ライフサイエンスコーパス: molecular

1 However, elucidating the molecular adaptions that produce tolerance and determini

2 ed 14-day mortality rate was observed in the molecular adsorbent recirculating system group (9.5% vs

3 and reliably identified by microscopical and molecular analysis.

4 Our findings highlight the molecular and anatomical heterogeneity of midbrain dopam

5 Here we provide a review of the ecology and molecular and cellular biology of New World arenaviruses

6 However, little is known about the molecular and cellular determinants in mPFC for stress-a

7 In vitro techniques at the molecular and cellular levels were now applied to assess

8 eclinical models of atherosclerosis, and the molecular and cellular mechanisms involved.

9 ling systems that function to slowly degrade molecular and cellular memory traces.

10 Despite significant improvement, molecular and functional readouts were not completely re

11 Molecular and genetic evidence suggests that CPSF30-L wo

12 We found molecular and genetic evidence that reductions in Reln e

13 Our results define the molecular and neural pathways through which parallel bio

14 Molecular and physiological techniques were used to func

15 The atlas is created from molecular and structural high-resolution neuroimaging da

16 The molecular and structural studies presented here thus rev

17 our findings provide insight into the unique molecular architecture and export mechanism of the Pel a

18 The structure reveals the molecular architecture of the TFIIH core complex, the de

19 lt form, in which the AP axis converges on a molecular architecture similar to that of the direct dev

20 een made in recent years to decipher various molecular aspects of the regulatory cascade that causes

21 e comprehensive WGS assay has replaced seven molecular assays and has resulted in resistance profiles

22 eractions for enabling novel forms of guided molecular assembly.

23 misregulation of both pre- and postsynaptic molecular assembly.

24 different spindle locations and in different molecular backgrounds and quantify the immediate relaxat

25 This pilot study, integrating clinical and molecular-based techniques, begins to elucidate the FH h

26 al structure of UbV.7.2 and rationalized the molecular basis for enhanced affinity and specificity fo

27 To gain insight into the molecular basis for how these mutations contribute to ep

28 of how technology drove the discovery of the molecular basis for signal transduction in the initiatio

29 TE-GPR75 pairing presented here provides the molecular basis for the signaling and pathophysiological

30 es with three different ligands revealed the molecular basis for the strict specificity of this lecti

31 ar Ca(2+) oscillations and reveal a possible molecular basis for zinc-induced cancer prevention and O

32 her distinct process that contributes to the molecular basis of graphene cytotoxicity.

33 ermore, it offers fundamental clues into the molecular basis of MMP regulation by N-TIMP2 and identif

34 To investigate the molecular basis of TAD formation, we performed Hi-C expe

35 Our findings elucidate the molecular basis underlying inter-segment interactions in

36 sion in EHEC, we propose that DHMA acts as a molecular beacon to target pathogens to their preferred

37 io molecular dynamics (AIMD) simulations and molecular beam vacuum-UV (VUV) photoionization mass spec

38 on rutile-TiO2(110) by combining supersonic molecular beam, scanning tunneling microscopy (STM), and

39 ul tool for characterising the vibrations of molecular bonds and is therefore ideal for label-free de

40 ur study identifies miR-146a as an important molecular brake that blocks the autocrine IL-6- and IL-2

41 is the first time that RE-MOFs based on 12-c molecular building blocks (MBBs), d6R building units, ha

42 the least negative potential reported for a molecular catalyst.

43 will facilitate the development of synthetic molecular catalysts for hydrogen conversion.

44 able thermal transport studies in atomic and molecular chains, which will be key to investigating num

45 extremely large amounts of GFAP causes many molecular changes in astrocytes, including proteasome in

46 w that a reduction in the expression of this molecular chaperone accelerates prion pathogenesis in vi

47 , a class of ubiquitous and highly conserved molecular chaperone.

48 To identify the molecular characteristics of CM using next-generation wh

49 cused on urban centers and have not included molecular characterization.

50 -Blodgett method to organize two-dimensional molecular charge transfer crystals into arbitrarily and

51 y (host-guest interactions with uncaging and molecular cleavage).

52 encodes a TTI2 (Tel2-interacting protein 2) molecular cochaperone.

53 Mediator is a multi-unit molecular complex that plays a key role in transferring

54 may lead to detectable perturbations in the molecular composition of residual skin surface component

55 rption edges that are defined by the twisted molecular conformation.

56 Here we interrogate the molecular consequences of CRISPR/Cas9-mediated deletions

57 ible permutations and analyzed the resulting molecular consequences.

58 f ion mobility separation (IMS) improved the molecular coverage, selectivity, and identification of t

59 end-on attachment provides geometry-specific molecular cues or force on specific kinetochore linkages

60 ally accessible biopsy samples, high-quality molecular data for psoriasis patients are widely availab

61 his article, we discuss ways we can leverage molecular data sets to develop new hypotheses for diseas

62 he predictor, based on eight software-chosen molecular descriptors, was optimized using CCS values of

63 This Communication describes a new molecular design that yields ultranarrowband organic pho

64 However, the molecular details of how these two proteins interact hav

65 with its cognate promoter DNA, revealing the molecular details of promoter recognition by sigma(N) Th

66 Elucidation of the molecular details of the interplay between membrane and

67 To enable inexpensive molecular detection at the point-of-care and at home wit

68 tent with conduction slowing, genes encoding molecular determinants of atrial conduction velocity, in

69 ve target for drug development; however, the molecular determinants that govern the interactions and

70 ial territory is determined by intracortical molecular determinants.

71 lives of patients, yet the present benchtop molecular diagnosis is time-consuming and labor-intensiv

72 A molecular diagnosis was rendered for 2076 of 7374 patien

73 Recently, emerging molecular diagnostics have met requirements for speed, l

74 l cis-1,2-dihydrocatechol in inter- or intra-molecular Diels-Alder reactions.

75 cation of a synapse, but offers only limited molecular discrimination and is slow and costly.

76 Molecular dispersion spectroscopy encompasses a group of

77 aternary complex providing the basis for the molecular dissection of GAPDH1 structure-function relati

78 Western blotting and molecular docking studies suggested that these compounds

79 the first demonstration of applicability of molecular docking to show both enantioselective electroc

80 A computational study by molecular docking was made to complement the structural

81 enables a new paradigm for using air-stable molecular dopants to improve conductivity in, and provid

82 Ab initio molecular dynamics (AIMD) simulations and molecular beam

83 , we present an NMR-guided all-atom discrete molecular dynamics (DMD) platform, iFoldNMR, for rapid a

84 Molecular dynamics (MD) simulations suggest that LSD's s

85 -deuterium exchange MS (HDX-MS) methods, and molecular dynamics (MD).

86 We use classical molecular dynamics and hybrid quantum mechanics/molecula

87 turbation (FEP) coupled with lambda-exchange molecular dynamics method to calculate the binding free

88 Moreover our NMR, mutagenesis and molecular dynamics simulation studies defined the sequen

89 Molecular dynamics simulations and density-functional me

90 phase field crystal approach with classical molecular dynamics simulations and quantum-mechanical de

91 Here, we performed molecular dynamics simulations of GLIC in the absence an

92 re authors perform classical and accelerated molecular dynamics simulations of vacancy-mediated catio

93 Kinetics and molecular dynamics simulations on several GalNAc-T2 flex

94 Molecular dynamics simulations revealed that these ligan

95 In this work, we report multiscale reactive molecular dynamics simulations that characterize the fre

96 We use molecular dynamics simulations to resolve the molecular

97 Molecular dynamics simulations were used to probe the st

98 on-based measurements and from force pulling molecular dynamics simulations, both in water.

99 Elastic modulus of lignin, calculated by molecular dynamics simulations, increases initially with

100 rvations, combined with large-scale reactive molecular dynamics simulations, reveal the details of th

101 ral dynamics of Aqy1 during freezing through molecular dynamics simulations.

102 spectroscopy, native mass spectrometry, and molecular dynamics simulations.

103 ng tunneling microscopy (STM), and ab initio molecular dynamics.

104 we characterize, in breast cancer cells, the molecular effects of a recently developed small-molecule

105 Use of molecular electron spins as qubits for quantum computing

106 es of particular nucleosomes in their native molecular environment.

107 canis genotyping, and can serve as a useful molecular epidemiological tool, especially for tracing t

108 , which are not ideally suited for real-time molecular epidemiology.

109 s with long-term aspirin use, the changes of molecular events in AM but not IM may be an important fa

110 nderstanding of nanoscale energy transfer in molecular excitonic systems and may designate a unique d

111 We believe that our data provide a molecular explanation for how circadian phases, such as

112 Collectively our study offers possible molecular explanation for the observable phenotypic diff

113 ectrometry revealed molecular insights about molecular factors controlling the antiparallel-to-parall

114 vival data were correlated with clinical and molecular factors, and patterns of postprotocol therapie

115 wed us to detect approximately 230 different molecular features (positive ion mode), including 70 kno

116 ossible to unambiguously assign one specific molecular formula to an experimental isotopic pattern.

117 pectrometry (FT-ICR-MS), which delivered the molecular formulae and ion intensities of the compounds

118 as possible to reduce the number of possible molecular formulas for organic compounds of relative hig

119 Comparing porewater and oceanic DOS molecular formulas, solar irradiation increased the simi

120 Here we report the 2.1 A X-ray structure and molecular function of ClbS, a gene product that confers

121 teins are conserved in eukaryotes, but their molecular function remains unknown.

122 gesting a new avenue for active control over molecular function.

123 and GATOR2, a positive regulator of unknown molecular function.

124 ed proteins were involved in a wide range of molecular functions and cellular processes, and showed d

125 To describe the detailed clinical and molecular genetic findings in a series of patients with

126 genetic variants and could elucidate shared molecular genetic mechanisms.

127 We aimed to use molecular genotyping to assess antimalarial drug resista

128 RP), we hypothesized that CGRP may provide a molecular identifier of the CO2 arousal circuit.

129 ymporter (hNIS) is an established target for molecular imaging and radionuclide therapy.

130 Three-dimensional (3D) molecular imaging enables the study of biological proces

131 Thus far, most trials of novel molecular imaging in oncology have been small, single-ce

132 cological, functional magnetic resonance and molecular imaging studies of dopamine function in bipola

133 the theranostic application of fluorescence molecular imaging.

134 ng, recognition and biocatalysis, as well as molecular information storage.

135 Additionally, molecular information was obtained with <100 nm spatial

136 mportant link between organ-specific spatial molecular information, patient pathology, and patient tr

137 euterium exchange mass spectrometry revealed molecular insights about molecular factors controlling t

138 Both structures provide molecular insights into malonate decarboxylase catalysis

139 sion, our study suggests a common pattern of molecular interactions between pneumococcal FnBPs and fi

140 Using the detailed information about the molecular interactions in two filament states, we succes

141 unique, and in some cases sequence-specific molecular interactions with the surface of carbon nanotu

142 we demonstrate that the distance over which molecular junctions are maintained is a measure of smear

143 tional sciences, environmental medicine, and molecular knowledge-based redox medicine.

144 in both living and nonviable systems at the molecular level and has a high potential on early diagno

145 d via insect vectors, little is known at the molecular level as to how the viruses are recognized and

146 olecular dynamics simulations to resolve the molecular level recognition mechanisms and calculate the

147 At molecular level we provide evidence for non-canonical mo

148 d adult reticulocytes functionally or at the molecular level, and importantly no aberrant protein exp

149 At the molecular level, the sites of abnormal oral adhesions ma

150 n is surprisingly difficult to obtain at the molecular level.

151 on and outcome of the immune response at the molecular level.

152 ships, but is often poorly understood at the molecular level.

153 -degrading bacteria at the physiological and molecular level.

154 better understanding of the technology at a molecular level.

155 Developing nanotechnology that would allow molecular-level phenomena to drive such movements in art

156 o the most active chemerin form, providing a molecular link between coagulation and inflammation.

157 d have uncovered an evolutionarily conserved molecular link between intracellular Ca(2+) levels and e

158 This study reveals a molecular link between thermosensory growth and immunity

159 s an autoinhibited scaffold that serves as a molecular linker between the synapsin-dependent reserve

160 done on the environment - the requisite of a molecular machine - is more likely than completion in a

161 "the ribosome" as a homogeneous, monolithic molecular machine.

162 ization, domestication, as well as about the molecular machineries underlying them.

163 pate that future generations of programmable molecular machines may have significant roles in chemica

164 states, indicating that flux is enhanced in molecular machines with fewer states.

165 has allowed a closer look at the biology and molecular makeup of these cells.

166 significant roles in chemical synthesis and molecular manufacturing.

167 bolomics methods have already identified new molecular markers and metabolomic signatures of cardiova

168 mulas for organic compounds of relative high molecular mass (e.g., between 400 and 900 Da) to less th

169 ostatic pressure processing (650MPa/9min) on molecular mass distribution, and hydrodynamic and struct

170 PepX comprises two subunits of equal molecular mass estimated, using SDS-PAGE and native-PAGE

171 lp permit the rational design of complex new molecular materials in which multiple optoelectronically

172 MCH in late gestation promotes molecular maturation of the fetal lung, which may be an

173 ecular dynamics and hybrid quantum mechanics/molecular mechanics calculations at the mPW1N/6-311+G(2d

174 Our study uncovers a novel molecular mechanism for regulating PD-L1 protein stabili

175 rather than the consequence of an underlying molecular mechanism measuring a fixed amount of growth.

176 our results extend the understanding of the molecular mechanism of transcription regulation on cellu

177 of its ciliary plasma membrane by an unknown molecular mechanism.

178 oteomic approach to elucidate cancer-related molecular mechanisms and to develop novel cancer therapi

179 of immunology is principally focused on the molecular mechanisms by which hematopoietic cells initia

180 Our findings suggest that molecular mechanisms for epigenetic regulation within th

181 cing of resistant subclones, to discover the molecular mechanisms of sensitivity.

182 We aimed to clarify the underlying molecular mechanisms of suspected RM in the skin of a pa

183 Yet, the exact molecular mechanisms of their function in complexes are

184 y to suppress T cell responses, although the molecular mechanisms of this suppression remain incomple

185 elegans germline as a model for identifying molecular mechanisms regulating intercellular bridges.

186 However, its primary molecular mechanisms remain incompletely understood in p

187 However, the molecular mechanisms that enable HD-PTP to regulate ESCR

188 Advances in understanding of the molecular mechanisms that underlie restless legs syndrom

189 hich overlap exists between the cellular and molecular mechanisms triggered by these various agents i

190 urons are essential in this process, but the molecular mechanisms underlying the influence of experie

191 can be used to elucidate clinically relevant molecular mechanisms underlying the pathogenesis of most

192 The molecular mechanisms underlying the regulation of MCU, i

193 The molecular mechanisms underlying vascular inflammation an

194 A better understanding of the underlying molecular mechanisms would be of help, but unlike the mo

195 l substrate for investigating the underlying molecular mechanisms.

196 binding regions, RT-dPCR may be the optimal molecular method for future HRV quantification studies a

197 result in stiffer mechanical properties, the molecular mobility of the sample almost always increases

198 The genetic/molecular model Dictyostelium and mammalian phagocytes s

199 Molecular modelling and mutagenesis studies indicate tha

200 We review current molecular models to explain ribosomopathies and attempt

201 quilibrium self-assembly, chemically fuelled molecular motion, compartmentalised chemical networks an

202 id racemization, a new class of light-driven molecular motors was designed, synthesized, and studied.

203 f systems such as photoresponsive materials, molecular motors, and photoactivated drugs.

204 Our studies reveal a complex molecular network that defines and restricts pluripotent

205 the new live-imaging tools for the study of molecular-neural interactions important for the operatio

206 h a ruthenium trisbipyridine chromophore and molecular Ni(II) catalyst on NiO films was also used to

207 ptibility of phoQ Salmonella to RNS requires molecular O2 and coincides with the nitrotyrosine format

208 From a molecular orbital perspective, the bonding scheme is rem

209 lose inspection of the calculated unoccupied molecular orbitals, in conjunction with experimentally m

210 take of solvent into the skin may change the molecular organization of skin lipids and proteins, whic

211 er system, we uncover the genuine effects of molecular orientation on charge generation and recombina

212 isclination lines are topological defects in molecular orientation widely found in liquid crystals.

213 The latter also crucially directs the molecular packing in the solid.

214 Given our increasing knowledge of the molecular pathogenesis of S. aureus disease, we suggest

215 However, the molecular pathogenesis of these complications remains po

216 disease, we suggest that the application of molecular pathological epidemiology to S. aureus infecti

217 pathy/dysplasia, although their cellular and molecular pathomechanisms are not precisely known.

218 tic risk factors that provide insights about molecular pathophysiology and potential drug targets.

219 re to determine whether the blood eosinophil molecular pattern of children with EoE is (i) distinct f

220 uding insulin receptors, pathogen-associated molecular pattern receptors, cytokine receptors, adipoki

221 ted with chitin (a fungal microbe-associated molecular pattern) have improved salt tolerance, was obs

222 ng microbial molecules and damage-associated molecular patterns released from host cells.

223 me experimental conditions and identified by molecular PCR assay based on the ITS-5.8S rDNA.

224 n skeletal muscle phenotype and function and molecular perturbations of hyperammonemia; these preclin

225 nstitute diverse and promising feedstock for molecular pharmaceuticals.

226 t the most extensive characterization of the molecular pharmacology of the most widely used CB2R liga

227 lls may possess a coordinated functional and molecular phenotype which can be targeted for therapy.

228 ee selection of cells for a highly expressed molecular phenotype.

229 cromolecule synthesis, where a high level of molecular precision or monomer sequence control confers

230 (NiFe-LDH) (<5 nm) and nanocarbon using the molecular precursor of metal and carbon sources is prese

231 Grafting molecular precursors on partially dehydroxylated silica

232 floxacin (CIPRO), were chosen as nonresonant molecular probes.

233 branes, it has been difficult to uncover the molecular process that underlies its antibacterial activ

234 -time multiparameter measurements of complex molecular processes.

235 At the same cell the molecular profiles of different organelles can strongly

236 new tools for high-throughput structural and molecular profiling of the diverse populations of synaps

237 High-throughput genomic and molecular profiling of tumors is emerging as an importan

238 Specific binding between biomolecules, i.e., molecular recognition, controls virtually all biological

239 nervous system, as well as the cellular and molecular reorganization of its neural circuits.

240 nt sensing through RagA contributes to their molecular resilience to nutritional stress, a characteri

241 e of its refractive index in the vicinity of molecular resonances.

242 ter at least 3 years of TKI treatment and in molecular response 4.5 (MR4.5) with undetectable BCR-ABL

243 idation is not yet sufficient to predict the molecular responses of PTPs to oxidative stress.

244 argets and lengthens the period of circadian molecular rhythms, providing a mechanistic link to DSPD

245 first time the high sorption properties of a molecular rotor with no permanent voids or channels in i

246 surfaces to Tra1, hence it does not act as a molecular scaffold within SAGA.

247 e biological scales, from the patient to the molecular scale, to more effectively study cancer.

248 o our knowledge, brings a new perspective to molecular-scale understanding of neurodegenerative disea

249 conductor type photocatalysts, such as Ti-Si molecular sieves and carbon quantum dots (CQDs), are als

250 oximately 40 mM, rt, CH2Cl2, piperidine/AcOH/molecular sieves) of a dihydrodipyrrin-carboxaldehyde (A

251 licable to other cage-containing microporous molecular sieves, where some of the most industrially re

252 develop a technique for fabrication of PAGE molecular sieving gels in PDMS microchannel networks.

253 activators have been engineered to visualize molecular signals or manipulate cellular functions.

254 SeptiCyte Lab (Immunexpress, Seattle, WA), a molecular signature measuring the relative expression le

255 e aimed to assess whether a patient-specific molecular signature of radiation sensitivity could be us

256 , an attempt has been made to understand the molecular signatures of bacterial fouling.

257 uch, they bridge traditional semiconductors, molecular solids, and nanocrystal arrays by combining th

258 s reliable for engineering the structures of molecular solids.

259 speeds of sound in ILs vs those in classical molecular solvents is presented to compare these two cla

260 ble to change their behavior from dampers to molecular springs.

261 ed cell, poxviruses use a range of different molecular strategies including the mimicry of prosurviva

262 DNA target sites in a process we have termed molecular stripping.

263 The exploration of molecular structure-property relations is crucial to opt

264 operties, which is heavily controlled by its molecular structure.

265 d many more eccDNAs with highly heterogenous molecular structure.

266 , and this is achieved by a diverse range of molecular structures, with some proteins undergoing sign

267 lysis and measurement of interactions in bio-molecular studies and cell-surface analysis without the

268 We used the Scoring Algorithm for Molecular Subphenotypes (SAMS) to classify patients into

269 or p100 and p105 signaling in defining DLBCL molecular subtypes and posit MYD88/p100 signaling as a r

270 While molecular subtypes of glioblastoma (GBM) are defined usi

271 R of Med13 plays a key role in controlling a molecular switch that dictates cell fate following expos

272 Here we describe a molecular system that can be programmed to control these

273 trafast electron transfer in condensed-phase molecular systems is often strongly coupled to intramole

274 friction and have been applied to disparate molecular systems, raising questions regarding the compa

275 response can form the basis of programmable molecular systems, wherein specific input sequences crea

276 s after burn injury and as a novel potential molecular target to improve the clinical outcome of seve

277 nomer sequence control confers potential for molecular targeting, recognition and biocatalysis, as we

278 Discovery of molecular targets or compounds that alter neuronal funct

279 overy of bioactive small molecules and their molecular targets.

280 One of the exciting applications of molecular technology is the direct detection of specific

281 icles by Ostwald ripening in the presence of molecular templates immobilised on glass beads (the soli

282 Our results identify promoter shape as a molecular trait that can evolve independently of promote

283 The molecular trigger of CNS myelination is unknown.

284 We discovered the molecular underpinnings of lowered affinity of Ca(2+) fo

285 providing a valuable resource to advance our molecular understanding of meiosis.

286 led (115 microm) sirolimus-eluting ultrahigh molecular weight amorphous poly-l-lactic acid-based BRS

287 mall mean pore diameter of 1.0-1.3 nm with a molecular weight cutoff (MWCO) of 1000-2000 Da but also

288 to various forms of PE, displaying different molecular weight distributions and oxidation levels, lea

289 The molecular weight of the complex was calculated from smal

290 glucosuria, phosphaturia, aminoaciduria, low molecular weight proteinuria, and albuminuria.

291 die did not have a measurable impact on the molecular weight reduction of waxy flour.

292 ther reactive intermediates, often of higher molecular weight than the Amadori rearrangement product,

293 Digestion of higher molecular weight whey proteins increased with decreased

294 ber of methyl- and ethyl- functional groups, molecular weight, and number of ring structures, in addi

295 The vapour pressure, the molecular weight, the Odor Activity Value (OAV) and the

296 ses was used to determine changes in the low-molecular-weight compound composition of peanuts due to

297 intact G1/S transition (Rb-positive and low-molecular-weight isoform of cyclin E (cytoplasmic)-negat

298 This results in soluble low-molecular-weight oligomers that can act as a therapeutic

299 -, penta-, hexa-, and hepta-saccharides with molecular weights of 689, 851, 1013 and 1151Da, respecti

300 low for polymerization of ethylene to higher molecular weights with reduced branching due to signific