ライフサイエンスコーパス: modulation

1 tics such as all-optical switching and light modulation.

2 entral synapses and their activity-dependent modulation.

3 a purely efficacy-driven positive allosteric modulation.

4 treatment pathway amenable to pharmacologic modulation.

5 terneurons did not show significant velocity modulation.

6 known about the downstream effects from this modulation.

7 may mediate the MOS1 function in cell-cycle modulation.

8 elements contribute independently to gating modulation.

9 inyl ring is not required for CB1 allosteric modulation.

10 lex, with overall loss of function in gating modulation.

11 y scores, supporting a role for PER3 in mood modulation.

12 reveal that the gap is due to the structure modulation.

13 'O-methyl phosphorothioate-mediated splicing modulation.

14 ing perceptual changes induced by contextual modulation.

15 de regulatory mechanism for NL-NRX signaling modulation.

16 electric effect enables a controlled spatial modulation.

17 n/derivatization prerequisite for electronic modulation.

18 structed more faithfully than other temporal modulations.

19 ed positively with functional and behavioral modulations.

20 bjecting engineered systems to time-periodic modulations.

21 cRNAs may introduce species-specific network modulations.

22 tion accuracy was higher for faster temporal modulations.

23 the same data set revealed that dopaminergic modulation activates several additional anatomically dis

24 681 and 684 metabolites revealed significant modulation and clear differentiation in resistant and su

25 easons, is always accompanied by cross-phase modulation and four-wave mixing.

26 progression, DNA damage response, and immune-modulation and may provide a novel therapeutic approach

27 ges in rivalry is driven by both attentional modulation and mutual inhibition, which have distinct se

28 n determinants, and suggest that both immune modulation and resistance contribute to persistent, nonh

29 s with adjustable amplitude using only phase modulation and the nonlinear response of a medium.

30 tional acoustic measures, including temporal modulations and spectral complexity, could not account f

31 opamine neuron connectivity, cotransmission, modulation, and activity.

32 NaV channels may be necessary for functional modulation, and that targeting the diverse S1-S2 region

33 particular regionally selective dopaminergic modulation, and the potential of genetic factors to stra

34 cutaneous reflexes and their phase-dependent modulation are altered with increasing speed and if this

35 he details of anesthetic binding and channel modulation are still debated.

36 strate the opposite: instantaneous frequency modulations are critical to regulate phase relations and

37 y from the cones using pulsed (3-s) spectral modulations around a photopic background.

38 h also relates to their scale-free amplitude modulation as indexed by the strength of long-range temp

39 picosecond-scale large absolute reflectance modulation at low pump fluences.

40 cadian rhythmicity in GHT output, indicating modulation at the SCN level.

41 non-fast-spiking INs displayed differential modulation by glutamate and 5-HT.

42 ns, suggesting they might mediate non-visual modulation by light in many systems.

43 nciples and a circuit diagram enabling speed modulation by mechanosensory feedback in the vertebrate

44 is likely to include the added dimensions of modulation by miRNAs and long-noncoding RNA (lncRNA).

45 endocytosis and is subject to bidirectional modulation by relevant pathologic perturbations.

46 The modulation by serotonin has qualitative similarities wit

47 e shape as deletion of Kv1.1; however, spike modulation by somatic prepulses was abolished.

48 n, myocardial ischemia; and summarizes LOX-1 modulation by some naturally occurring compounds and eff

49 lpha3beta4*-nicotinic acetylcholine receptor modulation by the prototoxin lynx1.

50 omatosensory input and neuropeptide-mediated modulation can produce robust modality-specific escape b

51 y, it remains unknown whether brainstem pain-modulation circuits are altered in individuals with chro

52 ojected effect of salt-driven hormone rhythm modulation corresponded well with the measured decrease

53 y allosteric agonism, rather than allosteric modulation, could be responsible for the adverse effects

54 The demonstrated modulation cutoff frequency exceeds 14 GHz indicating po

55 d ultrafast saturable absorption (SA) with a modulation depth of 0.43%.

56 etamaterial/graphene device, demonstrating a modulation depth of 100%.

57 Here we successfully exploit a modulation doping scheme to uncover, in conjunction with

58 ients with chronic pain display altered pain-modulation efficacy, it remains unknown whether brainste

59 terms of frequency-specific spectrotemporal modulations enables accurate and specific reconstruction

60 The modulation exerted by the cytoskeleton onto the nucleus

61 Consistent with a role in splicing modulation, exonic splice enhancers have a lower SSM den

62 t-adapted measurement from a pulse amplitude modulation fluorometer, was the best leaf fluorescence p

63 It enables the realisation of high-order modulation formats and offers high sensitivities, achiev

64 Here, we studied the patterns of modulation from PMd within the same and in the opposite

65 1 (PARP1), whose role in gene transcription modulation has been well established.

66 enitor, with subsequent post-transcriptional modulation highlighting the complexity of the processes

67 a collection of approaches that involve ROS modulation in cells as a strategy to target cancer and b

68 sensitive yardstick to probe the allosteric modulation in contrast to the traditionally used structu

69 as been linked to engagement and attentional modulation in earlier studies that used high-grade equip

70 R spectra, using a developed algorithm for J modulation in flexible organic biradicals, supports this

71 pound shows a unique concentration-dependent modulation in optical response toward uric acid.

72 The mechanism for fluorescence modulation in these sensors has been attributed to some

73 sively more in surrounding regions, temporal modulations in a range relevant for speech analysis ( ap

74 hich these interactions are subject to rapid modulations in response to signals is unknown.

75 or, cytokines (IL-7 and IL-22), and hormonal modulation including sex steroid inhibition and growth h

76 unt for further nonintuitive aspects of beta modulation, including beta phase resets after sensory cu

77 at conductivity in semiconductors provides a modulation index several orders of magnitude larger than

78 ges in plants like gene expression, hormonal modulation, induced antioxidant activity and calcium spi

79 This large phase modulation is afforded in the cost of low transmission e

80 The millivolt-scale optical modulation is attributed to a new modulation mechanism,

81 PS) has a crucial role for survival, and its modulation is fundamental when we interact with the envi

82 further supports the claim that fluorescence modulation is not primarily a result of binding, but of

83 very few studies have examined whether this modulation is reversible upon anthelmintic therapy.

84 ce that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects aga

85 The loss of excitatory cholinergic modulation may play a critical role in mPFC deactivation

86 icant genetic risk factor for AD, changes in modulation may provide additional information toward ide

87 le optical modulation is attributed to a new modulation mechanism, in which transport of silver ions

88 ty between regions within the brainstem pain-modulation network.

89 ll, post cues produced all of the behavioral modulations observed as a result of pre cues.

90 overview of the approaches explored for the modulation of 14-3-3 PPIs and review the examples result

91 vice is fabricated which shows THz intensity modulation of 96% at 0.25 THz carrier frequency with low

92 abis on anxiety in males are mediated by the modulation of amygdalar function by delta-9-THC and the

93 ia field effect-induced optical permittivity modulation of an ultrathin titanium nitride (TiN) film,

94 nfection by the malaria parasite through the modulation of Arg uptake and polyamine synthesis.

95 both bottom-up sensory encoding and top-down modulation of auditory cortex.

96 Interestingly, the modulation of auditory responses by estrogens was much l

97 We previously showed that modulation of autophagy and lysosomal exocytosis by over

98 ties of alpha oscillations themselves, and a modulation of baseline levels, presumably inhibitory.

99 We showed an age-dependent modulation of BBB integrity parameters suggesting increa

100 microbial environment-which function in the modulation of behavior.

101 This intricate modulation of binding affinity, and thus cooperativity,

102 es requires spatially and temporally precise modulation of biochemical signals within growth cones.

103 Among their multifaceted role in the modulation of biological responses, the involvement of E

104 Furthermore, positive modulation of BK channels in vivo can enhance short-term

105 V-proteins and/or cocaine due to severe down-modulation of bone morphogenetic protein receptor (BMPR)

106 Ragulator-dependent, but mTORC1-independent, modulation of BORC.

107 2), are known to play important roles in the modulation of both the host response to infection and th

108 These findings suggest that modulation of brain plasticity could be a major contribu

109 Parameters of ventricular remodeling and modulation of cardio-renal sympathetic axis were monitor

110 Modulation of cathepsin activity may prevent injury of o

111 ression, its interaction with CaValpha1, and modulation of CaV1.2 currents.

112 onse to sexual cues, which overall entails a modulation of cell cycle, meiosis-related and nutrient t

113 Instead, modulation of cell function by effector domains may depe

114 factors (HIFs) are centrally involved in the modulation of cellular function in response to low oxyge

115 st two important neurophysiological changes: modulation of cerebellar output mediated in-part by long

116 The modulation of chiroptical responses by manipulation of i

117 cerol, the major CNS endocannabinoid, in the modulation of chondroitin sulfate proteoglycan accumulat

118 lance), along with cardioprotective effects, modulation of circulatory inflammation and extended surv

119 provide a perspective on a nutrition-driven modulation of cognition.

120 nd the tumor microenvironment results in the modulation of complex signaling networks that facilitate

121 s may be useful in enabling rapid contextual modulation of cortical frequency representations.

122 ation and ethnicity play a major role in the modulation of CRC risk.

123 2-AG), the major CNS endocannabinoid, in the modulation of CSPGs deposition in a progressive model of

124 CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.

125 ntribute to immune dysregulation through the modulation of DC differentiation.

126 ules in the frontal cortex and ending in the modulation of developmental factors in the amygdala and

127 690 and PgLPS1435/1449 may contribute to the modulation of disease progression.

128 em, borne out in functional studies, for the modulation of distinct facets of homeostasis.

129 Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei.

130 Our findings demonstrate that modulation of dynamic cellular calcium homeostasis and T

131 europsychiatric disorders requires selective modulation of dysfunctional neuronal pathways.

132 DNA double-strand breaks are crucial to the modulation of early gene expression, which provides a me

133 Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be e

134 estion since the first reports of the strong modulation of electrical properties in 2002.

135 nd on its mechanisms of cardioprotection and modulation of energy metabolism.

136 Although pharmacologic modulation of excitatory amino acid receptors is well st

137 ferent ligands or signaling proteins through modulation of fast ps-ns sidechain dynamics.

138 Modulation of flap opening through protease-Gag interact

139 berization-related signals mainly though the modulation of GA metabolism.

140 production of infectious virions by targeted modulation of Gag PM targeting.

141 eatment of type 2 diabetes requires positive modulation of GLP-1R to inhibit glucagon secretion and s

142 the first demonstration of the dynamic cross-modulation of GluA1 ubiquitination and phosphorylation,

143 ia its effect on proton leak but instead via modulation of glucose-fueled respiration.

144 er of double bonds mostly contributed to the modulation of habituation.

145 R remodels the free energy landscape for the modulation of HCN4 by cAMP, i.e. the primary cyclic nucl

146 te this prediction, we demonstrated that the modulation of heat-shock factor-1 by knockdown in nCPCs

147 ed as an antidote during adverse therapeutic modulation of hemostasis.

148 toskeletal-F-actin proteins, correlated with modulation of hepatic ultrastructure.

149 study thus establishes a link between Dmrta2 modulation of Hes1 expression and the maintenance of NPC

150 e2, which produces strong lateral electronic modulation of hexagonal symmetry and discreet subbands.

151 playing an important role in novelty related modulation of hippocampal memory.

152 Since modulation of histones is important at many steps in spe

153 cells and may present useful targets in the modulation of host defences against viral pathogens.

154 ructural regions unique to NS1 contribute to modulation of host responses, including inhibition of ty

155 europeptides oxytocin and vasopressin in the modulation of human neural activity underlying social co

156 This evidence indicates that modulation of hypothalamic GRP78 activity may be a poten

157 the road to full understanding and effective modulation of immune responses in gene therapy is still

158 apeutic utility of GSTO1-1 inhibitors in the modulation of inflammation and suggest their possible ap

159 Therefore, the modulation of interdomain dynamics represents an importa

160 and tune the property of "memristance." The modulation of interfacial strain and the interface count

161 The modulation of ion channel activity by lipids is increasi

162 vity as a transcription factor relies on the modulation of its oligomeric state by 5'-deoxyadenosylco

163 Additionally, positive modulation of KCa2 channels prevented mGlu5 receptor-dep

164 ts that their actions are mediated mainly by modulation of KCNQ1 pore function.

165 ctural and dynamics basis for the inhibitory modulation of ketamine on pLGICs.

166 nd suppression of PtabZIP1L also resulted in modulation of key metabolites like proline, asparagine,

167 ken together, these results suggest that the modulation of Kv3.1 channels may provide a novel approac

168 30 bp deletion that could be responsible for modulation of leukotoxin production have not been define

169 on synaptic transmission via the allosteric modulation of ligand-gated chloride channels, such as he

170 findings and transcriptome changes indicated modulation of liver macrophage populations by the mutati

171 2-mediated vasculotrophism, but also through modulation of local complement proteins that could prote

172 o promote the resolution of inflammation via modulation of macrophage functions.

173 Electric field modulation of magnetic properties via magnetoelectric co

174 tion factor are dependent on copper-mediated modulation of MAPK signaling.

175 ally regulated by endothelial cell-intrinsic modulation of mFlt1, suggesting new ways to manipulate v

176 Together our results reveal modulation of miRNA-mediated repression by characteristi

177 Furthermore, our optometabolic tools allow modulation of mitochondrial functions in single cells an

178 thway activation and function through direct modulation of multiple pathway components acting both up

179 The independent vestibular modulation of muscle activity from each limb occurs rapi

180 mechanistic understanding of the functional modulation of Mvarphis by pathogens and pharmaceutical i

181 ested to also be responsible for the optical modulation of naturally occurring bacteriochlorophylls.

182 d noninvasive EEG signatures for attentional modulation of neural events following perceptible and im

183 but also serves as a potential drug by which modulation of neural glycan biosynthesis and thus functi

184 iophysical mechanism for the introduction or modulation of neural variability in this circuit.

185 an essential regulatory mediator involved in modulation of neutrophil migration throughout the course

186 In addition, the concept of complementary modulation of normally antagonistically targeted GSK3 su

187 Through modulation of ocean stratification and near-surface wind

188 These results are consistent with the modulation of ocular reflexes during OVAR being primaril

189 on response and suggest that epigenetic down-modulation of OXTR could contribute to behavioral differ

190 The modulation of p53 residence times on chromatin requires

191 xerted by JMJD2B on tumor growth through the modulation of p53 target genes.

192 ired to preserve CPC growth, suggesting that modulation of pathways downstream of it may re-activate

193 ledge, this is the first paradigm validating modulation of paxillin to inhibit angiogenesis.

194 Bidirectional modulation of PFC activity further refined this subset o

195 involvement of the CML protein family in the modulation of plant-autoinhibited Ca(2+) pumps.

196 n) were synthesised and their effects on the modulation of platelet function were evaluated.

197 In parallel, CORM-401-dependent modulation of PMN chemotaxis, F-actin expression/distrib

198 Our results show a selective modulation of preparatory motor activity following PA in

199 suggests potential learning-related in vivo modulation of presynaptic corticostriatal function.

200 ection against various target molecules; (b) modulation of protein function in vitro and in vivo; (c)

201 We modified this structure by modulation of protein kinase C, an enzyme regulating neu

202 ntly generate gene replacements allowing for modulation of protein levels for otherwise lethal knocko

203 to AMPH, and they raise the possibility that modulation of PV+ interneuron function may alter the dev

204 tinctly different mechanism for the temporal modulation of QD emission intensity at constant optical

205 e from a positive selection driven by BCL-XL modulation of RAS-induced self-renewal, and during which

206 leotide-gated channels and cyclic nucleotide modulation of related channels.

207 y encourages further research into circadian modulation of reward and underscores the methodological

208 12 upstream of auxin transport for the sugar modulation of root growth.

209 e mediated through phosphorylation-dependent modulation of ROP activity.

210 Selective disruption of D1 or D2 modulation of separate PFC output pathways was achieved

211 mechanism that regulates chondrogenesis via modulation of SOX9 ubiquitination.

212 etary restriction longevity and suggest that modulation of specific spliceosome components may prolon

213 s been hypothesized that such reward-related modulation of stimulus salience is conceptually similar

214 ded CD4(+)CD25(hi) tTregs and Teffs, whereas modulation of suppressive activities by PKC-theta and Dl

215 Reelin signaling is a critical player in the modulation of synaptic function.

216 Modulation of T cell proliferation and function by immun

217 n of mast cell activation, in the absence of modulation of T- or B-cell responses.

218 GHz indicating potential for the high-speed modulation of terahertz waves.

219 bit the BA output.SIGNIFICANCE STATEMENT The modulation of the amygdala by serotonin (5-HT) is import

220 inctive role for peripheral TNF-alpha in the modulation of the amyloid phenotype in mice by regulatin

221 led that this behaviour was accompanied by a modulation of the cells' fore-aft asymmetry.

222 xternal energy, for example, light, external modulation of the chemical and/or physical environment o

223 on the inhibitory activity, indicating that modulation of the conformational space accessible for th

224 Modulation of the coupling from frontal to early visual

225 ct physics involved to demonstrate the local modulation of the electronic properties and possible ben

226 ophyte-to-insect pathogen transition through modulation of the expression of a membrane protein, Mr-O

227 attention and it is commonly attributed to a modulation of the gain and tuning of feature-selective u

228 Here, we report on the modulation of the gain of excitatory signals from the AE

229 ucing inflammation in the CNS may start with modulation of the gut microbiome.

230 othesis by measuring the proximity-dependent modulation of the hand-blink reflex.

231 ance between sympathetic and parasympathetic modulation of the heart.

232 ative approaches that are based on the early modulation of the host microbiota and immunity.

233 improvements were notably associated with a modulation of the host urinary metabolomics profile and

234 ta perturbations precede arthritis, and that modulation of the intestinal microbiota after the onset

235 21 dB, demonstrating active, optoelectronic modulation of the laser frequency content between multi-

236 ty of Ar-Au-Ar intermediates, via systematic modulation of the length of aryl-aryl linkage, but also

237 nism is based on the electrically controlled modulation of the local density of optical states (LDOS)

238 randomly, but follow the ion-induced spatial modulation of the membrane.

239 Collectively, our results clearly prove that modulation of the microbiota induces positive effects on

240 interventions to treat dietary allergies by modulation of the microbiota.

241 s showed that incongruent stimuli elicited a modulation of the N400 in all comparisons except for bod

242 at the position of the QDs, resulting in the modulation of the QD spontaneous emission rate, far-fiel

243 In vitro mixed lymphocyte reactions revealed modulation of the recipient immune response after AD-MSC

244 es below the maximum permissible exposure, a modulation of the signal amplitude is observed in fluoro

245 at FTY720 protects against neural injury via modulation of the sphingosine-1-phosphate 1 receptor (S1

246 ategies for optimizing photon absorption via modulation of the structural organization of phytoelemen

247 plus-end, the presence of KIF3CC resulted in modulation of the tapered structure typically seen in gr

248 lockade of NF-kappaB pathway activation, and modulation of the Th17 immune response.

249 span extension by dietary restriction and by modulation of the TORC1 pathway components AMPK, RAGA-1

250 For example, a direct modulation of the vacuum Rabi frequency is obtained by d

251 Although these mutations lead to modulation of their chaperone activity in vitro, the in

252 However, allosteric modulation of their scaffolding abilities and direct tar

253 Here we observe the predicted density modulation of this stripe phase using Bragg reflection (

254 mical changes reflecting the transcriptional modulation of thousands of genes.

255 nce photosynthetic performance through their modulation of thylakoid membrane dynamics.

256 oximal domains could provide new targets for modulation of Tie receptor activity.

257 way that controls cellular clearance via Akt modulation of transcription factor EB (TFEB), a master r

258 rate a picosecond-scale absolute reflectance modulation of up to 0.35 at the magnetic dipole resonanc

259 groups of neurons, we show that multisensory modulation of V1 populations is strongly determined by t

260 visual stability; another is the oscillatory modulation of visibility synchronized with hand action.

261 is work proposes a function for a behavioral modulation of visual processing and illustrates how the

262 regulates protein-protein interactions, the modulation of which may protect against cancer, radiatio

263 rogeneity in xenograft models likely through modulation of Wnt signaling.

264 p4 is related to Lrp5/6 and is implicated in modulation of Wnt/beta-catenin signaling, presumably thr

265 the mechanistic details governing OM-induced modulation of XB behavior in failing human myocardium ar

266 Here we show, for the first time, that modulations of brain oscillations in the EEG alpha frequ

267 different type I BMP receptors and distinct modulations of the cell cycle.

268 e the current-induced interface ME effect to modulations of the strong double-exchange interaction be

269 Modulation optimization involved a systematic investigat

270 level and type (positive/negative allosteric modulation or full antagonism) of mGluR5 modulation requ

271 quantum Hall effect, parametric permittivity modulation or Josephson nonlinearities.

272 The modulation pattern consisted of a pre-CS rise in SS acti

273 In contrast, correlations between modulation phases across CSs of individual PCs were gene

274 ulation techniques like quadrature amplitude modulation (QAM) and phase-shift keying (PSK).

275 e notes of a song were encoded via amplitude-modulation rate of pulse trains on single electrodes at

276 We propose that the modulation reflects a decision-related state change, whi

277 ric modulation or full antagonism) of mGluR5 modulation required to translate existing knowledge into

278 This modulation requires CB1 receptors on cortical glutamater

279 PPI modulation requires novel approaches and the integrated

280 large natural cation involved in ion channel modulation, revealing a previously unrecognized P2X-medi

281 To have a dual-modulation sensor for convenient and accurate detection,

282 on the Systematic Protein Affinity Strength Modulation (SPASM) technique.

283 Here we use charge modulation spectroscopy to reveal a bipolaron sheet dens

284 ed with other state-of-the-art communication modulation techniques like quadrature amplitude modulati

285 g platform for the development of a new host modulation therapy in periodontitis.

286 hesis argues for a role in focal attentional modulation through positive feedback, consistent with ob

287 bo hypoalgesia, treatment context) with pain modulation through stimulus intensity cues (stimulus con

288 We compared pain modulation through treatment cues (placebo hypoalgesia,

289 earch is in identifying the impact of immune modulation, through differing immune selective pressures

290 sual system uses oculomotor-induced temporal modulations to sequentially encode different spatial com

291 cal response that operates at strikingly low modulation voltages is experimentally demonstrated.

292 ther, our results suggest that the beta-band modulation was a top-down signal associated with the pro

293 In a subgroup, sympathetic/parasympathetic modulation was assessed by power spectral analysis.

294 ematically by the attraction effect and this modulation was correlated across participants with the r

295 but the molecular mechanism underlying this modulation was not fully understood.

296 The amplitude modulation was not significantly altered by head-on-trun

297 This finding indicates that the beta-band modulation was unrelated to the execution of the motor a

298 strong optical nonlinearity, e.g. self-phase modulation, which, for fundamental reasons, is always ac

299 munosuppression and predicts that type I IFN modulation will be pivotal to cure human chronic infecti

300 engths (ZDWs) and the process of cross phase modulation with soliton fission, red-shifted dispersive