modest effects by AA.

40 Whereas blocking either pathway triggers modest effects, combining a ?-secretase inhibitor to blo

41 ng hexosamine biosynthetic pathway, but this modest effect did not fully account for the change in N-

42 ction in theta, alpha, and beta ranges, with modest effects during rule maintenance.

43 back pain, and duloxetine is associated with modest effects for chronic low back pain.

44 remains limited to short-term trials showing modest effects for chronic low back pain; trials were no

45 portant intervention strategy, albeit with a modest effect, for reducing lead in breast milk and thus

46 Further, the modest effects from several mutations suggest that there

47 Modest effects have been reported in some studies of old

48 ependent (CTL) levels, whereas having a more modest effect in decreasing ethanol consumption in CTL m

49 yridamole plus aspirin had a significant but modest effect in reducing the risk of stenosis and impro

50 ting the hypothesis that fructose has only a modest effect in relieving repression of frtA by FrtR.

51 opsis thaliana) deficient in phyB, but had a modest effect in the wild type.

52 not have any effect; TL2 mutation has only a modest effect in translation, but translation is reduced

53 Inhibiting single cytokines produced modest effects in clinical trials, in part because the c

54 iors in H-Agg animals, however yielding more modest effects in L-Agg animals; while high-dose DPAT ef

55 ny formation in methylcellulose but had only modest effects in liquid culture.

56 programs by professionals have demonstrated modest effects in the primary prevention of child abuse

57 py with either bexarotene or DHA resulted in modest effects in vitro and in vivo, combined treatment

58 tribute to disease risk, each with generally modest effects independently.

59 Multiple common genetic variants of modest effect influence IL-6 concentration.

60 The relatively modest effect may reflect 50% dose reduction for each al

61 alleles: rs1800693 is a common variant with modest effect (odds ratio = 1.2), whereas rs4149584 is a

62 thioflavin-S positive tangles, suggesting a modest effect of anti-amyloid-beta immunization on tangl

63 Except for a modest effect of cystatin-C, no biomarker was associated

64 A modest effect of DHA + aspirin on Porphyromonas gingival

65 Despite the modest effect of FASN inhibition on tumor growth in xeno

66 with a sedentary lifestyle, we report a very modest effect of HIT and no effect of resistance trainin

67 There was no effect of surgeon volume and a modest effect of hospital volume (odds ratio for highest

68 Our findings show a modest effect of influenza vaccination on disease severi

69 randomized clinical trial (n = 663) found a modest effect of intensive dietary counseling for a low-

70 No or only a modest effect of local realignment was detected on the t

71 s and suggests a molecular mechanism for the modest effect of myristoylation on binding, wherein the

72 Clinical trials have suggested a modest effect of naltrexone as a pharmacotherapy for alc

73 We here confirm a modest effect of purifying selection on the mtDNA coding

74 Despite the modest effect of survivin knockdown on tumor growth, red

75 greater than that for UL30 and explains the modest effect of the W780V mutation on foscarnet suscept

76 The available data suggest a modest effect of these fatty acids on increasing gestati

77 o the early termination of the trial, or the modest effect of treatment.

78 Coupled with previous reports showing modest effects of BRMS1 on adhesion and invasion, our re

79 ate cancer cell function as we observed only modest effects of chelation strategies on the growth of

80 The modest effects of clinical studies using intracoronary a

81 dox presented by our data by noting that the modest effects of crowding on elemental binding steps ar

82 The sample was too small to rule out modest effects of infliximab and included only patients

83 The bias was larger than expected given the modest effects of reward size on tracking of single targ

84 LS pharmacoresistance could both improve the modest effects of riluzole and set in motion a re-evalua

85 diation and Fe2+-EDTA/H2O2 showed relatively modest effects of sequence context on the proportions of

86 Modest effects of the catalyst nature on regioselectivit

87 Our data indicate that the modest effects of uroguanylin on energy and glucose home

88 ational debt relief programs may have only a modest effect on academic retention.

89 critical for activation, Gal11 contact has a modest effect on activation, and contact with TFIID and

90 anced substrate thermal stability has only a modest effect on activity, regardless of sequence.

91 the amino acid activation step, with only a modest effect on aminoacyl transfer.

92 circulating antinuclear antibodies and had a modest effect on anti-double-stranded DNA titers but sho

93 5/8S, and C221S, respectively, followed by a modest effect on C242S was observed.

94 t of uninfected endothelial cells had only a modest effect on CD1d expression, suggesting that optima

95 Cd5 enhancer deletion also had only a modest effect on CD5 expression in the T lineage.

96 In contrast, Pat1 depletion had a modest effect on cell growth but caused progressive telo

97 Knockdown of OSR1 has only a modest effect on cell survival and does not lead to spin

98 ty expected that such RD&D would have only a modest effect on cost, but would improve performance in

99 anscription at most cellular genes but has a modest effect on cotranscriptional termination.

100 le data, there is evidence that rs4641 has a modest effect on diabetes susceptibility (1.10 [1.04-1.1

101 in digital mammography has a measurable but modest effect on diagnostic accuracy.

102 inheritance, many DNA sequence variants with modest effect on disease risk contribute to the genetic

103 hy descriptors of atherosclerosis had only a modest effect on downstream MFR.

104 Variation within PCLO may have a modest effect on early-onset type 2 diabetes, possibly a

105 as blockade of Hedgehog signaling has only a modest effect on EFT cells.

106 ow here that although T790M alone has only a modest effect on EGFR function, when combined with the c

107 vivo, whereas the loss of Raptor had only a modest effect on endothelial cells (ECs).

108 The mutation has only a modest effect on enzyme activity and on the diversion of

109 relative to alanine, glycine has only a very modest effect on equilibrium loop stability.

110 contrast, in breast CSCs, biguanides have a modest effect on glycolytic and TCA cycle intermediates,

111 tion of either GP2 glycan individually had a modest effect on GP expression and no impact on antibody

112 While siRNA for RhoA had a modest effect on growth inhibition, downregulation of Rh

113 murine leukemia virus (N-MLV) but has only a modest effect on HIV-1.

114 s, but deletion of the IFHL motif has a very modest effect on Hmo1 binding.

115 The absence of signaling had a modest effect on host resistance in mice with secondary

116 a species pairs, the X chromosome has only a modest effect on hybrid male sterility between D. virili

117 uch as Dual Specificity Phosphatase 1, and a modest effect on IL-10 secretion.

118 that of IL-13, but lack of gammac had only a modest effect on IL-4 signaling.

119 oid tissue, and blockade of E-selectin has a modest effect on improving long-term graft survival.

120 r mHS-3.5 in embryonic stem cells has only a modest effect on in vitro erythroid differentiation, whe

121 singly, absence of palmitoylation has only a modest effect on in vitro or in vivo signaling.

122 virus produced in fibroblasts but had only a modest effect on infection by virus from epithelial cell

123 f of the siRNA seed region have a relatively modest effect on knockdown potency.

124 trations (2.5-5 muM) of SFB had a relatively modest effect on LCSC-2 or 293 T cell growth, but damage

125 r results may explain why climate has only a modest effect on leaf economic traits in general.

126 The large amount of food given and the modest effect on linear growth in newborns suggests that

127 s sufficient to activate Akt, but has only a modest effect on lymphomagenesis in the same model.

128 ural mechanism for estradiol alone to have a modest effect on mating behavior while setting the stage

129 amatically reduced with iron deficiency; the modest effect on mRNA levels suggests a stronger influen

130 ficantly worse health outcomes, apart from a modest effect on multiple physical symptoms.

131 rs58542926 is a low-frequency variant with a modest effect on NAFLD, suggesting that carriers of the

132 ha and ABT-737 alone or in combination had a modest effect on normal hematopoiesis but each individua

133 dramatic killing of bone cancer with only a modest effect on osteoclast number.

134 eatment, but thus far it has only provided a modest effect on overall survival benefits.

135 and demand--but these differences had only a modest effect on patient outcomes.

136 cate that, in general, mutations of small to modest effect on phenotype were involved.

137 into pretest atherosclerotic CVD risk has a modest effect on post-test atherosclerotic CVD risk.

138 SOCS3 has only a modest effect on promoting Brk degradation, and this req

139 l 70 as a crowding agent was found to have a modest effect on protein stability, in qualitative agree

140 nic perturbation of BARAC's aryl rings has a modest effect on reaction rate, whereas steric hindrance

141 e analyses, preoperative comorbidities had a modest effect on readmission; however, postoperative fac

142 nd new evidence that antioxidants may have a modest effect on reducing the dominant symptom in chroni

143 istration of desmopressin resulted in only a modest effect on renal concentrating ability.

144 duction in resection tract length has only a modest effect on repair of multiple, dirty DSBs in G2-ar

145 ion of the eye, ablation of Stra6 has only a modest effect on retinoid homeostasis and does not impai

146 n in the general population, and most have a modest effect on risk of RA (odds ratio approximately 1.

147 ffects of many alleles, each exerting only a modest effect on risk.

148 nuclease activity of the protein, and have a modest effect on RNA binding.

149 Overall, we propose a model wherein a modest effect on RNA splicing is sufficient to mediate t

150 hibited Akt phosphorylation, they had a very modest effect on S6rp and 4E-BP1 phosphorylation.

151 TG101348 treatment had modest effect on serum cytokine levels, but greater than

152 creasing it by hyperosmotic shock has only a modest effect on stiffness, whereas defects in the dpy-5

153 In addition, there is a modest effect on stimulation of MutH-catalyzed nicking.

154 ed EVH1-binding domain of SH3BGRL only had a modest effect on suppression of v-Rel transformation.

155 th chemotherapy or radiation leads to only a modest effect on survival.

156 ho are homozygous for phe508del CFTR, with a modest effect on sweat chloride concentration.

157 The loss of T-bet had a modest effect on T cell production of IFN-gamma but did

158 ion of regulatory T cells (day 7) and only a modest effect on T-cell proliferation (48 to 96 h) in re

159 notyped for 14 known common gene variants of modest effect on T2D risk.

160 MeaB alone has a modest effect on the affinity of the mutase for the 5'-d

161 sing influences, ovule oversupply has only a modest effect on the degree to which lifetime seed produ

162 y binding of ligands to exosite I has only a modest effect on the E*-E equilibrium for this mutant.

163 of both RANKL and OPG, and IL-17 had only a modest effect on the expression of RANKL or OPG.

164 IL-1beta treatment showed a modest effect on the expression profile of miRNAs in nor

165 Expression of Miro1(KK) had a modest effect on the frequency of these Ca(2+) spikes bu

166 Our work suggests that EBV has only a modest effect on the GC process, which allows it to acce

167 thogen-induced ROI production but had only a modest effect on the hypersensitive response.

168 Interestingly, although flupentixol had a modest effect on the immediate response invigoration pro

169 cine order in the heterologous regimen had a modest effect on the immune response.

170 mozygous deletion of Gab2 in mice had only a modest effect on the initiation of Neu-induced mammary t

171 inding constant for RNAP while having only a modest effect on the isomerization rate constant.

172 the enzyme for glycerolipids but had only a modest effect on the K(m).

173 n protein expression appeared to only have a modest effect on the kinetics of propagative IIF, and ev

174 al model, we show that the correlation has a modest effect on the mean evolutionary response and a la

175 In bipolar patients, older age had a modest effect on the metabolic syndrome rate.

176 's theory, the size of catalyst shows a more modest effect on the rate constants than expected.

177 t affect DNA methylation and only had a very modest effect on the release of transposable elements an

178 of HAdV-C5 in the liver, while it has only a modest effect on the replication of HAdV-C6.

179 Cholesterol has only a modest effect on the repulsive interactions between prot

180 general, genetic factors are known to have a modest effect on the risk of HL; however, familial risk

181 kely has no effect on homodimerization and a modest effect on the secondary structure of echinT.

182 Only a modest effect on the whole-cell responses was observed b

183 taneous and miniature EPSCs and IPSCs with a modest effect on their amplitudes.

184 With doctors experiencing no more than a modest effect on their work lives, open notes seem worth

185 percutaneous injections at S1-S2 had only a modest effect on thermal escape, even at higher doses.

186 systemic administration of rIL-10 had only a modest effect on tolerance.

187 A modest effect on transcript elongation and pausing was s

188 uced lytic replication of EBV but had only a modest effect on transcription activation function.

189 on translocation channel in MdtC has an only modest effect on transport yet in MdtB totally inactivat

190 y inhibited viral morphogenesis, with only a modest effect on viral gene expression, recapitulating a

191 t virus RNA replication or budding but had a modest effect on virus cell entry, indicating that the a

192 of the virus to promote FFWO, while having a modest effect on virus-cell fusion.

193 dual residues implicated in G4 binding had a modest effect on WRN binding to DNA, decreasing the pref

194 CCC inhibition had modest effects on [Cl(-)](i) and neuronal volume, but su

195 dies (SSGWAS) may fail to identify loci with modest effects on a trait.

196 isingly, absence of the TLR pathway had only modest effects on Ab production in an acute infection wi

197 alizations, whereas methamphetamine had only modest effects on affiliative behaviors.

198 ell self-renewal through deletion of Id1 has modest effects on animal survival, while knockdown of Ol

199 roduces additional stability with relatively modest effects on antigenicity.

200 egies, multiple common genetic variants with modest effects on blood pressure (<1 mmHg systolic) have

201 int mutations in this loop have either no or modest effects on catalytic efficiency.

202 We find that this additional term has modest effects on coarsening dynamics, but alters the st

203 VD in postmenopausal women and achieved only modest effects on CVD risk factors, suggesting that more

204 d alpha-granule secretion with comparatively modest effects on dense granule secretion.

205 nomodulatory therapies exist, they have only modest effects on disease progression.

206 The drug had modest effects on DNA fragmentation as a single agent at

207 ischemia around the probe tracks it had only modest effects on dopamine no-net-flux results.

208 productive transcription, while having only modest effects on either RNAP promoter association or th

209 ntrast, mutation of the Asn-67 site had only modest effects on enzyme stability and processing.

210 unctional complex." Individually, they exert modest effects on erythrocyte shape and membrane stabili

211 s with cell wall remodeling defects had more modest effects on fusion pore permeance.

212 urements to numerous mutants revealed fairly modest effects on gating kinetics despite significant ch

213 anslation, and the nonprotective IgM mAb had modest effects on gene expression.

214 A marked enteric neuronal loss with modest effects on GI function is found after buserelin t

215 ng by microarray hybridization revealed only modest effects on global gene expression: a one-third re

216 proteinuria and tubular injury but had more modest effects on glomerular pathology and podocyte numb

217 ctive concentrations of agonist but only had modest effects on glutamate and glycine EC50.

218 ll, and even severe alterations lead to only modest effects on growth proficiency.

219 nexpectedly, the switch I mutations had only modest effects on GTP binding and on GTPase activity and

220 SS20 had only modest effects on heart failure and this tracked with on

221 only minor defects in blood homeostasis and modest effects on HSC self-renewal.

222 DNMAML expression had modest effects on in vivo proliferation but preserved ov

223 Vitamin C had only modest effects on intracellular ROS and a more general c

224 Val131 or Val135 and glycine for Pro132 had modest effects on kinase activity, the introduction of b

225 continued expression of mutant Kras produced modest effects on life extension, whereas simultaneous d

226 However, mutation of Glu214 to Gln had only modest effects on ligand binding and catalysis.

227 A2 activity, PLA2G7 variants associated with modest effects on Lp-PLA2 activity were not associated w

228 eneficially affect abdominal AT loss and has modest effects on markers of MetS.

229 Treatment with inhaled corticosteroids had modest effects on miRNA expression in steroid-naive asth

230 The results indicate that flooding has modest effects on mobility that are most visible at mode

231 IQ in the analysis, and the CNV only confers modest effects on other cognitive traits.

232 anergy in lymphocytes) in CD4+ T cells, with modest effects on other E3 ubiquitin ligases such as c-C

233 tein convertase subtilisin/kexin type 1 with modest effects on PC1/3 in vitro have been associated wi

234 PB1-F2 expression had modest effects on polymerase activity, PB1 accumulation,

235 HbA1C has modest effects on predicted atherosclerotic CVD risk whe

236 SFK blockade alone had modest effects on proliferation, but significantly enhan

237 anner; protein also stimulates insulin, with modest effects on reducing blood glucose.

238 y affect the compaction of chromatin and has modest effects on remodeling by SWI/SNF and RSC.

239 pression of pax6 in the eye anlage, but only modest effects on retinal cell survival.

240 Although each individual mutation has only modest effects on RPA activity, a form combining both ph

241 wth or constitutive RcsC activation had only modest effects on RpoS expression, and these increases w

242 TOXCAT is insensitive to mutations that have modest effects on self-association in detergents but rea

243 rotocol dramatically altered SREBP-1 but had modest effects on SREBP-2 levels.

244 ound that checkpoint blockade alone had only modest effects on survival.

245 , but even high non-physiological doses have modest effects on synapses.

246 eas where bird numbers are highest will have modest effects on the availability of locations for powe

247 By contrast, ligand binding has only modest effects on the conformation and dynamics of the e

248 erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c.

249 re state-managed invertebrate fisheries, but modest effects on the groundfish fishery because individ

250 kinetics of l-leucine inhibition, with some modest effects on the kinetic parameters of catalysis.

251 etion of either of the BRD4 bromodomains had modest effects on the metastatic suppression ability of

252 In contrast, these ASIC antagonists had only modest effects on the reflex in rats with freely perfuse

253 motor neurons in an SMA mouse model had only modest effects on the SMA phenotype and survival.

254 Dicer ablation had modest effects on the steady-state levels of spliced Xis

255 reveal that this lipid modification has only modest effects on the structure and hydration of S1-S4 d

256 loid formation, (the lag time), while having modest effects on the total amount of amyloid fibrils pr

257 eproduction of the angle of knee flexion had modest effects on the trajectory of pain and physical fu

258 ical vein endothelial cells (HUVEC) but with modest effects on the unstimulated growth of HUVEC.

259 Preculturing islets with ANXA1 had modest effects on their capacity to regulate blood gluco

260 protein [BMP] antagonists) has surprisingly modest effects on these tissues.

261 e clock protein Period (PER) as well as more modest effects on Timeless (TIM).

262 '-fluoro substitutions in the mRNA have only modest effects on tRNA selection.

263 ough leading to genome instability, has only modest effects on V(D)J recombination or lymphocyte deve

264 o not incorporate to full occupancy and have modest effects on virus replication and pathogenesis.

265 We show that CTD deletion has modest effects on yeast growth, but poly-SUMO conjugates

266 the guide+PAM region had measurable (albeit modest) effects on cleavage.

267 signal was largely due to multiple genes of modest effects (P = 4 x 10(-4), after removing known loc

268 n NSAIDs but not NSAID-like drugs, with more modest effects persisting after adjustment for potential

269 dnCNVs are found likely to contain multiple modest-effect risk genes.

270 To detect variants with modest effect size and discriminate among false positive

271 is not broadly generalisable, but must be of modest effect size and only observable in limited situat

272 Many different genetic variants of modest effect size are likely to contribute to the regul

273 (50%); however, multiple genetic variants of modest effect size are likely to contribute to this heri

274 ts is hampered by genetic heterogeneity, the modest effect size of many alleles, and the likely invol

275 oci from the GWA studies, that confer only a modest effect size, could harbour a significantly greate

276 o multiple genetic variants, each exerting a modest effect size.

277 es (GWAS) have identified common variants of modest-effect size at hundreds of loci for common autoim

278 ange (IQR) 21%-53%] and were associated with modest effect sizes [median odds ratio (OR) 1.33, IQR 1.

279 s scepticism arises from such aspects as the modest effect sizes of associated variants and their unc

280 Despite the modest effect sizes of current GPS, quantile analyses il

281 e show that type 2 diabetes risk variants of modest effect sizes reduce the age at diagnosis in HNF1A

282 Due to modest effect sizes, large sample sizes of tens to hundr

283 With reasonable power to detect even modest effect sizes, the absence of genome-wide signific

284 Many signals identified by GWAS have modest effect sizes, useful for identifying novel biolog

285 M disease susceptibility, although with more modest effect sizes.

286 large patient collections powered to detect modest effect sizes.

287 s and the mean squared error, especially for modest effect sizes.

288 nes affect BP in the general population with modest effects sizes (<0.05 standard deviation units), a

289 QTL exhibit modest effects that are mostly additive.

290 nce in LDL-C is due to multiple alleles with modest effects that are present at low frequencies in th

291 /b4 deletion) and a single common variant of modest effect (the gr/gr deletion) are largely responsib

292 tionally identify several previously unknown modest-effect trans-acting QTL (quantitative trait loci)

293 strongly enhanced (10- to 50-fold), while a modest effect (two- to threefold) is also observed for t

294 As LPS exerts modest effects upon IL10 mRNA stability, we hypothesized

295 of substituents to the phenyl ring has only modest effects upon the S...O bond strength.

296 had limited power to identify variants with modest effects, we carried out meta-analysis of three T2

297 Modest effects were observed in PDE4AKO mouse embryonic

298 More modest effects were observed in the other lobes, includi

299 treatments studied have produced minimal or modest effects, which are not sustained when the therapy

300 (2+) has no effect with 100 nm liposomes and modest effect with giant unilamellar vesicles.