ライフサイエンスコーパス: molecular event

1 ne transcription through a series of defined molecular events.

2 ation and progression of a broad spectrum of molecular events.

3 hus important to understand underlying early molecular events.

4 is a complex process involving cellular and molecular events.

5 re often insufficient in examining transient molecular events.

6 d systems-level properties to the underlying molecular events.

7 nomic profiles and can be driven by distinct molecular events.

8 Inspired by these molecular events, a reconstructed ivy-mimetic adhesive c

9 udies define the metabolic, biochemical, and molecular events accompanyingHCCevolution, regression, a

10 ar that trisomy 21 causes Down syndrome, the molecular events acting downstream of the trisomy remain

11 memory process and instead suggest that the molecular events activated initially at recall act to co

12 the visual dark adaptation, the fundamental molecular event after photobleaching of rhodopsin is the

13 Elucidating the precise molecular events altered by disease-causing genetic vari

14 This argued strongly in favor of an isolated molecular event and against a common lymphoid CD19(-) pr

15 mation requires the temporal coordination of molecular events and cellular processes following a lear

16 s critical for understanding the dynamics of molecular events and electric currents that shape physio

17 To better understand the molecular events and explore new pathways responsible fo

18 However, further investigations on molecular events and pathways responsible for developmen

19 nsional tumor biomarker data to identify key molecular events and pathways that are central to an und

20 a more detailed understanding of pathologic molecular events and to identify biomarkers that may hav

21 Our method allows us to track single-molecular events, and it can be extended to work with an

22 ystems-based approach aids in characterizing molecular events, and thereby the cellular pathways that

23 intimately affect various cell responses and molecular events; and this range of mutually reinforcing

24 Finally, we confirm that the same key molecular events are also seen in human radiation dermat

25 thelium in healthy individuals and which key molecular events are defective in patients have been lar

26 on of the original memory, in which critical molecular events are needed to stabilize the memory, or

27 However, the defining molecular events are unknown.

28 precisely follow and measure subcellular and molecular events, are paving the way for a more complete

29 We observed several molecular events associated with acquired resistance, in

30 ted opportunities to understand the earliest molecular events associated with carcinogenesis, enablin

31 arious reproductive tissues and captured the molecular events associated with distinct reproductive p

32 hanges in regulatory sequences, but specific molecular events associated with major morphological tra

33 We compared the molecular events associated with nonopsonized- and opson

34 We also biochemically characterized the molecular events associated with refolding of the metast

35 This study has increased the knowledge of molecular events associated with tendon aging and injury

36 ic activity of CD16.NK-92 cells, we analyzed molecular events at the contact area of these cells expo

37 ction, a bottom-up approach was used to link molecular events at the single-cell level into the event

38 he mTORC1 cascade activation as an important molecular event by which D2R mediates its effects.

39 Together, these molecular events catalyze the genomic instability necess

40 ha-synuclein-rich deposits suggestive of one molecular event causing distinct disease phenotypes.

41 Our understanding of the molecular events contributing to myogenic control of dia

42 tococcus to unravel the nature and timing of molecular events contributing to the emergence, dissemin

43 eir maturation in peripheral organs, but the molecular events controlling maturation are incompletely

44 Similar molecular events could be detected in EPCs isolated from

45 The underlying molecular events could potentially be exploited to enhan

46 on of signal bias is an understanding of the molecular events coupling ligand binding to intracellula

47 d-beta aggregates that initiate a cascade of molecular events culminating in widespread neurodegenera

48 In molecular biology, molecular events describe observable alterations of biom

49 se findings provide further insight into the molecular events dictating species-specific polymerase f

50 hat can also generate hypotheses on specific molecular events disrupted by the variant.

51 It remains unclear, however, whether the molecular events downstream of cGMP involve BK channels

52 highlight yet unidentified insights into the molecular events driving cancer evasive resistance and s

53 The identity of the cells and molecular events driving deleterious calcification of he

54 their control, and thus uncover the specific molecular events driving disease risk.

55 e, CTNNB1 mutations as the likely initiating molecular events driving SN-HPC tumorigenesis, which pla

56 buting to proliferative immortality, but the molecular events driving TERT activation are largely unk

57 for other MFS members, the key residues and molecular events driving transport by Pi:H(+) symporters

58 and phosphorylated at threonine 206-an early molecular event during membrane fusion.

59 A key molecular event during NO-dependent activation of H-NOX

60 nsors toward subcellular FAs to report local molecular events during cancer cell adhesion.

61 Early molecular events during reprogramming involved the activ

62 onsiderable efforts, an understanding of how molecular events during the photocycle, including the re

63 y has played a key role in understanding the molecular events during the transport processes and thei

64 ge, indicating rapid progression of specific molecular events during this period.

65 ly assigned in the classical pathway view of molecular events (e.g. signal transduction).

66 abundant recombination that may be linked to molecular events essential for genome replication, herei

67 Here we identify the molecular events evoked by the HIV coat protein gp120 th

68 at belong to the mevalonate pathway as a key molecular event following CD40-mediated activation of B

69 A series of cellular and molecular events following biomaterial implantation pose

70 owledge, a previously unreported mechanistic molecular event for TGF-beta1-induced metastasis in huma

71 of genes instructs complex morphogenetic and molecular events for heart development.

72 t not following PTC sets in motion cascading molecular events for the acquisition (AMPARs) and subseq

73 A complete understanding of the molecular events governing cytokine expression will prov

74 PSDs is considered as one of the most basic molecular events governing synaptic plasticity in the ne

75 We aimed to determine molecular events governing T cell-derived IL-10 expressi

76 Investigating the temporal behavior of molecular events has been an important subject to unders

77 ic biomarkers and analysis of AKI-associated molecular events; however, most studies have adopted org

78 learned helplessness paradigm and regulates molecular events implicated in the mechanism of action o

79 iously unexplored studies of the dynamics of molecular events, improve uniformity of reactions carrie

80 GRM3 expression is a functionally important molecular event in colon cancer, and that GRM3 is a prom

81 onic increase in Ca(2+) influx is a critical molecular event in homeostatic downscaling of glutamater

82 ed conversion (RT-QuIC) to model the central molecular event in prion disease, the templated misfoldi

83 disease-causing isoform (PrP(Sc)) is the key molecular event in the formation of PrP(Sc) aggregates.

84 , cell-based view of early injury-associated molecular events in AKI and documents a versatile, genet

85 s with long-term aspirin use, the changes of molecular events in AM but not IM may be an important fa

86 Visualization of dynamic functional and molecular events in an unperturbed in vivo environment i

87 Key molecular events in atherogenesis such as oxidative modi

88 We studied early molecular events in axonal degeneration with single-axon

89 mechanistic, and quantitative description of molecular events in bacterial cells.

90 Here I discuss the regulation and molecular events in cancer that are associated with thes

91 rearrangements, which may involve different molecular events in different cells, contribute to a sel

92 hnologies provide useful approaches to study molecular events in different signalling pathways, produ

93 e evaluated whether ketamine elicits similar molecular events in dopaminergic (DA) neurons, known to

94 eral novel insights for our understanding of molecular events in EAC.

95 OTC platform to characterize the underlying molecular events in esophagitis.

96 To further delineate the early molecular events in HD, we performed RNA-sequencing (RNA

97 ly versatile means for sensitive analysis of molecular events in living organisms.

98 maging method that is widely used to explore molecular events in living subjects.

99 ossible to easily visualize the cellular and molecular events in play during nervous system formation

100 al activator input strength in the timing of molecular events in precise accordance with MBT morpholo

101 ed this interaction to identify cellular and molecular events in response to this oomycete, which has

102 Molecular events in signal transduction at the interface

103 should be conceived in terms of cellular and molecular events in specific circuits rather than in ter

104 The earliest molecular events in T-cell recognition have not yet been

105 able to identify a number of potentially key molecular events in the advance of breast cancer to mali

106 o discussing the various inputs and relevant molecular events in the endothelium, we address which ac

107 The molecular events in the iron-C3 pathway represent therap

108 Investigating the detailed molecular events in the Ras-PI3K interaction has been ch

109 temic effects is essential in unraveling key molecular events in the vascular tissue responsible for

110 To comprehensively characterize the molecular events in this dynamic process, we set to dete

111 The ability to record molecular events in vivo would enable monitoring of sign

112 This study reveals novel key molecular events in Wnt signaling: induction of Gsk3beta

113 tal carcinoma evolves through a multitude of molecular events including somatic mutations, epigenetic

114 veral-second timescales but are derived from molecular events, including protein-protein interactions

115 ility to write a stable record of identified molecular events into a specific genomic locus would ena

116 ocus duplications could provide insight into molecular events involved in alpha-synuclein aggregation

117 the past decades, very little is known about molecular events involved in cyst dormancy and hatching,

118 it is therefore important to understand the molecular events involved in HSV-1 entry into this cell

119 Some molecular events involved in initiating emergency granul

120 ated epigenomic approach to characterize the molecular events involved in LPS-induced tolerance in a

121 The molecular events involved in osteoblast dysfunction unde

122 ene expression profiling to characterize the molecular events involved in the multistep process of he

123 le to the host tissue and somehow underlying molecular events involved in tissue repair.

124 MSC (hMSC) delivery formula by investigating molecular events involving hMSCs incorporated in a uniqu

125 also demonstrate that perturbation of a key molecular event known to be critical for effective neutr

126 and experimental strategy that describes the molecular events leading from OPV to virulent strains.

127 uggest that the presence of AIRE can trigger molecular events leading to an altered chromatin landsca

128 a need for early diagnostic tools to detect molecular events leading to cartilage destruction.

129 kines that trigger a cascade of cellular and molecular events leading to extensive migration and infi

130 The molecular events leading to HCC following chronic HCV in

131 The molecular events leading to hormone sorting and secretor

132 both internalization of CdtB and subsequent molecular events leading to intoxication of cells.

133 Although many important details of the molecular events leading to LTP and LTD are known, exper

134 n PSC state and allows new insights into the molecular events leading to naive cell resetting.

135 irst time a comprehensive description of the molecular events leading to substrate/Na+ release to the

136 We have completed a detailed analysis of the molecular events leading to the above response.

137 shedding light on the main physiological and molecular events leading to the selective release of lat

138 Our results suggest that the various molecular events leading to transformation and/or immort

139 of plant innate immunity with a focus on the molecular events linking the circadian clock and defense

140 An array of cellular and molecular events mediate this response to collectively g

141 his organism could unveil novel cellular and molecular events mediated by folate and lead to new ways

142 ulation of focal adhesions (FAs) are crucial molecular events modulating cell adhesion in cancer meta

143 mor growth is well established; however, the molecular events modulating this phenomenon remain elusi

144 We sought to define the minimum molecular events necessary to induce dissemination of ce

145 hasing of the behavioral, developmental, and molecular events needed for the proper coordination of p

146 In this article, we describe the molecular events occurring at the IL-2 promoter leading

147 d MMP13 production we examined the potential molecular events occurring between the rapid, transient

148 among the earliest and most indispensable of molecular events occurring during synaptogenesis.

149 ata contribute to the evolving model for the molecular events occurring early in the T cell activatio

150 ng NK cells and to quantitatively assess the molecular events occurring in multi-cellular clusters of

151 The central molecular event of GSR activation entails aspartyl phosp

152 roaches we determined the precise sequential molecular events of a new estrogen signaling network in

153 However, elucidating the molecular events of AZ assembly in a spatiotemporal mann

154 are consistent with the hypothesis that the molecular events of chromosome morphogenesis are governe

155 etailed structural insights into the initial molecular events of GPCR function that are not easily ac

156 fords a useful means to examine in depth the molecular events of HTLV-1 replication and the mechanism

157 Besides delineating the molecular events of metastasis, this model could also im

158 ed us to observe in real time the individual molecular events of RAG-mediated cleavage.

159 Understanding the molecular events of reproduction requires a system to di

160 ure on the progressions of developmental and molecular events of the embryo.

161 Here, we sought to define the molecular events of this effect in an in vivo mouse inju

162 vitro allosteric activators of CTA1, but the molecular events of this process are not fully character

163 hat couple the hydrolysis of GTP to specific molecular events on the ribosome.

164 ellular events based on integrating discrete molecular events over several time scales.

165 ase Dnmt3b, in Dnmt3a-deficient lymphomas as molecular events potentially responsible for the delayed

166 ed sdaD2 and speA2 genes was the final major molecular event preceding the emergence and rapid interc

167 c alteration of the p53 pathway is a primary molecular event predictive of a high number of subclonal

168 ndrial suppression can also explain numerous molecular events previously not connected.

169 d combinatorial circuit of heparanase-driven molecular events promoting chronic inflammation and rena

170 ) combinations of RNA inputs, and a temporal molecular event recorder that records in the PER transcr

171 blood and lymphatic systems, and adapted for molecular event recording, anomaly detection, drug deliv

172 ypic features imply a role of FA proteins in molecular events regulating cellular homeostasis.

173 pathogenesis of many inflammatory disorders, molecular events regulating mitochondrial activity to co

174 In this Primer, we describe the molecular events regulating oligodendrocyte development

175 ogy is the inciting event driving downstream molecular events related to synaptic activity embedded i

176 tibility to disease; however, the underlying molecular events remain largely unknown.

177 efore, repurposing US9 to track/modify these molecular events represents a valid approach to investig

178 ate the hierarchy and temporal importance of molecular events required for clathrin-coated pit initia

179 Chd5 orchestrates a cascade of molecular events required for histone removal and replac

180 The complex molecular events required for robust regeneration of mat

181 The key molecular events required for the formation of ductal ca

182 Cellular and molecular events responsible for liver stage development

183 The identification of the molecular events responsible for strain emergence, enhan

184 lesion severity is to identify cellular and molecular events responsible for tissue damage and to ma

185 ult slices was used to determine the precise molecular-events sequence responsible for the rapid spin

186 condary insults, accompanying DNA damage and molecular events simultaneously impaired their prolifera

187 hese patients and to identify the downstream molecular events specific to transient vasoconstriction,

188 However, the molecular events subsequent to trypsin activation and th

189 lling evidence indicated that the sequential molecular events such as the synthesis and phosphorylati

190 mania promastigotes revealed that it induced molecular events, such as a loss in mitochondrial membra

191 Three molecular events take place upon encountering a target:

192 cytic deoxyhemoglobin S (HbS) is the primary molecular event that leads to hemolytic anemia in sickle

193 ts in bilayers, and suggest that the initial molecular event that leads to neuronal damage does not i

194 However, the major molecular event that occurs during physiological or path

195 ively, our studies offer novel insights into molecular events that are linked to fibrosis development

196 By focusing on molecular events that change among most mutants and in b

197 The molecular events that characterize postripening grapevin

198 ts depends on understanding the cellular and molecular events that connect innate and adaptive immune

199 However, little is known regarding the molecular events that connect Ras signaling with the cel

200 ssembly intermediates suggests a sequence of molecular events that constitute the pathway by which th

201 equires a comprehensive understanding of the molecular events that contribute to MDD pathophysiology.

202 Recent advances in the understanding of the molecular events that contribute to the development of l

203 sorder; however, little is known about early molecular events that contribute to the pathology of the

204 ptor that regulates T cell function, yet the molecular events that control its expression are largely

205 ficance of Perforin-2 and elucidate critical molecular events that culminate in Perforin-2-dependent

206 However, the intracellular molecular events that culminate in tolerance and functio

207 ies for ovarian cancer and identification of molecular events that determine responsiveness to these

208 er understanding of the complex cellular and molecular events that determine T-cell tolerance.

209 Elucidating the molecular events that distinguish how individual ATGs fu

210 The molecular events that drive hypertrophy decompensation a

211 ing proteins remain unclear, as the specific molecular events that drive neurodegeneration have been

212 The cellular and molecular events that drive the early development of inn

213 egulated by endosomal trafficking of Fz, the molecular events that enable this regulation are not com

214 tfertilization likely initiates a cascade of molecular events that eventually alters stress reactivit

215 dary-structure elements in globular proteins-molecular events that have previously been inaccessible

216 Despite the increasing knowledge of the molecular events that induce the glycolysis pathway in e

217 ntly, little is known about the cellular and molecular events that influence the induction of reconso

218 nt of obesity-related complications, but the molecular events that initiate and propagate such inflam

219 ings provide a new way of thinking about the molecular events that initiate catastrophe.

220 Little is known about the molecular events that initiate mesenchymal stem cells to

221 vide a more complete picture of the chain of molecular events that is triggered when the scanning PIC

222 Despite the importance of Swi1, the molecular events that lead to [SWI(+) ] prionogenesis re

223 The molecular events that lead to B cell lymphoma are only p

224 The molecular events that lead to fibrosis following HCV inf

225 The molecular events that lead to the differentiation of hum

226 yo development involves complex cellular and molecular events that lead to the establishment of three

227 The molecular events that lead to the induction of this phen

228 ts luminal sensor/transducer domain, but the molecular events that lead to UPR activation remain uncl

229 Here, we identify a sequence of molecular events that leads to rapid transcriptional rep

230 However, the upstream molecular events that link cellular stretch to the lengt

231 The molecular events that link NADPH oxidase activation and

232 gene-profiling as a means to determine early molecular events that may dictate pathological processes

233 the airway epithelium may dictate deviating molecular events that may explain the different patholog

234 rrelations between these inputs, and defines molecular events that may underpin complex disease risk.

235 nformation towards gaining insights into the molecular events that mediate allostery.

236 isms of resistance have primarily focused on molecular events that mediate primary or secondary resis

237 nd gain an in-depth understanding of the key molecular events that modulate CKD pathogenesis.

238 The molecular events that occur during UVB-induced skin carc

239 olic signaling networks and the cellular and molecular events that occur in the setting of altered nu

240 However, the molecular events that occur in this process are not well

241 gh the CCR4-NOT deadenylase complex, but the molecular events that occur on target mRNAs are poorly r

242 phy and electron microscopy to elucidate the molecular events that occurred during evolution of this

243 ocytes may provide critical insight into the molecular events that prevent adult myocytes from prolif

244 o be determined before Foxp3 expression; yet molecular events that prime Foxp3(-) Treg precursor cell

245 The upstream molecular events that promote SPP1 expression and activa

246 tumor progression, and shed light on the key molecular events that promote the progression of DCIS to

247 Understanding the molecular events that regulate all these stages requires

248 ction has been well studied, and many of the molecular events that regulate passage of leukocytes out

249 However, little is known about the molecular events that regulate PTEN signaling during lym

250 f the SAC occurs through a series of ordered molecular events that result in recruitment of Mad1:Mad2

251 Understanding the molecular events that take place at the YAP:TEAD interfa

252 Minireview, we discuss how understanding the molecular events that trigger NMD can facilitate strateg

253 However, the early molecular events that trigger the demyelination program

254 We deduce the molecular events that underlie acquisition and transport

255 sequential embryonic stages to decipher the molecular events that underlie bat wing development.

256 del that allows further investigation of the molecular events that underlie MN.

257 The molecular events that underlie the development of the di

258 erties can shed light upon the complexity of molecular events that underpin cellular functioning, the

259 Our understanding of the molecular events that underpin erythrocyte invasion rema

260 d as a progressive effect from an initiating molecular event through biological key events toward the

261 lioma that exhibits common key pro-oncogenic molecular events throughout the latency period of diseas

262 ant to breast cancer, including cellular and molecular events, tissue changes, and factors that alter

263 to efforts to understand the contribution of molecular events to APL cell differentiation, leukemia-i

264 hyperresponsiveness in the absence of other molecular events to induce a homogeneous MPN-like phenot

265 The molecular events triggered by IL-10 in LPS-activated mon

266 IL-13 leads to the activation of STAT6, the molecular events triggered by IL-13 binding to IL-13Ralp

267 These results illustrate the initial molecular event underlying platelet shear sensing and pr

268 upon autophosphorylation at Thr305/306 as a molecular event underlying the threshold shift.

269 Although the precise molecular events underlying alphaSyn aggregation are sti

270 However, the molecular events underlying carcinogenesis and their int

271 Thus, we have catalogued the molecular events underlying cell death induced by CQ in

272 The molecular events underlying cilia dynamics, and particul

273 transitions and offer new insights into the molecular events underlying disease progression.

274 To gain further insight into the molecular events underlying HOXB4-mediated HSC expansion

275 interleukin-6 levels might suggest important molecular events underlying its regulation.

276 e findings highlight the complex and dynamic molecular events underlying mammalian differentiation th

277 osis may afford an innovative target for the molecular events underlying oxidant-induced toxicity.

278 A mechanistic understanding of the molecular events underlying signaling, however, has been

279 Important molecular events underlying specific SAS responses have

280 anscriptome of Sgo1(-/+) mice to examine the molecular events underlying the altered carcinogenesis p

281 led to a step-change in our understanding of molecular events underlying the detection and transmissi

282 curate and noninvasive tracer able to detect molecular events underlying the development of rheumatoi

283 eading to excessive alcohol seeking, but the molecular events underlying the emergence of addictive r

284 ul template for future investigations of the molecular events underlying the exocytotic cascade.

285 pathologies, it is important to uncover the molecular events underlying the regulation of proteasome

286 imparting the regulatory activities and the molecular events underlying the regulatory processes, no

287 ator, providing a platform for investigating molecular events underlying the repair impact of nondiff

288 verse patterning of skin appendages, but the molecular events underlying their specification remain l

289 The molecular events underlying these effects are incomplete

290 However, the molecular events underlying these GNAQ-driven malignanci

291 The molecular events underlying these responses are the acti

292 ns are linked to gene transcription, but the molecular events underlying these structures and how the

293 tamine replacement and depict the cascade of molecular events underlying this process of extensive ch

294 The molecular events underlying this regenerative capacity r

295 Our knowledge of the molecular events underlying type 2 diabetes mellitus-a p

296 ne 47 (Pro47) within p53, an inherently rare molecular event, was required for BAX activation.

297 To elucidate these early molecular events, we incubated mouse beta-cells and isle

298 Understanding the molecular events which promote metastasis is thus critic

299 Understanding of these fundamental molecular events will be necessary to identify novel hos

300 gnal bias offers opportunities for sculpting molecular events, with the promise of better, safer ther