ライフサイエンスコーパス: modulatory

1 e is not homogenous and that it is primarily modulatory.

2 Mesenchymal stromal cells (MSCs) have immune modulatory abilities and earned their place in the treat

3 its a mechanism for amplifying noradrenergic modulatory actions and enhancing the processing of high-

4 h aromatase inhibitory and estrogen receptor modulatory activities could have special advantages for

5 cluding WN-8, for which "bryostatin-like PKC modulatory activities" previously was suggested solely o

6 on-elongation coupling that underlies robust modulatory activity of RA in innate immunity.

7 nding of these compounds to AcrB affects the modulatory activity on the efflux of other substrates.

8 ur results show that Tconvs exert a powerful modulatory activity on therapeutic Tregs and clearly dem

9 splayed robust allosteric agonism but little modulatory activity.

10 and inactive tPA demonstrated similar immune modulatory activity.

11 Curcumin seems to be a promising host modulatory agent in periodontal disease pathogenesis reg

12 We evaluated pomalidomide, an oral immune modulatory agent, in patients with symptomatic KS.

13 within 6 years (33.6 per 1000 p-y for immune-modulatory agents and 43.7 per 1000 p-y for anti-TNF age

14 rosis factor [anti-TNF], conventional immune-modulatory agents, or no immune suppression).

15 e index cancer (32.9 per 1000 p-y for immune-modulatory agents, P = .86; and 21.0 per 1000 p-y for an

16 een shown to disrupt both the sodium-current-modulatory and cell-adhesive functions of beta1 subunits

17 Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cell

18 Binding of a modulatory antibody to the cysteine-rich domain liberate

19 and the external environment, functions as a modulatory apparatus that controls not only microbial ki

20 ironment, suggesting the potential of immune-modulatory approaches for treating lung cancer with aber

21 2s from metazoa rather than protozoa, though modulatory aspects of myosin motor function are distinct

22 -activated potassium (BK) channels and their modulatory beta-subunits are able to dampen or stop exci

23 ptor states reveal a molecular switch in the modulatory binding site that mediate the allosteric inhi

24 ilitated pain processing and/or reduced pain-modulatory capabilities are regarded as pronociceptive,

25 ding nociceptive processing and reduced pain-modulatory capacities.

26 These features are in accordance with the modulatory capacity of G-Neutrophils on regulatory T cel

27 nd further highlight a novel thalamocortical modulatory capacity that may explain the efficacy of mag

28 ibody binding, endowed Bla g 2 with a T-cell modulatory capacity.

29 l the cholinergic basal forebrain as a major modulatory centre underlying feeding behaviour.

30 G) is a key structure in the descending pain modulatory circuit.

31 gests key differences in the organization of modulatory circuitry between the auditory and visual pat

32 nding nociceptive and weaker descending pain-modulatory components.

33 ng molecular mechanisms and binding sites of modulatory compounds, we know just the tip of the iceber

34 nicate through dense synaptic, electric, and modulatory connections and develop through concurrent gr

35 sponse properties: (1) surround suppression--modulatory contextual stimuli suppress responses to driv

36 Gene expression of interleukin-10, an immune-modulatory cytokine, was significantly (P < 0.05) increa

37 viral factors, type 1 interferon, and immune modulatory cytokines, that act in concert to restrict vi

38 P3-binding domain and varying lengths of the modulatory domain, did not form functional channels when

39 Next, we describe the main modulatory drives of sleep and wakefulness, including ho

40 5-83) years, and had received both an immune modulatory drug (IMiD) and proteasome inhibitor: (35 [73

41 can be reversed using alendronate, an immune modulatory drug.

42 Although in some cases space plays a modulatory effect (itself of interest), in other cases,

43 owing specific involvement of NMDARs in this modulatory effect and suggesting that activation of NMDA

44 that plasma hyperosmolality exerts a central modulatory effect governing efferent thermoregulatory ac

45 The modulatory effect is based on the joint action of three

46 To determine the immune modulatory effect of anti-LPS enriched hyperimmune colos

47 In this study, we investigated the modulatory effect of gedunin, a limonoid from species of

48 Importantly, the modulatory effect of PHB1 is not dependent on its known

49 We find that in the awake macaque the modulatory effect of serotonin is surprisingly uniform:

50 protein-coding MSI target locus itself has a modulatory effect on EWSR1 gene expression through alter

51 Second, this modulatory effect on intrinsic correlations exhibited a

52 polymorphism of amyloid aggregates and their modulatory effect on neurodegeneration.

53 sistent sodium current (INap), abolished the modulatory effect on sighs, while flufenamic acid, an an

54 functional A2A receptors, which have a weak modulatory effect on the A1-mediated suppression, at abo

55 lts suggest that attention has a cross-modal modulatory effect on the vestibular cortex during visual

56 minocervical complex, suggesting a potential modulatory effect that may underlie its utility in migra

57 ri coinfection effectuates a systemic immune modulatory effect with decreased T-cell activation in HI

58 strength with increasing anaplasia implied a modulatory effect.

59 t siblings exert a transferable early immune modulatory effect.

60 (2) a remarkable spatial specificity of this modulatory effect.

61 otransmitters act in conjunction with slower modulatory effectors that accumulate in restricted synap

62 otransmitters act in conjunction with slower modulatory effectors that accumulate in restricted synap

63 ata suggested that the positive and negative modulatory effects are mediated by different gating step

64 lator of Cav1.2 in neurons, but has distinct modulatory effects compared with its regulation of Cav1.

65 These contrasting patterns of modulatory effects could allow PMd and PMv to play disti

66 The patterns of modulatory effects from PMd were compared with those fro

67 ; moreover, they are associated with diverse modulatory effects in innate and adaptive immunity.

68 obtain a complete in vitro evaluation of the modulatory effects of a prebiotic on microbiota, it is n

69 The present study explored modulatory effects of acute, subanaesthetic doses of ket

70 fore argue that emphasis should shift toward modulatory effects of amygdala-driven changes at the net

71 both pleural cytokine environment and direct modulatory effects of antibiotics.

72 of these studies is confounded by potential modulatory effects of antipsychotic medication on microg

73 The current study focuses on studying the modulatory effects of b-AP15 on death receptor 5 (DR5) l

74 Antagonists were unresponsive to the modulatory effects of BMS-986122.

75 ) translation and Abeta levels, and that the modulatory effects of cAMP on LTP occur through the stim

76 In addition to analgesia, modulatory effects of EA on spinal sympathetic outflow r

77 To investigate the immune modulatory effects of ibrutinib, we completed comprehens

78 dative phosphorylation in MDMs prevented the modulatory effects of MSCs.

79 Little is known about immune-modulatory effects of nilotinib in vivo, potentially pre

80 These results do not support strong modulatory effects of OPRM1 genetic variation on opioid

81 osine 470 and 88 are critical for allosteric modulatory effects of SRI-compounds on the interaction o

82 However, the modulatory effects of stimulation frequency are not only

83 alitatively different mechanisms control the modulatory effects of stress on extinction and plasticit

84 We also investigated the modulatory effects of Th2 cytokines on Toll-like recepto

85 Several mechanisms mediate the modulatory effects of TLR10: on the one hand, cotransfec

86 Negative modulatory effects of trait anger on amygdala-dorsolater

87 Here we investigated the allosteric modulatory effects of two allosteric ligands, SRI-20041

88 to evaluate inherent toxicity and potential modulatory effects on Abeta42 toxicity.

89 LSD has profound modulatory effects on consciousness and was used extensi

90 Several mimics exhibited selective modulatory effects on hUII- and URP-associated vasoconst

91 een shown to have both positive and negative modulatory effects on NMDAR currents generally in a subt

92 rbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult an

93 n in normal blood B cells, but without clear modulatory effects on these factors.

94 udy revealed that buprenorphine mediates its modulatory effects on transmission at spinal C-fiber syn

95 Dopamine (DA) has long been known to have modulatory effects on vertebrate motor circuits.

96 Breastfeeding may have immune modulatory effects that influence the development of chi

97 Individual neurons can exhibit multiple modulatory effects, with considerable variability across

98 tic EPSP amplification mechanisms limit the "modulatory" effects of corticothalamic synaptic inputs o

99 Thus, Ska3 employs additional modulatory elements within the Ska complex to ensure rob

100 d isolates of rabies virus is a viral immune-modulatory factor playing an important role in this RelA

101 irely within individual subunits, almost all modulatory factors affecting iGluRs appear to bind to si

102 g, identifying the underlying mechanisms and modulatory factors involved, and establishing the most e

103 Our model requires only the existence of modulatory feedback connections between areas, and short

104 which provides a strong, activity-dependent modulatory feedback influence on information flow throug

105 We propose that Jmjd6 exerts its splice modulatory function by interacting with specific SR-rela

106 Contextual processing is a key modulatory function of hippocampal-prefrontal-thalamic c

107 The modulatory function of individual microRNAs (miRNAs) in

108 manner that was largely dependent on its own modulatory function.

109 inflamed tissue is crucial for their immune-modulatory function.

110 pic glutamate receptors have a wide range of modulatory functions in the central nervous system.

111 e paralemniscal route is chiefly involved in modulatory functions rather than simply being an informa

112 ntimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (

113 Chemokines have been shown to play immune-modulatory functions unrelated to steering cell migratio

114 coinhibitory molecule of the B7/CD28 immune modulatory gene family.

115 rther suggesting them as good candidates for modulatory genes in the auditory system.

116 enriched mushrooms extracts exerts an immune modulatory hepato-protective effect in NASH model.

117 the distributed, but anatomically specific, modulatory impact of cerebellar effects on large-scale n

118 f this complex exhibited negative allosteric modulatory impact on secretin-stimulated cAMP responses

119 ch a complex exhibited a positive allosteric modulatory impact on the same signaling event.

120 pendent on their origin, these inputs can be modulatory in many ways and, for example, change the neu

121 arious hypotheses put forward to explain the modulatory influence of helminth infection on allergic e

122 he findings highlight that accommodating the modulatory influence of ongoing experience represents a

123 f attitudes and values by exerting a distant modulatory influence on cortical areas and their recipro

124 extend fibers throughout the brain and exert modulatory influence over numerous physiological systems

125 o cortical excitatory input and broaden the "modulatory" influence exerted by corticothalamic synapse

126 t with the idea that the SSN can account for modulatory influences along different stimulus dimension

127 We tested for specific patterns of modulatory influences in the domain of motion direction,

128 ested the generality of the SSN by examining modulatory influences in the middle temporal area (MT) o

129 or brain region, we wondered whether similar modulatory influences might be observed for other stimul

130 We sought to assess the modulatory influences of a major neurotransmitter, dopam

131 not the pre-SMA- exerts intensity-dependent modulatory influences over M1 within the explored time w

132 These modulatory influences seem to disappear after 12lambda.

133 been proposed to account for these and other modulatory influences, and tested in V1.

134 ralinear network (SSN), can account for such modulatory influences, using a small set of computationa

135 rojection neurons convey sensory, motor, and modulatory information to several distinct anatomical re

136 neurons receive excitatory, inhibitory, and modulatory input from diverse sources.

137 ion of pauses typically involves synaptic or modulatory input, intrinsic membrane properties may also

138 by which sensory networks integrate multiple modulatory inputs are not well understood.

139 reconfiguration following altered sensory or modulatory inputs to generate stereotyped outputs.

140 ish orthogonal networks with feedback loops, modulatory inputs, and efferents.

141 ol of inhibition in PG neurons can allow for modulatory inputs, like the cholinergic inputs from the

142 sensory event over responses to less urgent, modulatory inputs.

143 Our observations suggest a modulatory (instead of a "driver") role of the corticoth

144 Understanding the function of modulatory interneuron networks is a major challenge, be

145 nomena (including a potential alternative QS-modulatory ligand binding site/partner) that provide new

146 stal structures of Japanin, an 18 kDa immune-modulatory lipocalin from the Brown Ear Tick (Rhipicepha

147 Here, we identified a conserved immune modulatory mechanism that governs the interaction betwee

148 th two stages, each incorporating a divisive modulatory mechanism, reproduces our experimental result

149 (ER), raising a possibility of S1R-mediated modulatory mechanisms different than conventionally thou

150 overies that have changed our view of immune modulatory mechanisms employed by bacterial pathogens, f

151 These results reveal novel modulatory mechanisms for GluN1/GluN3A receptors that fu

152 at intervening with endogenous ADAM sheddase modulatory mechanisms holds potential as a general strat

153 de it difficult to infer the impact of these modulatory mechanisms on behavioral responses.

154 ified in recent years, little is known about modulatory mechanisms.

155 lts in high surface expression of the immuno-modulatory molecule programmed death receptor ligand 1 (

156 egrin ligand (DC-HIL), a cell surface immune-modulatory molecule, is highly expressed on tumor-associ

157 tifies a novel class of host-directed immune modulatory molecules that activate IRF3 to promote host

158 are identifying key helminth-derived immune modulatory molecules that may have therapeutic usefulnes

159 Identifying allosteric modulatory molecules with potential attenuation of cocai

160 lammatory cytokines, increased production of modulatory molecules, and failure to restrict parasite r

161 e type I interferons (IFNs) and other immune modulatory molecules.

162 Enhancing immune responses with immune-modulatory monoclonal antibodies directed to inhibitory

163 conclude that phophocholine activates immuno-modulatory nAChR expressed by monocytes but does not sti

164 teroventral BST as a nodal point in a stress-modulatory network for coordinating neuroendocrine and b

165 s that they target, and that even a two cell modulatory network has highly heterogeneous, yet stereot

166 d with differential engagement of the limbic modulatory network.

167 tory immunoreceptors to produce C1q-mediated modulatory networking.

168 making requires characterizing the multiple modulatory neural circuits underlying the different mean

169 ified connections: reciprocal Kenyon cell to modulatory neuron connections, modulatory neuron to outp

170 stem as a model to establish a framework for modulatory neuron connectivity.

171 Additionally, modulatory neuron output can be stereotyped, yet nonunif

172 r target networks is not well understood, as modulatory neuron populations are heterogeneous in their

173 enyon cell to modulatory neuron connections, modulatory neuron to output neuron connections, and a su

174 The connectivity of individual modulatory neurons can be complex, as they often receive

175 We demonstrate that individual modulatory neurons can integrate neuron class-specific i

176 Our results demonstrate that modulatory neurons do not necessarily provide purely top

177 ttern of connectivity.SIGNIFICANCE STATEMENT Modulatory neurons often project broadly throughout the

178 Modulatory neurons project widely throughout the brain,

179 t for cortical plasticity, it is unknown how modulatory neurons themselves respond to changes of sens

180 However, the connectivity of individual modulatory neurons to their target networks is not well

181 nciples about the connectivity of individual modulatory neurons, we examined a pair of identified neu

182 wirelessly broadcast from a small number of modulatory neurons.

183 ationships that underlie network function of modulatory neurons.

184 Furthermore, FAK's immuno-modulatory nuclear activities may be specific to cancero

185 n Zn(2+) and Ca(2+) signalling in this Kv2.1 modulatory pathway is established.

186 , which could represent an underlying immune modulatory pathway.

187 s directed to pOFC expressed VGLUT1 found in modulatory pathways.

188 Application of the modulatory peptide neurotensin (NT) to midbrain dopamine

189 slices from mice we have discovered that the modulatory peptide neurotensin can induce a persistent s

190 Priming of radula opening occurs when two modulatory peptides [feeding circuit activating peptide

191 ion with Clostridium difficile and an immune-modulatory probiotic.

192 The modulatory processes include signaling by the neuropepti

193 ly variable across observers and can reflect modulatory processes that are dissociated from perceptua

194 This work shows that modulatory processes within the medial nucleus of the am

195 Attention, like other modulatory processes, is also associated with changes in

196 nes with potent anti-inflammatory and immune modulatory profiles.

197 a-2-macroglobulin (alpha2MG), a protein with modulatory properties in inflammation.

198 Here we report previously unrecognized modulatory properties of members of the Ly6 protein fami

199 ve, differentiative, chemotactic, and immune-modulatory properties required to promote tissue repair.

200 ine is a tetracycline antibiotic with immune-modulatory properties that decreases the severity of EAE

201 helps resolve infections through its immune modulatory properties.

202 anticancer drugs that have important immune-modulatory properties.

203 This modulatory property of hBD2, unrelated to antibacterial

204 Thus, Shisa7 is a bona-fide AMPAR modulatory protein affecting channel kinetics of AMPARs,

205 This regulation requires the chromatin modulatory protein Alhambra (Alh).

206 lete multidrug efflux pump in complex with a modulatory protein partner from E. coli.

207 Therefore, CaMKIIdeltaB may serve as a novel modulatory protein to enhance CPC survival and commitmen

208 diverse, including intact pathogens, immune-modulatory proteins, and molecules normally found within

209 Human cytomegalovirus encodes several immune modulatory proteins, including the G protein-coupled rec

210 neurons, suggesting that they have a largely modulatory rather than driving influence on auditory mid

211 TLR10 is a modulatory receptor of innate immune responses to cSSSI-

212 hanism, we found that AG binds to the immune modulatory receptors DC-specific ICAM-3 -: grabbing non

213 edial medulla (RVM) and other brainstem pain-modulatory regions, including the ventrolateral periaque

214 ication with vessel patterning might involve modulatory regulatory factors such as R-spondin 1 (Rspo1

215 re are dual systems of emotion and reason, a modulatory relationship more accurately reflects the cur

216 atal signal in these interactions suggests a modulatory relationship of the striatum over the hippoca

217 This suggests that the modulatory relationship of the subthalamic nucleus on in

218 nce of stable network activity, and mediates modulatory responses to the neuropeptide substance P.

219 during low-oxygen growth, saNOS also plays a modulatory role during aerobic respiration.

220 These results reveal a pivotal modulatory role for d-serine in neurodevelopment.

221 Together, these data support a modulatory role for phosphorylation at NEK3 Thr-165 in f

222 These results indicate a modulatory role for TAAR1 in sleep/wake and cortical act

223 important pathologic conditions and plays a modulatory role in adaptive immune responses.

224 bset of mouse FHR proteins have an important modulatory role in complement activation.

225 fer we have discovered that Ulk4 plays a key modulatory role in corticogenesis.

226 Thus, HBL1 plays a modulatory role in fine-tuning human-specific cardiomyoc

227 ast evolution and have only a minor, largely modulatory role in gene regulation under diverse trophic

228 e-related variation of TK is suggestive of a modulatory role in locomotion behavior in C. fortis.

229 eceptor tyrosine kinase, which has a central modulatory role in multiple proinflammatory signaling pa

230 G-protein signaling 9-2 (RGS9-2) plays a key modulatory role in opioid, monoamine, and other G-protei

231 -related changes in neuropeptides indicate a modulatory role in sensory input regions and higher orde

232 eosomal components that play a peripheral or modulatory role in splicing, presumably retaining those

233 Serum vitamin D may play an immune-modulatory role in the development of natural tolerance.

234 Our results provide novel evidence for a modulatory role of androgens in the differentiation of T

235 ort the knockout data indicating the crucial modulatory role of ASIC1a channels in the NMDAR-dependen

236 us, our data demonstrate an important immune modulatory role of B cells during Pneumocystis lung infe

237 lamic neurons to their activation, suggest a modulatory role of corticothalamic afferents upon the pr

238 Here we reveal a more complex modulatory role of GHS-R1b.

239 This study set to assess the potential modulatory role of harmane on the basal or K(+) stimulat

240 To confirm a possible modulatory role of IL-6 on MMPs, the relationship betwee

241 To investigate the modulatory role of lateral input from the same level of

242 plasma membrane, consistent with a specific modulatory role of NFM in D1-receptor recycling.

243 -based approach, we demonstrate an important modulatory role of PKMzeta in synaptic plasticity and se

244 nd dynamics, suggesting a dual counteracting modulatory role of SHOC2 in the control of ERK signallin

245 The modulatory role of spontaneous brain oscillations on per

246 The modulatory role of stability was sex specific, where hig

247 results demonstrate the network dynamics and modulatory role of the prefrontal cortex that underpin i

248 thereby revealing a tumor-supportive immune-modulatory role of the TRAIL/TRAIL-R system in cancer bi

249 usly unidentified molecular insight into the modulatory role of this protein in cardiac muscle contra

250 umocystis lung infection that complement the modulatory role of type I IFNs to prevent systemic compl

251 Taken together, our findings reveal a modulatory role of USP7 in PCNA ubiquitination-mediated

252 receptor-receptor coupling seems to serve a modulatory role on both channels, this might not be its

253 oreover, although visual stimulation plays a modulatory role, it is neither necessary nor sufficient

254 but also suggests that, in addition to their modulatory role, the family of P2X receptors could have

255 and/or postsynaptically, where they mediate modulatory roles and in glial cells.

256 the inflamed lung, with key microbicidal and modulatory roles in innate host defense against infectio

257 -AG production and CB1 activation play a key modulatory roles in normal intestinal mucosa permeabilit

258 These findings suggest differential modulatory roles of pIFG and pre-SMA in M1 excitability.

259 main" for AMPARs, with other domains playing modulatory roles.

260 n-directed conditions, the associated shared modulatory signal decreases in variance.

261 Finally, the recovered modulatory signals reflect previous reward, and are pred

262 el reveals four separate time-varying shared modulatory signals, the dominant two of which each targe

263 ant sensory neurons can reflect postdecision modulatory signals.SIGNIFICANCE STATEMENT When observers

264 The identification of a new NMDAR modulatory site and characterization of GluN2A-selective

265 ested that the A-967079 cavity is a positive modulatory site for propofol.

266 hese proteins also contain a large number of modulatory sites, making them attractive potential targe

267 ns to define the therapeutic value of immune-modulatory strategies in DS.

268 hese pathways are targeted as part of immune modulatory strategies to treat cancers, referred to gene

269 the LOST model to accommodate changes in the modulatory structure over the duration of the experiment

270 eraction between ks-vFLIP and the IKK kinase modulatory subunit IKKgamma.

271 a physical interaction between vFLIP and the modulatory subunit IKKgamma.

272 from its capacity to form a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, I

273 Thus, these modulatory subunits could be potential drug targets for

274 K(+) channel modulatory subunits KChIP1, KChIP2, and DPP10 are coexpr

275 study is the first to show that K(+) channel modulatory subunits KChIP1, KChIP2, and DPP10 are potent

276 x, this study demonstrates that K(+) channel modulatory subunits KChIP1, KChIP2, and DPP10 participat

277 e four pore-forming Kir6.2 subunits and four modulatory sulfonylurea receptor (SUR) subunits.

278 response to motivational demands may cause a modulatory switch from inhibition to enhancement of hipp

279 y (PAG), a key region in the descending pain modulatory system (DPMS) between migraine without aura (

280 ulla (RVM) is a relay in the descending pain modulatory system and an important site of endocannabino

281 m, and key structures of the descending pain-modulatory system such as the PAG, the hypothalamus, and

282 ting that dopamine constitutes an endogenous modulatory system.

283 stence of parallel opioid and nonopioid pain modulatory systems and highlight the ability to dissocia

284 , it remains unclear whether global, diffuse modulatory systems comprehensively affecting brain activ

285 whether these states are mediated by unitary modulatory systems globally affecting brain activity, or

286 riod of rapid brain development, before pain modulatory systems reach maturity, will predict pronounc

287 and depend upon the activation of endogenous modulatory systems.

288 plication, assembly, or secretion and immune modulatory therapies are in development.

289 th development of novel antiviral and immune modulatory therapies such that approval of new treatment

290 Combination of antiviral and immune modulatory therapies will likely be needed to achieve fu

291 ses, and it impacts the design of IL-1-based modulatory therapies.

292 mechanism is likely to benefit future immune-modulatory therapies.

293 tential impact on the optimization of immune-modulatory therapies.

294 ns have centered on the potential for immune modulatory therapy to improve long-term patient outcomes

295 Recent studies have centered on immune-modulatory therapy.

296 ct of which is subject to modulation by slow modulatory transmitter systems.

297 Neuropeptide Y (NPY), a stress modulatory transmitter, is associated with posttraumatic

298 The contribution of modulatory transmitters to anti-Hebbian LTP induction re

299 ensitivity and rate of fusion correlate with modulatory upstream roles in docking and priming rather

300 P platform can be used as an immune response modulatory vaccine for active cancer immunotherapy witho