ライフサイエンスコーパス: modification

1 nd TET-independent formation of this new RNA modification.

2 izing conditions they are highly amenable to modification.

3 at the core of this posttranscriptional RNA modification.

4 en as a possible mechanism for environmental modification.

5 ncreasing flavonoids content through genetic modification.

6 by chromatin modifiers to affect epigenetic modification.

7 1) and potential genes involved in chromatin modification.

8 by palmitoylation, a lipid posttranslational modification.

9 e protein targets of CRMs and their sites of modification.

10 (18)F-FDG PET/CT scans resulted in treatment modification.

11 s associated with human disease, "read" this modification.

12 rs (e.g., CLE peptides) and pectin/cell wall modification.

13 infectious foci, often leading to treatment modification.

14 e methyltransferases to generate double base modifications.

15 the abundance of histone post-translational modifications.

16 g and post transcriptional and translational modifications.

17 efined glycan library owing to unanticipated modifications.

18 RNA contains over 150 types of chemical modifications.

19 nd study design features and examined effect modifications.

20 environment and the influences of epigenetic modifications.

21 -related marks, and enhancer-related histone modifications.

22 ss GC bias, and the ability to read DNA base modifications.

23 We show that these modifications (1) differentially influence growth among

24 We showed that Dhb modifications accumulate in a long-lasting manner in Shi

25 fecting the viral RNA sequence and/or an RNA modification act on viruses lacking ExoN activity.IMPORT

26 introducing single-backbone H-bond impairing modifications (alpha)N-methyl Gln or l-Pro at key positi

27 The lack of the s(2) modification also slows down the rearrangements in the r

28 he selected zwitterions allows their in situ modification and affords a route to chemically trigger d

29 ngs reveal an important mechanism of histone modification and demonstrate that local generation of su

30 the acquisition of such differential histone modification and expression patterns at MAC-/OC-specific

31 opportunities for further synthetic biology modification and for a variety of biotechnological and b

32 Chromatin modification and higher-order chromosome structure play

33 lso reveals the putative virus region and PT modification and RE genes are present in 18-26%, 9-14% a

34 tion in applications such as targeted genome modification and site-directed mutagenesis.

35 Thus, dynamic SUMO modification and the presence of SIMs in RC components g

36 hat the SUMO (small ubiquitin-like modifier)-modification and ubiquitin-proteasome systems regulate t

37 iding new insights into the effects of these modifications and a dynamic view of RNA structure change

38 ion is complex, involving post-translational modifications and allosteric regulation with other prote

39 netic properties, which necessitate molecule modifications and complex delivery strategies.

40 Differences in chromatin modifications and epigenetic markers between subgenomes

41 itical regulator of MyD88 post-translational modifications and IL-1-driven inflammation.

42 hanges in Western societies, such as dietary modifications and increased antibiotic use.

43 nce of ASO backbone and hydrophobic 2' sugar modifications and revealed that the C-terminal region of

44 egy for interrogating the interactome of RNA modifications and reveals the biochemical mechanisms und

45 and significantly enriched for histone-tail modifications and transcription factor binding with part

46 gesting a cross-talk between these chromatin modifications and transcription through the BRWD protein

47 nvolving protein immobilization, sialic acid modification, and N-glycan release.

48 cochemical properties, chemical and physical modifications, and food and non-food uses of oat starch.

49 he relationship among ERK signaling, histone modifications, and transcription factor activity, focusi

50 llustrative examples of such postcyclization modifications are also presented.

51 FRET microscopy to protein interactions and modifications are discussed, and examples are given of t

52 ere in the life of a pre-mRNA transcript the modifications are made.

53 techniques to detect these posttranslational modifications are scarce.

54 amino acids and localized post-translational modifications, are identified using precursor mass and f

55 h sequencing (DMS-MaPseq), which encodes DMS modifications as mismatches using a thermostable group I

56 interactions, and 38 559 post-translational modifications, as manually annotated from 48 114 publica

57 to H2O2 treatment, nor did posttranslational modifications, as measured by two-dimensional (2-D) West

58 omains are transcriptionally active, contain modifications associated with euchromatic transcription,

59 ed, the availability of RNAs containing this modification at defined positions that can be used for i

60 g to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Luna

61 Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding

62 ibited more transcriptionally active histone modifications at M2 gene promoters than did macrophages

63 dentification of DNA methylation and histone modifications at specific genes.

64 tif DNA, and His24 and Arg26 were chosen for modification based on their potential ability to interac

65 cations of active enhancers based on histone modifications, but the accuracy and resolution of these

66 ls' adiposity; however, it was due to effect modification by baseline overweight status.

67 n term was used to estimate treatment effect modification by ECD.

68 As synaptic modifications by drugs of abuse are often tied to addict

69 from equilibrium, including high-temperature modifications by room-temperature synthesis.

70 gs indicate that ostensibly stable chromatin modifications can be dynamically regulated in quiescent

71 t that ASOs with specific backbone and sugar modifications can become localized to cytoplasmic ribonu

72 Post-transcriptional modifications can control protein abundance, but the ext

73 ulin isotypes and tubulin post-translational modifications-can generate microtubule diversity.

74 Epigenetics is the study of biochemical modifications carrying information independent of DNA se

75 tyrosines, some of which have more than one modification, cluster in the heme-binding site, supporti

76 cation of Diseases, Ninth Revision, Clinical Modification codes 299.0, 299.8, or 299.9 recorded in Ka

77 ication of Diseases, Ninth Revision-Clinical Modification codes to identify patients primarily admitt

78 Timing of this posttranslational modification coincides with the ATM-mediated DNA damage

79 tulated with purified protein in vitro, this modification completely ablated the activity of LLO, and

80 olves the interplay between covalent protein modifications, conformational fluctuations, catalysis, a

81 Of the practical immuno-PET tracer modifications considered, glycosylation was the most pro

82 des, can be reflow-soldered onto S4s without modifications, demonstrating the versatile and modular n

83 veal that mammalian RNAs can harbor a 5' end modification distinct from the classical m(7)G cap that

84 owing excision of Cdc73 placing this histone modification downstream of the PAFc and revealing a nove

85 lycine levels, suggesting sleep loss-induced modifications downstream of mGluR5 signaling.

86 pool functions in spine development and its modification during synaptic plasticity.

87 isplays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron defici

88 nucleosome with co-transcriptional chromatin modifications during transcription, which is affected by

89 activity by interacting proteins and subunit modifications, especially phosphorylation.

90 ory T cells are marked by activating histone modifications even in the resting state.

91 ecific members of CYP450 family in secondary modifications for the biosynthesis of bioactive triterpe

92 e, we experimentally eliminate environmental modifications from the developmental environment of Onth

93 mosome components shifts the balance of EGFR modifications from ubiquitination to neddylation, inhibi

94 Together, these modifications further stabilized the resulting SOSIP.v5.

95 nfidence interval, 46%-72%) in the Substrate-modification group (P=0.86).

96 28 PVI-only group patients and 24 Substrate-modification group patients, for 1-year freedom from tac

97 MeCP2 and with the active chromatin histone modification H3K4me2 in mouse neurons.

98 This modification has been shown to be involved in a wide ran

99 reported, and no biological role for such a modification has ever been proposed.

100 While multiple post-translational modifications have been reported to regulate the functio

101 ential impact of that small RNAs and histone modifications have in regulation of NAT expression, and

102 These modifications have significant functional consequences a

103 Third, Ser-3 modification (i.e. substitution with Asp or phosphorylat

104 Single amino acid modifications identified a novel peptide, DIIADDEPLT (Pe

105 tial and highly conserved post-translational modification in eukaryotes.

106 of this naturally occurring post-translation modification in neurodegenerative diseases as well as ot

107 ight the critical roles of METTL14 and m(6)A modification in normal and malignant hematopoiesis.

108 c adaptation to transgenerational epigenetic modification in response to acute periods of starvation.

109 ding how microglia respond to active synapse modification in the visual cortex.SIGNIFICANCE STATEMENT

110 lia because of limitations in detecting this modification in these organelles.

111 onsideration of nutritional and/or microbial modification in this population.

112 Any modification in TiOx properties resulting from the biofu

113 Here, we show how the s(2) modification in yeast tRNA(Lys) affects mRNA decoding an

114 (m6A) represents one of the most common RNA modifications in eukaryotes.

115 as on-off mechanosensing switches by sensing modifications in extracellular matrix (ECM) composition

116 s were used to measure the levels of histone modifications in human bronchial epithelial BEAS-2B cell

117 Rabies virus induces drastic behaviour modifications in infected hosts.

118 migration to different geographic locations, modifications in lifestyle choices, and shifts in social

119 rograms, but also induces lasting epigenetic modifications in many target tissues.

120 Modifications in mRNA constitute ancient mechanisms to r

121 gic role of N(6)-methyladenosine (m(6)A) RNA modifications in mRNA requires an understanding of when

122 little is known about the role of epigenetic modifications in pathological gene expression patterns i

123 ce introduces precise molecular and cellular modifications in PV+ cells that are required for learnin

124 ght into the role of Nt17 post-translational modifications in regulating the structure and aggregatio

125 nsing, and functions of adenosine to inosine modifications in retroviral life cycles.

126 t viral life cycles, the role of 2' O-methyl modifications in RNA stability and innate immune sensing

127 treatments that enhance experience-dependent modifications in spared areas.

128 have almost identical efficacies, but slight modifications in the dosing frequencies of the two drugs

129 mutations of CYP11B1 revealed that specific modifications in the heme-binding (R374W and R448C) or s

130 on our original series by presenting several modifications in the lead compounds 1 (HS665) and 2 (HS6

131 gnificant difference in the oil yield or any modifications in the legal parameters.

132 ative splicing and histone posttranslational modifications in the nucleus accumbens (NAc), a brain re

133 resent study, we associated ripening-induced modifications in the profile of carotenoids with fundame

134 All pathogenic viruses had modifications in the regulatory elements in their long t

135 Radiotracer design modifications included chelate, glycosylation, and radio

136 peptide removal, and some post-translational modifications including oxidation and acetylation were d

137 now identifies most sugar types and chemical modifications (including various glycolipids) in the PDB

138 144; 86%) underwent more than 1 postapproval modification, including more than 1 design modification

139 how peptidases accommodate posttranslational modifications, including glycosylation, has not been add

140 RNAs besides tRNA and rRNA contain chemical modifications, including the recently described 5' nicot

141 However, this modification increases its polarity by approximately 100

142 cs is critical for understanding of how this modification influences protein stability, localization,

143 particular significance as their structural modification inhibits activation by GABA.

144 n mitochondrial KMT that introduces a methyl modification into a metabolic enzyme and whose activity

145 o frameworks that coerce trophic interaction modifications into pairwise relationships.

146 DNA methylation is a key epigenetic modification involved in gene regulation whose contribut

147 dopsis and show that this post-translational modification is central to the rewiring of plants for ph

148 Mechanical flour modification is frequently associated with a reduced bre

149 dimethylated at arginine 175 (R175) and this modification is lost in a PRMT5 and WDR77-dependent mann

150 This protein modification is often added by ADP-ribosyltransferases,

151 study, we set out to determine whether this modification is required for the binding of NS5A to othe

152 The effect of this modification is to lock the hydroxymethyl side chain of

153 al contributions of these different chemical modifications is beginning to take shape, but it's clear

154 , the mechanism for the biosynthesis of most modifications is not fully understood, owing, in part, t

155 ese transcriptional and post-transcriptional modifications is sparse.

156 Global DNMT-dependent epigenetic modifications lead to changes in protein expression with

157 cterial quorum-sensing signals and that this modification leads to a phenotypic switch in the bacteri

158 icle oxidation, resistance against oxidative modification, main lipid and protein composition, and si

159 Combined, these results suggest that Fringe modifications "mark" different regions in the Notch1 ext

160 re, it is shown that this type of C-terminal modification may be combined with a second peripheral (4

161 Here we report a second lipid A modification mechanism that only functions in the V. cho

162 orylation is a widespread post-translational modification mechanism underlying cell physiology.

163 nscriptional regulation" encompasses the RNA modification-mediated regulation of genes.

164 rotein products using the two-step enzymatic modification method involving thermolysin and transgluta

165 Almost all the current genetic modification methods require regeneration from tissue cu

166 Therefore, lifestyle modification might have a positive effect in the treatme

167 SARM is a new type of multi-gene restriction-modification module, expanding the arsenal of defence sy

168 The conserved modification N(6)-methyladenosine (m(6)A) modulates mRNA

169 l modification, including more than 1 design modification (n = 84; 50%).

170 A novel DNA adenine modification, N(6)-methyladenine (6mA), has recently bee

171 that function in cell differentiation, tRNA modification, nuclease activity and protein dephosphoryl

172 porate the reported pathways used so far for modification of 2-D graphene sheets to make is three-dim

173 Our analysis demonstrated that modification of a single H7 epitope by changing 3 amino

174 d responsiveness to IL-20 that manifested as modification of actin polymerization and inhibition of a

175 g autophagosome formation through reversible modification of ATG8.

176 umoylation is a posttranslational reversible modification of cellular proteins through the conjugatio

177 Covalent, reversible, post-translational modification of cellular proteins with the small modifie

178 c lethal (MSL) complex to X-linked genes and modification of chromatin to increase expression.

179 c cleavage and posttranslational acetylation modification of CREBH are regulated by the circadian clo

180 Random oxidative modification of cryptic side chains exposed by mechanica

181 rotein-protein interactions through covalent modification of cysteine residues within the RGS domain

182 nner, via S-nitrosation (SNO), a redox-based modification of cysteine thiols.

183 dney Disease and Hypertension (AASK) and 761 Modification of Diet in Renal Disease (MDRD) Trial parti

184 lar filtration rate was calculated using the Modification of Diet in Renal Disease formula.

185 elieved to occur mainly through its covalent modification of DNA, resulting in the formation of BPDE-

186 el platform for nATC delivery using a slight modification of existing cancer drugs with significantly

187 The modification of graphene-based materials is an important

188 echanism, dependent on the posttranslational modification of GRP78, allows cells to differentially re

189 ur findings reveal a novel posttranslational modification of HBx by HDM2 which regulates its stabilit

190 in remodeling mediated by post-translational modification of histone is extensively studied in carcin

191 sequences, in addition to post-translational modification of histones, serves to modulate the chromat

192 x vivo expansion and pharmacological/genetic modification of human cardiac progenitor cells (hCPCs) a

193 Climatic modification of LSWT has numerous consequences for water

194 sive toolkit that enables targeted, specific modification of monocot and dicot genomes using a variet

195 mber, providing direct evidence that surface modification of nanoparticles with the cell-penetrating

196 ex multistranded architectures, and specific modification of natural antibodies has proven quite chal

197 -GlcNAcylation is a common posttranslational modification of nucleocytoplasmic proteins with beta-N-a

198 Alternatively, the single-atom, O-to-S modification of peptide backbone thioamidation has the p

199 further demonstrate that this postsynthetic modification of PG can be extended to use click chemistr

200 improving the production of biofuels is the modification of plant cell walls.

201 concerns have led to critical revisiting and modification of prior pain management practices (e.g., g

202 Post-translational modification of proteins with carbohydrates shapes their

203 hydratases involved in the posttranslational modification of ribosomal peptides, and transferases fro

204 rocess results in fragmentation and chemical modification of RNA, rendering it less suitable for anal

205 In the present study, we characterize the modification of shivering and whole-body thermal sensati

206 Here, we identify extensive genome-wide modification of sites bearing the active histone mark H3

207 Results also suggest that direct human modification of streams through actions such as water ab

208 nm, SN-38-encapsulated nanoparticles without modification of the chemical structure.

209 ids the inactivation of cellular enzymes and modification of the cytoskeleton.

210 t the need for added surfactants or chemical modification of the graphene.

211 Polysialic acid is a glycan modification of the neural cell adhesion molecule (NCAM)

212 The easy modification of the position of the pins allows designin

213 photoreceptor outer segment (OS) is a unique modification of the primary cilium, specialized for ligh

214 ion of TRPA1 nociceptors stimulates targeted modification of the receptor.

215 Using a novel modification of the reinstatement paradigm, we show that

216 Modification of the sensitive surface of a conventional

217 A modification of the task, with a temporal gap of 2 s add

218 rain to semiconductors allows for controlled modification of their band structure.

219 U18, the unusual C/D alone is enough for the modification of two nucleotides.

220 osal, they are created by simple geometrical modifications of an existing and experimentally proven p

221 um, nor the effects of any posttranslational modifications of FOXP2 in the brain and disorders have b

222 than 100 residue-specific posttranslational modifications of histones forming the nucleosome core th

223 Post-translational modifications of histones have been shown to regulate ce

224 al property of the brain, causing persistent modifications of neuronal communication thought to provi

225 ling with biological assays to ascertain how modifications of phosphonocarboxylates, the first report

226 Posttranscriptional modifications of RNA bases are not only found in many no

227 is primarily mediated by activity-dependent modifications of synaptic strength within neuronal circu

228 The effects of modifications of the 2-(pyridin-2-yl)benzo[d]thiazole li

229 by screening natural Bt isolates or through modifications of the Cry proteins.

230 In addition, further modifications of the cyclization products enabled stereo

231 Substituent modifications of the quinone core allow absorption from

232 s been developed using late-stage structural modifications of the tert-leucinol-derived chiral subuni

233 arge and susceptibility to posttranslational modifications of these lysines contributed to gB/gH-gL c

234 ein S-acylation, a common post-translational modification on proteins frequently affecting their memb

235 ns are particularly challenging, as multiple modifications on a single ubiquitin preclude the use of

236 native conditions to study the influence of modifications on the interaction of recombinant mAbs wit

237 s are marked by conserved post-translational modifications on the RNA pol II C-terminal domain (CTD)

238 ighlights the influence of posttranslational modifications on viral protein function and provides add

239 ability to install protective postsynthetic modifications onto its bacterial peptidoglycan (PG), the

240 g GPCR signaling suffer from low throughput, modification or overexpression of effector proteins, and

241 tains CPS antigens from 13 serotypes undergo modifications or degradation during isolation and conjug

242 After the 2013 modification, over 20% of all deceased organ donors in t

243 lower heart failure incidence than lifestyle modification patients (hazard ratio, 0.54; 95% confidenc

244 Epigenetic modifications play critical roles in diverse biological

245 methylation triggers changes in the histone modification profile and chromatin-remodeling events lea

246 The combination of CHC coating and genetic modification provided the greatest compatibility with hu

247 Messenger RNA (mRNA) modification provides an additional layer of gene regula

248 tly emerged as a dominant post-translational modification (PTM) in Alzheimer's disease (AD) and relat

249 aneous quantification and post-translational modification (PTM) profiling of targeted protein in biof

250 lei using histone type- or posttranslational modification- (PTM-) specific antibodies and automated,

251 an be modified by multiple posttranslational modifications (PTMs), creating a PTM code that controls

252 ighlights the latest findings on how protein modifications regulate SC dynamics and functions.

253 Small ubiquitin-like modifier (SUMO) modification regulates numerous cellular processes.

254 y cost-effective genome-wide analyses of DNA modifications rely on restriction enzymes capable of dig

255 t in both coding and noncoding RNAs, dynamic modifications represent a new layer of control of geneti

256 We first optimized the size, surface modification [rifampicin (RF) conjugation], and concentr

257 ysis showed greater phosphoproteomic profile modification(s) in response to combined MEK/mTOR inhibit

258 lly assess the degree to which environmental modifications shape developmental and fitness outcomes,

259 Intensive risk factor modification significantly improves outcomes for patient

260 Sequential glycan KO modifications significantly reduce antibody binding of w

261 Thus, chromatin histone modification state is a major determinant of nuclear ble

262 fic nucleosome substrates according to their modification state.

263 These experiments demonstrate that the SEFL modifications successfully eliminated Fc-associated effe

264 Chromatin modifications, such as cytosine methylation of DNA, play

265 ts is emerging as a very influential protein modification system.

266 nstrating that ubiquitylation is a versatile modification that can be used to fine-tune these cell cy

267 enosine (m(6)A) is an essential internal RNA modification that is critical for gene expression contro

268 ucosamine (O-GlcNAc) is an important protein modification that is hydrolyzed by O-GlcNAcase (OGA).

269 ar ubiquitination is a key posttranslational modification that regulates immune signaling and cell de

270 biquitination, the crucial posttranslational modification that regulates the eukaryotic proteome, is

271 uantification of intracellular mitochondrial modifications that alter cytoplasmic conductivity, and t

272 partial recapitulation of bivalent chromatin modifications that are lost along with pluripotency, sug

273 ymes introduce additional post-translational modifications that are unique to each lanthipeptide and

274 We present a method for identifying genomic modifications that optimize a complex phenotype through

275 g of large macrocyclic peptides with diverse modifications thereby expanding the accessible chemical

276 assing a wide variety of photocatalysts, and modifications thereof, as well as the related vital proc

277 tweight implementation, but requires surface modification to achieve detection with high sensitivity

278 vate SMN2 can be combined with SMN2 splicing modification to ameliorate SMA and demonstrates the prom

279 This study provides a simple modification to improve microbial models for inclusion i

280 These findings link the O-GlcNAc modification to mammalian neurogenesis and highlight the

281 s study, we explored the effects of chemical modifications to a natural product macrocycle upon its a

282 bination with rigidifying post-translational modifications to achieve high-potency binding.

283 We describe modifications to an Orbitrap mass spectrometer, enabling

284 Targeted modifications to CP2 based on crystallographic and mass

285 iologically relevant, but poorly understood, modifications to cytosine affect the local conformationa

286 a novel candidate mechanism linking histone modifications to hESC fate decision.

287 April 2014) we implemented several technical modifications to reduce environmental contamination by a

288 of enhancer RNAs, circular RNAs and chemical modifications to RNA in cellular processes.

289 ase (AMPK) plays a critical role in blocking modifications to the chromatin landscape.

290 ZIC2 shifted the balance of bivalent histone modifications toward more active forms and induced KSHV

291 These modifications tuned the homopolymerization rate constant

292 us, which is a target for post-translational modifications, typically is ignored.

293 ine 396 phosphorylation, and this particular modification was shown to be vital for axonal growth and

294 oteins and ALKBH5, known interactors of this modification, we find that FMR1 and LRPPRC, two proteins

295 al enhancer-associated proteins, and histone modifications, we determine that both enhancer classes a

296 The threshold, type, and extent of the modifications were completely controlled by solvent comp

297 tion enrichment, enhancer-associated histone modifications were evident, and known functional motifs

298 residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific pro

299 This occurrence of slow structural modification with changes in trap state occupancy is lik

300 The postsynthetic modification would not only produce the desired function