ライフサイエンスコーパス: modular

1 t least one of the cross-linked FFLs remains modular.

2 nct, densely connected subsystems are called modular.

3 rosstalk interaction) and remain dynamically modular.

4 We employ a modular 2-D strategy wherein the central module, common

5 neral intelligence in nonhumans implies that modular abilities can arise in two ways, primarily throu

6 e describe a new methodology for a rapid and modular access to this privileged scaffold.

7 scalable and easily deployed for a range of modular alternating-current-powered electroluminescent l

8 Immune deconvolution, flow cytometry, and modular analysis suggested a central role for neutrophil

9 A modular and bench-stable diazaphospholane ligand enables

10 These approaches are becoming modular and broadly applicable, and show a strong potent

11 ple of a covalent CB-DNA conjugate-is highly modular and can be adapted to enable responsiveness to o

12 aRNApipe is highly modular and can be easily migrated to any high-performan

13 mpositions, surface charges, dipole moments, modular and combined functionalities, which enable excel

14 The system is modular and easily expandable, allows the extraction of

15 We present ConKit , an open source, modular and extensible Python interface which allows fac

16 The tools are extensible, modular and flexible, so that they are tunable to partic

17 Intramolecular SF materials are modular and have the potential to overcome certain desig

18 r developing machine-learning algorithms for modular and hierarchical networks such as biological sys

19 ging, however, since biological pathways are modular and may exhibit co-expression only in specific c

20 Because this approach is inherently modular and places minimal requirements on the structura

21 We report a modular and streamlined synthetic strategy to access a l

22 rs allow riboswitches to be treated as truly modular and tunable components, thus increasing their re

23 Here we report a modular and versatile framework enabling rapid implement

24 Herein, we detail a simple, modular, and robust approach that combines various amine

25 of light-harvesting complexes, mimicking the modular antenna/transducer architecture of natural photo

26 This modular approach also enables us to unravel static and p

27 ally available starting materials, enables a modular approach for the synthesis of imidazoles.

28 We demonstrate that this modular approach is applicable to various protein/peptid

29 Our results illustrate that this modular approach is promising for repositioning drugs fo

30 ed protein/peptide-polymer therapeutics by a modular approach that consists of three steps: 1) fusion

31 The building block modular approach that lies behind coordination polymers

32 rs of moderate chain length were formed in a modular approach that tolerated the inclusion of functio

33 Here we demonstrate a new high-yielding modular approach to a broad range of trimeric and hexame

34 We describe a novel modular approach to procedural training that considers e

35 amer-based (E-AB) sensor platform provides a modular approach to the continuous, real-time measuremen

36 In a modular approach, using cross-coupling reactions, we syn

37 unctionalities and applications by bottom-up modular approach.

38 uggest that AMPAR auxiliary subunits share a modular architecture and use a common transmembrane scaf

39 Their modular architecture enables recognition of numerous sub

40 Here we develop a novel modular architecture for multi-dimensional tasks in whic

41 Recent studies have revealed an underlying modular architecture in which nociceptive, pruritic, and

42 Our data infer a modular architecture of four tertiary domains: 1) C2A, w

43 Antibodies have a well-established modular architecture wherein the antigen-binding site re

44 nnectivity dynamics, subnetwork patterns and modular architecture while subjects watched identical vi

45 ght elucidate how brain diseases change this modular architecture within brain areas.

46 wledge engineering methods within a flexible modular architecture, and was evaluated using a manually

47 sk complexity did not change the established modular architecture, but affected selective patterns of

48 that use high-dimensional quantum codes in a modular architecture, have potential benefits, but need

49 there is a hierarchical organisation of the modular architecture.

50 in addition to a more general, task-induced modular architecture.

51 standing the emergence of robustness in such modular architectures from the interconnections of its p

52 rates multiple cellobiohydrolases with multi-modular architectures that overall enhance the catalytic

53 However, the components, modular assembly mechanism and functional role of fungal

54 This convergent and modular assembly of intact cyclotryptamines offers the f

55 tionalizations of complex molecules; a rapid modular assembly of MC2050, a potent PARP-1 inhibitor; a

56 We demonstrated the utility of this modular assembly technology by making numerous modificat

57 ks from primary metabolism and a strategy of modular assembly to build a great diversity of signaling

58 phosphatase, Shp2-iSNAP, is designed through modular assembly.

59 Many species that possess whiskers lack the modular "barrel" organization found in the primary somat

60 these mutations provide further support for modular behavior of RNA elements and suggest that tertia

61 In this study, we show that modular binding sites that do not function cooperatively

62 ments CRISPR itself, matching a powerful and modular biological system with a flexible online web too

63 peptide protectase in combination with other modular biosynthetic enzymes, we describe the total synt

64 Modular boundaries continue to become increasingly disti

65 or by a building block approach (also called modular build-up approach), introducing fluorine-18 in a

66 We demonstrate three modular building blocks for a DNA robot that performs ca

67 loidal capsules, by which the integration of modular building blocks with distinct physical, chemical

68 Overall, our findings are consistent with modular but complex energetic properties of RNA structur

69 The matricellular protein SMOC (Secreted Modular Calcium binding protein) is conserved phylogenet

70 Modular cellulases contain non-catalytic type A carbohyd

71 rid and complex types) that were prepared by modular chemo-enzymatic methods to detect the presence o

72 P. yoelii linear peptide chimera/recombinant modular chimera), engineered to express several autologo

73 n be used in synthetic biology to facilitate modular circuit design.

74 SPR)/Cas9 system, are systematized for fast, modular cloning and accommodate diverse regulatory seque

75 the coexistence of general intelligence and modular cognitive adaptations, and why we believe that t

76 emonstrates the feasibility and potential of modular, combinatorial approaches to engineering and ana

77 TL networks are organized into dense, highly modular communities grouping genes often involved in coh

78 es an ingenious interplay of the interacting modular components.

79 e potential as they cannot yet be treated as modular components.

80 It is structurally and functionally modular, comprised of a C-terminal regulatory domain (CT

81 ISAMBARD is open-source, modular, computationally scalable and intuitive to use.

82 The OCP is structurally and functionally modular, consisting of a sensor domain, an effector doma

83 We find that the avian cranium is highly modular, consisting of seven independently evolving anat

84 ing blocks for application-driven design and modular construction of foldable structures with desired

85 in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines

86 erein, we describe the assembly and use of a modular continuous flow apparatus from readily available

87 A rapid and modular continuous flow synthesis of highly functionaliz

88 inciples exist that permit both rational and modular control of foldamer secondary structure, while m

89 e adapt liposome encapsulation to enable the modular, controlled compartmentalization of genetic circ

90 Synells thus enable a more modular creation of synthetic biology cascades, an essen

91 tal-organic frameworks (MOFs) are a class of modular, crystalline, and porous materials that hold pro

92 A modular Cu/ABNO catalyst system has been identified that

93 Such cycles have now been complemented by modular cycles that measure energetic coupling between s

94 oil (CC) dimers serve as building blocks for modular de novo design of polyhedral protein cages that

95 rld structures undergo a critical shift from modular (decentralised) to centralised ones.

96 ful in quantifying the inherent ambiguity of modular decomposition.

97 d networks designed to maximise ambiguity of modular decomposition.

98 Finally, ProteoModlR's modular design and interchangeable format are optimally

99 Here we adopted a modular design approach that uses colloidal nanoparticle

100 INDOS employs a modular design consisting of the fusion of two proteins:

101 The results validate the modular design of human Kv channels and highlight the PM

102 Due to the modular design of NHCs and the ease of access to their a

103 vation in cancer, therefore we leveraged the modular design of our fusion gene construction methodolo

104 The modular design of Syn-TEF1 defines a general framework f

105 The modular design of the gemini monomers used to create pol

106 ms from the direct correlation between their modular design principle and various interesting propert

107 e defined assembly of all components using a modular design results in an artificial biohybrid electr

108 rm of plasmid copy number oscillations via a modular design that can be readily adapted for use with

109 The NP sensing platform offer a modular design that can incorporate different sensing co

110 Due to its modular design, minute-scale temporal resolution, and mi

111 Through modular design, we can generate active tensegrities that

112 Moss gametophores have modular development and each module develops from a sing

113 roduce and implement a novel technique named Modular Dirichlet Energy (MDE) which allows robust and f

114 It is based on the use of modular disaccharides to assemble several selectively pr

115 bon-carbon bond forming cycles that enable a modular disconnection of a target structure into cellula

116 rotein-DNA specificity, outside of extremely modular DNA binding proteins such as TAL effectors, has

117 ular shapes with varied dimensions using the modular DNA brick method for the systemic delivery of si

118 an artificial molecular array assembled from modular DNA structural units.

119 ny RNA granule proteins are composed of both modular domains and intrinsically disordered regions (ID

120 nation, demonstrating that such elements are modular domains controlling Rho.

121 ories of the mind are either domain-specific/modular (DSM) or domain-general (DG); (2) DSM systems ar

122 Furthermore, the modular DVD platform was used to prepare potent and spec

123 e the pattern of brain activations to form a modular environment that is robust.

124 ox) ubiquitin ligases comprise several dozen modular enzymes that have diverse roles in biological re

125 Such wall hydrolases are modular enzymes, composed of discrete domains for high-a

126 ing conformational changes with catalysis in modular enzymes, like the PMT, provides new insights on

127 ), and customized control software, enabling modular experimentation packages and automated data pre-

128 hemical markers that reveal an emerging LCIC modular-extramodular microarchitecture.

129 outcomes suggest that use of an independent modular filter may be associated with a lower rate of em

130 The data suggest that independent modular filter use in carotid artery stenting in high su

131 spectral hybrid nanotransistor consisting of modular fluorescent block copolymers with discrete and s

132 We report the modular formulation of ciprofloxacin-based pure theranos

133 neuronal populations provides evidence for a modular functional organisation of the LC.

134 an be conceptualized as the rearrangement of modular functional units occurring on several different

135 array performs CTC mutation profiling using modular gene panels.

136 rom this study can inform rational design of modular heteromultivalent nanoparticles for enhanced spe

137 f an efficient and rapid approach based on a modular hybrid minigene combined with antisense oligonuc

138 sent a generalized strategy for constructing modular hybridization probes (M-Probes) that overcomes t

139 erved to possible connections) and were more modular, i.e. they had more connections between nodes wi

140 everal genes have been assembled together by modular idempotent cloning, it is unclear if such simpli

141 x active colloids (RACs) that are inherently modular in their design and overcome challenges faced by

142 Here we use a refactored, modular in vivo system containing the micrococcin P1 (MP

143 This cluster showed a modular induction during early growth on HMO and fucosyl

144 OpenSimRoot has a plugin, modular infrastructure, coupling single plant and crop s

145 rk controlling the pupal ecdysis sequence: a modular input layer, an intermediate central pattern gen

146 hod obtained molecular complexity up to four modular inputs and divergence of two different skeletons

147 thways often involve proteins with multiple, modular interaction domains.

148 The client includes a modular Java backend with a novel streaming.mzML parser

149 We present JS-MS, a 3-D, modular JavaScript client application for viewing MS dat

150 We report a modular LC organization in rats, endowed with distinct n

151 aging and behavioral-health data sets; and a modular level, testing associations between subsets of t

152 pathic helical layering and bundling to form modular lipid-binding compartments and discuss the funct

153 l, we provide instructions on how to build a modular low-light microscope (1-4 d) by coupling two mic

154 e perspective that RNA tertiary structure is modular, made of locally stable domains that retain thei

155 cially, POMzites differ from zeolites in the modular manner of their preparation.

156 d into the repetitive genomic sequences in a modular manner using robotic automation.

157 t NADPH-d, the most consistent developmental modular marker, and CR label separate, nonoverlapping LC

158 Alignment of modular markers in serial sections suggests each highlig

159 In fact, recent studies have shown that, "modular markers," that integrate multiple genes with pot

160 haracterized by heterologous expression in a modular metabolic engineering system in Escherichia coli

161 Here, a modular metabolic engineering system is used in a combin

162 scent core-shell MIP sensor particles into a modular microfluidic platform that allows for an in-line

163 rategies to tune their thermal half-lives by modular molecular design as well as the lack of proper s

164 oxes together reveal the particle's nonlocal modular momentum spatially separated from its mass.

165 The modular motif affords efficient syntheses using building

166 a acquisition platform to acquire VWD, and a modular, multi-algorithm analytic platform (ventMAP) to

167 an attractive building block for assembling modular nanostructures.

168 Given the modular nature and broad substrate scope of imine format

169 Owing to the modular nature and mild conditions of MOF synthesis, the

170 Taken together, the low cost and modular nature as well as fully open design of FlyPi mak

171 nd multispecific scaffolds by exploiting the modular nature of a repeat protein scaffold and avoiding

172 dium-sized networks due to the intrinsically modular nature of cluster states, and paves the way to s

173 difications, demonstrating the versatile and modular nature of S4s.

174 ity for this docking domain, emphasizing the modular nature of the components of PKS-NRPS hybrid syst

175 The modular nature of their layered structures offers opport

176 The modular nature of this synthesis affords flexibility and

177 rst postnatal week, yielding an identifiable modular network prior to hearing onset.

178 r GAD-67 and other markers revealed a single modular network throughout the rostrocaudal extent of th

179 a multimodal mosaic, consisting of a patchy modular network with surrounding extramodular domains.

180 mages generated by three distinct walks on a modular network.

181 seed dispersal by animals, than in small and modular networks formed by intimate mutualisms, such as

182 This method efficiently couples modular on-column immobilized metal ion affinity purific

183 Here, we present a low-cost and modular open-source alternative called 'FlyPi'.

184 These results demonstrate a modular organization in LC in which combinatorial activa

185 Although modular organization is thought to reduce this cost in a

186 ith global networking features may determine modular organization of allosteric interactions and dict

187 ve widespread distal effects, disrupting the modular organization of cortical functional networks.

188 ly disperse, with some degree of non-random, modular organization.

189 cial networks is driven by two mechanisms of modular organization: network fragmentation and subgroup

190 We describe a modular, palladium catalyzed synthesis of aryl(hetero)ar

191 f the metabolic and regulatory networks in a modular, parallel, and high-throughput manner.

192 By modular peptide design, we demonstrate that mammalian ce

193 characterization of a regularized and truly modular peptide-specific binding protein, based on desig

194 ected evolution method based on a robust and modular phenotype-genotype linkage.

195 ein (OCP) is a structurally and functionally modular photoactive protein involved in cyanobacterial p

196 xamples of apparent non-colinearity in other modular PKS systems.

197 This modular platform also enables PD-1-targeted delivery of

198 ab-paclitaxel binding antibodies, creating a modular platform for antibody directed chemotherapeutic

199 s toolkit of CRISPR-coupled GPCRs provides a modular platform for rewiring diverse ligand sensing to

200 NCTs therefore present a modular platform that enables the construction of compos

201 The modular "plug and play" configuration of the platform al

202 ar redefinition: A long-standing paradigm in modular polyketide synthase enzymology, namely the defin

203 eful polyketide natural products produced on modular polyketide synthase multienzymes by an assembly-

204 p to 2017, should thus be informative to the modular polyketide synthase novice and expert alike.

205 Modular polyketide synthases (PKSs) and nonribosomal pep

206 plausible mechanism of natural evolution for modular polyketide synthases.

207 can be used to engineer new self-assembling modular polymers that will open new avenues for applicat

208 idirectional transmission of signals, embody modular processes that conserve their input/output behav

209 auditory cortical processing have suggested modular processing, with different brain regions prefere

210 The angiosperm flower develops through a modular programme which, although ancient and conserved,

211 eceptor-related protein 1 (LRP1) is a highly modular protein and the largest known mammalian endocyti

212 ) is caused by loss of function of sacsin, a modular protein that is required for normal mitochondria

213 Toward elucidating the response of this modular protein to mechanical stress, we studied its for

214 P), which is a structurally and functionally modular protein.

215 nding domains (dsRBDs) are commonly found in modular proteins that interact with RNA.

216 Here we introduce a simple, modular protocol for deriving the four main ectodermal l

217 We report a divergent and modular protocol for the preparation of acyclic molecula

218 The modular quorum sensing-dependent architecture for interf

219 The modular reactivity of these intermediates is exemplified

220 which are exquisitely controlled by a set of modular, reconfigurable DNA nanocages.

221 Modular redefinition: A long-standing paradigm in modula

222 subdivided into multiple processing streams: modular regions, which are targeted by somatosensory inp

223 Enhancers are modular regulatory elements that are central to the spat

224 x2.2 functions as an integral component of a modular regulatory program to correctly specify pancreat

225 The P2Ns exhibited modular release in vivo, as a function of surface GA den

226 nts in the JavaScript ecosystem to provide a modular, reliable and easily embedded library.

227 A newly-developed modular reporter system proved possible to demonstrate t

228 measurements; (2) that by leveraging sparse, modular representations of gene expression, we can use r

229 We developed a modular RNA aptamer-streptavidin strategy, termed S1mple

230 de synthesis (SPPS), giving an efficient and modular route to thiopeptide variants.

231 port that the Hsp70 co-chaperone, BAG3, is a modular, scaffolding factor to bring together sHsps and

232 cellulosome assembly and a variety of multi-modular scaffoldins were identified, and the dockerins w

233 Here we report a modular, scalable synthesis of group A streptogramin ant

234 This modular screening strategy is applicable to other develo

235 idual network motifs, some resist and remain modular, seemingly insulated from extrinsic perturbation

236 Critically, both modular segregation and network efficiency are associate

237 Here, we describe a modular, self-aligned, amplitude-division electron inter

238 Cross-presentation is a modular series of intracellular events dictating the int

239 SIMToolbox is an open-source, modular set of functions for MATLAB equipped with a user

240 we have developed a method of manufacturing modular skeletal muscle actuators that can generate up t

241 Here, we demonstrate a modular small molecule screen in embryonic zebrafish tha

242 hat the lowering of disease burden in highly modular social networks is driven by two mechanisms of m

243 GB-eaSy is built from existing open-source, modular software packages that are regularly updated and

244 Therefore, a modular strategy based on the connectivity of tpy-Ru(2+)

245 Our modular strategy enables the union of complex polycyclic

246 have distinct folding properties serves as a modular strategy for controlling structural complexity i

247 ly ordered materials can be constructed by a modular strategy in which properly designed molecular co

248 escribe proof-of-principle experiments for a modular strategy to produce discrete oligomers by a visi

249 y, we show that network models incorporating modular structure are necessary only when prior knowledg

250 study of the epidemiological consequences of modular structure in animal societies.

251 the cerebral cortex as well as maintain the modular structure of cortical functional networks.SIGNIF

252 Based on the highly modular structure of P-OP ligands employed, catalyst scr

253 the Intensification approach, which uses the modular structure of repeat protein domains to amplify s

254 The modular structure of the proposed methods, that consists

255 Key for these results is the modular structure of these new ligands, and the enhanced

256 Nab2 has a modular structure that includes seven CCCH Zn fingers th

257 ction assays that suggest Scc2-Scc4 uses its modular structure to make multiple contacts with cohesin

258 ur work does not support the hypothesis that modular structure universally mitigates the disease impa

259 d that disease risk is largely unaffected by modular structure, although social networks beyond a mod

260 Efficient complex systems have a modular structure, but modularity does not guarantee rob

261 egions when network is highly clustered with modular structures as in the normal brain networks.

262 n-based modularity algorithms yield variable modular structures.

263 These structured RNA elements consist of two modular subunits: an aptamer domain that binds with high

264 This study shows that modular synergism between miRNAs and neuronal subtype-sp

265 We report the first modular synthesis of a library of 20 halogenated phenazi

266 A (2+2+2) modular synthesis of multisubstituted quinazolines has b

267 Here we disclose a modular synthesis of pleuromutilins by the convergent un

268 Finally, a modular synthesis of the Staphylococcus aureus type 5 ca

269 The enamine exchange allows for a rapid and modular synthesis of various amides, including challengi

270 Their iterative modular synthesis provides efficient access to sequence

271 A modular synthetic approach was used to explore the chemi

272 Subtle sequence variation in the modular synthetic ligand dictates assembly morphology.

273 We have developed a modular synthetic route to combretastatin analogs based

274 Here, we report a modular system based on programmable transcription activ

275 This modular system features fused azaacene units to a corone

276 he elemental paradigm of an efficient robust modular system interconnected as a network of networks (

277 A and purification of monovalent MPNs, (iii) modular targeting of MPNs to cell-surface receptors, and

278 ally, the WGS performance specifications and modular template are adaptable for the validation of oth

279 of microorganisms, and (v) the creation of a modular template for the validation of WGS processes in

280 ant barcodes, invariant linker sequences and modular template-specific primers to allow for the simul

281 al trajectories, implying the existence of a modular temporal program controlled by neuromodulators.

282 oid mycorrhizal fungal communities were more modular than ectomycorrhizal and root endophytic communi

283 models: CSC-TD, MS-TD, Learning to Time and Modular Theory.

284 structure, although social networks beyond a modular threshold experience smaller disease burden and

285 report on a bottom-up approach to assemble a modular tissue consisting of multiple layers with distin

286 To address this problem, we demonstrate that modular tissue engineering results in an s.c. vasculariz

287 Evolving modular topology facilitates global network efficiency a

288 For the first time, we uncovered modular topology in CAE patients that was similar to hea

289 Detailed analysis of the modular Type I polyketide synthase (PKS) involved in the

290 However, manipulation of modular type I polyketide synthases (PKSs) to make unnat

291 orce the description of iron-sulfur cores as modular units subject to various covalent bond interacti

292 rat and human cardiomyocytes or through the modular use of dedicated light-sensitive somatic 'spark'

293 ction, weak measurements, deterministic, and modular variables.

294 The data do not support a modular view of word retrieval in speech production but

295 od is thus introduced to directly synthesize modular water-soluble probes with broad potential utilit

296 The design of the Hex nanocarrier is modular, which enables functionalization beyond Fc-bindi

297 The Mire microbial network was modular with module cores consisting of clusters of Acid

298 -down proteomics can follow, in principle, a modular workflow similar to that of bottom-up proteomics

299 itation assays, which also demonstrated that modular WW domain 1 of WWP1 was most critical for bindin

300 bset of host proteins containing one or more modular WW domains that then function to facilitate effi