ライフサイエンスコーパス: modulator

1 hotocaged mGlu5 receptor negative allosteric modulator.

2 nt with a positive allosteric GABAA receptor modulator.

3 (HDAC1) that functions as a transcriptional modulator.

4 ed by the GABAB receptor positive allosteric modulator.

5 GM-CSF was identified as an upstream modulator.

6 ptor (sigma1R), an inter-organelle signaling modulator.

7 er of pixels controlled by the spatial light modulator.

8 ework was synthesized with propanoic acid as modulator.

9 eceptor occupancy of eliprodil, a GluN2B NTD modulator.

10 tor were 30-55% narrower than with the valve modulator.

11 n studies using pyruvate as a cellular redox modulator.

12 rboxylic acid derivative (Cmpd-15PA) of this modulator.

13 noma cell-cell adhesion on pHe and NHE1 as a modulator.

14 roduct-based agents as an important class of modulators.

15 bandwidth (100 GHz) of current electro-optic modulators.

16 sing drugs developed as photoreactive GABAAR modulators.

17 a central node for binding to these splicing modulators.

18 the assessment of receptor occupancy by NTD modulators.

19 biological phenotypes and effective disease modulators.

20 for the development of selective allosteric modulators.

21 romosome drive the recruitment of epigenetic modulators.

22 s a key-step towards realizing spatial sound modulators.

23 depend on endocrine and autocrine/paracrine modulators.

24 eted and sold as selective androgen receptor modulators.

25 tive D1 ligands, and D1R positive allosteric modulators.

26 g but inhibits the global action of splicing modulators.

27 was susceptible to multiple capsid assembly modulators.

28 The allosteric modulator 1-(4-chlorophenyl)-3-(3-(6-(pyrrolidin-1-yl)py

29 However, for regular phase modulators, a large phase change comes with a slow time

30 lective, full agonist or positive allosteric modulator activity against RXFP1.

31 used to quantify in situ positive allosteric modulator activity in vivo.

32 exhibit promising affinity, selectivity, and modulator activity on the cluster of differentiation 36

33 anel of small molecules targeting epigenetic modulators against human metastatic melanoma cells.

34 l mGlu receptor subtype-selective allosteric modulators along with knockout mice we now report that t

35 ere, we show that a diverse spectrum of H-NS modulators alter the DNA-bridging activity of H-NS.

36 luation as AMPA receptor positive allosteric modulators (AMPApams).

37 y of mGluR5 negative and positive allosteric modulators (an mGluR5 NAM and PAM) for TSC, using a muta

38 BCMA and transmembrane activator and calcium-modulator and cyclophilin ligand (TACI).

39 competitive mechanism between the allosteric modulator and the dibenzodiazepinone derivatives, and th

40 Their contribution as modulators and effectors during allergy and autoimmunity

41 odels to perturbations such as pharmacologic modulators and genetic perturbations.

42 the addition of NADP (NADPH) oxidase pathway modulators and inhibitors of Toll-like receptors (TLRs).

43 ealization of the next generation of on-chip modulators and switches at THz frequencies.

44 cific electrostatic interactions between the modulators and their binding pocket.

45 lexes with agonists, antagonists, allosteric modulators, and auxiliary proteins.

46 rs, binary and quadrature phase-shift keying modulators are discussed.

47 Many identified candidate modulators are known to be involved in biological meanin

48 Many of the identified NMNAT2 positive modulators are predicted to increase cAMP concentration,

49 Thirdly, candidate modulators are selected from significant genes by cluste

50 provide evidence, using a silent allosteric modulator as an allosteric antagonist, that BMS-986187 a

51 In the search for 5-HT2CR allosteric modulators as safer antiobesity drugs, a chemical librar

52 onmental sensing, signaling, transcriptional modulators as well as chromatin modifications.

53 l device as it allows the placement of a PET modulator at the strategically important and less explor

54 he recent development of a potassium channel modulator, AUT1-an imidazolidinedione compound that spec

55 erently stable, reconfigurable spatial-light-modulator-based polarization-interferometer, we have con

56 lar mechanisms of coupling between substrate/modulator binding and catalytic activity remain to be el

57 However, identification of nAChR allosteric modulator binding sites has been facilitated by using dr

58 We conclude that ACh is not only a potent modulator but also a requirement for the full expression

59 present our progress towards building such a modulator by demonstrating the optically-resonant half o

60 nd 25 showed to be LXR target gene-selective modulators, by strongly inducing the expression of ABCA1

61 se and derive power consumption analysis for modulator-class neurons that, as opposed to laser-class

62 Understanding the mechanism of action of modulator compounds for the cystic fibrosis transmembran

63 NADPH oxidase pathway modulators decreased ROS production but not NET producti

64 ed optoelectronic devices (e.g. solar cells, modulators, detectors, and diodes) used in space probes

65 that MoGsk1, as a highly conservative signal modulator, dictates growth, conidiation and pathogenicit

66 Downstream regulatory element antagonist modulator (DREAM), a transcriptional repressor, is known

67 signaling caused by the accumulation of a Wg modulator, Drosophila Nek2 (dNek2).

68 henones and compared to a conventional valve-modulator employing sample loops.

69 A doubly-resonant electro-optic modulator (EOM) is a promising platform to realize this

70 oxydiphenyl borate (2-APB), a broad-spectrum modulator for a number of membrane proteins.

71 en peroxide was characterized as the central modulator for altered MMP-3 expression in prostate cance

72 ential of the longitudinal on-column thermal modulator for separation of a complex sample.

73 that the iron curtain serves as an inorganic modulator for the supply of DOM from groundwaters to the

74 atives with excellent potency (50-100 nM) as modulators for cancer invasion and metastasis.

75 initiated, or are planned to test new immune modulators for cancer therapy using a variety of modifie

76 een treated with different immune checkpoint modulators, form the rationale for the design of immune

77 Non-steroidal selective-AR modulator, GTx-026, which selectively builds muscle and

78 The therapeutic potential of some of these modulators has been tested in human samples from patient

79 Several P-gp inhibitors or modulators have been investigated in clinical trials in

80 The realization of graphene-based modulators, however, faces challenges connected with gra

81 A screen of small molecule metabolism modulators identified combinatorial activity between a C

82 nal injury and identify IRAK-M as a possible modulator in driving an alternatively activated profibro

83 ationale for the clinical evaluation of PAK4 modulator in myeloma.

84 onic 116-gigabits per second electro-optical modulator in which all the elements-the vertical grating

85 , suggesting a role for additional signaling modulators in hypothyroidism.

86 at the difference in potency of the positive modulators in potentiating SK2 channel activity may be a

87 elects for human MCU-specific small-molecule modulators in primary drug screens.

88 g resonators, and the incorporation of phase modulators in the microring resonators enables continuou

89 F) and nerve growth factor (NGF) are crucial modulators in the neurodevelopment and maintenance of ce

90 epicardial cell-cycle dynamics with chemical modulators indicated autonomous regenerative capacity in

91 Moreover, PHF5A-Y36C alters splicing modulator-induced intron-retention/exon-skipping profile

92 BS, as well as the contribution of signaling modulators involved in host immune defense, have not bee

93 Thus, a potent BK channel peptide modulator is open to neurological applications, such as

94 The field of biologic immune modulators is currently mushrooming at a dizzying pace.

95 ent with orally bioavailable PAK4 allosteric modulator (KPT-9274) significantly impacted MM cell grow

96 receptor transmembrane activator and calcium modulator ligand interactor (TACI) is important for T-in

97 hat PTC suppression in combination with CFTR modulators may be beneficial for the treatment of CF pat

98 d that small molecular core protein assembly modulators may disrupt one or multiple steps of HBV repl

99 s embodied by the fact that targeted pathway modulators may have opposing effects on tolerance based

100 Identification of chemical GR modulators may provide insights into the regulatory mech

101 The synthesis of the gamma-secretase modulator MK-8428 (1) is described.

102 tes (NHP) with the mGlu5 negative allosteric modulator (NAM) 7.

103 The NF-kappaB essential modulator (NEMO) is the scaffolding subunit of the inhib

104 ia interactions with the NF-kappaB essential modulator (NEMO) subunit of the IkappaB kinase (IKK) com

105 nuclear factor kappaB (NF-kappaB) essential modulator (NEMO; the regulatory subunit of the IkappaB k

106 l series of oxadiazine-based gamma secretase modulators obtained via isosteric amide replacement and

107 nal cells and suggest that it could be a key modulator of a novel Golgi export checkpoint that coordi

108 protein that was identified in a screen as a modulator of alpha-synuclein accumulation in vivo.

109 nabinoids by acting as a negative allosteric modulator of alpha7 nicotinic receptors (alpha7nAChRs).

110 d by pretreatment with a positive allosteric modulator of alpha7nAChRs.

111 one as an inhibitor of splicing in vitro and modulator of alternative splicing in cells.

112 of the proapoptotic molecule p53-upregulated modulator of apoptosis (PUMA) and showed that these cell

113 channels and identify Rab11A serine 177 as a modulator of arterial contractility.

114 sed receptors and identify the retromer as a modulator of beta-arrestin-mediated signaling from CB2R.

115 activation has been suggested as a potential modulator of bronchoconstriction.

116 We conclude that TRPV1 is a modulator of Ca(2+) homeostasis in a subset of RGCs that

117 In this study, we evaluate KCa3.1 as a modulator of Ca(2+)-induced NFAT-dependent osteoclast di

118 s a recently discovered novel small-molecule modulator of cardiac myosin that targets the underlying

119 article, we show that PRMT5 is an important modulator of CD4(+) T cell expansion.

120 atory disorders; however, its role as a dual modulator of CD4(+) T cell function and metabolism has n

121 tifies a novel function for this kinase as a modulator of cell adhesion and migration.

122 ence that the sex of animals is an important modulator of circadian rhythms in gene expression and th

123 potential role for d-serine as an endogenous modulator of circuit refinement.SIGNIFICANCE STATEMENT A

124 in the prefrontal cortex (PFC) and is a key modulator of cognitive performance in primates.

125 Furthermore, a small molecule modulator of CR3 reduces soluble Abeta levels and Abeta

126 stulate that CXCL14 is a positive allosteric modulator of CXCR4 that enhances the potency of CXCR4 li

127 eceptors, was actually a negative allosteric modulator of D2- and D3-receptor dimers, thus identifyin

128 homeostasis, and implicate the pathway as a modulator of degenerative diseases.

129 miR-125a-5p is an important modulator of differentiation, proliferation, and migrati

130 n of allopregnanolone, a positive allosteric modulator of gamma-aminobutyric acid (GABAA) receptors,

131 ectively, our results identify PON2 as a new modulator of glucose transport that regulates a pharmaco

132 by cAMP, i.e. the primary cyclic nucleotide modulator of HCN channels.

133 ar factor E2-related factor 2 (Nrf2) being a modulator of hepatic lipid accumulation in models of NAF

134 oybean pathogen Phytophthora sojae acts as a modulator of histone acetyltransferase (HAT) in plants.

135 e endocannabinoid (eCB) system is a critical modulator of homeostasis in vertebrates.

136 HIR operates as a crucial modulator of hyphal development, since genetic ablation

137 miR-146a has emerged as a critical modulator of immune reactions, but its role in regulatin

138 Activin is a critical modulator of inflammatory responses, but has not been as

139 e of the miR390/TAS3 pathway in legumes as a modulator of lateral root organs, playing opposite roles

140 rinic acetylcholine receptor is an important modulator of medial prefrontal cortex (mPFC) functions,

141 here we demonstrate that TRIB3 is a negative modulator of megakaryocytopoiesis.

142 w rubone acts as an efficient small-molecule modulator of miR-34a to reverse chemoresistance and furt

143 ation-in particular, at tyrosine 48-is a key modulator of mitochondrial signaling, its action and mol

144 bservations posit Arc as a major homeostatic modulator of molecular and behavioral responses to cocai

145 ent and repair is of interest as a potential modulator of MS disease course.

146 the MtrC/E binding interface is an important modulator of MtrE function, which could potentially be t

147 on regulatory factor (IRF)-5 is an important modulator of myeloid function and programming.

148 at the corticotrigeminal pathway is a potent modulator of nociception and a potential target for inte

149 ved, thus identifying L3MBTL3 as a universal modulator of Notch signaling in metazoans.

150 exerting its toxic effect on nematodes as a modulator of oxidative phosphorylation.

151 gastrointestinal microbiome is an important modulator of physiological responses induced by chronic

152 Protein methylation is an important modulator of signal transduction pathways, but methyltra

153 t regulation of glycolysis as a multifaceted modulator of single-cell metabolic dynamics that is requ

154 Here we show that ITK, an important modulator of TCR signalling, is required for the TCR-ind

155 Therefore, SPARC appears to be an important modulator of the actin cytoskeleton, implicating mainten

156 These findings not only establish YAP as a modulator of the activation of IRF3 but also identify a

157 Compound 15 (Cmpd-15) is an allosteric modulator of the beta2 adrenergic receptor (beta2AR) tha

158 Treatment with CC-220, a modulator of the cullin ring ligase 4-cereblon E3 ubiqui

159 r results suggest that MRAP2 is an important modulator of the energy homeostasis machinery that opera

160 This first-in-class macrocyclic peptide modulator of the hedgehog pathway is expected to provide

161 ACKGROUND & AIMS: Cholera toxin can act as a modulator of the immune response with anti-inflammatory

162 Although light is a strong modulator of the neural circadian clock, time of food in

163 therefore represents a key-albeit overlooked-modulator of the strength of sexual selection.

164 omes and that the STAT1 pathway is a crucial modulator of this phenotypic spectrum.

165 urthermore, soluble TLR2 (sTLR2), a negative modulator of TLRs that we detected in PDE, inhibited PDE

166 dy identifies TRIM21 as a previously unknown modulator of Toxoplasma gondii resistance in vivo thereb

167 munoglobulin kappa J region (RBPjkappa), key modulators of adipogenesis and osteogenesis, respectivel

168 Here, we develop a screening strategy for modulators of ATP-PRT and identify 3-(2-thienyl)-L-alani

169 ic architecture of the PR interval comprises modulators of atrial fibrillation risk and obesity.

170 emical properties are published as selective modulators of biomolecules without sufficient validation

171 tion of the cGMP pathway and by using direct modulators of BK.

172 Testing a panel of modulators of cAMP and cGMP signaling pathways, FASS-LTP

173 ept that PTPs are indispensable and specific modulators of cellular signaling.

174 growth and survival, and their potential as modulators of chemoresistance.

175 zyme topoisomerase-II (topo-II) as candidate modulators of chromosome size.

176 structural insight paving the way for novel modulators of complement.

177 ntral oscillator components were proposed as modulators of core clock function in mammals (Per) and f

178 ir contrast independently with raised-cosine modulators of different orientations and spatial frequen

179 tion study (GWAS) meta-analysis to determine modulators of ER stress-mediated inflammation.

180 Allosteric modulators of G protein-coupled receptors, including opi

181 nguished DCUK-OEt from other currently known modulators of GABA function (e.g., anesthetics, neuroste

182 MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous bi

183 es of sequence-specific, posttranscriptional modulators of gene expression.

184 iae we show that epistatic NEMs can point to modulators of genetic interactions.

185 rotein signaling (RGS) proteins are critical modulators of GPCR activity, yet their role in beta cell

186 e-3-carbohydrazide derivatives as allosteric modulators of GSK-3beta are presented here.

187 These findings suggest that the allosteric modulators of GSK-3beta may be used for future developme

188 and PTMs of mutant Htt are likely important modulators of HD pathogenesis.

189 Endothelial cells (ECs) are major modulators of hemostasis by expressing and releasing pro

190 his potentiometric probe to assay functional modulators of heterologous expressed GABAA receptor (GAB

191 ve implications for the development of novel modulators of HH-driven developmental disorders and dise

192 atform for the exploration of small molecule modulators of hPINK1.

193 , InsPs and PtdInsPs can serve as endogenous modulators of IDE activity, as well as regulators of its

194 has become clear that platelets also act as modulators of inflammatory processes, such as atheroscle

195 findings show that monoamines are important modulators of lOFC excitability and suggest that disrupt

196 or other non-amyloid APP fragments as acute modulators of mitochondrial metabolism.

197 Drugs acting as positive allosteric modulators of muscle-type alpha2betagammadelta nAChRs, o

198 hemokines, such as CCL3, CCL4, and XCL1, and modulators of NK cell effector functions (TNFRSF9, CRTAM

199 Subunit-selective positive allosteric modulators of NMDA receptor function have therapeuticall

200 ries of GluN2C-selective positive allosteric modulators of NMDA receptors.

201 Allosteric modulators of pentameric ligand-gated ion channels are t

202 Here, we propose that meiosis I-specific modulators of reductional segregation can contribute to

203 To identify modulators of reprogramming-induced senescence, we perfo

204 status and trisomy 12 as the most important modulators of response to kinase inhibitors in CLL.

205 te genome potentially makes it vulnerable to modulators of RNA splicing, such as digoxin and digitoxi

206 her specific agonists or positive allosteric modulators of RXFP1, affirming the low druggability of t

207 ning shows that these receptors are critical modulators of short-term working memory.

208 Modulators of Siglec function are likely to be developed

209 egulators of apoptosis and inflammation, and modulators of signalling pathways that regulate stem-cel

210 Over the past two decades, positive modulators of SK channels such as NS309 and 1-EBIO have

211 In our attempt to delineate genetic modulators of smoking persistence, we have earlier shown

212 e K(+) (SK) channels have been implicated as modulators of spontaneous depolarization and electrical

213 To identify molecular modulators of synaptic stability and degeneration, we ha

214 Because intestinal bacteria are potent modulators of systemic immune responses, including antit

215 Pharmacological modulators of TEADs could therefore find application in

216 lowed delineation of both the generators and modulators of the cue-triggered event-related oscillator

217 hanism to increase protein expression of key modulators of the DNA damage response.Sequestering mRNA

218 S) proteins are key interactors and critical modulators of the Galpha protein of the heterotrimer.

219 e NDT80 regulon, indicating that they act as modulators of the general Ime2/Rim4 pathway for specific

220 fforts toward the identification of chemical modulators of the hedgehog pathway have yielded several

221 TKIs, glesatinib and foretinib, as negative modulators of the Hh pathway, widens their application i

222 SBD is a potential target for small molecule modulators of the Hsp70 allosteric cycle.

223 is-proof-of-principle study, we screened for modulators of the interaction between Hsp90 and its co-c

224 numerous small-molecule positive allosteric modulators of the ligand-binding domain of (S)-2-amino-3

225 errucosanoid-derived esters were examined as modulators of the membrane transporter proteins ABCB1 (P

226 on TRPV1 activation was emulated by positive modulators of the protein kinase A (PKA) pathway, inhibi

227 Mast cells are powerful immune modulators of the tissue microenvironment.

228 enable the structure-based design of potent modulators of these clinically relevant enzymes.

229 h should facilitate screening for additional modulators of this important metabolic enzyme.

230 es indicated that motoneurons participate as modulators of this rhythmic motor pattern.

231 Modulators of transmitter-gated ion channels have a wide

232 PP/P25-alpha domain, both of which are known modulators of tubulin polymer structure.

233 Existing small-molecule modulators of V-ATPase either are restricted to targetin

234 Allosteric modulators offer an alternative mechanism of action to t

235 ulti-layer liquid crystal (LC) spatial light modulator offers a large phase change while keeping fast

236 be used to assign the mechanistic effects of modulators on amyloid fibril formation.

237 To detect consistent effects of MDD and its modulators on cortical thickness and surface area estima

238 fer and photoinduced electron transfer (PET) modulators on the same molecule.

239 ibitors only vs selective oestrogen receptor modulators only vs both therapies), and used permuted bl

240 r by a subtype-selective positive allosteric modulator (PAM) contributes to the gastrointestinal (GI)

241 ation, suggesting that a positive allosteric modulator (PAM) of alpha7 receptors, JNJ-39393406, may a

242 UK-OEt was shown to be a positive allosteric modulator (PAM) of GABA currents with alpha1beta2gamma2,

243 BMS-986122 is a positive allosteric modulator (PAM) of the mu-opioid receptor (micro-OR).

244 Positive allosteric modulators (PAM) of metabotropic glutamate receptor 2 (m

245 2), two highly selective positive allosteric modulators (PAMs) of M1 mAChRs.

246 A number of positive allosteric modulators (PAMs) that enhance GABA's actions on neurona

247 The NOTCH modulator POFUT1 critically regulates this signaling axi

248 ommon binding pocket for negative allosteric modulators, present in both GLP-1R and GCGR and located

249 h poly(ethylene glycol) and/or immunological modulators, prevent robust macrophage recognition, resul

250 which has been implicated as central immune modulator promoting allergic airway inflammation.

251 lly been pursued to target GPCRs, allosteric modulators provide several mechanistic advantages, inclu

252 (HDAC) inhibitors and protein kinase C (PKC) modulators, provides a promising strategy to reduce if n

253 type 5 (mGlu5) receptor negative allosteric modulator raseglurant.

254 cluding cell-adhesion molecules, transmitter-modulator receptors, ion channels, signaling proteins, n

255 ion of K(+)-channel subunits and ion channel modulators, relevant in human AF.

256 reasing number of successful examples of PPI modulators, resulting in growing interest in this field.

257 The glutamate modulator, riluzole, which was recently shown to improve

258 was blocked in vitro and in vivo by the NTD modulators Ro-25-6981 and eliprodil.

259 re decreased while ROS and expression of its modulator (ROMO1) were increased.

260 t effects of the selective androgen receptor modulator (SARM) nandrolone phenylpropionate (Nandrosol)

261 novel series of selective androgen receptor modulators (SARMs).

262 enable the design of new positive allosteric modulators selective for KARs, which will be of great in

263 drugs, including selective estrogen receptor modulators (SERMs), possess selective anti-Ebola activit

264 in, we investigated a widely distributed CNS modulator, serotonin (5-HT), for its ability to modulate

265 indazole ether-based glucocorticoid receptor modulators (SGRMs) was developed for the inhaled treatme

266 The thermal modulator showed a reduced modulation-induced pressure i

267 ssion pattern of genes, such as synaptogenic modulator sparc and transcriptional factors (emx2, lhx2,

268 tly discovered control mechanisms, but other modulators still remain to be characterized.

269 denosine (ADO), which is a potent endogenous modulator, stimulates PKC, thereby causing immunosuppres

270 Furthermore, nAChR positive allosteric modulators such as NS9283 and CMPI have been shown to po

271 For global modulators such as serotonin, the use of distinct neuroe

272 monstrate the benefits of an active focusing modulator, such as reduced detection limits and increase

273 esistance to the selective estrogen receptor modulator tamoxifen and to aromatase inhibitors that low

274 inhibitor is the selective estrogen receptor modulator tamoxifen.

275 es indicate that agonist positive allosteric modulators target the same general region, but in a dist

276 de (BPAM121) at the highest concentration of modulator tested (300 muM).

277 her, our results suggest that cGMP acts as a modulator that enhances downstream signaling while dampe

278 on assay (167 nM), whereas ponesimod, a S1P1 modulator that is currently in advanced clinical develop

279 ctors, RNA stability factors, and epigenetic modulators that act in complex, interconnected positive

280 basis for the development of small molecule modulators that would reduce Abeta production.

281 CFTR modulator therapy with tezacaftor-ivacaftor or ivacaftor

282 measure a cell's transcriptome and its sgRNA modulators, thus quantifying the effects of dCas9-KRAB-m

283 Thus, MB-10 is the first small molecule modulator to attenuate PAM complex activity, likely thro

284 the ability of three benzothiadiazine-based modulators to potentiate glutamate-evoked currents at re

285 it the Hm1a spider toxin, a Nav1.1-selective modulator, to better understand the relationship between

286 s a close relationship with the neuropeptide modulator vasopressin.

287 s adverse effect is to develop selective VDR modulators (VDRMs) that differentially activate BGLAP bu

288 as reversed by the mGlu3-negative allosteric modulator VU0650786.

289 riments in the presence of the allosteric MR modulators W84 (8) or LY2119620 (9) (Schild-like analysi

290 GAT211, a novel CB1 positive allosteric modulator, was evaluated for antinociceptive efficacy an

291 ks in the second dimension using the thermal modulator were 30-55% narrower than with the valve modul

292 -encoding gene and B-cell receptor signaling modulator, were associated with improved PFS.

293 Caffeine, one identified NMNAT2 positive-modulator, when systemically administered restored NMNAT

294 These results describe a new cereblon modulator which achieves greater substrate degradation v

295 Here the authors develop hPXR modulators, which are of potential therapeutic interest

296 potentiating effects of positive allosteric modulators, which can be used to quantify in situ positi

297 of nonsteroidal selective androgen receptor modulators, which have not been approved by the US Food

298 that acts as an N-methyl-D-aspartate (NMDA) modulator with glycine-like partial agonist properties;

299 We hypothesized that S1P1 receptor modulators with pathway-selective signaling properties c

300 s then co-binding with a positive allosteric modulator would greatly enhance their function in physio