ライフサイエンスコーパス: modifying factor

1 kn]1b/p27, Cdkn1c/p57, and B-cell lymphoma 2-modifying factor).

2 Rainfall is an important modifying factor.

3 iable phenotypes suggesting the influence of modifying factors.

4 transcriptional co-regulators, and chromatin-modifying factors.

5 nts previously considered causal may only be modifying factors.

6 onset of disease, suggesting the presence of modifying factors.

7 known Polycomb proteins and other chromatin-modifying factors.

8 relation to major potential confounding and modifying factors.

9 , which could provide a strategy to discover modifying factors.

10 ests the existence of at least two non-ABCA4 modifying factors.

11 ion by P-TEFb involves chromatin binding and modifying factors.

12 at mutation, but is also influenced by other modifying factors.

13 ms of epithelial carcinogenesis and evaluate modifying factors.

14 propriate set of mRNA-processing and histone-modifying factors.

15 as a platform for the assembly of chromatin-modifying factors.

16 to investigate phenotypic heterogeneity and modifying factors.

17 repeat length, however, suggests a role for modifying factors.

18 quential action of DNA-binding and chromatin-modifying factors.

19 ibutions from other genetic or environmental modifying factors.

20 , these variables were examined as potential modifying factors.

21 remainder of the vWF protein and additional modifying factors.

22 isorder caused by mutations in the sulfatase modifying factor 1 (SUMF1) gene.

23 t are activated by another enzyme, Sulfatase-Modifying Factor 1 (SUMF1), whose inactivation in humans

24 tide polymorphism within the gene sulphatase modifying factor 1.

25 acterize this diversity and examine possible modifying factors amongst a large number of individuals

26 ident that for many common chronic diseases, modifying factors amplify disease mechanisms to make the

27 ignificantly mutated genes include chromatin-modifying factors and candidate contributors SPG20, TLR4

28 plexes with chromatin remodeling and histone-modifying factors and cofactors, including the TIP60 his

29 ncreasing expression of extracellular matrix-modifying factors and lysyl oxidase genes and by facilit

30 o reveal new relationships between chromatin-modifying factors and to create a functional map of the

31 cluded components of methanogenesis, protein-modifying factors, and leucyl-tRNA synthetase (LeuRS).

32 the phenotype classification, the search for modifying factors, and the development and evaluation of

33 weight (EBW) and related diseases and their modifying factors are an unmet research need that may le

34 cycle in a general population, and potential modifying factors are not investigated.

35 One possible reason is that disease-modifying factors are tissue-specific.

36 des both general transcription and chromatin-modifying factors, as well as FRI-specific components su

37 dismutase (MCF+SOD cells) demonstrated dose-modifying factors at 10% isosurvival of 1.8 and 2.3, res

38 in formation involves spreading of chromatin-modifying factors away from initiation points over large

39 Bcl2-modifying factor (Bmf) is a member of the BH3-only group

40 Bcl-2-modifying factor (Bmf) was differentially upregulated (P

41 Modifying factors, both genetic and environmental, must

42 The bromodomain-containing chromatin-modifying factor BRD4 is an inherited susceptibility gen

43 echanism by which three classes of chromatin-modifying factors-Brg1, HDAC and PARP-cooperate to contr

44 occur via directed recruitment of chromatin modifying factors by the master regulator, X-inactive sp

45 en postulated that the loss of an additional modifying factor contributes to the severity of type I S

46 d increased clonogenic radioresistance [dose-modifying factor (DMF), 1.47], reduced apoptotic respons

47 ledge of the role of chromatin and chromatin-modifying factors during DDR in plants with equivalent s

48 In addition, age should be a modifying factor, especially in moderate kidney impairme

49 cluding risk determinants for nonsmokers and modifying factors for smokers.

50 ll remains to identify causative and disease modifying factors for this devastating disease.

51 nce, and the existence of additional genetic modifying factors has been suggested in these diseases.

52 ndividuals, and genomic and/or environmental modifying factors have been evoked to explain these obse

53 se data suggest that BBB disruption may be a modifying factor in the development of schizophrenia and

54 This "grace period" may serve as a modifying factor in the epidemiology of this newly emerg

55 se type 2N mutation (R91Q) was excluded as a modifying factor in these groups of patients.

56 in thiamin homeostasis and could serve as a modifying factor in thiamin nutritional deficiency as we

57 isorders implies the existence of additional modifying factors in pathways that can potentially be mo

58 pending on the cellular environment or other modifying factors in the cell.

59 parallel functions for these three chromatin-modifying factors in the regulation of TATA-containing g

60 the pathogenic pathways and identify new or modifying factors involved in muscular dystrophy, expres

61 ilial clustering of phenotypes suggests that modifying factors may influence the clinical manifestati

62 It seems most likely that a small number of modifying factors may radically affect the course of dis

63 Although ER stress can be a cause or a modifying factor of human disease, little is known of th

64 tor-transfected cells, corresponding to dose-modifying factors of approximately 2.0 and 1.5 in the mi

65 Future studies will explore the effects of modifying factors on the development of HCC.

66 y concordant effects of the KL-VS allele and modifying factors on the risk of occult CAD were seen in

67 ideal system to monitor the role of disease-modifying factors over a long time.

68 Beyond its role as a chromatin-modifying factor, p300 displays an acetyltransferase-ind

69 luding thrombospondin 1, delta-like 4, BclII modifying factor, phospholipase C, beta 2, adrenergic re

70 Growing evidence for genetic risk and modifying factors, plus strong evidence that only a mino

71 re an excellent model for delineation of the modifying factors postulated to affect human OI phenotyp

72 regions, presumably as a result of chromatin modifying factors recruited to the PBRU.

73 Chromatin-modifying factors regulate both transcription and DNA re

74 uses on how chromatin-remodeling and histone-modifying factors regulate gene expression to control ca

75 pression, but our knowledge of the chromatin-modifying factors regulating these events remains incomp

76 t there are many additional risk alleles and modifying factors remaining to be discovered.

77 remodeling, we propose that these chromatin-modifying factors represent auspicious targets for the p

78 These data identify BRG1 as a chromatin-modifying factor required for nucleosome remodeling and

79 o our knowledge, Brg1 is the first chromatin-modifying factor shown to be required for beta-globin re

80 Modifying factors such as fluoride and dental hygiene wo

81 te cancer and the effects of confounding and modifying factors, such as age, family history of prosta

82 ered susceptibility of the mutant protein to modifying factors, such as androgen production at pubert

83 The impact of modifying factors, such as chronic disease and material

84 Chromatin-modifying factors that control TPE in yeast have been ex

85 ordinated development, however, must involve modifying factors that enable differentiation and growth

86 scribed, triggering recruitment of chromatin modifying factors that establish and maintain gene silen

87 tions, HP1 proteins associate with chromatin-modifying factors that in turn cooperate to assemble rep

88 amilies regulate transcription via chromatin-modifying factors, the precise mechanisms underlying gen

89 of transcriptional modulators and epigenome-modifying factors to any genomic site, leading to new in

90 We sought to identify potential response-modifying factors to determine whether specific groups o

91 control, the relative contribution of these modifying factors to the impairments observed in T2DM re

92 oordinates recruitment of RNA- and chromatin-modifying factors to transcription complexes.

93 We show here that the chromatin-modifying factor TRIM28 is highly expressed in double-po

94 the mitochondrial transfer ribonucleic acid modifying factor (TRMU) in a single patient only, presen

95 a on disease manifestation, progression, and modifying factors, with relevance for counseling of HSP