ライフサイエンスコーパス: molecular function

1 and GATOR2, a positive regulator of unknown molecular function.

2 include voids and channels, are critical for molecular function.

3 collection, defined by shared Gene Ontology molecular function.

4 tradeoffs between immunogenic potential and molecular function.

5 ty of highly magnetic handles on cellular or molecular function.

6 s of BLOC-2, a protein complex with no known molecular function.

7 ss species is predictive of sites with known molecular function.

8 such as the target gene or the location of a molecular function.

9 ll maintain their conserved H3K36me3-binding molecular function.

10 icate that cellular source can indeed impact molecular function.

11 e defects, we tested for changes in cell and molecular function.

12 o the PUR family both by fold similarity and molecular function.

13 d into a stable conformation and exert their molecular function.

14 be neutral or weakly disruptive for protein molecular function.

15 ess, seven in cellular component, and six in molecular function.

16 or of purifying selection and, consequently, molecular function.

17 may be involved in the execution of a shared molecular function.

18 vidence from genetic association to specific molecular function.

19 elated disease, diversity, biogeography, and molecular function.

20 gesting a new avenue for active control over molecular function.

21 NA binding and RNA binding were enriched for molecular function.

22 and GATOR2, a positive regulator of unknown molecular function.

23 on TSC2/tuberin with novel insight into the molecular function.

24 y a role in multiple biological processes or molecular functions.

25 s and to study their splicing mechanisms and molecular functions.

26 y structures that are enriched for different molecular functions.

27 ving an excess of coding genes with specific molecular functions.

28 ly might have novel regulatory mechanisms or molecular functions.

29 s, respectively indicative of host-dependent molecular functions.

30 esulting in extraction or control of desired molecular functions.

31 ww.geneontology.org Biological Processes and Molecular Functions.

32 tive proteins in haloarchaea, have different molecular functions.

33 ul way to link disease-associated changes to molecular functions.

34 Do these impact molecular function?

35 targets covered 220 biological processes, 67 molecular functions, 45 cellular components, and 10 KEGG

36 ation may be an important determinant of its molecular functions, a clear understanding of GPS2 diffe

37 in several key aspects, and they have myriad molecular functions across many cellular pathways and pr

38 ct temporal patterns attributable to diverse molecular functions, although the majority of differenti

39 reproduces 48% of cellular component, 41% of molecular function and 41% of biological process GO term

40 We generated the final molecular function and biological process assignments by

41 grees of coverage of the biological process, molecular function and cellular component ontologies, de

42 blishes a benchmark standard for mapping the molecular function and cellular connectivity of the rode

43 ligand-binding sites, prediction of protein molecular function and design of novel drug compounds.

44 effects of combinations of mutations on both molecular function and epitope content.

45 eptibility loci that might subserve a shared molecular function and has experienced selective pressur

46 pite the abundance of work demonstrating the molecular function and identifying binding partners of p

47 actions of a protein can help understand its molecular function and its association with different bi

48 ult, the effect of most genome variations on molecular function and overall fitness remains unknown a

49 rference and an inhibitor to investigate the molecular function and physiological impact of the delta

50 However, its precise molecular function and regulation are not fully understo

51 So far, the molecular function and regulation of ATP13A2 remains und

52 The molecular function and structural action of the dehydrin

53 However, both the molecular function and the disease relevance of the spli

54 leton, yet little is known about its precise molecular function and the effects of IIN mutations.

55 infection, thus providing a link between TCS molecular function and the epidemiology of deadly bacter

56 Our findings establish a direct link between molecular function and the large-scale topology of neuro

57 in proteins to both elucidate mechanisms of molecular function and to develop therapeutic strategies

58 Assessment of molecular functions and biological processes reveals tha

59 which were associated with several important molecular functions and biological processes, including

60 s of CaM-interacting proteins with undefined molecular functions and biological roles.

61 ed proteins were involved in a wide range of molecular functions and cellular processes, and showed d

62 from these mice were extensively analyzed on molecular functions and compared with platelets from a p

63 ive interface for linking compounds to their molecular functions and higher level biological effects.

64 for tissue development, the link between its molecular functions and its roles in any given different

65 Molecular functions and mechanisms implicating SCA genes

66 that regulate downstream cellular processes, molecular functions and protein-protein interactions.

67 ex-related variations in biological process, molecular function, and cellular component ontologies, a

68 protein target-disease, -signaling pathway, -molecular function, and protein-protein interactions enh

69 s in superkingdoms, influence the make up of molecular functions, and enhance organismal complexity b

70 ve by small sets of mutations in genes whose molecular functions appear to be unrelated to each other

71 latory secretory pathway, but details on its molecular function are currently unknown.

72 ted FAIME-derived mechanisms of pathways and molecular functions are comparable to those produced by

73 ontology analysis indicated that their main molecular functions are in nucleotide binding (20.9%), h

74 nes with respect to biological processes and molecular functions are preferentially expressed either

75 ia parasite, but in many cases their precise molecular functions are unknown.

76 A2/FANCD1 to suppress tumorigenesis, but the molecular functions ascribed to them cannot fully explai

77 proteins, however this is the first specific molecular function assigned to any variant of this famil

78 fs (MbI, MbII, MbIIIa and MbIIIb) have had a molecular function assigned to them, but the precise rol

79 tissue units, and biophysical constraints to molecular function associated with these units, to prese

80 Identifying the molecular functions associated with microbiome-plant int

81 otype to normal, which indicates a conserved molecular function between OsRZFP34 and AtRZFP34.

82 ilico methods focusing on the micro level of molecular function can help to understand the macro syst

83 d by mEN are from the biological process and molecular function categories, suggesting that the GO te

84 , anatomies, pathways, biological processes, molecular functions, cellular components, pharmacologic

85 shared 3' untranslated region motifs, and a molecular function collection, defined by shared Gene On

86 Intra-cluster molecular function consistency was examined by analysis

87 to find covariance networks that can predict molecular functions, correlations between profiles of re

88 specially useful for the dissection of actin molecular function due to redundancy and neofunctionaliz

89 Experimental evidence of PB1-F2 molecular function during infection has been collected p

90 ll greatly enhance investigations into their molecular functions during hair follicle morphogenesis.

91 in terms of their contribution to function, molecular functions emerge from the specific interaction

92 tly share common biological processes and/or molecular functions (empirical p = 6e-5 and 0.03 respect

93 llular localization, biological process, and molecular function, enabling functional characterization

94 ical processes, 64 cellular component and 42 molecular functions, enriched in 22 KOG groups, and clas

95 in many different biological activities and molecular functions, especially transcription factors, w

96 This is the first evidence of a molecular function for Bves and NDRG4 proteins within br

97 Our findings define a molecular function for ectopic ATP synthase at the plasm

98 ther, these data reveal a previously unknown molecular function for EWS/FLI, demonstrate a more highl

99 ther, these data reveal a previously unknown molecular function for EWS/FLI, demonstrate a more highl

100 These findings provide a cellular and molecular function for MAGE-L2-TRIM27 in retrograde tran

101 Together, these data expose a molecular function for MbIV and indicate that HCF-1 is a

102 o forms of syndromic deafness and suggests a molecular function for Myosin IIa in auditory organs.

103 bundles of F-actin, providing an unexpected molecular function for septins in cytokinesis.

104 our knowledge, the first demonstration of a molecular function for Sequence Insertion 1 in the beta

105 a role for RagC/D in mTORC1 activation and a molecular function for the FLCN tumor suppressor.

106 Collectively, we identified the first molecular function for the HCMV-encoded orphan UL33 and

107 llular localization, biological process, and molecular function for the human gene and homologs in th

108 There are distinct molecular functions for each Ubl, suggesting divergent b

109 ries of mutant proteins for all of the known molecular functions for eEFSec: GTP hydrolysis, Sec-tRNA

110 However, the exact molecular functions for the four proteins are unknown.

111 No molecular function had been linked to this accessory pro

112 Thus far, no enzymatic activity or precise molecular function has been ascribed to NS5A that is com

113 otein required for myoblast fusion but whose molecular function has been elusive.

114 e proteins, we found that APP1, a gene whose molecular function has been unknown, confers ~30% PAP ac

115 ale studies of their expression dynamics and molecular function have provided conflicting interpretat

116 demonstrated in recent years, the underlying molecular functions have only recently begun to be eluci

117 Their molecular functions, however, were previously unknown, i

118 sion and histone profiling have revealed UTX molecular function in establishing appropriate chromatin

119 symmetry, but a detailed knowledge of their molecular function in instructing cell fates is lacking.

120 However, their molecular function in mammals remains largely unknown.

121 lusters bring together proteins of identical molecular function in more than 97% of the clusters, imp

122 ationship between nanoscale organization and molecular function in real time.

123 Here, we characterized human myosin-18A molecular function in the interaction with nucleotides,

124 tages of mouse limb development and distinct molecular functions in different tissue compartments.

125 the role of FANCJ in genomic stability, its molecular functions in G4 metabolism were examined.

126 schizophrenia candidate genes with specific molecular functions in neurons, which could be used to e

127 s known about how the parasite performs most molecular functions in such different environments.

128 To shed light on Tob1 molecular functions in the immune system, we have conduc

129 n while Eukarya acquired a number of diverse molecular functions including those involved in extracel

130 l and appeared to affect a broad spectrum of molecular function, including hotspots at paralogous res

131 were associated across several categories of molecular function, including mitochondria integrity mai

132 -CFC proteins have been described, but their molecular functions, including how the mammalian homolog

133 in a wide range of biological processes and molecular functions, including three pathogenesis-relate

134 er, these proteins appear to harbor opposing molecular functions, indicating that they may act indepe

135 Remarkably, we find that the emergence of molecular functions induces hierarchical modularity and

136 ultifunctionality is defined with respect to molecular functions instead of biological processes.

137 hat act in a migrating cell, identify unique molecular functions involved in nematode cell migration,

138 been implicated in assembly but ascribing a molecular function is confounded by the observation that

139 nization in nonadipose tissues; however, its molecular function is incompletely understood.

140 esponse to and repair of DNA damage, but its molecular function is not clear.

141 Nevertheless, its molecular function is not completely understood, and its

142 actor EWS-FLI1 drives Ewing sarcoma, but its molecular function is not completely understood.

143 de regulation of replication timing, but its molecular function is poorly understood.

144 Molecular function is revealed from analysis of the crys

145 d in many aspects of plant biology but their molecular function is still unclear.

146 e associated with centrioles, although their molecular function is unclear.

147 actors are known to regulate this, and their molecular function is unclear.

148 mbers of the Velvet family of proteins whose molecular function is unknown.

149 lopment in vertebrates; however, its precise molecular function is unknown.

150 hanism by which O3-derived oxysterols affect molecular function is unknown.

151 n recognize m(6)A marks and are mediators of molecular functions like RNA splicing, mRNA decay, and t

152 on of Kcnq1 and Scn10a and suggest that this molecular function may underlie pathophysiology associat

153 of missense mutations that focus on specific molecular functions may be increasingly useful for the p

154 ese results indicate that genes with similar molecular functions may have distinct genetic roles in d

155 This is the first report suggesting a molecular function not yet described for Gal-3 as the re

156 The biogenesis and molecular function of 21U-RNAs and piRNAs are poorly und

157 We investigated the molecular function of a chloroplastic NFU-type iron-sulf

158 To gain a better understanding of the molecular function of A6, we established a HeLa cell lin

159 Thus, the work presented here links the molecular function of Bicc1 in mRNA target-specific tran

160 We investigated the molecular function of C2 calcium-dependent domain contai

161 Strikingly, the molecular function of Cerberus remains poorly understood

162 However, the orientation and therefore the molecular function of chloroplast Toc75 POTRA domains re

163 Here we report the 2.1 A X-ray structure and molecular function of ClbS, a gene product that confers

164 To elucidate the molecular function of CLYBL, we used comparative operon

165 The molecular function of coilin, which is intrinsically dis

166 with observations in neurons [8, 9] and the molecular function of DCX is not well understood, we rev

167 Thus, our study characterizes the molecular function of Dph7 for the first time and provid

168 The molecular function of enzymes is defined as their abilit

169 The molecular function of Erv14 thus remains unclear, with p

170 The molecular function of Fam65b and whether misregulation o

171 Moreover, these findings reveal a specific molecular function of free basal intracellular Mg(2+) in

172 Deep characterization of molecular function of genetic variants in the human geno

173 Our work reveals the molecular function of Hh signaling in extrinsic sheath t

174 eview discusses our current knowledge of the molecular function of IFN-inducible GTPases in providing

175 The molecular function of ISCA1 and ISCA2 proteins, i.e., ho

176 We analyzed the molecular function of JUNB in experimental models of hep

177 rein, we report the genome-wide location and molecular function of LRH-1 in breast cancer cells and r

178 pendent nucleosome remodeling is the primary molecular function of Lsh, which may promote de novo met

179 The identification of this clear molecular function of Matrin3 should help to clarify the

180 Our findings elucidate an important molecular function of Merlin and highlight the plasma me

181 rous vacuole (PV) of T. gondii; however, the molecular function of mGBP2 and its domains in T. gondii

182 Nevertheless, the molecular function of MOZART1/Mzt1 is largely unknown.

183 etastasis in a tumor type, and second, which molecular function of MSG controls metastasis.

184 ting mitotic MT generation in flies, but the molecular function of Mst remains unknown.

185 The molecular function of nematode effectors is currently th

186 prosurvival signaling pathways post-IR, the molecular function of NF-kappaB with other key elements

187 ABSTRACT: The molecular function of non-muscle (NM) isoforms of myosin

188 However, the molecular function of other Dkks remains largely unknown

189 The molecular function of Pex11, however, is not known.

190 However, the molecular function of PLAC8 remained unclear, and accumu

191 The molecular function of PNUTS in these processes is comple

192 We have uncovered the molecular function of protein domain family domain of un

193 ype PPR proteins can help in elucidating the molecular function of proteins encoded in the organellar

194 Here, we characterize the cellular and molecular function of REP34, a REP protein with a mass o

195 To unravel the molecular function of RPGRIP1L, we analyzed Rpgrip1l(-/-

196 icated in many cellular functions, the exact molecular function of RVB proteins in the various comple

197 The molecular function of Sam37 has been unknown.

198 Thus, we identify a novel molecular function of Sirt7 as a negative regulator of H

199 yo2 smy1 conditional mutants, we uncover the molecular function of Smy1 as a factor that enhances the

200 er, our data provide support for a conserved molecular function of TCF7L1 as a transcriptional repres

201 ly control these activities, how they affect molecular function of the active center during terminati

202 ined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC

203 nnel signaling, advance our knowledge of the molecular function of the CRAC channel, and suggest new

204 Characterization of the molecular function of the human genome and its variation

205 ater channel is an important feature for the molecular function of the membrane part of F(1)F(o)-ATP

206 This study uncovers the molecular function of the natural variant, TZP (Tandem Z

207 ovide the first mechanistic insight into the molecular function of the previously orphan clock factor

208 We characterized the molecular function of the Pseudomonas syringae pv. tomat

209 for class switch recombination (CSR), but no molecular function of the transcripts has been described

210 synchronous regulation of Hox genes and the molecular function of their colinearity remain unknown.

211 organization of the plasma membrane, but the molecular function of their major protein subunits, the

212 iated via GABAB receptors (GABABRs), but the molecular function of these receptors in cognition is il

213 analysis provides the first insight into the molecular function of this cell type in C3 species, and

214 patic differentiation was identified and the molecular function of this factor was examined in embryo

215 oxylate side chain are unable to explain the molecular function of this mutant.

216 act to shape these structures; however, the molecular function of this protein is not yet resolved.

217 However, the molecular function of this virulence determinant was unc

218 the biogenesis of the respiratory chain, the molecular function of twin Cx9C proteins is largely unkn

219 This is the first report of a molecular function of zygote arrest proteins.

220 e specificity beyond the LXXLL motif and the molecular functioning of flanking residues still require

221 The molecular functions of brain gangliosides include regula

222 ene expression patterns in leukemic cells to molecular functions of defined transcription factors in

223 neurotransmitter receptors through distinct molecular functions of differentially localized proteoly

224 tribute to tendon repair, but the origin and molecular functions of extrinsic tissues in tendon repai

225 To understand the molecular functions of FTO, we performed a yeast two-hyb

226 can be used to successfully investigate the molecular functions of genes inE.

227 To study the molecular functions of hnRNPLL at a genome-wide level, w

228 These results identify novel molecular functions of Hox genes in the development of t

229 This study investigates the molecular functions of human FRG1, along with mouse FRG1

230 This enabled us to dissect the molecular functions of intracellular and extracellular L

231 Despite their abundance, the molecular functions of long non-coding RNAs in mammalian

232 bunits (Rpt1-6) in the cellular assembly and molecular functions of mammalian 26 S proteasome.

233 s over the past two decades to elucidate the molecular functions of MeCP2, the mechanisms underlying

234 The molecular functions of most of the factors that have bee

235 ment and physiology have been described, but molecular functions of mTERF proteins in plants are unkn

236 Here we compare the molecular functions of Myf5 and MyoD, two highly related

237 update on recent progress in elucidating the molecular functions of nematode effectors.

238 Here, we dissected the molecular functions of NKX2-1 by defining its chromosoma

239 Together these findings identify the molecular functions of PAXX in KU accumulation at DNA en

240 ovide powerful strategies for modulating the molecular functions of proteins in mammalian cells.

241 on with HuR and provide new insight into the molecular functions of RBPs in the regulation of intesti

242 impact of this accelerated evolution on the molecular functions of retained paralogs.

243 Dissecting the molecular functions of Rif1 is essential to understand h

244 Here we describe two molecular functions of RVBs in TIP60.com.

245 The diverse molecular functions of SR45 uncovered in this study are

246 To gain insight into the molecular functions of synucleins, we performed an unbia

247 To elucidate the molecular functions of the ATG8 proteins, we engineered

248 In this study, we investigated the molecular functions of the BacL1 and BacA proteins.

249 Nevertheless, the molecular functions of the greatest number of miRNA gene

250 However the molecular functions of the Hps1-Hps4 complex BLOC-3 rema

251 mammalian cells but we know little about the molecular functions of the majority of these.

252 phenotypes and provide new insights into the molecular functions of the two protein families.

253 hair-cell mechanotransduction; however, the molecular functions of these and other TMC proteins have

254 To dissect the molecular functions of this domain, we generated a serie

255 the essential substrates of enzymes, and the molecular functions of uncharacterized proteins.

256 Methods optimized to capture effects upon molecular function often correctly predict human (OMIM)

257 otations for both the Biological Process and Molecular Function Ontology.

258 uclear protein but little is known about its molecular function or the cell types responsible for SMS

259 y comparison, very little is known about the molecular functions or physiological roles of PTBP3, alt

260 owever limited in scope to either individual molecular functions or were concerned with functional ef

261 ciated with a particular biological process, molecular function, or cellular component are over- or u

262 ER is a state-of-the-art sequence-based gene molecular function prediction algorithm that uses a stat

263 Most current methods perform well on molecular function prediction, but struggle to provide u

264 In line with previous studies, we find that molecular function predictions are more accurate than bi

265 e Curve (AUC) accuracy of Gene Ontology (GO) molecular function predictions of 0.728 when 7,412 human

266 ments of each given sample into pathways and molecular function profiles that can be applied to analy

267 arious types of experimental data, including molecular function, protein structure, and associated ph

268 conserved developmental regulators, but the molecular function provided by the regions flanking the

269 tivity of a gene cannot be defined simply as molecular function; rather, it is a consequence of spati

270 esponse signatures for 87 endpoints covering molecular functions relevant to toxic and therapeutic pa

271 e glycans, questions regarding their precise molecular function remain unanswered.

272 entional T-cell development, but its precise molecular function remains elusive.

273 in prokaryotes; except for cystinosin, their molecular function remains elusive.

274 iology, notably diabetes and cancer, but its molecular function remains poorly characterized.

275 teins are conserved in eukaryotes, but their molecular function remains unknown.

276 is required for B cell development, but its molecular function(s) in B cell fate specification and c

277 id dendritic cell (pDC) development, but its molecular function(s) in early B cell fate specification

278 These facilitate complex associations of molecular function, structure and evolution.

279 rk neighborhoods, and exhibit enrichment for molecular functions such as xylan metabolism and cell wa

280 Molecular function, such as binding and catalysis, howev

281 0.71 and 0.64 respectively for gene ontology molecular function terms.

282 mporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive

283 WRM-1 exhibits two independent and distinct molecular functions that are novel for beta-catenins: WR

284 ting the key viral target proteins and their molecular functions that can be used in drug design, as

285 a result of mutations in genes with multiple molecular functions, they appear to converge on common b

286 rithm can leverage knowledge of cellular and molecular function through biosimulation to propose clea

287 implement a diverse range of tissue-specific molecular functions throughout development and into adul

288 earlier work that suggested some links from molecular function to disease.

289 genesis, this work provides evidence pairing molecular function to physical structure for processes f

290 However, the leap from the micro level of molecular function to the macro level of the whole organ

291 data provide a principled means of assigning molecular functions to autoimmune and cardiovascular dis

292 overy of primordial proteins, cofactors, and molecular functions using phylogenomic information in th

293 To explore its molecular function, we determined a 2.2 A-resolution cry

294 To gain insight into FRMD7 molecular function, we used an IP-MS approach and identi

295 ith cancer susceptibility and studying their molecular functions, we hope to help the interpretation

296 however, the resulting perturbations on Gle1 molecular function were unknown.

297 re genes with similar expressions or similar molecular functions were grouped together.

298 des an effective strategy for modulating its molecular function within the nuclear compartment.

299 ubiquitination, their interactors and their molecular function within the regulatory context.

300 r evolution has focused on the divergence of molecular functions, yet we know little about how struct