ライフサイエンスコーパス: molecular entity

1 nucleophilic region in another, or the same, molecular entity.

2 ses on the role of lipid classes rather than molecular entities.

3 ary containing approximately 2 million small molecular entities.

4 nd that SOCE and ECCE represent two distinct molecular entities.

5 on the basis of prior information) and other molecular entities.

6 f 170 genes identified UC and CD as distinct molecular entities.

7 re recently revealed to exist as independent molecular entities.

8 The underlying challenge is to design new molecular entities able to act as allosteric chemical sw

9 ated nanoparticles (NPs) targeted with small molecular entities, able to bind to prostate specific me

10 mine whether, as recently proposed, the same molecular entity accounts for excitation by both types o

11 irectional instructions made up of different molecular entities and address it to specific recipient

12 th were reviewed to obtain the number of new molecular entities and biologic license applications app

13 fundamental properties relating to these two molecular entities and discuss the potential impact on e

14 od and Drug Administration approvals for new molecular entities and medical devices for indications w

15 step process characterized by a multitude of molecular entities and their interactions.

16 c region associated with a halogen atom in a molecular entity and a nucleophilic region in another, o

17 r all four parathyroid glands, is a distinct molecular entity and does not represent the molecular pa

18 broadly comparable with that for established molecular entity and event extraction tasks.

19 ar entities, ChEBI contains groups (parts of molecular entities) and classes of entities.

20 ar entities, ChEBI contains groups (parts of molecular entities) and classes of entities.

21 l-hazards models of review times for all new molecular entities approved between 1950 and 2005.

22 as estimated by both life expectancy and New Molecular Entities approved by the Food and Drug Adminis

23 The three molecular entities are prepared from the same monomeric

24 ike subtype were found to represent a unique molecular entity as any other cancer type, including the

25 together organic chemistry and neuroscience, molecular entities can be generated that match the endog

26 of these disorders, illustrating how a novel molecular entity can contribute to our understanding of

27 ch on Alzheimer disease is the nature of the molecular entity causing dementia.

28 the relative concentration of 394 out of 423 molecular entities changed significantly during maturati

29 In addition to molecular entities, ChEBI contains groups (parts of mole

30 In addition to molecular entities, ChEBI contains groups (parts of mole

31 Discovering new molecular entities combined with dereplication of known

32 There are several molecular entities common to the immune and nervous syst

33 ing (131)I) involves radioiodinating a small molecular entity, conjugating it to the mAb, and purific

34 These new molecular entities, designated "CNS neuroblastoma with F

35 ul MS/MS information for at least 80% of all molecular entities detected in the MS scan replicates.

36 What molecular entity determines the extracellular function o

37 of the nature of fluorescence, with discrete molecular entities emitting a stream of single photons.

38 novel signature for further analysis of the molecular entities emitting these fluorescent signatures

39 Volcano tests enabled to detect significant molecular entities explaining the variability associated

40 (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds

41 (ChEBI) is a freely available dictionary of molecular entities focused on 'small' chemical compounds

42 r results establish Cav2-enzyme complexes as molecular entities for fast electrochemical coupling tha

43 Food and Drug Administration approved 40 new molecular entities for indications within the neuroscien

44 ug discovery has successfully identified new molecular entities for neglected protozoan disease resea

45 eta-d-glucopyranosylgenistein as a promising molecular entity for intervention in amyloid events of b

46 suggest that the KChIP proteins represent a molecular entity for the observed difference between ara

47 h, that deals with new uses for a well known molecular entity has been used extensively in cancer dru

48 knitted threads of two exclusively different molecular entities have created some really interesting

49 Peptides are important biological molecular entities in biomedical research.

50 ll molecules are able to serve as functional molecular entities in cellular environments.

51 n a simulation using historical data for new molecular entities in oncology from 1990 to 2011, we fin

52 The molecular entities in question are either natural produc

53 The molecular entities in question are either natural produc

54 lication in molecular sorting of two or more molecular entities in solid devices, or become useful as

55 With the growing number of new molecular entities in the pipeline, a fast and direct ch

56 nce is expected to form one dominant, stable molecular entity in solution with well-resolved NMR peak

57 ion in a murine model to determine how these molecular entities influence the development of immunity

58 agonism with the use of 2 discrete, specific molecular entities led to substantial exacerbation of ar

59 In the future new molecular entities may be screened directly in human ES

60 to a failure to generate new propagons, the molecular entities necessary for [PSI(+) ] propagation i

61 Cost estimates for developing new molecular entities (NME) are reaching non-sustainable le

62 The terms new chemical entity (NCE), new molecular entity (NME), new active substance (NAS), and

63 ials of AAs and regular FDA approvals of new molecular entities (NMEs) for oncology indications since

64 ted to the FDA between 2000 and 2012 for new molecular entities (NMEs), which are active ingredients

65 y is accomplished by the self-assembly of 21 molecular entities of four different kinds, one central,

66 l be of particular utility for profiling the molecular entities of heparin materials, as well as for

67 Our knowledge of how the different molecular entities of the cell interact with one another

68 ification, whereby the relationships between molecular entities or classes of entities and their pare

69 ification, whereby the relationships between molecular entities or classes of entities and their pare

70 two Ca(2+) entry pathways represent distinct molecular entities or two different activation mechanism

71 The molecular entities present on a cell or organ transplant

72 Elucidating the molecular entities required for the catalytic activation

73 tion of the myokine irisin, which may be the molecular entity responsible for muscle-bone connectivit

74 ted that endogenous ClC-3 represents a major molecular entity responsible for native VSOACs in cardia

75 n the identification and optimization of new molecular entities selectively targeting ion channels of

76 terprise has always been the creation of new molecular entities, such as pharmaceuticals or polymeric

77 Numerous different molecular entities, such as various crystals, pore-formi

78 We aimed to identify final molecular entities targeted by the autoimmune assault on

79 The conjugation of small molecular entities that capture RCA with high affinity i

80 Macrocycles are molecular entities that display a combination of molecul

81 e been described in different cells, but the molecular entities that mediate polyamine influx and eff

82 rmone Jasmonic Acid (JA) has been shown, the molecular entities that mediate this interaction have ye

83 rade signaling has been elusive, because the molecular entities that propagate Trk receptor tyrosine

84 t group for subsequent derivatization with a molecular entity that comprises the electrolyte.

85 of integrating these hormones into a single molecular entity that offers unique potential for treatm

86 regates proteins, RNA, and DNA into a single molecular entity that selectively destroys invading nucl

87 ed, Egl-10, Pleckstrin (DEP) domain, but the molecular entity that serves as the plasma membrane anch

88 The system consists of three molecular entities: the right-handed and left-handed con

89 The transition from independent molecular entities to cellular structures with integrate

90 binding affinity of multiple ligands on one molecular entity to receptors.

91 polymers (it is unclear if the monomer is a molecular entity tout court) but demonstrate a physical

92 recently, and it is now clear that distinct molecular entities underlie the various electrophysiolog

93 ents of thiophene and fluorene into a single molecular entity was synthesized and characterized.

94 These molecular entities were created by covalently linking tw

95 These molecular entities were synthesized by first covalently

96 We conclude that distinct molecular entities, which are both likely to be derived

97 ion of the multitude of interactions between molecular entities, which in turn is a prerequisite for

98 Sixty-two new molecular entities with a primary oncology indication.

99 that the G-quadruplex grooves can recognize molecular entities with better drug-like and selectivity

100 gmuir's concept of isovalency, in which 'two molecular entities with the same number of valence elect

101 ITI-007 is a new molecular entity with a pharmacologic profile that combi

102 channel Kv1.2, were described to cause a new molecular entity within the epileptic encephalopathies.