ライフサイエンスコーパス: mole rat

1 furred African mole-rat species (the common mole-rat).

2 insects), and in specialized habitats (naked mole rats).

3 g to the subterranean evolution of the blind mole rat.

4 considering the small body mass of the naked mole rat.

5 nization of somatosensory areas in the naked mole-rat.

6 the remarkable tumor resistance of the naked mole-rat.

7 ps, and beetles), snapping shrimp, and naked mole rats.

8 ge from 4 years in mice to 32 years in naked mole rats.

9 lmost cancer-proof naked mole rats and blind mole rats.

10 ociality and the unusual physiology of naked mole-rats.

11 entations of oral structures in primates and mole-rats.

12 approximately 15% of somatosensory cortex in mole-rats.

13 ular nucleus display a greater level in Cape mole-rats.

14 s were under purifying selection in bats and mole-rats.

15 and Natal (Cryptomys hottentotus natalensis) mole-rats.

16 known to occur in species ranging from naked mole rats [1] to owls [2], chimpanzees are the most acco

17 We explore this in the naked mole-rat, a species with the most rigidly organized repr

18 Here we show that the full-length mole rat alphaB-crystallin intergenic region behaves sim

19 ligonucleotides from the wild-type mouse and mole rat alphaB-crystallin promoter region under study f

20 Our data support the idea that blind mole rats' alphaB-crystallin promoter activity was modif

21 Naked mole-rats also were completely lacking in cutaneous C-fi

22 Recent studies in naked mole rat and long-lived sea urchins showed that these sp

23 cer-prone mice and almost cancer-proof naked mole rats and blind mole rats.

24 ranscriptomic data from 26 bat species, five mole-rats and 38 outgroup species.

25 GF1 axis relates to the longevity of African mole-rats and bats, we compared and analysed the homolog

26 udied in species with reduced vision such as mole-rats and bats.

27 nd examined Nrf2-signaling activity in naked mole-rats and nine other rodent species with varying max

28 erested in the genome and genes of the naked mole rat, and also to facilitate further studies on this

29 bonobo/chimpanzee, guinea pig/degu/tuco-tuco/mole rat, and cattle/yak.

30 he neurobiology of social hierarchy in naked mole-rats, and add to a growing body of work that links

31 is consistent with the hypothesis that naked mole rats are neotenous, with retention of juvenile char

32 Naked mole rats are the longest-living rodents, whose nervous

33 Naked mole-rats are eusocial rodents that live in large subter

34 atures of the cutaneous innervation in naked mole-rats are presumably adaptations to their subterrane

35 Cape mole-rats are solitary; they tolerate conspecifics only

36 African naked mole-rats are subterranean rodents that have a robust or

37 pain, which would be advantageous for naked mole-rats as they normally live under chronically high l

38 Here we cloned naked mole-rat ASIC3 (nmrASIC3) and used a cell-surface biotin

39 The blind mole rat (BMR), Spalax galili, is an excellent model for

40 campal and olfactory structures of the naked mole rat brain.

41 neuronal migration are not unusual in naked mole rat brains.

42 HMW-HA triggers hypersensitivity of naked mole rat cells to contact inhibition, which is associate

43 Furthermore, the naked mole-rat cells are more sensitive to HA signalling, as t

44 essing the HA-degrading enzyme, HYAL2, naked mole-rat cells become susceptible to malignant transform

45 In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, supporti

46 robust anchorage-independent growth in naked mole-rat cells, while it readily transforms mouse fibrob

47 f mouse fibroblasts fails to transform naked mole-rat cells.

48 of nonreproductive individuals in Damaraland mole rats closely resembles that found in other cooperat

49 Multi-year observations of large naked mole-rat colonies did not detect a single incidence of c

50 The discovery of a disperser morph in naked mole-rat colonies has revealed the first possible outbre

51 s that the more stable proteome of the naked mole-rat contributes to its longevity.

52 T(INK4a/b) of the INK4a/b locus in the naked mole rat, contributes to the increased resistance to tum

53 Naked mole-rats, despite having functional ASICs, are insensit

54 Behaviorally, naked mole-rats did not avoid fumes from moderately high conce

55 ersibly inhibits ASIC-like currents in naked mole-rat dorsal root ganglia neurons.

56 Finally, somatosensory cortex in naked mole-rats encompasses virtually all of the neocortex nor

57 at which the level of CRF1 binding in naked mole-rats exceeds that in Cape mole-rats include the bas

58 in five further members of the Bathyergidae mole-rat family: silvery (Heliophobius argenteocinereus)

59 In cell culture, naked mole-rat fibroblasts arrest at a much lower density than

60 Here we show that naked mole-rat fibroblasts display hypersensitivity to contact

61 We report that naked mole-rat fibroblasts have significantly increased transl

62 We found that naked mole-rat fibroblasts secrete extremely high-molecular-ma

63 ial DNA in the control region and ATP6 in 28 mole rats from basalt and in 14 from chalk habitats.

64 rats, Heterocephalus glaber, and Damaraland mole rats, Fukomys damarensis) suggest that individual d

65 ped a freely available web portal, the Naked Mole Rat Genome Resource, featuring the data and results

66 aneous saphenous and sural nerves, the naked mole-rat had the lowest C:A-fiber ratio ( approximately

67 In contrast to the furred species, naked mole-rats had a paucity of Abeta-fiber Merkel endings at

68 In contrast, the hairless skin of the naked mole-rats had an exceptional abundance of presumptive Ad

69 However, naked mole-rats had very few VP-ir cells in the bed nucleus of

70 region of the alpha A-cry gene of the mouse, mole rat, hamster, and human, as well as the previously

71 Blind mole rats have degenerated subcutaneous eyes that are vi

72 We speculate that naked mole rats have evolved a higher concentration of HA in t

73 In addition to its longevity, naked mole-rats have an extraordinary resistance to cancer as

74 The naked mole rat (Heterocephalus glaber) displays exceptional lo

75 The naked mole rat (Heterocephalus glaber) is a long-lived and tum

76 The naked mole rat (Heterocephalus glaber) is an exceptionally lon

77 showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber deficit m

78 The strictly subterranean naked mole-rat (Heterocephalus glaber) has markedly reduced vi

79 The naked mole-rat (Heterocephalus glaber) is a subterranean eusoc

80 The naked mole-rat (Heterocephalus glaber) is unusual in numerous

81 Naked mole-rats (Heterocephalus glaber) have a large cortical

82 Naked mole-rats (Heterocephalus glaber) have numerous anatomic

83 Naked mole-rats (Heterocephalus glaber) live in groups that ar

84 ther long-lived and cancer-resistant African mole rat, Heterocephalus glaber, the naked mole rat in w

85 studies of social mole rats (including naked mole rats, Heterocephalus glaber, and Damaraland mole ra

86 n mole rat, Heterocephalus glaber, the naked mole rat in which cells display hypersensitivity to cont

87 s; in contrast, the level is greater in Cape mole-rats in the shell of the nucleus accumbens and medi

88 ing, the sites with a greater level in naked mole-rats include the basolateral amygdaloid nucleus and

89 ding in naked mole-rats exceeds that in Cape mole-rats include the basolateral amygdaloid nucleus, hi

90 In contrast, some studies of social mole rats (including naked mole rats, Heterocephalus gla

91 Here we show that, in Damaraland mole rats, individual contributions to cooperative behav

92 The blind subterranean mole rat is a model for hypoxia tolerance with the abili

93 Tumor resistance in the naked mole rat is mediated by the extracellular matrix compone

94 sh and amphibians, suggesting that the naked mole-rat is a powerful model for exploring the mechanism

95 contrast, early contact inhibition in naked mole-rat is associated with the induction of p16(Ink4a).

96 e retinogeniculocortical system in the naked mole-rat is considerably smaller than that of rodents th

97 ution of the LG to brain volume in the naked mole-rat is less than a third of that of the rat.

98 t that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments of uneq

99 The naked mole-rat is the longest living rodent with a maximum lif

100 ber deficit in the cutaneous nerves of naked mole-rats is unlikely to be due primarily to lack of ski

101 odents were found to be more conserved, with mole-rats lacking uniquely conserved amino acid substitu

102 The preternaturally long-lived naked mole-rat, like other long-lived species and experimental

103 Naked mole-rats live in large eusocial colonies that are chara

104 Naked mole-rats live in large, subterranean colonies where bre

105 The ratios of mole rat/mouse promoter activity were 0.01 for lens, 1.7

106 Naked mole rat (MR) Heterocephalus glaber is a rodent model of

107 from the longest-living rodent known, naked mole-rats [MRs; mass 35 g; maximum lifespan (MLSP) > 28.

108 In naked mole-rat (NMR) colonies, breeding is monopolized by the

109 Naked mole rats (NMRs) live in sizable colonies where breeding

110 The blind subterranean mole rat of the Spalax ehrenbergi superspecies is an exc

111 the brains of breeding and subordinate naked mole-rats of both sexes, including several regions linke

112 the brains of subordinate and breeding naked mole-rats of both sexes.

113 When overexpressed in naked mole rat or human cells, pALT(INK4a/b) has stronger abil

114 or cortical remodeling has occurred in naked mole-rats, paralleling the anatomical and behavioral spe

115 Many different species of animals including mole rats, pigeons, and sea turtles are thought to use t

116 The reciprocal mutation in the mole rat promoter fragment ((-272)G-->CA) did not affect

117 e promoter fragment to that of the wild-type mole rat promoter when tested in transgenic mice.

118 RF1 binding in the nucleus accumbens of Cape mole-rats reflects their lack of affiliative behavior.

119 The excised fragment is unique to the naked mole-rat rRNA and does not show homology to other genomi

120 entify a mechanism responsible for the naked mole rat's cancer resistance.

121 ve contributed to the evolution of the naked mole rat's extraordinary traits, including in regions of

122 The African naked mole-rat's (Heterocephalus glaber) social and subterrane

123 er/promoter fragment mimicking the wild-type mole rat sequence functionally converted the mouse promo

124 ce lost binding ability, whereas the mutated mole rat sequence gained the ability to form a complex s

125 Overall, we conclude that naked mole rats show an extremely protracted period of brain m

126 In addition to their longevity, naked mole rats show an unusual resistance to cancer.

127 gh concentration of acetic acid (50%), naked mole-rats showed significant avoidance behavior and incr

128 pite relatively few changes in sequence, the mole rat shsp/alphaB-crystallin promoter/enhancer has se

129 We investigated naked mole-rat somatosensory cortex to determine how brain are

130 Subterranean blind mole rats (Spalacidae) are considered to speciate allopa

131 expression of Flk1 in the blind subterranean mole rat Spalax ehrenbergi.

132 Blind mole rats Spalax (BMR) are small subterranean rodents co

133 tallin enhancer/promoter fragment from blind mole rats (Spalax ehrenbergi), which have nonfunctional

134 pared with that in rats and a furred African mole-rat species (the common mole-rat).

135 RF and urocortin 3, respectively, in African mole-rat species with diametrically opposed social behav

136 the long lifespans observed in many bat and mole-rat species.

137 ein (shsp)/alphaB-crystallin promoter of the mole rat superspecies, Spalax ehrenbergi, with that of t

138 During anoxia, the naked mole-rat switches to anaerobic metabolism fueled by fruc

139 In five mole-rats the lower right incisor was extracted on eithe

140 Here, we show that, in the naked mole rat, the INK4a/b locus encodes an additional produc

141 The exception is the naked mole-rat, the only known vertebrate to show physiologica

142 performed optic nerve injury in adult naked mole-rats, the longest living rodent, with a maximum lif

143 d than that of the extensively studied blind mole-rat; this may facilitate limited responses to visua

144 is present in both cultured cells and naked mole rat tissues but is absent in human and mouse cells.

145 nsistent with exceptional endurance of naked mole rat tissues to various genotoxic stresses.

146 ctose-driven glycolytic respiration in naked mole-rat tissues avoids feedback inhibition of glycolysi

147 ular-mass HA accumulates abundantly in naked mole-rat tissues owing to the decreased activity of HA-d

148 ay reflect a further adaptation of the naked mole-rat to living in an environment with high-carbon di

149 Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive

150 r binding densities in female and male naked mole-rats varying in breeding status.

151 air follicles, and intervening skin in naked mole-rats was compared with that in rats and a furred Af

152 in other species, its distribution in naked mole-rats was of interest.

153 dinates from reproducing (for example, naked mole-rats, wasps and ants).

154 vealed that the body hair follicles in naked mole-rats were exceptionally large and well innervated,

155 sponsible for the cancer resistance of naked mole-rats were unknown.

156 kedly from this pattern are bats and African mole-rats, with members of both groups being extremely l