ライフサイエンスコーパス: molecular basis

1 nd that could pave the way to unraveling the molecular basis behind ACR4-mediated signaling.

2 ls, thus providing critical insight into the molecular basis by which AR promotes development of leth

3 accompany UbcH7 Ub binding and provides a molecular basis by which HHARI recruits E2 Ub in an 'o

4 4) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation

5 These findings provide evidence for the molecular basis by which phthalates may alter placental

6 Here, we characterize the molecular basis by which She1 affects dynein, providing

7 The molecular basis by which the thymus allows high-efficien

8 In 294 of 2,620 (11.2%) of ASD cases, a molecular basis could be determined and 7.2% of these ca

9 nization at cis-regulatory elements, but the molecular basis, extent, and impact of these alterations

10 However, the molecular basis for a majority of epilepsy patients rema

11 To identify the molecular basis for abnormal KSC function, RNA sequencin

12 However, the molecular basis for antibiotic nephrotoxicity is not cle

13 ve implications for better understanding the molecular basis for autoimmune disease and cancer.

14 he post-endoplasmic reticulum compartment as molecular basis for blinatumomab resistance.

15 To investigate the molecular basis for circadian control of guard cell aper

16 MCs between the MOB and AOB could provide a molecular basis for differential chemosensory behaviours

17 This finding reveals the molecular basis for disease and provides evidence that Z

18 However, the molecular basis for domestication and divergence among t

19 is of PARP inhibitor potencies establishes a molecular basis for either selectivity or promiscuity an

20 al structure of UbV.7.2 and rationalized the molecular basis for enhanced affinity and specificity fo

21 We have unraveled the molecular basis for filament assembly and dynamics combi

22 Our findings provide a molecular basis for future rational design of agents tha

23 metabolite transport by DASS, establishing a molecular basis for future studies on the regulation of

24 lthough identified nearly a century ago, the molecular basis for growth phase control of speB gene ex

25 Here, we explore the molecular basis for GusR-mediated regulation of GUS expr

26 The underlying molecular basis for heterosis, particularly for allopoly

27 this system to investigate the cellular and molecular basis for Hirschsprung's disease caused by a m

28 2) following fluoxetine treatment, showing a molecular basis for hormone-independent nuclear transloc

29 The molecular basis for how clamps facilitate unfolding and

30 In this issue, Gama et al. reveal the molecular basis for how dynein and its adaptor protein S

31 nvironmental monitoring, and elucidating the molecular basis for how organisms respond to spaceflight

32 of the activity of complex IV; however, the molecular basis for how Rcf1 influences the activity of

33 bly with the replication fork, providing the molecular basis for how the E. coli replisome can mainta

34 To gain insight into the molecular basis for how these mutations contribute to ep

35 MF2 disrupt harmonin binding, revealing the molecular basis for how they impact the formation of the

36 re, whole exome sequencing uncovered a novel molecular basis for idiopathic end-stage heart failure i

37 biochemical analysis sheds new light on the molecular basis for IFIT1 translational inhibition of ca

38 o prevent inflammatory disease; however, the molecular basis for IL-10-mediated inhibition remains el

39 de an approach for exploring the genetic and molecular basis for impairment in the disease.

40 However, as the molecular basis for its ability to inhibit DNA repair, w

41 power stroke of a single MVI, we provide the molecular basis for its motility.

42 mbrane helices 1 and 2 of BR may provide the molecular basis for lipid translocation by coordinating

43 We then identified the molecular basis for M1 inhibitory function.

44 Most studies addressing the molecular basis for macrophage heterogeneity have focuse

45 ivated, intimating a possible shared circuit/molecular basis for mechanism of action; (3) caffeine ca

46 ed, inferring a shared and divergent circuit/molecular basis for mechanism of action; and 4) PZ(Vgat)

47 Together, these studies describe a molecular basis for mucin-based nutrient acquisition by

48 o E2F5 and its dimer partner DP1 reveals the molecular basis for pocket protein-E2F binding specifici

49 To study the molecular basis for predator-prey coevolution, we invest

50 he activation mechanism of CB1 and provide a molecular basis for predicting the binding modes of Delt

51 anding of Wnt-FZD receptor interactions, the molecular basis for recognition of Wnt cis-unsaturated f

52 ugh computational analyses to understand the molecular basis for recognition.

53 RAG2 in a human cell line model, laying the molecular basis for recombination activity.

54 In this study the molecular basis for reduced potency of current inhibitor

55 Our work elucidates the molecular basis for regulation of LPL activity by ANGPTL

56 To understand the molecular basis for resistance from MAb PL-2 neutralizat

57 However, the molecular basis for robust kinetochore-microtubule inter

58 wledge of shape diversity and uncovering the molecular basis for shape generation in noncanonical and

59 of how technology drove the discovery of the molecular basis for signal transduction in the initiatio

60 lates sleep and circadian behavior; yet, the molecular basis for sleep-metabolism interactions remain

61 Together, these studies reveal the molecular basis for SMC3 acetylation by ESCO1 and have b

62 However, the molecular basis for SPD-2 centriolar localization remain

63 treatment of thyroid cancer and provide the molecular basis for studies aimed at extending the use o

64 However, the molecular basis for the 14-3-3-dependent inhibition of P

65 iency of actomyosin interactions establish a molecular basis for the ability of these complexes to su

66 pping sites on the tubulin tail, providing a molecular basis for the anticorrelation between glutamyl

67 2/1992 (BJ/92), were chosen to determine the molecular basis for the antigenic difference between A(H

68 study contributes to the description of the molecular basis for the biosynthesis of fatty acid-deriv

69 suppress TGFbeta-induced EMT, establishing a molecular basis for the dichotomy of TGFbeta function du

70 1A, an observation that may partly provide a molecular basis for the differences in activities in the

71 mode of binding for VSP-51 and provides the molecular basis for the discrimination between VSP-51 fr

72 We provide a molecular basis for the distinct circadian roles of diff

73 However, the molecular basis for the diverse roles of these enzymes i

74 72R-induced variations in dynamics provide a molecular basis for the electrophysiological phenotypes

75 oids, notably natural bile salts, provides a molecular basis for the emerging association of ATX with

76 The molecular basis for the O1 --> O2 transition and how ChR

77 16 in complex with the N-domain revealed the molecular basis for the observed selectivity.

78 hift variants, yielding a previously unknown molecular basis for the pathogenesis of Aalpha-chain amy

79 Taken together, these observations provide a molecular basis for the phyB-mediated suppression of hyp

80 These findings not only provide a molecular basis for the potential use of exercise-genera

81 Our findings provide a molecular basis for the progression of age-dependent car

82 sent a step further toward understanding the molecular basis for the protein kinase catalytic activit

83 Here the authors reveal the molecular basis for the selectivity of RCC1 for importin

84 TE-GPR75 pairing presented here provides the molecular basis for the signaling and pathophysiological

85 cH7 Ub thioester mimetic which reveals the molecular basis for the specificity of this cognate E2/R

86 es with three different ligands revealed the molecular basis for the strict specificity of this lecti

87 malian and the mosquito vector and provide a molecular basis for the structure-based design of next-g

88 een related cell and tissue types and reveal molecular basis for their similarity.

89 euron firing often accompany ataxia, but the molecular basis for these changes is poorly understood.

90 The molecular basis for these defects included transcription

91 main in complex with IncE define the precise molecular basis for these interactions.

92 evidence supporting the conservation of the molecular basis for these lophotrochozoan hallmarks.

93 The molecular basis for this activity was characterized as a

94 However, the molecular basis for this adaptive process is unclear.

95 Here, we address the molecular basis for this asymmetric conduction by invest

96 on re-ascent is seen in humans; however, the molecular basis for this enhanced adaptive response is u

97 To uncover the molecular basis for this heterogeneity, we performed gen

98 Although the molecular basis for this inhibited state is unknown, pre

99 However, the molecular basis for this is largely unknown.

100 However, the molecular basis for this mitochondrial MTOC and other no

101 sitide clustering, little is known about the molecular basis for this or its significance in cellular

102 To investigate the molecular basis for this phenomenon, we conducted a geno

103 However, the molecular basis for tumor cell response to CQ remains po

104 foamy cell" development, thus establishing a molecular basis for understanding human diseases associa

105 Together, the data provide a molecular basis for understanding serine integrase direc

106 42) versus its amyloid self-assembly offer a molecular basis for understanding the underlying mechani

107 ral reservoir; thus, an understanding of the molecular basis for viral latency and persistence is par

108 ar Ca(2+) oscillations and reveal a possible molecular basis for zinc-induced cancer prevention and O

109 function and transcriptional regulation, the molecular basis governing its posttranslational modifica

110 ell invasion and virulence, but studying its molecular basis has been hampered by unavailability of s

111 h-affinity interaction is now clear, and its molecular basis is being unraveled, while recent studies

112 py is largely lacking because the underlying molecular basis is poorly understood.

113 We sought to investigate the molecular basis of 3 pustular skin disorders: generalize

114 In this article, we focus mainly on the molecular basis of activation and drug modulation of alp

115 rs based on our current understanding of its molecular basis of activity.

116 fferent lineages has been used to define the molecular basis of acute virulence in the mouse.

117 e sought to reveal the neuronal circuits and molecular basis of ADHD and its potential treatment usin

118 digm of the ground work needed to tackle the molecular basis of all the protein-aggregation-related d

119 and may offer a deeper understanding of the molecular basis of Alzheimer's disease.

120 Our study therefore reveals the molecular basis of an interaction that is crucial for op

121 crystal structure provides insight into the molecular basis of antibody-carbohydrate interactions an

122 ontaining high quality reference data on the molecular basis of antimicrobial resistance (AMR), with

123 onally important insertions, and reveals the molecular basis of AR-JP-causing mutations, some of whic

124 the NSs core domain in crystals reveals the molecular basis of assembly of this key virulence factor

125 ield important insight into the cellular and molecular basis of astrocyte-neuron communication, focus

126 rial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilita

127 ions curtailed our ability to understand the molecular basis of bacterial cell size control.

128 To elucidate the molecular basis of BMP4-induced differentiation of human

129 l will lead to a deeper understanding of the molecular basis of bone marrow failure in FA and the cel

130 However, the molecular basis of cancer preventive functions of zinc a

131 ential to advancing our understanding of the molecular basis of cancer.

132 oRNAs (miRNAs) play an important role in the molecular basis of caste determination and differentiati

133 A powerful approach is to compare the molecular basis of caste determination and differentiati

134 First, we wished to determine the molecular basis of cholesterol homeostatic responses ind

135 disorder chilling injury (CI); however, the molecular basis of CI development remains largely unexpl

136 nctions and provide a model for studying the molecular basis of cnidarian disease and immunity.

137 model accounts for adult-onset disease, the molecular basis of congenital DM (CDM) is unknown.

138 ility of genetic adaptation, we examined the molecular basis of convergence in hemoglobin function in

139 ngs lay the foundation for understanding the molecular basis of coupling selectivity within individua

140 The molecular basis of differences between larval and adult

141 tal understanding of structural biology, the molecular basis of diseases, and possible routes to addr

142 f associated SNPs and interpretations of the molecular basis of diseases.

143 lthy subjects, can provide insights into the molecular basis of diseases.

144 ructures are essential for understanding the molecular basis of diverse biological events and importa

145 We report the molecular basis of DNA-binding autoinhibition of ETS tra

146 However, the molecular basis of Eco1 substrate recognition and acetyl

147 These findings reveal a molecular basis of electroreception and demonstrate how

148 the drug metformin with implications for the molecular basis of epigenetic dysregulation in cancer.

149 ll help frame future investigations into the molecular basis of ER-driven neuronal disease states.

150 e a limited understanding of the genetic and molecular basis of evolutionary changes in the size and

151 To study the molecular basis of facilitated dissociation (FD), we hav

152 This work expands our understanding of the molecular basis of fibre formation laying the foundation

153 ar filaments, and begin to shed light on the molecular basis of filament switching.

154 ata towards genome-wide understanding of the molecular basis of FLC resistance in T. asahii.

155 However, the cellular and molecular basis of germ-layer segregation is poorly unde

156 mplex is a crucial step in understanding the molecular basis of glycoprotein quality control but has

157 her distinct process that contributes to the molecular basis of graphene cytotoxicity.

158 spinal gene expression asymmetries form the molecular basis of handedness.

159 n the fetal cortex has been suggested as the molecular basis of handedness.

160 These findings highlight the molecular basis of HCS pathogenesis and provide clinical

161 y to near-atomic resolution, elucidating the molecular basis of helicase function by relaxases and re

162 minent role in lysosome pathophysiology, the molecular basis of hENT3-mediated transport is unknown.

163 can improve our knowledge of the genetic and molecular basis of heritable phenotypic variation.

164 The molecular basis of how cargo engagement affects the bala

165 Our results define the molecular basis of how PIK3CD and PIK3R1 mutations resul

166 morigenesis in vivo Our findings uncover the molecular basis of how the metabolism of myristic acid s

167 The molecular basis of how the N-terminal non-catalytic CD1

168 However, the molecular basis of how these endosomal NHEs control endo

169 xplored, currently much is unknown about the molecular basis of HUWE1-promoted XLID.

170 Consistent with the complex genetic and molecular basis of hydrogen peroxide resistance, we show

171 To ascertain the molecular basis of ichthyosis patients in Iran, a countr

172 We sought to establish the molecular basis of IL-13 overproduction by CD8(+) T cell

173 eat models for understanding the genetic and molecular basis of immune and parasitic processes.

174 ted in response to physiologic cues, and the molecular basis of inherited diseases characterized by L

175 ts RNAPII transcription, suggesting that the molecular basis of inhibition is conserved between archa

176 Understanding the molecular basis of insecticide resistance is key to impr

177 n binding partners have been identified, the molecular basis of interactions with the C-terminal MF d

178 s to provide a framework for teasing out the molecular basis of interfacial self-assembly.

179 Our structure reveals not only the molecular basis of ion conduction but also the unique ar

180 comere that are strongly bound to actin, the molecular basis of its action is still not completely cl

181 ges to the investigation of the cellular and molecular basis of its regeneration.

182 lvable life and what constitutes the minimal molecular basis of life remains far from complete.

183 Previous work has discussed the molecular basis of maize - C. graminicola interaction.

184 Uncovering the molecular basis of mammalian cardiomyocyte proliferation

185 Our results provide insights into the molecular basis of mechanotransduction in a tactile-spec

186 ave provided unprecedented insights into the molecular basis of microbial phenotypes and enabled the

187 However, the underlying molecular basis of mitochondria-associated neuronal and

188 tethering, and our results shed light on the molecular basis of mitochondrial fusion and mitofusin-re

189 ermore, it offers fundamental clues into the molecular basis of MMP regulation by N-TIMP2 and identif

190 The molecular basis of most pustular skin conditions has rem

191 ontogeny of OSM progenitors and compare the molecular basis of Mrf activation in OSM versus ASM.

192 l activation, and provides insights into the molecular basis of mucolipidosis type IV pathogenesis.

193 To gain insights into the molecular basis of mutant TG6-induced neurotoxicity, we

194 in the cardiovascular system, including the molecular basis of mutations in AMPK that alter cardiac

195 Recent studies have revealed the molecular basis of mycobacterial lipid recognition by CD

196 er partnership and provide insights into the molecular basis of myoblast fusion.

197 tion, clone emergence and expansion, and the molecular basis of niche adaptation.

198 The molecular basis of NSAID inhibition of ASICs has remaine

199 hese findings provide new information on the molecular basis of OCD and suggest new avenues for its t

200 Little is known about the molecular basis of pathogenesis in B. cookei, in large p

201 We therefore sought to identify the molecular basis of PEITC-mediated epigenetic tumor restr

202 A more thorough understanding of the molecular basis of plant biomass traits should provide a

203 mical characterizations, we investigated the molecular basis of PME3 inhibition by PMEI7 in Arabidops

204 e reconfiguration as a way to understand the molecular basis of prion aggregation.

205 Amyloid polymorphs may be the molecular basis of prion strains.

206 challenges with respect to understanding the molecular basis of protein/membrane interactions.

207 to gene flow that are shaping the underlying molecular basis of pyrethroid resistance across southern

208 ersity analyses, we show that a shift in the molecular basis of pyrethroid resistance in southern Afr

209 ious attention for full understanding of the molecular basis of Rab GTPase-regulated membrane traffic

210 Here, we overview the molecular basis of racial disparity in cancer susceptibi

211 State-of-the-art knowledge of the molecular basis of RCC and its treatment and imaging wil

212 s alternative sources of phosphorus, but the molecular basis of reduced phosphorus acquisition from t

213 etween these different roles, as well as the molecular basis of Rif1 function is still unclear.

214 To determine the molecular basis of selectivity we generated a series of

215 formation will not only help to unravel the molecular basis of skeletal muscle diseases, but also pr

216 Improved understanding of the molecular basis of SMA, disease pathogenesis, natural hi

217 al protease specificity profiling reveal the molecular basis of some of these changes.

218 s provide new insights into the cellular and molecular basis of sour taste.

219 To investigate the molecular basis of such regularity, mutants with altered

220 lated by extracellular protons; however, the molecular basis of such regulation remains unidentified.

221 To investigate the molecular basis of TAD formation, we performed Hi-C expe

222 Here we elucidate the molecular basis of TCS mutations in Saccharomyces cerevi

223 However, understanding the molecular basis of the disease has been impaired by the

224 in patients with sporadic ALS; however, the molecular basis of the disease mechanism is not yet full

225 ution to healthy aging and longevity and the molecular basis of the DNA methylation clock.

226 These findings establish the molecular basis of the extracellular function of ISG15 a

227 nd nonpermissive lipid ligands clarifies the molecular basis of the frequently observed but poorly un

228 The molecular basis of the incomplete penetrance of monogeni

229 he G1MDR-mediated silencing machinery is the molecular basis of the initial activation of the Gata1 g

230 rce microscopy imaging, we characterized the molecular basis of the interaction of CsgB with a membra

231 Here we investigate the molecular basis of the interaction of RNA with LAF-1 and

232 tricted autoreactivity, thus elucidating the molecular basis of the observed V gene bias.

233 The molecular basis of the optical properties of chromophori

234 The molecular basis of the purported functional differences

235 CD4-17b-induced intermediate and provide the molecular basis of the receptor-binding-induced conforma

236 This review discusses the cellular and molecular basis of the S1P gradients and aims to interpr

237 ium/aspartate symporter GltPh, suggested the molecular basis of the transporter cycle.

238 translocation across membranes revealing the molecular basis of the unconventional secretory pathway

239 Understanding the molecular basis of the vernalisation requirement in this

240 ase enzymes is critical for illuminating the molecular basis of their diverse and complex roles in a

241 phasizes the importance of understanding the molecular basis of their function.

242 insects, but their behavioral roles and the molecular basis of their hygrosensitivity remain unclear

243 lexes with TCA1 derivatives to elucidate the molecular basis of their inhibitory activities and an un

244 y interconnected and interdependent, but the molecular basis of their mutual regulation has only begu

245 he TCGA-COAD database gave insights into the molecular basis of their phenotypic changes.

246 Understanding the molecular basis of thermoadaptation has progressed in tw

247 Elucidating the molecular basis of these effects, mutation of four previ

248 In order to understand the molecular basis of these MYB-associated changes, we cond

249 To understand the molecular basis of these observations, we compare the ef

250 Knowledge of the molecular basis of these rhythms has exploded in the las

251 To understand the molecular basis of this architecture, we examined the bi

252 PP1 also associates with NCX1; however, the molecular basis of this association is unknown.

253 Although the molecular basis of this constitutive JAK/STAT signaling

254 g BR and autophagy pathways and identify the molecular basis of this crosstalk.

255 hysiological and cellular functions, but the molecular basis of this decline remains unclear.

256 To determine the molecular basis of this deficiency we have investigated

257 The structural and molecular basis of this encephalitis is not fully unders

258 n neuronal cell types, but in most cases the molecular basis of this heterogeneity is unknown.

259 crop fields and natural ecosystems, but the molecular basis of this humidity effect is not understoo

260 mulation phase of biofilm formation, but the molecular basis of this interaction remains poorly under

261 rrently available vary considerably, and the molecular basis of this is unclear.

262 ed to impaired fatty acid oxidation, but the molecular basis of this link is unclear.

263 Molecular basis of this metabolic syndrome is not yet co

264 is study, we have attempted to determine the molecular basis of this paradox.

265 However, the molecular basis of this process remains unknown.

266 To understand the molecular basis of this region-specific variability we a

267 We address the molecular basis of this regulation using crystallographi

268 rough its effector calmodulin (CaM), but the molecular basis of this regulation was previously unknow

269 So far, the molecular basis of this tripartite relationship and the

270 Unravelling the molecular basis of TLR1 and TLR6-driven heterodimerizati

271 ntly contributed to our understanding of the molecular basis of trainability.

272 mplex traits and at the same time reveal the molecular basis of trait variation.

273 The molecular basis of transgene susceptibility to silencing

274 To better understand the molecular basis of tung tree chloroplasts, we sequenced

275 Ala-d-Lac binding that directly overcome the molecular basis of vancomycin resistance, peripheral str

276 However, the molecular basis of viral pathogenesis remains poorly und

277 ism of EAV is critical for understanding the molecular basis of viral persistence and for development

278 s the viral transcriptional template, is the molecular basis of viral persistence.

279 e valuable information for understanding the molecular basis of virus neutralization.

280 at the nanoscale provides insights into the molecular basis of wetting.

281 Understanding the molecular basis of zinc (Zn) uptake and transport in sta

282 with changes in macrolide resistance and the molecular basis over time in our population.

283 r of mitochondrial signaling, its action and molecular basis remain unknown.

284 ssion can develop on ibrutinib, although the molecular basis remains to be clarified.

285 Dissection of the underlying molecular basis revealed that Jmjd2c is re-distributed t

286 inical trials, a lack of knowledge about the molecular basis that governs the antigen presentation, a

287 focused our investigations to elucidate the molecular basis that render this Aalpha-chain variant am

288 independent homologs, we have determined the molecular basis that underlies the use dependence of tem

289 This provides a molecular basis to explain the induction of RAS-RAF asso

290 ts ability to suppress HDR and providing the molecular basis to guide pre-clinical development of 3E1

291 expression and stability, which can offer a molecular basis to improve the clinical response rate an

292 With this discovery the genetic and molecular basis underlying FA has emerged as a field of

293 gger lymphatic expansion and remodeling, the molecular basis underlying flow-induced lymphatic growth

294 Our findings elucidate the molecular basis underlying inter-segment interactions in

295 nsiderably expanded our understanding of the molecular basis underlying lignin biosynthesis and pertu

296 The bsl1 mutants provide insight into the molecular basis underlying morphological variation in in

297 Our study provides insights into the molecular basis underlying the striking racial dispariti

298 will have implications in understanding the molecular basis underlying their role in PD and ALS.

299 Little is known about the molecular basis underpinning the functional effects of T

300 n an explosion in our understanding of their molecular basis with the arrival of next-generation sequ