ライフサイエンスコーパス: molecular mimicry

1 iruses bearing homologues of self peptides ("molecular mimicry").

2 crobial epitopes, consistent with neoantigen molecular mimicry.

3 lation) act to limit autoimmune disease from molecular mimicry.

4 ctivation of autoimmune T cells may occur by molecular mimicry.

5 proving the occurrence of infection-induced molecular mimicry.

6 miting the risk of autoimmune disease due to molecular mimicry.

7 D.radiodurans revealed striking examples of molecular mimicry.

8 a second characteristic of these systems of molecular mimicry.

9 self-reactive lymphocytes via the process of molecular mimicry.

10 multiple sclerosis (MS) potentially through molecular mimicry.

11 couples infection with autoimmune disease is molecular mimicry.

12 result of a virus infection, in part through molecular mimicry.

13 of viruses in the genesis of autoimmunity is molecular mimicry.

14 yptic self-epitopes, antigen persistence and molecular mimicry.

15 stigations are centered on the hypothesis of molecular mimicry.

16 cur by either bystander T-cell activation or molecular mimicry.

17 ing pathogens subvert this mechanism through molecular mimicry.

18 n-I (beta2GPI) and thus can induce antiCl by molecular mimicry.

19 g that their initial priming could occur via molecular mimicry.

20 t Toll-like receptor (TLR) signaling through molecular mimicry.

21 s possible triggering factors of ITP through molecular mimicry.

22 en it and self-AQP4 was observed, supporting molecular mimicry.

23 ed mechanisms with the most postulated being molecular mimicry.

24 uned structural instability and coupled with molecular mimicry.

25 tability changed in a manner consistent with molecular mimicry.

26 main, which may represent an unusual form of molecular mimicry.

27 tochondrial Ag or a similar breakdown due to molecular mimicry.

28 crossreactivity can occur in the absence of molecular mimicry.

29 ct with self-peptides, a phenomenon known as molecular mimicry.

30 This surprising case of molecular mimicry (1) shows a key potential selective ad

31 l T cell-mediated autoimmune disorders, with molecular mimicry a likely mechanism.

32 In an unusual example of molecular mimicry, a negatively charged surface on this

33 e potential of virus-induced autoimmunity by molecular mimicry, a nonpathogenic neurotropic Theiler's

34 g a host inhibitory receptor via sialoglycan molecular mimicry, a novel mechanism of bacterial immune

35 infectious agent can, through the process of molecular mimicry, also recognize healthy cells.

36 individuals with type 2 disease may reflect molecular mimicries and cross-reacting autoantibodies.

37 ultaneously in the interface, not limited to molecular mimicry and CDR loop shifts.

38 hat r(UNCG) and r(GNRA) hairpin families use molecular mimicry and electrostatic factors to attain ex

39 Molecular mimicry and engagement of TLRs have been assig

40 icrobial proteins as possible substrates for molecular mimicry and for the identification of possible

41 Here, we discuss the theory of molecular mimicry and its continued evolution from the i

42 iation of autoimmunity by mechanisms such as molecular mimicry and more toward activation of an intri

43 Here, we examine the relative roles of molecular mimicry and nonspecific inflammatory stimuli i

44 rgues against ZnT8 autoimmunity arising from molecular mimicry and suggests a mechanistic link betwee

45 elopment of autoimmunity, which are based on molecular mimicry and/or the bystander effect, and sugge

46 The process termed "molecular mimicry' and the use of transgenic models in w

47 itope spread or drift, the bystander effect, molecular mimicry, anti-idiotype theory, antigenic compl

48 er than viral antigen recognition, and hence molecular mimicry, are at play and are sufficient to cau

49 nd is tRNA-like, suggesting the IRES employs molecular mimicry as a functional strategy.

50 tating the Esc1-Sir4 interaction and suggest molecular mimicry as a general mechanism that enables mo

51 (LOSs) of GBS-inducing microbes, suggesting molecular mimicry as a mechanism for disease induction.

52 Several studies support molecular mimicry as a mechanism for the involvement of

53 induces protective CD8+ T cells, identifying molecular mimicry as a mechanism to enforce tolerance in

54 afficking pathway, suggests the co-option of molecular mimicry as a strategy for achieving its functi

55 ity of an infectious etiology for PBC and of molecular mimicry as an etiologic mechanism.

56 Molecular mimicry as evidenced in these two stable but o

57 dimers formed by risk haplotypes, supporting molecular mimicry as the key mechanism of RHD pathogenes

58 cross-reactive T-cell recognition, known as molecular mimicry, as well as bystander T-cell activatio

59 For example, molecular mimicry between a dominant T-cell epitope of B

60 These data demonstrate the importance of molecular mimicry between an infecting agent and hnRNP-A

61 Because of the immunologic molecular mimicry between bacterial and human HSP60, it

62 l autoimmunity in human lupus arises through molecular mimicry between EBNA-1 and lupus autoantigens

63 These studies show molecular mimicry between epitopes of oxLDL and S. pneum

64 Molecular mimicry between foreign and self Ags is a mech

65 enesis of most human autoimmune diseases and molecular mimicry between foreign and self ligands has b

66 s that probably reflect referral biases, and molecular mimicry between foreign and self-antigens is t

67 is unknown, but autoimmunity resulting from molecular mimicry between gliadin and nervous system pro

68 remains speculative, but the possibility of molecular mimicry between glycosylated flagellin and euk

69 Studies that have demonstrated molecular mimicry between Helicobacter pylori and consti

70 The results suggest that molecular mimicry between HLA-B27-restricted bacterial a

71 amples of postinfectious autoimmunity due to molecular mimicry between host and pathogen.

72 Molecular mimicry between human and GAS proteins trigger

73 Molecular mimicry between immunodominant autoepitopes an

74 Molecular mimicry between pathogen and host causes furth

75 arditis, may be autoimmunity mediated due to molecular mimicry between the bacterium Borrelia burgdor

76 Most models focus on issues of molecular mimicry between the E2 subunit of the pyruvate

77 Molecular mimicry between viral and self antigens could,

78 ct of eliminating a sequence responsible for molecular mimicry between virus and host.

79 ity between TMEV and self epitopes (that is, molecular mimicry), but because of de novo priming of se

80 , as well as substantiating evidence for the molecular mimicry by beta-lactam antibiotics of the pept

81 Group A Streptococcus (GAS) employs molecular mimicry by direct interactions between the cel

82 Thus, molecular mimicry by HIV-1 Env that promotes the evasion

83 coding TMEV serves as an excellent model for molecular mimicry by inducing pathologic myelin-specific

84 We developed an infectious model of molecular mimicry by inserting a sequence encompassing t

85 xtracellular matrix, we investigated whether molecular mimicry by the GAS hyaluronic acid capsule mig

86 The results also suggest a mechanism (molecular mimicry) by which pathogenic aPL may be genera

87 Overall, these findings help clarify how molecular mimicry can drive self/nonself cross-reactivit

88 scribed previously, provide evidence for the molecular mimicry concept.

89 -antigens during inflammatory responses, and molecular mimicry contribute to the initiation of autoan

90 A humoral immune response predicated on molecular mimicry could explain persistent or ongoing ne

91 haring antigenic epitopes with CNS antigens (molecular mimicry) elicits a virus-specific immune respo

92 ell responses, humoral fine specificity, and molecular mimicry evidence for differences between syste

93 d the need for regulatory devices to prevent molecular mimicry from progressing to autoimmune disease

94 This novel molecular mimicry function of Vpr might lead to its pote

95 In an example of molecular mimicry, globomycin appears to inhibit by acti

96 Furthermore, because molecular mimicry has been postulated as a possible caus

97 Molecular mimicry has been proposed as a pathogenetic me

98 Molecular mimicry has been suggested to play a role in t

99 This may indicate that molecular mimicry has occurred, because several pathogen

100 Our results cast doubt on the molecular mimicry hypothesis as an explanation for the p

101 T cell cross-reactivity underpins the molecular mimicry hypothesis in which microbial peptides

102 The present report reevaluates the molecular mimicry hypothesis to explain HSK pathogenesis

103 One of these, the molecular mimicry hypothesis, postulates that myelin-rea

104 lines of evidence also failed to support the molecular mimicry hypothesis, such as the failure to aff

105 er jejuni, are discussed in the context of a molecular mimicry hypothesis.

106 in pathway and a framework for understanding molecular mimicry in bacterial pathogenesis.

107 The data provide a mechanistic framework for molecular mimicry in Graves' disease, where early precur

108 These data provide strong support for molecular mimicry in HIV-1-immunologic thrombocytopenia

109 Consistent with the idea of molecular mimicry in protein interactions, RidL outcompe

110 The theme of molecular mimicry in streptococcal autoimmune sequelae i

111 two molecules and raises the possibility of molecular mimicry in the pathogenesis of Graves' disease

112 We have proposed a mechanism of molecular mimicry in which Abs against DENV nonstructura

113 of the function of the immune response and 'molecular mimicry' in the CB-3-induced autoimmune myocar

114 r understanding of the mechanisms underlying molecular mimicry-induced CNS autoimmunity.

115 complete Freund's adjuvant, indicating that molecular mimicry-induced disease initiation requires vi

116 trains in patients with SSc, and evidence of molecular mimicry inducing autoimmune responses suggest

117 This provides structural evidence for molecular mimicry involving HLA molecules.

118 Molecular mimicry is a possible explanation for autoimmu

119 Molecular mimicry is characterized by an immune response

120 For our purpose, molecular mimicry is defined as similar structures share

121 Molecular mimicry is implicated in the pathogenesis of a

122 These findings also suggest that bacterial molecular mimicry is not involved in initiating disease.

123 ther autoimmune diseases, microbial mediated molecular mimicry is the most widely studied trigger tha

124 Molecular mimicry is the process by which T cells activa

125 Molecular mimicry is the process by which virus infectio

126 study represents the first example of direct molecular mimicry leading to clinically relevant fatal t

127 GBS evolved to display CPS Sia as a form of molecular mimicry limiting the activation of an effectiv

128 Toward deciphering the structural basis of molecular mimicry, mAb 2D10 was isolated from a maturing

129 Molecular mimicry manifests antagonistically with respec

130 In a process called molecular mimicry, many bacterial pathogens decorate the

131 Our finding also supports the thesis that molecular mimicry may be implicated in the initiation of

132 Molecular mimicry may be important in breaking self-tole

133 This study documents that molecular mimicry may play a role in stability and organ

134 Autoimmunity based on molecular mimicry may play a role in the pathogenesis of

135 g that epitope spreading may occur through a molecular mimicry mechanism.

136 Recent studies have shown additional molecular mimicry mechanisms between early events in lup

137 findings contribute to the tracing of novel molecular mimicry mechanisms employed by pathogenic viru

138 ase antibody and RRV proteins indicates that molecular mimicry might activate humoral autoimmunity in

139 The molecular mimicry model proposes that the tip of domain

140 A commonly proposed model (the molecular mimicry model) used to explain TCR cross-react

141 en EF-G and the ribosome are consistent with molecular mimicry models for EF-G function.

142 Molecular mimicry occurs when T cells specific for pepti

143 Tyr residues to binding as well as striking molecular mimicry of a maltose-binding protein substrate

144 Molecular mimicry of chemokine ligands has been describe

145 Molecular mimicry of cytokines and cytokine receptors is

146 effector of Legionella pneumophila exhibits molecular mimicry of eukaryotic F-box proteins and is es

147 receptors evolved as a response to pathogen molecular mimicry of host ligands for inhibitory recepto

148 d that HDMs modulate the immune response via molecular mimicry of host molecules.

149 Molecular mimicry of host proteins by pathogens can lead

150 Molecular mimicry of human antigens related to RA was al

151 Cancer cell molecular mimicry of stem cells (SC) imbues neoplastic c

152 Molecular mimicry of TAC by peptides is an alternative a

153 gs shed light on the structural basis of the molecular mimicry of the chemokine function by a pathoge

154 nteraction surface is extensive and involves molecular mimicry of the DNA substrate.

155 The possible molecular mimicry of the Epstein-Barr virus (EBV) peptid

156 However, molecular mimicry of the lipooligosaccharide (LOS) of mo

157 e S. flexneri utilizes a remarkable level of molecular mimicry of the talin-vinculin interaction to a

158 Remarkably, this occurs through molecular mimicry of the vinculin-talin interaction that

159 e proteins likely associated with microbial "molecular mimicry" of host characteristics and involved

160 lf Ags may represent a mechanism by which Ag molecular mimicry operates.

161 he allogeneic molecule itself either through molecular mimicry or by novel pMHC binding modes.

162 cination, pointing towards processes such as molecular mimicry or bystander activation as crucial for

163 tion of hypocretin producing neurons include molecular mimicry or bystander activation, and are likel

164 are not paraneoplastic, and are triggered by molecular mimicry or unknown mechanisms.

165 These observations suggest that although molecular mimicry plays a pivotal role in initially trig

166 unodominant epitope of tax and suggests that molecular mimicry plays a role in the pathogenesis of HA

167 for advancing our understanding of the role molecular mimicry plays in the induction of autoimmunity

168 he role that mycoplasma adhesins may play in molecular mimicry, postinfectious autoimmunity, and immu

169 Molecular mimicry refers to structural homologies betwee

170 nd specificity, but the structural basis for molecular mimicry remains unclear.

171 Molecular mimicry, resulting from structural similaritie

172 cts of autoimmunity: the mechanism of T cell molecular mimicry; T-->B epitope spreading, as a basis f

173 cious "pseudonormal" phenotype, may enable a molecular mimicry that allows metastasizing tumor cells

174 gical processes and provides a blueprint for molecular mimicry that drives drug discovery.

175 Molecular mimicry, the sharing of epitopes among self an

176 The molecular mimicry theory has become a dominant paradigm

177 The molecular-mimicry theory proposes that immune crossreact

178 ella flexneri and Listeria monocytogenes use molecular mimicry to create their own actin-based motors

179 neumoniae disables neutrophils by exploiting molecular mimicry to degrade platelet-activating factor

180 By applying the concept of molecular mimicry to identify potential CD8 T-cell epito

181 To study the potential of virus-induced molecular mimicry to initiate autoimmune demyelination,

182 ype 1 diabetes but do not support a role for molecular mimicry to insulin in the pathogenesis of this

183 obacteria, small non-coding RNAs (sRNAs) use molecular mimicry to sequester multiple CsrA dimers away

184 the effects of direct infection by means of molecular mimicry to tissue autoantigens.

185 e historic background of clonal deletion and molecular mimicry, two major pillars underlying our pres

186 Ternary structures showed that induced-fit molecular mimicry underpins TRAV27/TRBV19(+)TCR specific

187 We propose that rather than simple molecular mimicry, unpredictable arrays of common and di

188 Molecular mimicry was sought by screening a phage peptid

189 y processes underlying the phenomenon of Sia molecular mimicry, we performed phylogenomic analyses of

190 As a model for molecular mimicry, we studied patients with human T-lymp

191 Thermodynamic contributions of this molecular mimicry were investigated using substitutions

192 If molecular mimicry were not common, protective adaptive i

193 immunity can in many cases be attributed to "molecular mimicry", where linear peptide epitopes, proce

194 gger lupus through structural and functional molecular mimicry, whereas the accumulation of ERV-deriv

195 S1 can induce Plg cross-reactive Abs through molecular mimicry, which can enhance Plg activation and

196 , B cells may trigger autoimmune disease via molecular mimicry, which occurs when a single B-cell rec

197 The etiology of PBC is unknown, although molecular mimicry with bacterial PDC has been proposed.

198 EBV antigens exhibit structural molecular mimicry with common SLE antigens and functiona

199 icry with common SLE antigens and functional molecular mimicry with critical immune-regulatory compon

200 ell responses, humoral fine specificity, and molecular mimicry with EBV, further supporting potential

201 re envelope 1 can induce thrombocytopenia by molecular mimicry with GPIIIa49-66.

202 DL immunoglobulin M (IgM) antibodies, due to molecular mimicry with oxLDL.

203 al foreign antigen for anti-Ro autoimmunity, molecular mimicry with regard to La and CCHB, as well as

204 re of one such cationic molecule suggested a molecular mimicry with spermine, a ubiquitous endogenous