ライフサイエンスコーパス: module

1 ing a hydrophobic patch on the catalytic AA9 module.

2 nd intolerance documented in the EHR allergy module.

3 naffected by deletion of the kidney-specific module.

4 n-RING ubiquitin ligase complex' in the TQ-r module.

5 ulate transcription independently of the HAT module.

6 rategy to identify an asthma-associated gene module.

7 embedded but self-sufficient quality control module.

8 we found that SMIT1 binds to the KCNQ2 pore module.

9 WbbB contains three glycosyltransferase (GT) modules.

10 by a significant change in functional brain modules.

11 y curved association fibers terminate within modules.

12 and robustness of detecting DC pairs and DC modules.

13 ormation processing difference between these modules.

14 ally expressed kidney-active or liver-active modules.

15 lude samples or enable additional processing modules.

16 ing networks is one strategy for identifying modules.

17 e the structural, replication and expression modules.

18 nabling us to find optimally scoring sets of modules.

19 connects the Mediator head, middle and tail modules.

20 quires chromosomally encoded toxin-antitoxin modules.

21 d functional or biosynthetically constrained modules.

22 structures of the Seb1 CTD- and RNA-binding modules.

23 vergence between the MPK3- and MPK4-guarding modules.

24 ograms have now been designed to predict RNA modules.

25 ween modules and stronger connections within modules.

26 lysis revealed key driver genes within these modules.

27 catalyzed by the Nan[KS1][AT1] didomain from module 1 of the nanchangmycin synthase generates exclusi

28 vated in the dehydratase domain of extension-module 1 showed that this module catalyzes two successiv

29 After pressure overload, the TF genes in Module 1 were up-regulated before the occurrence of sign

30 It provides three functional modules: 1) visualization of numerical representation of

31 , -9, -10 of MgsF (i.e., DH6, DH9, DH10) and module-11 of MgsG (i.e., DH11) in vivo, followed by stru

32 (9) were incubated with SAM and BonMT2 from module 2 of the bongkrekic acid polyketide synthase.

33 ere down-regulated gradually, while those in Modules 2 and 3 took over the regulation as the heart si

34 ted by systematic inactivation of the DHs in module-6, -9, -10 of MgsF (i.e., DH6, DH9, DH10) and mod

35 losely by workshops (68%), structured online modules (63.9%) and small local working groups (59.75%).

36 domains, Atg20 uses a third membrane-binding module, a membrane-inducible amphipathic helix present i

37 We decomposed the effective model into three modules; a signal initiation module that sensed and tran

38 e patterns of genes, pathways and functional modules across different diseases and corresponding muri

39 hole picture of such higher-order regulatory modules across the transcriptome is lacking.

40 al vs. physiological responses in signalling modules acting on RLC phosphorylation and force response

41 The A.C protonation module allows extraction of new properties of the ion at

42 tissue-specific kinase-substrate interaction modules altered by somatic mutations identified by KNMPx

43 that the protein is a fusion of two distinct modules: an N-terminal sugar phosphate isomerase-like do

44 n construct consisting of an rcSso7d binding module and a cellulose-binding domain.

45 heral element of the RNA that forms a T-loop module and a subset of nucleotides in the cobalamin-bind

46 s H3K9 acetylation mediated by the ADA2/GCN5 module and increases plant susceptibility.

47 HKRD and the interaction between C-terminal module and PIF3, abrogates PHYB nuclear accumulation, ph

48 s (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction

49 cessfully to identify disease genes, genetic modules and drug targets.

50 ified with high weighted connectivity within modules and exhibited coexpression patterns with other g

51 s each or sequentially completed 11 internet modules and had weekly email contacts.

52 complex topological organization comprising modules and high-degree hubs.

53 e to the smaller size of the whisker-related modules and interference between the ipsilateral and con

54 ence, enabling identifications of functional modules and networks in the human brain.

55 ed with age, with weaker connections between modules and stronger connections within modules.

56 rmining a personalized array of intervention modules and subsequent success monitoring.

57 network that integrates distinct behavioral modules and suggest that central amygdala neurons instru

58 ication of post-transcriptional coregulatory modules and the genetic factors that impact miRNA functi

59 y usually contain sensor, linker, and kinase modules and the structure of many of these components is

60 nt-SGTA complex, a self-sufficient targeting module, and an embedded but self-sufficient quality cont

61 , strong hydrodynamic mixing in the membrane module, and high heat exchanger efficiencies.

62 se natural signal transduction networks into modules, and at the same time, they establish a library

63 ethods, content of interview and examination modules, and measurement protocols.

64 the evolutionary rate and disparity of skull modules are associated with their developmental origin,

65 e analysis revealed that a majority of these modules are conserved in Picea abies The high spatial re

66 e first time morphological and developmental modules are described for the paired fins of chimaeras.

67 Differentially co-expressed seed modules are first detected by optimizing an energy funct

68 The modules are popular with the students and usually oversu

69 Discontinuous layer 2 modules are positive for AChE, NADPH-d, GAD, and CO thro

70 11726 has shown that only nineteen extension modules are required to accomplish twenty cycles of poly

71 inus-end-binding and dynein-dynactin-binding modules are required to rescue focused, bipolar spindle

72 The polymerase GT modules are separated from the GT99 chain terminator by

73 We operationalize functional modules as independent components (ICs) yielded by an in

74 Strawberry consists of two modules: assembly and quantification.

75 ocesses are coupled to co-expression network modules associated with cell proliferation, revealing ca

76 eviously unknown family-specific interaction module associations with plant reproductive development,

77 Evidence of this gene module at the protein level is found in patient tumor sl

78 oncerted rearrangements of local interacting modules at the inter-domain interface may be responsible

79 Result: we proposed a network module-based generalized linear model for differential e

80 But the module-based statistical model has not been adequately a

81 ing, the sequential activity across cortical modules became temporally more compressed, and its trial

82 hort, we demonstrate that structural network modules become more segregated with age, with weaker con

83 2-ulosonic acid) residue added by a third GT module belonging to the recently discovered GT99 family.

84 to discern driving effects in the occipital module between 100-140 ms, coinciding with the P100 visu

85 followed by a driving effect in the frontal module between 140-180 ms, suggesting that the differenc

86 ene co-expression network modules: the Brown Module (Br) containing 449 genes and the Turquoise modul

87 the YEATS domain as an acetyl-lysine-binding module, but its functional importance in human cancer re

88 hat activation of the miR390/TAS3 regulatory module by overexpression of miR390 in Medicago truncatul

89 In this way, specific neural modules called barreloids and barrels in the contralater

90 als a mechanism by which the dynamic TTD-PHD module can be allosterically targeted with small molecul

91 An alignment-free module can be run directly on FASTQ files for a quick in

92 Furthermore, we found that the DUB module can bind to chromatin and regulate transcription

93 Our PWM module can combine up to six different inputs and select

94 endently controllable, and show that the PWM module can execute rapid concentration changes as well a

95 The module can produce concentrations with a dynamic range o

96 As a result, such conserved functional modules can be identified through comparative analysis o

97 omain of extension-module 1 showed that this module catalyzes two successive elongations with differe

98 d coils and a family-48 carbohydrate binding module (CBM48) and are homologs of the PROTEIN TARGETING

99 in non-catalytic type A carbohydrate-binding modules (CBMs) that specifically bind to the crystalline

100 ein containing 20 complement-control protein modules (CCPs 1-20), may be compromised by disease-linke

101 ified four functional pathways within the Br module (cellular respiration, intracellular transport, e

102 he input gene set into coherent co-expressed modules (CEMs), while assigning the posterior probabilit

103 0 kilobases in size that encode a structural module characteristic of head-tailed viruses and, unusua

104 Each of the GT102 and GT103 modules characterized here represents a previously unrec

105 GroES(7) variants with two or three mutated modules collaborated with GroEL(SR) to perform chaperone

106 y a modular 2-D strategy wherein the central module, common to all our compounds, is a norbornyl moie

107 verexpression, shares a conserved regulatory module, composed by a double SOX6 binding site and a GAT

108 ned structural pathways, inter- versus intra-module connections, and rich club edge types.

109 Cis-regulatory modules contain multiple transcription factor (TF)-bindi

110 CD31(+)CD41(+)MPs), eosinophil MPs (EGF-like module-containing mucin-like hormone receptor-like 1[EMR

111 The HDAC3-PROX1 module controls the expression of a gene program regulat

112 trate that a Nek9, Nek6, and Mklp2 signaling module controls the timely localization and bundling act

113 tage; E-box-binding homeobox 1 (ZEB1) in the module correlated with postcardiac mesoderm.

114 network analysis identified three expression modules correlated with GLS disease scores.

115 ndings, we hypothesized that this BBX32-COL3 module could be an additional regulatory mechanism affec

116 raction network analysis to identify network modules critical to the PD pathway and disease mechanism

117 lesions within the endogenous cis-regulatory module (CRM) required for kni expression in the L2 vein

118 ntification of de novo active cis-regulatory modules (CRMs) and individual transcription factor (TF)

119 odal/TGF-beta signaling, with cis-regulatory modules (CRMs) during mesendodermal specification.

120 of technologies for locating cis-regulatory modules (CRMs) genome-wide, the next pressing challenge

121 Functional correlations suggest the lateral module deals preferentially with environmental sensory-m

122 sory-motor interactions and the ventromedial module deals preferentially with visceral control, affec

123 udy has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basa

124 tive mechanical behavior of the two types of modules distinguished by unique force-extension signatur

125 mber of its commissural connections; and the module (dorsomedial) lying closest to the corpus callosu

126 isomal membrane at the docking/translocation module (DTM).

127 the Shape condition in occipital and frontal modules during the encoding period of the right screen c

128 Accordingly, inactivation of the miR390/TAS3 module, either by expression of a miR390 target mimicry

129 mQTL is in ARHGEF3 (rs1354034) and affects a module enriched for platelet function, independent of pl

130 30), the EORTC head and neck cancer-specific module (EORTC QLQ-H&N35), and the three-level European Q

131 ould be sufficient to engage the appropriate modules, even in the absence of contextual information n

132 type of multi-gene restriction-modification module, expanding the arsenal of defence systems known t

133 Genome-wide scans for module expression quantitative trait loci (mQTLs) reveal

134 The self-complementary design of these modules facilitates their assembly in both toluene-d8 an

135 ppress host immunity, a carbohydrate-binding module family 1 (CBM1) protein domain suppressed GH12 pr

136 that SMITE outperforms Functional Epigenetic Modules (FEM), the current paradigm of using the spin-gl

137 tion in keratocytes may constitute a general module for establishing excitable actin dynamics in othe

138 These structures reveal a module for lipid binding that is unparalleled within the

139 h 2015 and was the pilot site for an RI data module for the National Health Management Information Sy

140 ein kinases (MAPKs) form important signaling modules for a variety of cellular responses in eukaryoti

141 network analysis is applied to explore gene modules for gene expression profiles through weighted co

142 acquisition hardware, and includes standard modules for implementing common electrophysiology protoc

143 s, 30% consist of strongly co-expressed gene modules for which new members are predicted.

144 an easy-to-use UNIX package, and as a python module, for integration into pipelines of paired-genomic

145 inatory scoring function using enzyme design modules from Rosetta and AMBER's MMPBSA.

146 ere, we identified a kidney-specific control module governed by a renal cell-specific chromatin struc

147 Unsteady modules happen owing to strengthen links among funds dur

148 Our results suggest that the DUB module has functions within SAGA and independent functio

149 d allergy, suggesting that the EHR's allergy module has the potential to be used for clinical and epi

150 thase enzymology, namely the definition of a module, has been challenged by Abe and co-workers in the

151 lberg Retina Tomograph 3 with Rostock Cornea Module; Heidelberg Engineering, Heidelberg, Germany).

152 YEATS domain as a novel acetyllysine-binding module; however, the functional importance of YEATS doma

153 ese MRs may correlate with the innate immune module identified by Breen et al.

154 nomic deletion of key components within this module in mice resulted in loss of either PTH induction

155 terestingly, we also observed the same motif module in the in silico constructed ancestral TE that al

156 Zf-GRF domain as a nucleic acid interaction module in the regulation of a key single-strand break re

157 A lipid-binding module in TMEM24 transports the phosphatidylinositol 4,5

158 be the substrate tolerance of the PikAIII-TE module in vitro.

159 dagogical and research results from a sample module in which we challenged our students to study the

160 hromosomal contact map and densely connected modules in a network, we formulate TAD identification as

161 Functional modules in biological networks consist of numerous biomo

162 g modules in ovine strains, compared to five modules in bovine strains (C-type).

163 spacer, facilitates the aggregation of these modules in DCM-d2 solution, through halogen bonding, for

164 incorporate I25 mutations in selected GroES modules in GroES(7).

165 (RNA-seq) reveals enrichment of homeostatic modules in monocytes and DCs from human metastatic melan

166 y mps1, contains three amino acid specifying modules in ovine strains, compared to five modules in bo

167 There are mainly five functional modules in TFBSbank aimed at characterizing ChIP peaks,

168 dentified networks of interacting functional modules in the gray-matter, limited research was directe

169 Client-SGTA engagement of the targeting module induces rapid, private, and committed client tran

170 of the retromer complex, an ancient protein module initially discovered in yeast that regulates the

171 Our Significance-based Modules Integrating the Transcriptome and Epigenome (SMI

172 ertions might have brought in cis-regulatory modules into the mouse genome.

173 ession network analysis also identified gene modules involved in cell migration and adhesion, process

174 differential evolutionary constraints on the modules involved in the signaling cascade.

175 elopment is regulated by distinct signalling modules involving protein phosphorylations.

176 t a separate Nek9, Nek7, and Kif14 signaling module is required for the recruitment of the Rho-intera

177 The T2D module led to a significant increase in the percentage o

178 network selectively identified SA, genes in modules linked to epithelial growth and repair and neuro

179 nt), and one functional pathway within the T module (M-phase).

180 ese genes belonged to the same co-expression module, mapped to the epidermal differentiation complex,

181 mechanisms controlling these transcriptional modules may open new avenues for the development of ther

182 onjugation of two angiogenesis-related small modules may result in novel and stable molecules, which

183 ivated protein kinases 2/3 (MK2/3) signaling module mediates the IL-13, but not the IL-6, production.

184 The gene module most highly associated for COPD in Weighted Gene

185 ze of only 82 amino acids, resemble the pore module of all complex K(+) channels in terms of structur

186 Here we show that the C-terminal module of Arabidopsis phytochrome B (PHYB) is sufficient

187 ructure of PRL-1 in complex with the Bateman module of CNNM2 (CNNM2BAT), which consists of two cystat

188 JAK-dependent activation of the rho module of integrin affinity triggering mediates chemokin

189 evidence of mouse-specific TEs that encode a module of TF-binding sites in mouse embryonic stem cells

190 LUMED-ISDB, an open-source, freely-available module of the popular PLUMED library, which enables the

191 iting the CDK-7/CYH-1 (CDK7/cyclin H) kinase module of the transcription initiation factor TFIIH.

192 ) and represents an intracellular regulatory module of the transporter.

193 perone system promotes the assembly of a key module of U5 snRNP while assuring the quality control of

194 imate evolvability in the face and braincase modules of a clade of teleost fishes (Gymnotiformes) and

195 ysis suggests that, although the replication modules of at least some classes of viruses might descen

196 lant homeodomain mutants reveals that reader modules of BAZ1A and BAZ1B, even when non-standard, are

197 pression network analysis identified 5 and 3 modules of genes correlated with PK parameters and a por

198 Co-expression network analysis revealed 20 modules of highly interconnected genes; two of the modul

199 nal coactivator that contains four different modules of subunits.

200 was enhanced considerably by adding two new modules of The Cancer Genome Atlas (TCGA) RNA-Seq analys

201 sights into their regulatory role in defined modules of the JA network.

202 y of p53 in TECs altered multiple functional modules of the mTEC transcriptome, including tissue-rest

203 nd for the non-canonical PHD and bromodomain modules of the paralog BAZ1A.

204 ing IPV introduction and the value of the RI module on monitoring new vaccine introduction.

205 -helix bundle in the middle and zinc-binding modules on each side.

206 The gluconeogenic module operates through assisted loading, whereby GR dou

207 n superior ability as compared to the single modules or their simple combinations.

208 climate model EMAC with the organic aerosol module ORACLE to predict the phase state of atmospheric

209 ggest that spatial locations of white matter modules overlap with cytoarchitecturally distinct grey m

210 The assembly module parses aligned reads into splicing graphs, and us

211 he S148C mutation into a polyketide synthase module (PikAIII-TE) to impart increased substrate flexib

212 lapI, loop L6c, and helix alpha1c of the RFK module (positions K202, E203, F206, D298, V300, E301 and

213 omodomains, which are structurally conserved modules present in transcription-associated proteins tha

214 le that, along with the antigen presentation module, promoted the generation of effector T cells.

215 onging to clusters of at least 15 glomerular modules, providing a potential mechanism to integrate si

216 re-Core 30 (QLQ-C30) and -Oesophageal Cancer Module (QLQ-OES24) questionnaires pretreatment and at 3,

217 Human MSN modules recapitulate known cortical cytoarchitectonic di

218 The analysis revealed known and novel gene modules regulated by the NF-Y motif.

219 TransDetect was used to identify novel TF modules regulating the expression of Arabidopsis (Arabid

220 a previously unidentified chromatin-binding module related to Royal Family Tudor domains, which we n

221 1124 and uncharacterized RNA AK127400 in the module related to the mesoderm stage; E-box-binding home

222 how integration takes place over segregated modules remains elusive.

223 Hence, the Nek6-Hsp72 module represents a novel actionable pathway for selecti

224 nological deployment of organic photovoltaic modules requires improvements in device light-conversion

225 d short-term memory, whereas the dorsomedial module resembles the default mode network.

226 istence of a COI1-JAZ2-MYC2,3,4-ANAC19,55,72 module responsible for the regulation of stomatal apertu

227 Second, each module's contribution adapts across trials in proportion

228 ues (fastCGP), and proposed a parallel dense-module search and cross-selection strategy to identify a

229 This TCP/HD-ZIP genetic module seems to be conserved in dicot and monocotyledono

230 t that two interacting processes account for module selection during sensorimotor control and learnin

231 Basic modules sharing common pathways are merged into pathway-

232 atronic implantable artificial organs, these modules should be self-powered and autonomously operated

233 Community or module structure is a natural property of complex networ

234 containing phosphotyrosine-dependent binding modules such as Src homology 2 (SH2) and phosphotyrosine

235 ot well suited for custom MS data processing modules, such as MS storage systems or data processing a

236 tes of evolvability and constraints in these modules suggest differential responses to selection aris

237 (Br) containing 449 genes and the Turquoise module (T) containing 905 genes.

238 titute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune

239 ram activation signals; a signal integration module that controlled the expression of upstream transc

240 The co-expression module that correlated best with resistance (TQ-r; 1498

241 We designed a microfluidic module that generates complex and dynamic concentration

242 ive regulators are part of a fungal-specific module that includes a transcription factor (a Ste12 fam

243 Here we present an optical module that is easily integrated into standard two-photo

244 odel into three modules; a signal initiation module that sensed and transformed an ATRA signal into p

245 lts identify a novel intracellular signaling module that synergistically regulates CAFs and CSCs.

246 ced expression of a proinflammatory cytokine module that, along with the antigen presentation module,

247 olutionarily conserved eukaryotic signalling modules that are essential for the virulence of human pa

248 Toxin-antitoxin (TA) systems are gene modules that are ubiquitous in free-living prokaryotes.

249 c lncRNAs are intimately involved in network modules that control multiple cancer-associated signalli

250 ome, which could also contain cis-regulatory modules that coordinate the control of multiple genes wi

251 urces for the discovery of genes and genetic modules that drive disease.

252 e report a 86-kb mosaic PAI composed of four modules that encode 80 genes, including novel and known

253 ain is organized into large-scale functional modules that have been shown to evolve in childhood and

254 The application features visualization modules that include time course expression profiles, cl

255 ithFun helped identify functionally coherent modules that might be relevant for cancer progression.

256 plored the functionality of two terminal PKS modules that produce the 16-membered tylosin macrocycle,

257 ulated hierarchically by interfacing protein modules that sort polarized motility proteins to the cor

258 pression Network Analysis revealed four gene modules that were significantly correlated with disease

259 network analysis (WGCNA) identified several modules that were strongly correlated with different sta

260 verall, SUSP4 appears to use two synergizing modules, the p53 rescue motif described here and a globu

261 ented PD-specific gene co-expression network modules: the Brown Module (Br) containing 449 genes and

262 The electronic module then acquires and wirelessly transmits the data t

263 he distinction between primary and secondary modules they propose is indeed essential.

264 g highly favorable contacts to the signaling modules through rearrangement of a hydrogen bond network

265 ortable, evolutionarily tractable regulatory modules through which to create pattern.

266 upted networks contained topological network modules (TNMs) with shared properties that mapped onto d

267 cation of the recorded activity, and (iii) a module to compute the Grey Matter Proximity Index, i.e.

268 a from a thresholded post-implant CT, (ii) a module to determine the most probable cerebral location

269 SEEG Assistant consists of (i) a module to localize the electrode contact positions using

270 logical organization where trans-regulatory modules (TRMs), which consist of subsets of preferential

271 V system consisting of cascaded PV-converter modules, under partial shading conditions (PSCs).

272 he [4Fe-4S] cluster functions as the sensory module, undergoing reaction with O2 that leads to conver

273 Through its different modules, users can (i) rank a list of variants (ii) perf

274 the elevated expression of inflammasome gene modules was associated with all-cause mortality.

275 on biological networks with known functional modules, we show that CUFID-query outperforms the existi

276 s of highly interconnected genes; two of the modules were significantly enriched for BD susceptibilit

277 tream transcription factors; and a phenotype module which encoded the expression of functional differ

278 study, we focus on finding gene-gene network modules which are functionally similar in nature in the

279 Forkhead domain, a winged-helix DNA binding module, which is conserved among eukaryotes from yeast t

280 is formed by a heterohexameric AAA(+) ATPase module, which unfolds and translocates substrates into t

281 Both are members of the Cdk8 kinase module, which, with Med12 and Med13, associate with the

282 Both plant and animal CCDs were composed of modules, which are groups of strongly covarying compound

283 This action was mediated by the CABIT modules, which bound to the phosphatase domain of SHP-1

284 drug delivery" system based on two distinct modules, which is composed of a signal transmission nano

285 could identify more significantly biological modules, which related to the liver cancer.

286 range connections terminate between specific modules, whilst short range connections via highly curve

287 dentify master host cell regulator nodes and modules whose tweaking by the microbes promote aberrant

288 We identified a co-expression module with peak expression in early brain development f

289 ative approach integrates gene co-expression modules with biomolecular interaction network analysis t

290 a general framework, BeWith, for identifying modules with different combinations of mutation and inte

291 l treatments associated individual conserved modules with distinct biological processes underlying wo

292 Nine connector modules with distinct geometries were designed; for eigh

293 by the power grid express interactions among modules with fragile couplings that amplify even small s

294 First, we search for transcriptomic modules with genes that are differentially expressed in

295 Integration of Sp1 modules with genomic and epigenomic data indicates epige

296 quantitative trait loci (mQTLs) reveal five modules with mQTLs that have both cis and trans effects.

297 roaches we identify a nucleosome interaction module within KDM2A consisting of a CXXC type zinc finge

298 BB does not function independently, but as a module within the greater context of a multicellular neu

299 Specifically, modules within brain areas are spatially localised.

300 by allows detection of functional subnetwork modules within these single-cell genomic networks.